Testing the Effects of Early Treatment With Venetoclax and Obinutuzumab Versus Delayed Treatment With Venetoclax and Obinutuzumab for Newly Diagnosed Patients With High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Who Do Not Have Symptoms, the EVOLVE CLL/SLL Study
Study Details
Study Description
Brief Summary
This phase III trial compares early treatment with venetoclax and obinutuzumab versus delayed treatment with venetoclax and obinutuzumab in patients with newly diagnosed high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Immunotherapy with monoclonal antibodies, such as obinutuzumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Starting treatment with the venetoclax and obinutuzumab early (before patients have symptoms) may have better outcomes for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma compared to starting treatment with the venetoclax and obinutuzumab after patients show symptoms.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Detailed Description
PRIMARY OBJECTIVE:
- To evaluate whether early treatment with venetoclax and obinutuzumab (V-O) extends overall survival (OS) compared with delayed treatment with V-O in high-risk (Chronic Lymphocytic Leukemia [CLL] International Prognostic Indicator [CLL-IPI] >= 4 or complex cytogenetics), newly diagnosed asymptomatic CLL/small lymphocytic lymphoma (SLL) patients.
SECONDARY OBJECTIVES:
-
To compare overall response rates (complete response [CR] + partial response [PR]), CR rates, progression-free survival (PFS), and event-free survival (EFS) between arms.
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To evaluate safety and tolerability of each arm. III. To compare time to second CLL-directed treatment (from randomization and from response) between arms.
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To compare relapse-free survival (RFS) and time to second objective disease progression (PFS2) between arms.
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To compare the rates of Richter's transformation between arms. VI. To describe distribution of Cumulative Illness Rating Scale across the study, in each treatment arm, and to estimate the interaction between the scale and treatment arm and OS.
PATIENT-REPORTED OUTCOMES OBJECTIVES:
-
To assess the impact of early intervention with V-O versus delayed therapy with V-O in CLL patients in relation to Health-Related Quality of Life (HRQoL) using the Functional Assessment of Cancer Therapy (FACT)-Leukemia scale.
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To assess the impact of the two treatment arms on the specific domains of the FACT-Leukemia, including physical, social, emotional, and functional well-being and leukemia-specific HRQoL.
TRANSLATIONAL MEDICINE OBJECTIVES (INTEGRATED):
- To evaluate the prognostic association between OS and measurable residual disease (MRD) undetectable disease state at 15 months after treatment initiation, across and between treatment arms. (Primary) II. To describe the prognostic association between the endpoints RFS and OS and MRD undetectable disease state at all measured time points (cycle [C]7day[D]1, C9D1, C12D1, and 15, 21, 27, 33, 39, 45, 51, 57, 63, 69, 75, 81, 87, 93, and 99 months after treatment initiation) using landmark analyses, across and between treatment arms (Secondary)
- To evaluate the prognostic association of MRD undetectable disease state over time in each treatment arm with respect to OS and RFS using time-dependent covariate analyses. (Secondary) IV. To describe the proportion of variation in OS and RFS explained by MRD sampling schemes with the goal of providing information on how much additional variation in OS and RFS is explained by additional MRD sampling for future trial designs. (Secondary) V. To compare the rate of MRD undetectable disease state at 15 months after initiation of treatment between treatment arms. (Secondary) VI. To compare duration of MRD undetectable disease state between treatment arms. (Secondary) VII. To describe associations between pretreatment stimulated karyotype risk, p53 mutation, IGHV mutational analysis, fluorescence in situ hybridization (FISH) for del(13q), del(11q), trisomy 12, and del(17p), and beta-2-microglobulin levels and other biomarkers with OS, PFS, overall and complete response rates, achievement of MRD undetectable disease state, and Richter's transformation. (Secondary) VIII. To describe associations between clinical complete or partial response (by International Workshop on Chronic Lymphocytic Leukemia [IWCLL] 2018 criteria) and response as assessed by MRD status and CT scans at 15 months after treatment initiation. (Secondary)
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM I (DELAYED V-O): Treatment begins once 2018 IWCLL indications are met. Patients receive obinutuzumab intravenously (IV) over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax orally (PO) once daily (QD) on days 22-28 of cycle 1 and on days 1-28 of cycles 2-12. Treatment repeats every 28 days for 12 cycles in the absence of disease progression or unacceptable toxicity.
ARM II (EARLY V-O): Treatment begins as soon as eligibility criteria are met. Patients receive obinutuzumab IV over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO QD on days 22-28 of cycle 1 and on days 1-28 of cycles 2-12. Treatment repeats every 28 days for 12 cycles in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up for 10 years after registration.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Arm I (delayed V-O) Treatment begins once 2018 IWCLL indications are met. Patients receive obinutuzumab IV over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO QD on days 22-28 of cycle 1 and on days 1-28 of cycles 2-12. Treatment repeats every 28 days for 12 cycles in the absence of disease progression or unacceptable toxicity. |
Biological: Obinutuzumab
Given IV
Other Names:
Other: Quality-of-Life Assessment
Ancillary studies
Other Names:
Other: Questionnaire Administration
Ancillary studies
Drug: Venetoclax
Given PO
Other Names:
|
| Experimental: Arm II (early V-O) Treatment begins as soon as eligibility criteria are met. Patients receive obinutuzumab IV over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO QD on days 22-28 of cycle 1 and on days 1-28 of cycles 2-12. Treatment repeats every 28 days for 12 cycles in the absence of disease progression or unacceptable toxicity. |
Biological: Obinutuzumab
Given IV
Other Names:
Other: Quality-of-Life Assessment
Ancillary studies
Other Names:
Other: Questionnaire Administration
Ancillary studies
Drug: Venetoclax
Given PO
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Overall survival [From the day of registration on study until death from any cause with observations censored on the day of last contact for patients not known to have died, assessed up to 10 years]
The final analysis will use stratified Cox proportional hazards regression stratified by Chronic Lymphocytic Leukemia [CLL] International Prognostic Indicator [CLL-IPI] Risk score status (high risk versus very high risk) with a two-sided alpha of 0.042. The final analysis will occur after 58 OS events have been observed, or at 4 years after accrual completes, whichever occurs first. Under the alternative hypothesis, the final analysis is expected to occur at approximately 7.9 years after study activation (about 3.8 years after accrual completes).
- Functional Assessment of Cancer Therapy (FACT)-Leukemia total score [At 2 years]
A single comparison in the FACT-Leukemia total scores between patients randomized to early V-O versus delayed V-O will be conducted at the alpha=.05 level. The analysis of the 2-year FACT-Leukemia Total score will be conducted using multiple linear regression analysis, adjusting for stratification factor and the baseline FACT-Leukemia Total score as covariates. Will also conduct longitudinal modeling of the outcome measures over time.
Secondary Outcome Measures
- Incidence of adverse events [Up to 10 years]
Will utilize the CTCAE (National Cancer Institute [NCI] Common Terminology Criteria for Adverse Events) version 5.0 for toxicity and adverse event reporting.
- Overall Response rate [Up to 10 years]
Will be compared using Fisher's exact test.
- Progression free survival [From the day of registration on study until the first of: relapse from complete response, progression, or death from any cause, assessed up to 10 years]
Will be estimated using the Kaplan-Meier method and will be compared using log-rank tests and Cox regression models.
