Testing the Effects of Early Treatment With Venetoclax and Obinutuzumab Versus Delayed Treatment With Venetoclax and Obinutuzumab for Newly Diagnosed Patients With High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Who Do Not Have Symptoms, the EVOLVE CLL/SLL Study

National Cancer Institute (NCI) (NIH)
Overall Status
CT.gov ID
Anticipated Duration (Months)
Patients Per Site
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This phase III trial compares early treatment with venetoclax and obinutuzumab versus delayed treatment with venetoclax and obinutuzumab in patients with newly diagnosed high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma. Venetoclax may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as obinutuzumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Starting treatment with the venetoclax and obinutuzumab early (before patients have symptoms) may have better outcomes for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma compared to starting treatment with the venetoclax and obinutuzumab after patients show symptoms.

Condition or DiseaseIntervention/TreatmentPhase
  • Biological: Obinutuzumab
  • Other: Quality-of-Life Assessment
  • Other: Questionnaire Administration
  • Drug: Venetoclax
Phase 3

Detailed Description

  1. To evaluate whether early treatment with venetoclax and obinutuzumab (V-O) extends overall survival (OS) compared with delayed treatment with V-O in high-risk (Chronic Lymphocytic Leukemia [CLL] International Prognostic Indicator [CLL-IPI] >= 4 or complex cytogenetics), newly diagnosed asymptomatic CLL/small lymphocytic lymphoma (SLL) patients.
  1. To compare overall response rates (complete response [CR] + partial response [PR]), CR rates, progression-free survival (PFS), and event-free survival (EFS) between arms.

  2. To evaluate safety and tolerability of each arm. III. To compare time to second CLL-directed treatment (from randomization and from response) between arms.

  3. To compare relapse-free survival (RFS) and time to second objective disease progression (PFS2) between arms.

  4. To compare the rates of Richter's transformation between arms. VI. To describe distribution of Cumulative Illness Rating Scale across the study, in each treatment arm, and to estimate the interaction between the scale and treatment arm and OS.

  1. To assess the impact of early intervention with V-O versus delayed therapy with V-O in CLL patients in relation to Health-Related Quality of Life (HRQoL) using the Functional Assessment of Cancer Therapy (FACT)-Leukemia scale.

  2. To assess the impact of the two treatment arms on the specific domains of the FACT-Leukemia, including physical, social, emotional, and functional well-being and leukemia-specific HRQoL.

  1. To evaluate the prognostic association between OS and measurable residual disease (MRD) undetectable disease state at 15 months after treatment initiation, across and between treatment arms. (Primary) II. To describe the prognostic association between the endpoints RFS and OS and MRD undetectable disease state at all measured time points (cycle [C]7day[D]1, C9D1, C12D1, and 15, 21, 27, 33, 39, 45, 51, 57, 63, 69, 75, 81, 87, 93, and 99 months after treatment initiation) using landmark analyses, across and between treatment arms (Secondary)
  2. To evaluate the prognostic association of MRD undetectable disease state over time in each treatment arm with respect to OS and RFS using time-dependent covariate analyses. (Secondary) IV. To describe the proportion of variation in OS and RFS explained by MRD sampling schemes with the goal of providing information on how much additional variation in OS and RFS is explained by additional MRD sampling for future trial designs. (Secondary) V. To compare the rate of MRD undetectable disease state at 15 months after initiation of treatment between treatment arms. (Secondary) VI. To compare duration of MRD undetectable disease state between treatment arms. (Secondary) VII. To describe associations between pretreatment stimulated karyotype risk, p53 mutation, IGHV mutational analysis, fluorescence in situ hybridization (FISH) for del(13q), del(11q), trisomy 12, and del(17p), and beta-2-microglobulin levels and other biomarkers with OS, PFS, overall and complete response rates, achievement of MRD undetectable disease state, and Richter's transformation. (Secondary) VIII. To describe associations between clinical complete or partial response (by International Workshop on Chronic Lymphocytic Leukemia [IWCLL] 2018 criteria) and response as assessed by MRD status and CT scans at 15 months after treatment initiation. (Secondary)

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM I (DELAYED V-O): Treatment begins once 2018 IWCLL indications are met. Patients receive obinutuzumab intravenously (IV) over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax orally (PO) once daily (QD) on days 22-28 of cycle 1 and on days 1-28 of cycles 2-12. Treatment repeats every 28 days for 12 cycles in the absence of disease progression or unacceptable toxicity.

