GANIFU-Card: Follow-up of GANI_MED Cardio Cohorts
Study Details
Study Description
Brief Summary
Follow-up of two hospital-based patient cohorts (heart failure, metabolic comorbidities in CVD), recruited at baseline by the GANI_MED-project (Greifswald Approach to Individualized Medicine). Standardized protocols will be used for the assessment of medical history, laboratory biomarkers, and the collection of various biosamples for bio-banking purposes. Comparisons with the general background population will be performed.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Detailed Description
5-year follow-up of two hospital-based patient cohorts (heart failure, metabolic comorbidities in CVD), recruited at baseline by the GANI_MED-project (Greifswald Approach to Individualized Medicine). Subjects will be comprehensively phenotypes using standardized protocols for the assessment of medical history, laboratory biomarkers, and the collection of various biosamples for bio-banking purposes. A multi-omics based biomarker assessment including genome-wide genotyping, transcriptome, metabolome, and proteome analyses complements the multi-level approach of GANI_MED. Comparisons with the general background population as characterized by the Study of Health in Pomerania (SHIP) will be performed.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Heart Failure Patients with chronic heart failure and with/without reduced left ventricular ejection fraction (EF) at baseline (HFrEF, HFmrEF, HFpEF) |
Other: no intervention, only observational
no intervention, only observational
|
Cardiometabolic risk Patients with cardiovascular diseases and metabolic risk factors at baseline |
Other: no intervention, only observational
no intervention, only observational
|
Outcome Measures
Primary Outcome Measures
- Cardiovascular events [1-year follow-ups]
Hospitalization (HF based. all-cause), myocardial infarction
Secondary Outcome Measures
- VO2peak [1-year follow-ups]
Exercise capacity by CPET
- QOL [1-year follow-ups]
Quality of life by questionnaire (Minnesota Living with heart failure questionnaire)
- 6MW [1-year follow-ups]
6 minute walk test distance
- LVEF [1-year follow-ups]
Left ventricular ejection fraction by echo at time of follow-up
Other Outcome Measures
- PWA [1-year follow-ups]
pulse wave analysis parameters by Vascular Explorer device (neverdis GmbH, Germany)
Eligibility Criteria
Criteria
Inclusion Criteria:
- Participation in baseline examination of GANI_MED cohorts (heart failure, metabolic risk)
Exclusion Criteria:
- none
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Department of Internal Medicine B, University Medicine Greifswald | Greifswald | MV | Germany | 17475 |
Sponsors and Collaborators
- University Medicine Greifswald
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
- GANIFU-C-001