- Event free survival [From the day of registration on study until the first of: relapse from complete response, death from any cause, start of new (non-protocol) therapy, or completion of protocol therapy without documentation of complete response, assessed up to 10 years]
Will be estimated using the Kaplan-Meier method and will be compared using log-rank tests and Cox regression models.
- Relapse free survival [From the date the patient first achieves complete response until relapse from complete response or death from any cause, assessed up to 10 years]
Will be estimated using the Kaplan-Meier method and will be compared using log-rank tests and Cox regression models.
- Time to second treatment [Up to 10 years]
Will be defined as the next chronic lymphocytic leukemia (CLL) treatment the patient receives after removal from protocol therapy. Will be estimated using the Kaplan-Meier method and will be compared using log-rank tests and Cox regression models.
- Patient compliance [Up to 10 years]
Will be reported descriptively by arm.
Other Outcome Measures
- FACT-Leukemia total score [At randomization and at months 3, 6, 9, 12, 15, 18, 24, 30, and 36]
Will include linear regression analyses by arm.
- The individual components of the FACT-Leukemia [At randomization and at months 3, 6, 9, 12, 15, 18, 24, 30, and 36]
Will include physical, social, emotional, and functional well-being. Will include linear regression analyses by arm.
- Patient-reported health-related quality of life (HRQoL) [Up to 36 months]
Will use simple descriptive statistics (means, medians, standard deviations, ranges) to describe patient-reported health related quality of life using the FACT-Leukemia and its individual domains between randomized arms. To assess potential trends, P-values using t-tests will be provided.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Participants must have a confirmed diagnosis of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) (collectively referred to as CLL throughout) according to the 2018 International Workshop on CLL. Participants must have been diagnosed within 12 months prior to registration
-
Participants must have CLL-International Prognostic Index (CLL-IPI) score >= 4 and/or complex cytogenetics (defined as 3+ chromosomal abnormalities)
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Cytogenetic AND/OR fluorescence in situ hybridization (FISH) analyses must be completed at a Clinical Laboratory Improvement Act (CLIA)-approved laboratory within 12 months prior to registration. FISH panel should use probes to detect for abnormalities in chromosomes 13q, 12, 11q, and 17p
-
TP53 mutation status (if completed) must be obtained within 12 months prior to registration
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Immunoglobulin heavy chain locus variable (IgVH) mutational status must be obtained prior to registration (at any time prior to registration)
-
Serum beta-2 microglobulin level must be obtained within 28 days prior to registration
-
Treatment with high dose corticosteroids and/or intravenous immunoglobulin for autoimmune complications of CLL must be complete at least 4 weeks prior to enrollment
-
Steroids used for treatment of conditions other than CLL/SLL must be at a dose of at most 20 mg/day of prednisone or equivalent corticosteroid at the time of registration
-
Prior therapy with anti CD20 monoclonal antibodies is not allowed
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Participants must be >= 18 years of age
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Participants must have Eastern Cooperative Oncology Group (ECOG) performance status =< 2
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Platelet count >= 100,000/mm^3 within 28 days prior to registration
-
Absolute neutrophil count (ANC) >= 1,000/mm^3 within 28 days prior to registration
-
Creatinine clearance >= 30mL/min (by Cockcroft Gault) within 28 days prior to registration
-
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3.0 x upper limit of normal (ULN) within 28 days prior to registration
-
Total bilirubin =< 2.0 x ULN (or 5.0 x ULN if the patient has a history of Gilbert's disease), within 28 days prior to registration
-
Participants must be able to take oral medications
-
Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
-
Participants with history of malignancy are allowed providing the cancer has not required active treatment within 2 years prior to registration (hormonal therapy is permissible). The following exceptions are permissible: basal cell, squamous cell skin, or non-melanomatous skin cancer, in situ cervical cancer, superficial bladder cancer not treated with intravesical chemotherapy or Bacillus Calmette-Guerin (BCG) within 6 months, localized prostate cancer requiring no more than chronic hormonal therapy, or localized breast cancer requiring no more than chronic hormonal therapy
-
Obinutuzumab has been associated with hepatitis reactivation. Participants must not have uncontrolled active infection with hepatitis B or C. Participants with latent hepatitis B infection must agree to take prophylaxis during and for 6 months following active protocol therapy with V-O.
-
Active infection with hepatitis B or C:
-
Active infection is defined as detectable hepatitis B deoxyribonucleic acid (DNA) or hepatitis C ribonucleic acid (RNA) by quantitative polymerase chain reaction (PCR).
-
Latent infection with hepatitis B:
-
Latent infection is defined as meeting all of the following criteria:
-
Hepatitis B surface antigen positive
-
Anti-hepatitis B total core antibody positive
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Anti-hepatitis IgM core antibody undetectable
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Hepatitis B PCR undetectable
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Participants with latent hepatitis B infection must agree to take prophylaxis with anti-hepatitis agents during and for 6 months following active protocol therapy with V-O.
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Participants who have received intravenous immunoglobulin (IVIG) therapy within 6 months who are hepatitis B core total antibody positive but PCR undetectable are not mandated to take prophylaxis
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Participants must agree to have specimens submitted for translational medicine (MRD) and specimens must be submitted
-
Participants must be offered participation in banking for future research. With patient's consent, specimens must be submitted
-
Participants who are able to complete patient reported outcome (PRO) forms in English, Spanish, French, German, Russian or Mandarin must agree to participate in the quality of life assessments. (Those participants who are unable to read and write in English, Spanish, French, German, Russian or Mandarin may be registered to S1925 without contributing to the quality of life portion of the study.)
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Participants must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.