ARM II (EARLY V-O): Treatment begins as soon as eligibility criteria are met. Patients receive obinutuzumab IV over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO QD on days 22-28 of cycle 1 and on days 1-28 of cycles 2-12. Treatment repeats every 28 days for 12 cycles in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up for 10 years after registration.

Study Design

Study Type:
Anticipated Enrollment :
247 participants
Intervention Model:
Parallel Assignment
None (Open Label)
Primary Purpose:
Official Title:
Randomized, Phase III Study of Early Intervention With Venetoclax and Obinutuzumab Versus Delayed Therapy With Venetoclax and Obinutuzumab in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): EVOLVE CLL/SLL Study
Actual Study Start Date :
Dec 14, 2020
Anticipated Primary Completion Date :
Oct 1, 2028
Anticipated Study Completion Date :
Oct 1, 2028

Arms and Interventions

Active Comparator: Arm I (delayed V-O)

Treatment begins once 2018 IWCLL indications are met. Patients receive obinutuzumab IV over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO QD on days 22-28 of cycle 1 and on days 1-28 of cycles 2-12. Treatment repeats every 28 days for 12 cycles in the absence of disease progression or unacceptable toxicity.

Biological: Obinutuzumab
Given IV
Other Names:
  • Anti-CD20 Monoclonal Antibody R7159
  • GA-101
  • GA101
  • Gazyva
  • huMAB(CD20)
  • R7159
  • RO 5072759
  • RO-5072759
  • RO5072759
  • Other: Quality-of-Life Assessment
    Ancillary studies
    Other Names:
  • Quality of Life Assessment
  • Other: Questionnaire Administration
    Ancillary studies

    Drug: Venetoclax
    Given PO
    Other Names:
  • ABT-0199
  • ABT-199
  • ABT199
  • GDC-0199
  • RG7601
  • Venclexta
  • Venclyxto
  • Experimental: Arm II (early V-O)

    Treatment begins as soon as eligibility criteria are met. Patients receive obinutuzumab IV over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO QD on days 22-28 of cycle 1 and on days 1-28 of cycles 2-12. Treatment repeats every 28 days for 12 cycles in the absence of disease progression or unacceptable toxicity.

    Biological: Obinutuzumab
    Given IV
    Other Names:
  • Anti-CD20 Monoclonal Antibody R7159
  • GA-101
  • GA101
  • Gazyva
  • huMAB(CD20)
  • R7159
  • RO 5072759
  • RO-5072759
  • RO5072759
  • Other: Quality-of-Life Assessment
    Ancillary studies
    Other Names:
  • Quality of Life Assessment
  • Other: Questionnaire Administration
    Ancillary studies

    Drug: Venetoclax
    Given PO
    Other Names:
  • ABT-0199
  • ABT-199
  • ABT199
  • GDC-0199
  • RG7601
  • Venclexta
  • Venclyxto
  • Outcome Measures

    Primary Outcome Measures

    1. Overall survival [From the day of registration on study until death from any cause with observations censored on the day of last contact for patients not known to have died, assessed up to 10 years]

      The final analysis will use stratified Cox proportional hazards regression stratified by Chronic Lymphocytic Leukemia [CLL] International Prognostic Indicator [CLL-IPI] Risk score status (high risk versus very high risk) with a two-sided alpha of 0.042. The final analysis will occur after 58 OS events have been observed, or at 4 years after accrual completes, whichever occurs first. Under the alternative hypothesis, the final analysis is expected to occur at approximately 7.9 years after study activation (about 3.8 years after accrual completes).