-
NOTE: As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
Exclusion Criteria:
-
Patients must not meet any of the IWCLL specified criteria for active CLL therapy
-
Participants must not have received or be currently receiving any prior CLL-directed therapy, including non-protocol-related therapy, anti-cancer immunotherapy, experimental therapy (with exception of agents approved for emergency access use for the prevention or treatment of COVID-19), or radiotherapy
-
Participants must not be receiving or planning to receive any other investigational agents before completing protocol therapy
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Participants must not have current, clinically significant gastrointestinal malabsorption, in the opinion of treating doctor
-
Participants must not have cirrhosis
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Participants must not have had major surgery within 30 days prior registration or minor surgery within 7 days prior to registration. Examples of major surgery include neurosurgical procedures, joint replacements, and surgeries that occur inside the thoracic or abdomino-pelvic cavities. Examples of minor surgery include dental surgery, insertion of a venous access device, skin biopsy, or aspiration of a joint. If there is a question about whether a surgery is major or minor, this should be discussed with the study chair
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Participants must not have known bleeding disorders (e.g., von Willebrand's disease or hemophilia)
-
Participants must not have a history of stroke or intracranial hemorrhage within 6 months prior to enrollment
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Participants must not require continued therapy with a strong inhibitor or inducer of CYP3A4/5, as venetoclax is extensively metabolized by CYP3A4/5
-
Participants must not have uncontrolled autoimmune hemolytic anemia or idiopathic thrombocytopenia purpura
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Participants must not have any currently active, clinically significant cardiovascular disease, such as uncontrolled arrhythmia or class 3 or 4 congestive heart failure as defined by the New York Heart Association Functional Classification
-
Participants must not have a history of myocardial infarction, unstable angina, or acute coronary syndrome within 6 months prior to enrollment
-
Participants must not be pregnant or nursing, as there are no safety data available for these drug regimens during pregnancy. Women/men of reproductive potential must have agreed to use an effective contraceptive method. A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | United States | 35233 |
| 2 | Anchorage Associates in Radiation Medicine | Anchorage | Alaska | United States | 98508 |
| 3 | Anchorage Radiation Therapy Center | Anchorage | Alaska | United States | 99504 |
| 4 | Alaska Breast Care and Surgery LLC | Anchorage | Alaska | United States | 99508 |
| 5 | Alaska Oncology and Hematology LLC | Anchorage | Alaska | United States | 99508 |
| 6 | Alaska Women's Cancer Care | Anchorage | Alaska | United States | 99508 |
| 7 | Anchorage Oncology Centre | Anchorage | Alaska | United States | 99508 |
| 8 | Katmai Oncology Group | Anchorage | Alaska | United States | 99508 |
| 9 | Providence Alaska Medical Center | Anchorage | Alaska | United States | 99508 |
| 10 | Fairbanks Memorial Hospital | Fairbanks | Alaska | United States | 99701 |
| 11 | Cancer Center at Saint Joseph's | Phoenix | Arizona | United States | 85004 |
| 12 | Mercy Hospital Fort Smith | Fort Smith | Arkansas | United States | 72903 |
| 13 | CHI Saint Vincent Cancer Center Hot Springs | Hot Springs | Arkansas | United States | 71913 |
| 14 | Mission Hope Medical Oncology - Arroyo Grande | Arroyo Grande | California | United States | 93420 |
| 15 | Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | United States | 91505 |
| 16 | UC Irvine Health Cancer Center-Newport | Costa Mesa | California | United States | 92627 |
| 17 | City of Hope Comprehensive Cancer Center | Duarte | California | United States | 91010 |
| 18 | City of Hope at Irvine Lennar | Irvine | California | United States | 92618 |
| 19 | UCI Health Laguna Hills | Laguna Hills | California | United States | 92653 |
| 20 | Tibor Rubin VA Medical Center | Long Beach | California | United States | 90822 |
| 21 | Fremont - Rideout Cancer Center | Marysville | California | United States | 95901 |
| 22 | UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | United States | 92868 |
| 23 | Stanford Cancer Institute Palo Alto | Palo Alto | California | United States | 94304 |
| 24 | University of California Davis Comprehensive Cancer Center | Sacramento | California | United States | 95817 |
| 25 | Pacific Central Coast Health Center-San Luis Obispo | San Luis Obispo | California | United States | 93401 |
| 26 | Mission Hope Medical Oncology - Santa Maria | Santa Maria | California | United States | 93444 |
| 27 | Rocky Mountain Cancer Centers-Aurora | Aurora | Colorado | United States | 80012 |
| 28 | The Medical Center of Aurora | Aurora | Colorado | United States | 80012 |
| 29 | Boulder Community Foothills Hospital | Boulder | Colorado | United States | 80303 |
| 30 | Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado | United States | 80304 |
| 31 | Rocky Mountain Cancer Centers - Centennial | Centennial | Colorado | United States | 80112 |
| 32 | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | United States | 80907 |
| 33 | Rocky Mountain Cancer Centers-Penrose | Colorado Springs | Colorado | United States | 80907 |
| 34 | Cancer Center of Colorado at Sloan's Lake | Denver | Colorado | United States | 80204 |
| 35 | National Jewish Health-Main Campus | Denver | Colorado | United States | 80206 |
| 36 | The Women's Imaging Center | Denver | Colorado | United States | 80209 |
| 37 | Porter Adventist Hospital | Denver | Colorado | United States | 80210 |
| 38 | Colorado Blood Cancer Institute | Denver | Colorado | United States | 80218 |
| 39 | Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado | United States | 80218 |
| 40 | Rocky Mountain Cancer Centers-Midtown | Denver | Colorado | United States | 80218 |
| 41 | SCL Health Saint Joseph Hospital | Denver | Colorado | United States | 80218 |
| 42 | Rocky Mountain Cancer Centers-Rose | Denver | Colorado | United States | 80220 |
| 43 | Rose Medical Center | Denver | Colorado | United States | 80220 |
| 44 | Western Surgical Care | Denver | Colorado | United States | 80220 |
| 45 | Mercy Medical Center | Durango | Colorado | United States | 81301 |
| 46 | Southwest Oncology PC | Durango | Colorado | United States | 81301 |
| 47 | Mountain Blue Cancer Care Center - Swedish | Englewood | Colorado | United States | 80113 |
| 48 | Rocky Mountain Cancer Centers - Swedish | Englewood | Colorado | United States | 80113 |
| 49 | Swedish Medical Center | Englewood | Colorado | United States | 80113 |
| 50 | The Melanoma and Skin Cancer Institute | Englewood | Colorado | United States | 80113 |
| 51 | National Jewish Health-Western Hematology Oncology | Golden | Colorado | United States | 80401 |
| 52 | Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado | United States | 81501 |
| 53 | Grand Valley Oncology | Grand Junction | Colorado | United States | 81505 |
| 54 | North Colorado Medical Center | Greeley | Colorado | United States | 80631 |
| 55 | Good Samaritan Medical Center | Lafayette | Colorado | United States | 80026 |
| 56 | Rocky Mountain Cancer Centers-Lakewood | Lakewood | Colorado | United States | 80228 |
| 57 | Saint Anthony Hospital | Lakewood | Colorado | United States | 80228 |
| 58 | Rocky Mountain Cancer Centers-Littleton | Littleton | Colorado | United States | 80120 |
| 59 | Littleton Adventist Hospital | Littleton | Colorado | United States | 80122 |
| 60 | Rocky Mountain Cancer Centers-Sky Ridge | Lone Tree | Colorado | United States | 80124 |
| 61 | Sky Ridge Medical Center | Lone Tree | Colorado | United States | 80124 |
| 62 | Longmont United Hospital | Longmont | Colorado | United States | 80501 |
| 63 | Rocky Mountain Cancer Centers-Longmont | Longmont | Colorado | United States | 80501 |
| 64 | McKee Medical Center | Loveland | Colorado | United States | 80539 |
| 65 | Parker Adventist Hospital | Parker | Colorado | United States | 80138 |
| 66 | Saint Mary Corwin Medical Center | Pueblo | Colorado | United States | 81004 |
| 67 | National Jewish Health-Northern Hematology Oncology | Thornton | Colorado | United States | 80260 |
| 68 | Rocky Mountain Cancer Centers-Thornton | Thornton | Colorado | United States | 80260 |
| 69 | Beebe South Coastal Health Campus | Frankford | Delaware | United States | 19945 |
| 70 | Beebe Medical Center | Lewes | Delaware | United States | 19958 |
| 71 | Delaware Clinical and Laboratory Physicians PA | Newark | Delaware | United States | 19713 |
| 72 | Helen F Graham Cancer Center | Newark | Delaware | United States | 19713 |
| 73 | Medical Oncology Hematology Consultants PA | Newark | Delaware | United States | 19713 |
| 74 | Christiana Care Health System-Christiana Hospital | Newark | Delaware | United States | 19718 |
| 75 | Beebe Health Campus | Rehoboth Beach | Delaware | United States | 19971 |
| 76 | TidalHealth Nanticoke / Allen Cancer Center | Seaford | Delaware | United States | 19973 |
| 77 | Christiana Care Health System-Wilmington Hospital | Wilmington | Delaware | United States | 19801 |
| 78 | Holy Cross Hospital | Fort Lauderdale | Florida | United States | 33308 |
| 79 | Sacred Heart Hospital | Pensacola | Florida | United States | 32504 |
| 80 | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | United States | 83706 |
| 81 | Saint Luke's Cancer Institute - Boise | Boise | Idaho | United States | 83712 |
| 82 | Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | United States | 83605 |
| 83 | Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | United States | 83814 |
| 84 | Walter Knox Memorial Hospital | Emmett | Idaho | United States | 83617 |
| 85 | Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | United States | 83619 |
| 86 | Idaho Urologic Institute-Meridian | Meridian | Idaho | United States | 83642 |
| 87 | Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | United States | 83642 |
| 88 | Saint Alphonsus Medical Center-Nampa | Nampa | Idaho | United States | 83686 |
| 89 | Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | United States | 83686 |
| 90 | Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | United States | 83854 |
| 91 | Kootenai Cancer Clinic | Sandpoint | Idaho | United States | 83864 |
| 92 | Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho | United States | 83301 |
| 93 | Saint Anthony's Health | Alton | Illinois | United States | 62002 |
| 94 | Rush - Copley Medical Center | Aurora | Illinois | United States | 60504 |
| 95 | Illinois CancerCare-Bloomington | Bloomington | Illinois | United States | 61704 |
| 96 | Loyola Center for Health at Burr Ridge | Burr Ridge | Illinois | United States | 60527 |
| 97 | Illinois CancerCare-Canton | Canton | Illinois | United States | 61520 |
| 98 | Memorial Hospital of Carbondale | Carbondale | Illinois | United States | 62902 |
| 99 | SIH Cancer Institute | Carterville | Illinois | United States | 62918 |
| 100 | Illinois CancerCare-Carthage | Carthage | Illinois | United States | 62321 |
| 101 | Centralia Oncology Clinic | Centralia | Illinois | United States | 62801 |
| 102 | Northwestern University | Chicago | Illinois | United States | 60611 |
| 103 | University of Chicago Comprehensive Cancer Center | Chicago | Illinois | United States | 60637 |
| 104 | Carle on Vermilion | Danville | Illinois | United States | 61832 |
| 105 | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | United States | 62526 |
| 106 | Decatur Memorial Hospital | Decatur | Illinois | United States | 62526 |
| 107 | Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois | United States | 60115 |
| 108 | Illinois CancerCare-Dixon | Dixon | Illinois | United States | 61021 |
| 109 | Carle Physician Group-Effingham | Effingham | Illinois | United States | 62401 |
| 110 | Crossroads Cancer Center | Effingham | Illinois | United States | 62401 |
| 111 | Illinois CancerCare-Eureka | Eureka | Illinois | United States | 61530 |
| 112 | NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | United States | 60201 |
| 113 | Illinois CancerCare-Galesburg | Galesburg | Illinois | United States | 61401 |
| 114 | Western Illinois Cancer Treatment Center | Galesburg | Illinois | United States | 61401 |
| 115 | Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | United States | 60134 |
| 116 | NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois | United States | 60026 |
| 117 | Ingalls Memorial Hospital | Harvey | Illinois | United States | 60426 |
| 118 | NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois | United States | 60035 |
| 119 | Loyola Medicine Homer Glen | Homer Glen | Illinois | United States | 60491 |
| 120 | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | United States | 61443 |
| 121 | Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | United States | 60045 |
| 122 | Illinois CancerCare-Macomb | Macomb | Illinois | United States | 61455 |
| 123 | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | United States | 61938 |
| 124 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 125 | Marjorie Weinberg Cancer Center at Loyola-Gottlieb | Melrose Park | Illinois | United States | 60160 |
| 126 | Good Samaritan Regional Health Center | Mount Vernon | Illinois | United States | 62864 |
| 127 | UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | United States | 60451 |
| 128 | Cancer Care Center of O'Fallon | O'Fallon | Illinois | United States | 62269 |
| 129 | University of Chicago Medicine-Orland Park | Orland Park | Illinois | United States | 60462 |
| 130 | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | United States | 61350 |
| 131 | Illinois CancerCare-Pekin | Pekin | Illinois | United States | 61554 |
| 132 | Illinois CancerCare-Peoria | Peoria | Illinois | United States | 61615 |
| 133 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 134 | Illinois CancerCare-Peru | Peru | Illinois | United States | 61354 |
| 135 | Valley Radiation Oncology | Peru | Illinois | United States | 61354 |
| 136 | Illinois CancerCare-Princeton | Princeton | Illinois | United States | 61356 |
| 137 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62702 |
| 138 | Springfield Clinic | Springfield | Illinois | United States | 62702 |
| 139 | Memorial Medical Center | Springfield | Illinois | United States | 62781 |
| 140 | Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 141 | The Carle Foundation Hospital | Urbana | Illinois | United States | 61801 |
| 142 | Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | United States | 60555 |
| 143 | Illinois CancerCare - Washington | Washington | Illinois | United States | 61571 |
| 144 | Rush-Copley Healthcare Center | Yorkville | Illinois | United States | 60560 |
| 145 | Reid Health | Richmond | Indiana | United States | 47374 |