    2. Functional Assessment of Cancer Therapy (FACT)-Leukemia total score [At 2 years]

      A single comparison in the FACT-Leukemia total scores between patients randomized to early V-O versus delayed V-O will be conducted at the alpha=.05 level. The analysis of the 2-year FACT-Leukemia Total score will be conducted using multiple linear regression analysis, adjusting for stratification factor and the baseline FACT-Leukemia Total score as covariates. Will also conduct longitudinal modeling of the outcome measures over time.

    Secondary Outcome Measures

    1. Incidence of adverse events [Up to 10 years]

      Will utilize the CTCAE (National Cancer Institute [NCI] Common Terminology Criteria for Adverse Events) version 5.0 for toxicity and adverse event reporting.

    2. Overall Response rate [Up to 10 years]

      Will be compared using Fisher's exact test.

    3. Progression free survival [From the day of registration on study until the first of: relapse from complete response, progression, or death from any cause, assessed up to 10 years]

      Will be estimated using the Kaplan-Meier method and will be compared using log-rank tests and Cox regression models.

    4. Event free survival [From the day of registration on study until the first of: relapse from complete response, death from any cause, start of new (non-protocol) therapy, or completion of protocol therapy without documentation of complete response, assessed up to 10 years]

      Will be estimated using the Kaplan-Meier method and will be compared using log-rank tests and Cox regression models.

    5. Relapse free survival [From the date the patient first achieves complete response until relapse from complete response or death from any cause, assessed up to 10 years]

      Will be estimated using the Kaplan-Meier method and will be compared using log-rank tests and Cox regression models.

    6. Time to second treatment [Up to 10 years]

      Will be defined as the next chronic lymphocytic leukemia (CLL) treatment the patient receives after removal from protocol therapy. Will be estimated using the Kaplan-Meier method and will be compared using log-rank tests and Cox regression models.

    7. Patient compliance [Up to 10 years]

      Will be reported descriptively by arm.

    Other Outcome Measures

    1. FACT-Leukemia total score [At randomization and at months 3, 6, 9, 12, 15, 18, 24, 30, and 36]

      Will include linear regression analyses by arm.

    2. The individual components of the FACT-Leukemia [At randomization and at months 3, 6, 9, 12, 15, 18, 24, 30, and 36]

      Will include physical, social, emotional, and functional well-being. Will include linear regression analyses by arm.

    3. Patient-reported health-related quality of life (HRQoL) [Up to 36 months]

      Will use simple descriptive statistics (means, medians, standard deviations, ranges) to describe patient-reported health related quality of life using the FACT-Leukemia and its individual domains between randomized arms. To assess potential trends, P-values using t-tests will be provided.

    Eligibility Criteria


    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    Accepts Healthy Volunteers:
    Inclusion Criteria:
    • Participants must have a confirmed diagnosis of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) (collectively referred to as CLL throughout) according to the 2018 International Workshop on CLL. Participants must have been diagnosed within 12 months prior to registration

    • Participants must have CLL-International Prognostic Index (CLL-IPI) score >= 4 and/or complex cytogenetics (defined as 3+ chromosomal abnormalities)

    • Cytogenetic and fluorescence in situ hybridization (FISH) analyses must be completed at a Clinical Laboratory Improvement Act (CLIA)-approved laboratory within 12 months prior to registration. FISH panel should use probes to detect for abnormalities in chromosomes 13q, 12, 11q, and 17p

    • TP53 mutation status (if completed) must be obtained within 12 months prior to registration

    • Immunoglobulin heavy chain locus variable (IgVH) mutational status must be obtained prior to registration (at any time prior to registration)

    • Serum beta-2 microglobulin level must be obtained within 28 days prior to registration