| 146 | Mary Greeley Medical Center | Ames | Iowa | United States | 50010 |
| 147 | McFarland Clinic PC - Ames | Ames | Iowa | United States | 50010 |
| 148 | McFarland Clinic PC-Boone | Boone | Iowa | United States | 50036 |
| 149 | Saint Anthony Regional Hospital | Carroll | Iowa | United States | 51401 |
| 150 | Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa | United States | 50325 |
| 151 | Mercy Cancer Center-West Lakes | Clive | Iowa | United States | 50325 |
| 152 | Alegent Health Mercy Hospital | Council Bluffs | Iowa | United States | 51503 |
| 153 | Greater Regional Medical Center | Creston | Iowa | United States | 50801 |
| 154 | Iowa Methodist Medical Center | Des Moines | Iowa | United States | 50309 |
| 155 | Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa | United States | 50309 |
| 156 | Broadlawns Medical Center | Des Moines | Iowa | United States | 50314 |
| 157 | Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa | United States | 50314 |
| 158 | Mercy Medical Center - Des Moines | Des Moines | Iowa | United States | 50314 |
| 159 | Iowa Lutheran Hospital | Des Moines | Iowa | United States | 50316 |
| 160 | McFarland Clinic PC-Trinity Cancer Center | Fort Dodge | Iowa | United States | 50501 |
| 161 | Trinity Regional Medical Center | Fort Dodge | Iowa | United States | 50501 |
| 162 | McFarland Clinic PC-Jefferson | Jefferson | Iowa | United States | 50129 |
| 163 | McFarland Clinic PC-Marshalltown | Marshalltown | Iowa | United States | 50158 |
| 164 | Methodist West Hospital | West Des Moines | Iowa | United States | 50266-7700 |
| 165 | Mercy Medical Center-West Lakes | West Des Moines | Iowa | United States | 50266 |
| 166 | Central Care Cancer Center - Garden City | Garden City | Kansas | United States | 67846 |
| 167 | Central Care Cancer Center - Great Bend | Great Bend | Kansas | United States | 67530 |
| 168 | Flaget Memorial Hospital | Bardstown | Kentucky | United States | 40004 |
| 169 | Commonwealth Cancer Center-Corbin | Corbin | Kentucky | United States | 40701 |
| 170 | Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky | United States | 40504 |
| 171 | Saint Joseph Hospital East | Lexington | Kentucky | United States | 40509 |
| 172 | Saint Joseph London | London | Kentucky | United States | 40741 |
| 173 | Jewish Hospital | Louisville | Kentucky | United States | 40202 |
| 174 | Saints Mary and Elizabeth Hospital | Louisville | Kentucky | United States | 40215 |
| 175 | UofL Health Medical Center Northeast | Louisville | Kentucky | United States | 40245 |
| 176 | Jewish Hospital Medical Center South | Shepherdsville | Kentucky | United States | 40165 |
| 177 | Hematology/Oncology Clinic PLLC | Baton Rouge | Louisiana | United States | 70809 |
| 178 | Ochsner LSU Health Monroe Medical Center | Monroe | Louisiana | United States | 71202 |
| 179 | Tulane University Health Sciences Center | New Orleans | Louisiana | United States | 70112 |
| 180 | Ochsner LSU Health Saint Mary's Medical Center | Shreveport | Louisiana | United States | 71101 |
| 181 | LSU Health Sciences Center at Shreveport | Shreveport | Louisiana | United States | 71103 |
| 182 | Hickman Cancer Center | Adrian | Michigan | United States | 49221 |
| 183 | Saint Joseph Mercy Hospital | Ann Arbor | Michigan | United States | 48106 |
| 184 | Bronson Battle Creek | Battle Creek | Michigan | United States | 49017 |
| 185 | Saint Joseph Mercy Brighton | Brighton | Michigan | United States | 48114 |
| 186 | Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Michigan | United States | 48114 |
| 187 | Henry Ford Cancer Institute-Downriver | Brownstown | Michigan | United States | 48183 |
| 188 | Saint Joseph Mercy Canton | Canton | Michigan | United States | 48188 |
| 189 | Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Michigan | United States | 48188 |
| 190 | Caro Cancer Center | Caro | Michigan | United States | 48723 |
| 191 | Saint Joseph Mercy Chelsea | Chelsea | Michigan | United States | 48118 |
| 192 | Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Michigan | United States | 48118 |
| 193 | Hematology Oncology Consultants-Clarkston | Clarkston | Michigan | United States | 48346 |
| 194 | Newland Medical Associates-Clarkston | Clarkston | Michigan | United States | 48346 |
| 195 | Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan | United States | 48038 |
| 196 | Henry Ford Medical Center-Fairlane | Dearborn | Michigan | United States | 48126 |
| 197 | Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
| 198 | Ascension Saint John Hospital | Detroit | Michigan | United States | 48236 |
| 199 | Great Lakes Cancer Management Specialists-Doctors Park | East China Township | Michigan | United States | 48054 |
| 200 | Genesee Cancer and Blood Disease Treatment Center | Flint | Michigan | United States | 48503 |
| 201 | Genesee Hematology Oncology PC | Flint | Michigan | United States | 48503 |
| 202 | Genesys Hurley Cancer Institute | Flint | Michigan | United States | 48503 |
| 203 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
| 204 | Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids | Michigan | United States | 49503 |
| 205 | Mercy Health Saint Mary's | Grand Rapids | Michigan | United States | 49503 |
| 206 | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | United States | 49503 |
| 207 | Academic Hematology Oncology Specialists | Grosse Pointe Woods | Michigan | United States | 48236 |
| 208 | Great Lakes Cancer Management Specialists-Van Elslander Cancer Center | Grosse Pointe Woods | Michigan | United States | 48236 |
| 209 | Michigan Breast Specialists-Grosse Pointe Woods | Grosse Pointe Woods | Michigan | United States | 48236 |
| 210 | Allegiance Health | Jackson | Michigan | United States | 49201 |
| 211 | Bronson Methodist Hospital | Kalamazoo | Michigan | United States | 49007 |
| 212 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 49007 |
| 213 | Ascension Borgess Cancer Center | Kalamazoo | Michigan | United States | 49009 |
| 214 | Borgess Medical Center | Kalamazoo | Michigan | United States | 49048 |
| 215 | Sparrow Hospital | Lansing | Michigan | United States | 48912 |
| 216 | Hope Cancer Clinic | Livonia | Michigan | United States | 48154 |
| 217 | Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | United States | 48154 |
| 218 | Great Lakes Cancer Management Specialists-Macomb Medical Campus | Macomb | Michigan | United States | 48044 |
| 219 | Michigan Breast Specialists-Macomb Township | Macomb | Michigan | United States | 48044 |
| 220 | Saint Mary's Oncology/Hematology Associates of Marlette | Marlette | Michigan | United States | 48453 |
| 221 | Toledo Clinic Cancer Centers-Monroe | Monroe | Michigan | United States | 48162 |
| 222 | Mercy Health Mercy Campus | Muskegon | Michigan | United States | 49444 |
| 223 | Lakeland Hospital Niles | Niles | Michigan | United States | 49120 |
| 224 | Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores | Michigan | United States | 49444 |
| 225 | Henry Ford Medical Center-Columbus | Novi | Michigan | United States | 48377 |
| 226 | 21st Century Oncology-Pontiac | Pontiac | Michigan | United States | 48341 |
| 227 | Hope Cancer Center | Pontiac | Michigan | United States | 48341 |
| 228 | Newland Medical Associates-Pontiac | Pontiac | Michigan | United States | 48341 |
| 229 | Saint Joseph Mercy Oakland | Pontiac | Michigan | United States | 48341 |
| 230 | Spectrum Health Reed City Hospital | Reed City | Michigan | United States | 49677 |
| 231 | Ascension Saint Mary's Hospital | Saginaw | Michigan | United States | 48601 |
| 232 | Oncology Hematology Associates of Saginaw Valley PC | Saginaw | Michigan | United States | 48604 |
| 233 | Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan | United States | 49085 |
| 234 | Marie Yeager Cancer Center | Saint Joseph | Michigan | United States | 49085 |
| 235 | Henry Ford Macomb Health Center - Shelby Township | Shelby | Michigan | United States | 48315 |
| 236 | Ascension Providence Hospitals - Southfield | Southfield | Michigan | United States | 48075 |
| 237 | Bhadresh Nayak MD PC-Sterling Heights | Sterling Heights | Michigan | United States | 48312 |
| 238 | Ascension Saint Joseph Hospital | Tawas City | Michigan | United States | 48764 |
| 239 | Munson Medical Center | Traverse City | Michigan | United States | 49684 |
| 240 | Advanced Breast Care Center PLLC | Warren | Michigan | United States | 48088 |
| 241 | Great Lakes Cancer Management Specialists-Macomb Professional Building | Warren | Michigan | United States | 48093 |
| 242 | Macomb Hematology Oncology PC | Warren | Michigan | United States | 48093 |
| 243 | Michigan Breast Specialists-Warren | Warren | Michigan | United States | 48093 |
| 244 | Saint John Macomb-Oakland Hospital | Warren | Michigan | United States | 48093 |
| 245 | Henry Ford West Bloomfield Hospital | West Bloomfield | Michigan | United States | 48322 |
| 246 | Saint Mary's Oncology/Hematology Associates of West Branch | West Branch | Michigan | United States | 48661 |
| 247 | Metro Health Hospital | Wyoming | Michigan | United States | 49519 |
| 248 | Huron Gastroenterology PC | Ypsilanti | Michigan | United States | 48106 |
| 249 | Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus | Ypsilanti | Michigan | United States | 48197 |
| 250 | Fairview Ridges Hospital | Burnsville | Minnesota | United States | 55337 |
| 251 | Minnesota Oncology - Burnsville | Burnsville | Minnesota | United States | 55337 |
| 252 | Cambridge Medical Center | Cambridge | Minnesota | United States | 55008 |
| 253 | Mercy Hospital | Coon Rapids | Minnesota | United States | 55433 |
| 254 | Fairview Southdale Hospital | Edina | Minnesota | United States | 55435 |
| 255 | Unity Hospital | Fridley | Minnesota | United States | 55432 |
| 256 | Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Minnesota | United States | 55369 |
| 257 | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | United States | 55109 |
| 258 | Saint John's Hospital - Healtheast | Maplewood | Minnesota | United States | 55109 |
| 259 | Abbott-Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
| 260 | Hennepin County Medical Center | Minneapolis | Minnesota | United States | 55415 |
| 261 | Minneapolis VA Medical Center | Minneapolis | Minnesota | United States | 55417 |
| 262 | Health Partners Inc | Minneapolis | Minnesota | United States | 55454 |
| 263 | Monticello Cancer Center | Monticello | Minnesota | United States | 55362 |
| 264 | New Ulm Medical Center | New Ulm | Minnesota | United States | 56073 |
| 265 | Fairview Northland Medical Center | Princeton | Minnesota | United States | 55371 |
| 266 | North Memorial Medical Health Center | Robbinsdale | Minnesota | United States | 55422 |
| 267 | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | United States | 55416 |
| 268 | Regions Hospital | Saint Paul | Minnesota | United States | 55101 |
| 269 | United Hospital | Saint Paul | Minnesota | United States | 55102 |
| 270 | Saint Francis Regional Medical Center | Shakopee | Minnesota | United States | 55379 |
| 271 | Lakeview Hospital | Stillwater | Minnesota | United States | 55082 |
| 272 | Ridgeview Medical Center | Waconia | Minnesota | United States | 55387 |
| 273 | Rice Memorial Hospital | Willmar | Minnesota | United States | 56201 |
| 274 | Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | United States | 55125 |
| 275 | Fairview Lakes Medical Center | Wyoming | Minnesota | United States | 55092 |
| 276 | Baptist Memorial Hospital and Cancer Center-Golden Triangle | Columbus | Mississippi | United States | 39705 |
| 277 | Baptist Cancer Center-Grenada | Grenada | Mississippi | United States | 38901 |
| 278 | Baptist Memorial Hospital and Cancer Center-Union County | New Albany | Mississippi | United States | 38652 |
| 279 | Baptist Memorial Hospital and Cancer Center-Desoto | Southhaven | Mississippi | United States | 38671 |
| 280 | Saint Louis Cancer and Breast Institute-Ballwin | Ballwin | Missouri | United States | 63011 |
| 281 | Central Care Cancer Center - Bolivar | Bolivar | Missouri | United States | 65613 |
| 282 | Saint Francis Medical Center | Cape Girardeau | Missouri | United States | 63703 |
| 283 | Southeast Cancer Center | Cape Girardeau | Missouri | United States | 63703 |
| 284 | Saint Luke's Hospital | Chesterfield | Missouri | United States | 63017 |
| 285 | Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | United States | 63141 |
| 286 | Parkland Health Center - Farmington | Farmington | Missouri | United States | 63640 |
| 287 | Capital Region Southwest Campus | Jefferson City | Missouri | United States | 65109 |
| 288 | Freeman Health System | Joplin | Missouri | United States | 64804 |
| 289 | Mercy Hospital Joplin | Joplin | Missouri | United States | 64804 |
| 290 | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | United States | 65401 |
| 291 | Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | United States | 65401 |
| 292 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64506 |
| 293 | Saint Louis Cancer and Breast Institute-South City | Saint Louis | Missouri | United States | 63109 |
| 294 | Washington University School of Medicine | Saint Louis | Missouri | United States | 63110 |
| 295 | Mercy Hospital South | Saint Louis | Missouri | United States | 63128 |
| 296 | Siteman Cancer Center-South County | Saint Louis | Missouri | United States | 63129 |
| 297 | Missouri Baptist Medical Center | Saint Louis | Missouri | United States | 63131 |
| 298 | Siteman Cancer Center at Christian Hospital | Saint Louis | Missouri | United States | 63136 |
| 299 | Mercy Hospital Saint Louis | Saint Louis | Missouri | United States | 63141 |
| 300 | Siteman Cancer Center at Saint Peters Hospital | Saint Peters | Missouri | United States | 63376 |
| 301 | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | United States | 63670 |
| 302 | Mercy Hospital Springfield | Springfield | Missouri | United States | 65804 |
| 303 | CoxHealth South Hospital | Springfield | Missouri | United States | 65807 |
| 304 | Missouri Baptist Sullivan Hospital | Sullivan | Missouri | United States | 63080 |
| 305 | Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | United States | 63127 |
| 306 | Mercy Hospital Washington | Washington | Missouri | United States | 63090 |
| 307 | Community Hospital of Anaconda | Anaconda | Montana | United States | 59711 |
| 308 | Billings Clinic Cancer Center | Billings | Montana | United States | 59101 |
| 309 | Saint Vincent Healthcare | Billings | Montana | United States | 59101 |
| 310 | Saint Vincent Frontier Cancer Center | Billings | Montana | United States | 59102 |
| 311 | Bozeman Deaconess Hospital | Bozeman | Montana | United States | 59715 |
| 312 | Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | United States | 59405 |
| 313 | Great Falls Clinic | Great Falls | Montana | United States | 59405 |
| 314 | Kalispell Regional Medical Center | Kalispell | Montana | United States | 59901 |
| 315 | Saint Patrick Hospital - Community Hospital | Missoula | Montana | United States | 59802 |
| 316 | Community Medical Hospital | Missoula | Montana | United States | 59804 |