    • Treatment with high dose corticosteroids and/or intravenous immunoglobulin for autoimmune complications of CLL must be complete at least 4 weeks prior to enrollment

    • Steroids used for treatment of conditions other than CLL/SLL must be at a dose of at most 20 mg/day of prednisone or equivalent corticosteroid at the time of registration

    • Prior therapy with anti CD20 monoclonal antibodies is not allowed

    • Participants must be >= 18 years of age

    • Participants must have Eastern Cooperative Oncology Group (ECOG) performance status =< 2

    • Platelet count >= 100,000/mm^3 within 28 days prior to registration

    • Absolute neutrophil count (ANC) >= 1,000/mm^3 within 28 days prior to registration

    • Creatinine clearance >= 30mL/min (by Cockcroft Gault) within 28 days prior to registration

    • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3.0 x upper limit of normal (ULN) within 28 days prior to registration

    • Total bilirubin =< 2.0 x ULN (or 5.0 x ULN if the patient has a history of Gilbert's disease), within 28 days prior to registration

    • Participants must be able to take oral medications

    • Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial

    • Participants with history of malignancy are allowed providing the cancer has not required active treatment within 2 years prior to registration (hormonal therapy is permissible). The following exceptions are permissible: basal cell, squamous cell skin, or non-melanomatous skin cancer, in situ cervical cancer, superficial bladder cancer not treated with intravesical chemotherapy or Bacillus Calmette-Guerin (BCG) within 6 months, localized prostate cancer requiring no more than chronic hormonal therapy, or localized breast cancer requiring no more than chronic hormonal therapy

    • Obinutuzumab has been associated with hepatitis reactivation. Participants must not have uncontrolled active infection with hepatitis B or C. Participants with latent hepatitis B infection must agree to take prophylaxis during and for 6 months following active protocol therapy with V-O.

    • Active infection with hepatitis B or C:

    • Active infection is defined as detectable hepatitis B deoxyribonucleic acid (DNA) or hepatitis C ribonucleic acid (RNA) by quantitative polymerase chain reaction (PCR).

    • Latent infection with hepatitis B:

    • Latent infection is defined as meeting all of the following criteria:

    • Hepatitis B surface antigen positive

    • Anti-hepatitis B total core antibody positive

    • Anti-hepatitis IgM core antibody undetectable

    • Hepatitis B PCR undetectable

    • Participants with latent hepatitis B infection must agree to take prophylaxis with anti-hepatitis agents during and for 6 months following active protocol therapy with V-O.

    • Participants who have received intravenous immunoglobulin (IVIG) therapy within 6 months who are hepatitis B core total antibody positive but PCR undetectable are not mandated to take prophylaxis

    • Participants must agree to have specimens submitted for translational medicine (MRD) and specimens must be submitted

    • Participants must be offered participation in banking for future research. With patient's consent, specimens must be submitted

    • Participants who are able to complete patient reported outcome (PRO) forms in English, Spanish, French, German, Russian or Mandarin must agree to participate in the quality of life assessments. (Those participants who are unable to read and write in English, Spanish, French, German, Russian or Mandarin may be registered to S1925 without contributing to the quality of life portion of the study.)

    • Participants must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.

    • NOTE: As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

    Exclusion Criteria:
    • Patients must not meet any of the IWCLL specified criteria for active CLL therapy

    • Participants must not have received or be currently receiving any prior CLL-directed therapy, including non-protocol-related therapy, anti-cancer immunotherapy, experimental therapy, or radiotherapy

    • Participants must not be receiving or planning to receive any other investigational agents before completing protocol therapy

    • Participants must not have current, clinically significant gastrointestinal malabsorption, in the opinion of treating doctor