| 317 | CHI Health Saint Francis | Grand Island | Nebraska | United States | 68803 |
| 318 | CHI Health Good Samaritan | Kearney | Nebraska | United States | 68847 |
| 319 | Saint Elizabeth Regional Medical Center | Lincoln | Nebraska | United States | 68510 |
| 320 | Cancer Partners of Nebraska - Pine Lake | Lincoln | Nebraska | United States | 68516 |
| 321 | Southeast Nebraska Cancer Center - 68th Street Place | Lincoln | Nebraska | United States | 68516 |
| 322 | Alegent Health Immanuel Medical Center | Omaha | Nebraska | United States | 68122 |
| 323 | Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska | United States | 68124 |
| 324 | Alegent Health Lakeside Hospital | Omaha | Nebraska | United States | 68130 |
| 325 | Creighton University Medical Center | Omaha | Nebraska | United States | 68131 |
| 326 | Midlands Community Hospital | Papillion | Nebraska | United States | 68046 |
| 327 | Memorial Sloan Kettering Basking Ridge | Basking Ridge | New Jersey | United States | 07920 |
| 328 | Cooper Hospital University Medical Center | Camden | New Jersey | United States | 08103 |
| 329 | Memorial Sloan Kettering Monmouth | Middletown | New Jersey | United States | 07748 |
| 330 | Memorial Sloan Kettering Bergen | Montvale | New Jersey | United States | 07645 |
| 331 | MD Anderson Cancer Center at Cooper-Voorhees | Voorhees | New Jersey | United States | 08043 |
| 332 | Hematology Oncology Associates of Central New York-Auburn | Auburn | New York | United States | 13021 |
| 333 | Memorial Sloan Kettering Commack | Commack | New York | United States | 11725 |
| 334 | Hematology Oncology Associates of Central New York-East Syracuse | East Syracuse | New York | United States | 13057 |
| 335 | Glens Falls Hospital | Glens Falls | New York | United States | 12801 |
| 336 | Memorial Sloan Kettering Westchester | Harrison | New York | United States | 10604 |
| 337 | Memorial Sloan Kettering Cancer Center | New York | New York | United States | 10065 |
| 338 | Rochester General Hospital | Rochester | New York | United States | 14621 |
| 339 | University of Rochester | Rochester | New York | United States | 14642 |
| 340 | Hematology Oncology Associates of Central New York-Onondaga Hill | Syracuse | New York | United States | 13215 |
| 341 | Memorial Sloan Kettering Nassau | Uniondale | New York | United States | 11553 |
| 342 | Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina | United States | 28328 |
| 343 | Durham VA Medical Center | Durham | North Carolina | United States | 27705 |
| 344 | Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina | United States | 27534 |
| 345 | Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina | United States | 28546 |
| 346 | Vidant Oncology-Kenansville | Kenansville | North Carolina | United States | 28349 |
| 347 | Vidant Oncology-Kinston | Kinston | North Carolina | United States | 28501 |
| 348 | Vidant Oncology-Richlands | Richlands | North Carolina | United States | 28574 |
| 349 | Indu and Raj Soin Medical Center | Beavercreek | Ohio | United States | 45431 |
| 350 | Strecker Cancer Center-Belpre | Belpre | Ohio | United States | 45714 |
| 351 | Saint Elizabeth Boardman Hospital | Boardman | Ohio | United States | 44512 |
| 352 | Cleveland Clinic Mercy Hospital | Canton | Ohio | United States | 44708 |
| 353 | Mercy Hematology and Oncology Associates Inc | Canton | Ohio | United States | 44708 |
| 354 | Dayton Physicians LLC-Miami Valley South | Centerville | Ohio | United States | 45459 |
| 355 | Miami Valley Hospital South | Centerville | Ohio | United States | 45459 |
| 356 | Adena Regional Medical Center | Chillicothe | Ohio | United States | 45601 |
| 357 | Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio | United States | 45220 |
| 358 | Oncology Hematology Care Inc-Kenwood | Cincinnati | Ohio | United States | 45236 |
| 359 | Bethesda North Hospital | Cincinnati | Ohio | United States | 45242 |
| 360 | TriHealth Cancer Institute-Westside | Cincinnati | Ohio | United States | 45247 |
| 361 | TriHealth Cancer Institute-Anderson | Cincinnati | Ohio | United States | 45255 |
| 362 | Cleveland Clinic Foundation | Cleveland | Ohio | United States | 44195 |
| 363 | Ohio State University Comprehensive Cancer Center | Columbus | Ohio | United States | 43210 |
| 364 | Mount Carmel East Hospital | Columbus | Ohio | United States | 43213 |
| 365 | Columbus Oncology and Hematology Associates Inc | Columbus | Ohio | United States | 43214 |
| 366 | Riverside Methodist Hospital | Columbus | Ohio | United States | 43214 |
| 367 | Grant Medical Center | Columbus | Ohio | United States | 43215 |
| 368 | The Mark H Zangmeister Center | Columbus | Ohio | United States | 43219 |
| 369 | Mount Carmel Health Center West | Columbus | Ohio | United States | 43222 |
| 370 | Doctors Hospital | Columbus | Ohio | United States | 43228 |
| 371 | Miami Valley Hospital | Dayton | Ohio | United States | 45409 |
| 372 | Dayton Physician LLC-Miami Valley Hospital North | Dayton | Ohio | United States | 45415 |
| 373 | Miami Valley Hospital North | Dayton | Ohio | United States | 45415 |
| 374 | Delaware Health Center-Grady Cancer Center | Delaware | Ohio | United States | 43015 |
| 375 | Grady Memorial Hospital | Delaware | Ohio | United States | 43015 |
| 376 | Dublin Methodist Hospital | Dublin | Ohio | United States | 43016 |
| 377 | Armes Family Cancer Center | Findlay | Ohio | United States | 45840 |
| 378 | Blanchard Valley Hospital | Findlay | Ohio | United States | 45840 |
| 379 | Orion Cancer Care | Findlay | Ohio | United States | 45840 |
| 380 | Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | United States | 45005-1066 |
| 381 | Dayton Physicians LLC-Atrium | Franklin | Ohio | United States | 45005 |
| 382 | Central Ohio Breast and Endocrine Surgery | Gahanna | Ohio | United States | 43230 |
| 383 | Dayton Physicians LLC-Wayne | Greenville | Ohio | United States | 45331 |
| 384 | Wayne Hospital | Greenville | Ohio | United States | 45331 |
| 385 | Mount Carmel Grove City Hospital | Grove City | Ohio | United States | 43123 |
| 386 | Greater Dayton Cancer Center | Kettering | Ohio | United States | 45409 |
| 387 | Kettering Medical Center | Kettering | Ohio | United States | 45429 |
| 388 | Fairfield Medical Center | Lancaster | Ohio | United States | 43130 |
| 389 | Saint Rita's Medical Center | Lima | Ohio | United States | 45801 |
| 390 | OhioHealth Mansfield Hospital | Mansfield | Ohio | United States | 44903 |
| 391 | Marietta Memorial Hospital | Marietta | Ohio | United States | 45750 |
| 392 | OhioHealth Marion General Hospital | Marion | Ohio | United States | 43302 |
| 393 | Knox Community Hospital | Mount Vernon | Ohio | United States | 43050 |
| 394 | Licking Memorial Hospital | Newark | Ohio | United States | 43055 |
| 395 | Newark Radiation Oncology | Newark | Ohio | United States | 43055 |
| 396 | Mercy Health Perrysburg Cancer Center | Perrysburg | Ohio | United States | 43551 |
| 397 | Southern Ohio Medical Center | Portsmouth | Ohio | United States | 45662 |
| 398 | Springfield Regional Cancer Center | Springfield | Ohio | United States | 45504 |
| 399 | Springfield Regional Medical Center | Springfield | Ohio | United States | 45505 |
| 400 | ProMedica Flower Hospital | Sylvania | Ohio | United States | 43560 |
| 401 | Saint Vincent Mercy Medical Center | Toledo | Ohio | United States | 43608 |
| 402 | Mercy Health - Saint Anne Hospital | Toledo | Ohio | United States | 43623 |
| 403 | Toledo Clinic Cancer Centers-Toledo | Toledo | Ohio | United States | 43623 |
| 404 | Dayton Physicians LLC-Upper Valley | Troy | Ohio | United States | 45373 |
| 405 | Upper Valley Medical Center | Troy | Ohio | United States | 45373 |
| 406 | Saint Joseph Warren Hospital | Warren | Ohio | United States | 44484 |
| 407 | Saint Ann's Hospital | Westerville | Ohio | United States | 43081 |
| 408 | Wright-Patterson Medical Center | Wright-Patterson Air Force Base | Ohio | United States | 45433 |
| 409 | Saint Elizabeth Youngstown Hospital | Youngstown | Ohio | United States | 44501 |
| 410 | Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | United States | 43701 |
| 411 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 412 | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | United States | 73120 |
| 413 | Saint Alphonsus Medical Center-Baker City | Baker City | Oregon | United States | 97814 |
| 414 | Saint Charles Health System | Bend | Oregon | United States | 97701 |
| 415 | Clackamas Radiation Oncology Center | Clackamas | Oregon | United States | 97015 |
| 416 | Providence Cancer Institute Clackamas Clinic | Clackamas | Oregon | United States | 97015 |
| 417 | Bay Area Hospital | Coos Bay | Oregon | United States | 97420 |
| 418 | Providence Newberg Medical Center | Newberg | Oregon | United States | 97132 |
| 419 | Saint Alphonsus Medical Center-Ontario | Ontario | Oregon | United States | 97914 |
| 420 | Providence Portland Medical Center | Portland | Oregon | United States | 97213 |
| 421 | Providence Saint Vincent Medical Center | Portland | Oregon | United States | 97225 |
| 422 | Saint Charles Health System-Redmond | Redmond | Oregon | United States | 97756 |
| 423 | Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | United States | 18103 |
| 424 | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | United States | 18017 |
| 425 | Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | United States | 19317 |
| 426 | Pocono Medical Center | East Stroudsburg | Pennsylvania | United States | 18301 |
| 427 | Lehigh Valley Hospital-Hazleton | Hazleton | Pennsylvania | United States | 18201 |
| 428 | Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | United States | 19107 |
| 429 | University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | United States | 15232 |
| 430 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425 |
| 431 | Bristol Regional Medical Center | Bristol | Tennessee | United States | 37620 |
| 432 | Ballad Health Cancer Care - Kingsport | Kingsport | Tennessee | United States | 37660 |
| 433 | Wellmont Holston Valley Hospital and Medical Center | Kingsport | Tennessee | United States | 37660 |
| 434 | Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee | United States | 38120 |
| 435 | Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | United States | 37232 |
| 436 | Saint Joseph Regional Cancer Center | Bryan | Texas | United States | 77802 |
| 437 | UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | United States | 75390 |
| 438 | STCC at DHR Health Institute for Research and Development | Edinburg | Texas | United States | 78539 |
| 439 | Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | United States | 84112 |
| 440 | Wellmont Medical Associates-Bristol | Bristol | Virginia | United States | 24201 |
| 441 | Southwest VA Regional Cancer Center | Norton | Virginia | United States | 24273 |
| 442 | Providence Regional Cancer System-Aberdeen | Aberdeen | Washington | United States | 98520 |
| 443 | Seattle Cancer Care Alliance at Overlake Medical Center | Bellevue | Washington | United States | 98004 |
| 444 | PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | United States | 98225 |
| 445 | Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington | United States | 98310 |
| 446 | Harrison Medical Center | Bremerton | Washington | United States | 98310 |
| 447 | Highline Medical Center-Main Campus | Burien | Washington | United States | 98166 |
| 448 | Providence Regional Cancer System-Centralia | Centralia | Washington | United States | 98531 |
| 449 | Swedish Cancer Institute-Edmonds | Edmonds | Washington | United States | 98026 |
| 450 | Saint Elizabeth Hospital | Enumclaw | Washington | United States | 98022 |
| 451 | Providence Regional Cancer Partnership | Everett | Washington | United States | 98201 |
| 452 | Saint Francis Hospital | Federal Way | Washington | United States | 98003 |
| 453 | Swedish Cancer Institute-Issaquah | Issaquah | Washington | United States | 98029 |
| 454 | Kadlec Clinic Hematology and Oncology | Kennewick | Washington | United States | 99336 |
| 455 | Seattle Cancer Care Alliance at EvergreenHealth | Kirkland | Washington | United States | 98034 |
| 456 | Providence Regional Cancer System-Lacey | Lacey | Washington | United States | 98503 |
| 457 | Saint Clare Hospital | Lakewood | Washington | United States | 98499 |
| 458 | PeaceHealth Saint John Medical Center | Longview | Washington | United States | 98632 |
| 459 | Jefferson Healthcare | Port Townsend | Washington | United States | 98368 |
| 460 | Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo | Washington | United States | 98370 |
| 461 | Pacific Gynecology Specialists | Seattle | Washington | United States | 98104 |
| 462 | Swedish Medical Center-Ballard Campus | Seattle | Washington | United States | 98107 |
| 463 | Swedish Medical Center-First Hill | Seattle | Washington | United States | 98122-4307 |
| 464 | Swedish Medical Center-Cherry Hill | Seattle | Washington | United States | 98122-5711 |
| 465 | Seattle Cancer Care Alliance at Northwest Hospital | Seattle | Washington | United States | 98133 |
| 466 | PeaceHealth United General Medical Center | Sedro-Woolley | Washington | United States | 98284 |
| 467 | Providence Regional Cancer System-Shelton | Shelton | Washington | United States | 98584 |
| 468 | Franciscan Research Center-Northwest Medical Plaza | Tacoma | Washington | United States | 98405 |
| 469 | Northwest Medical Specialties PLLC | Tacoma | Washington | United States | 98405 |
| 470 | PeaceHealth Southwest Medical Center | Vancouver | Washington | United States | 98664 |
| 471 | Providence Saint Mary Regional Cancer Center | Walla Walla | Washington | United States | 99362 |
| 472 | Providence Regional Cancer System-Yelm | Yelm | Washington | United States | 98597 |
| 473 | ThedaCare Regional Cancer Center | Appleton | Wisconsin | United States | 54911 |
| 474 | Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | United States | 54701 |
| 475 | Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States | 54601 |
| 476 | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | United States | 54449 |
| 477 | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin | United States | 54548 |
| 478 | Cancer Center of Western Wisconsin | New Richmond | Wisconsin | United States | 54017 |
| 479 | Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | United States | 54868 |
| 480 | Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin | United States | 54482 |
| 481 | Marshfield Medical Center - Weston | Weston | Wisconsin | United States | 54476 |
| 482 | Cheyenne Regional Medical Center-West | Cheyenne | Wyoming | United States | 82001 |
| 483 | Billings Clinic-Cody | Cody | Wyoming | United States | 82414 |
| 484 | Welch Cancer Center | Sheridan | Wyoming | United States | 82801 |
| 485 | BCCA-Vancouver Cancer Centre | Vancouver | British Columbia | Canada | V5Z 4E6 |
Sponsors and Collaborators
- National Cancer Institute (NCI)
Investigators
- Principal Investigator: Deborah M Stephens, Southwest Oncology Group
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NCI-2020-00752
- NCI-2020-00752
- S1925
- S1925
- U10CA180888