    • Participants must not have cirrhosis

    • Participants must not have had major surgery within 30 days prior registration or minor surgery within 7 days prior to registration. Examples of major surgery include neurosurgical procedures, joint replacements, and surgeries that occur inside the thoracic or abdomino-pelvic cavities. Examples of minor surgery include dental surgery, insertion of a venous access device, skin biopsy, or aspiration of a joint. If there is a question about whether a surgery is major or minor, this should be discussed with the study chair

    • Participants must not have known bleeding disorders (e.g., von Willebrand's disease or hemophilia)

    • Participants must not have a history of stroke or intracranial hemorrhage within 6 months prior to enrollment

    • Participants must not require continued therapy with a strong inhibitor or inducer of CYP3A4/5, as venetoclax is extensively metabolized by CYP3A4/5

    • Participants must not have uncontrolled autoimmune hemolytic anemia or idiopathic thrombocytopenia purpura

    • Participants must not have any currently active, clinically significant cardiovascular disease, such as uncontrolled arrhythmia or class 3 or 4 congestive heart failure as defined by the New York Heart Association Functional Classification

    • Participants must not have a history of myocardial infarction, unstable angina, or acute coronary syndrome within 6 months prior to enrollment

    • Participants must not be pregnant or nursing, as there are no safety data available for these drug regimens during pregnancy. Women/men of reproductive potential must have agreed to use an effective contraceptive method. A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures

    Contacts and Locations


    SiteCityStateCountryPostal Code
    1University of Alabama at Birmingham Cancer CenterBirminghamAlabamaUnited States35233
    2Anchorage Associates in Radiation MedicineAnchorageAlaskaUnited States98508
    3Anchorage Radiation Therapy CenterAnchorageAlaskaUnited States99504
    4Alaska Breast Care and Surgery LLCAnchorageAlaskaUnited States99508
    5Alaska Oncology and Hematology LLCAnchorageAlaskaUnited States99508
    6Alaska Women's Cancer CareAnchorageAlaskaUnited States99508
    7Anchorage Oncology CentreAnchorageAlaskaUnited States99508
    8Katmai Oncology GroupAnchorageAlaskaUnited States99508
    9Providence Alaska Medical CenterAnchorageAlaskaUnited States99508
    10Fairbanks Memorial HospitalFairbanksAlaskaUnited States99701
    11Cancer Center at Saint Joseph'sPhoenixArizonaUnited States85004
    12Mercy Hospital Fort SmithFort SmithArkansasUnited States72903
    13CHI Saint Vincent Cancer Center Hot SpringsHot SpringsArkansasUnited States71913
    14Mission Hope Medical Oncology - Arroyo GrandeArroyo GrandeCaliforniaUnited States93420
    15Providence Saint Joseph Medical Center/Disney Family Cancer CenterBurbankCaliforniaUnited States91505
    16UC Irvine Health Cancer Center-NewportCosta MesaCaliforniaUnited States92627
    17City of Hope Comprehensive Cancer CenterDuarteCaliforniaUnited States91010
    18Tibor Rubin VA Medical CenterLong BeachCaliforniaUnited States90822
    19UC Irvine Health/Chao Family Comprehensive Cancer CenterOrangeCaliforniaUnited States92868
    20Stanford Cancer Institute Palo AltoPalo AltoCaliforniaUnited States94304
    21Pacific Central Coast Health Center-San Luis ObispoSan Luis ObispoCaliforniaUnited States93401
    22Mission Hope Medical Oncology - Santa MariaSanta MariaCaliforniaUnited States93444
    23Rocky Mountain Cancer Centers-AuroraAuroraColoradoUnited States80012
    24The Medical Center of AuroraAuroraColoradoUnited States80012
    25Boulder Community Foothills HospitalBoulderColoradoUnited States80303
    26Rocky Mountain Cancer Centers-BoulderBoulderColoradoUnited States80304
    27Rocky Mountain Cancer Centers - CentennialCentennialColoradoUnited States80112
    28Penrose-Saint Francis HealthcareColorado SpringsColoradoUnited States80907
    29Rocky Mountain Cancer Centers-PenroseColorado SpringsColoradoUnited States80907
    30Cancer Center of Colorado at Sloan's LakeDenverColoradoUnited States80204
    31National Jewish Health-Main CampusDenverColoradoUnited States80206
    32The Women's Imaging CenterDenverColoradoUnited States80209
    33Porter Adventist HospitalDenverColoradoUnited States80210
    34Colorado Blood Cancer InstituteDenverColoradoUnited States80218
    35Presbyterian - Saint Lukes Medical Center - Health OneDenverColoradoUnited States80218
    36Rocky Mountain Cancer Centers-MidtownDenverColoradoUnited States80218
    37SCL Health Saint Joseph HospitalDenverColoradoUnited States80218
    38Rocky Mountain Cancer Centers-RoseDenverColoradoUnited States80220
    39Rose Medical CenterDenverColoradoUnited States80220
    40Western Surgical CareDenverColoradoUnited States80220
    41Mercy Medical CenterDurangoColoradoUnited States81301
    42Southwest Oncology PCDurangoColoradoUnited States81301
    43Mountain Blue Cancer Care Center - SwedishEnglewoodColoradoUnited States80113
    44Rocky Mountain Cancer Centers - SwedishEnglewoodColoradoUnited States80113
    45Swedish Medical CenterEnglewoodColoradoUnited States80113
    46The Melanoma and Skin Cancer InstituteEnglewoodColoradoUnited States80113
    47National Jewish Health-Western Hematology OncologyGoldenColoradoUnited States80401
    48Saint Mary's Hospital and Regional Medical CenterGrand JunctionColoradoUnited States81501
    49North Colorado Medical CenterGreeleyColoradoUnited States80631
    50Good Samaritan Medical CenterLafayetteColoradoUnited States80026
    51Rocky Mountain Cancer Centers-LakewoodLakewoodColoradoUnited States80228
    52Saint Anthony HospitalLakewoodColoradoUnited States80228
    53Rocky Mountain Cancer Centers-LittletonLittletonColoradoUnited States80120
    54Littleton Adventist HospitalLittletonColoradoUnited States80122
    55Rocky Mountain Cancer Centers-Sky RidgeLone TreeColoradoUnited States80124
    56Sky Ridge Medical CenterLone TreeColoradoUnited States80124
    57Longmont United HospitalLongmontColoradoUnited States80501
    58Rocky Mountain Cancer Centers-LongmontLongmontColoradoUnited States80501
    59McKee Medical CenterLovelandColoradoUnited States80539
    60Parker Adventist HospitalParkerColoradoUnited States80138
    61Saint Mary Corwin Medical CenterPuebloColoradoUnited States81004
    62National Jewish Health-Northern Hematology OncologyThorntonColoradoUnited States80260
    63Rocky Mountain Cancer Centers-ThorntonThorntonColoradoUnited States80260
    64Beebe South Coastal Health CampusFrankfordDelawareUnited States19945
    65Beebe Medical CenterLewesDelawareUnited States19958
    66Delaware Clinical and Laboratory Physicians PANewarkDelawareUnited States19713
    67Helen F Graham Cancer CenterNewarkDelawareUnited States19713
    68Medical Oncology Hematology Consultants PANewarkDelawareUnited States19713
    69Christiana Care Health System-Christiana HospitalNewarkDelawareUnited States19718
    70Beebe Health CampusRehoboth BeachDelawareUnited States19971
    71TidalHealth Nanticoke / Allen Cancer CenterSeafordDelawareUnited States19973
    72Christiana Care Health System-Wilmington HospitalWilmingtonDelawareUnited States19801
    73Holy Cross HospitalFort LauderdaleFloridaUnited States33308
    74Sacred Heart HospitalPensacolaFloridaUnited States32504
    75Saint Alphonsus Cancer Care Center-BoiseBoiseIdahoUnited States83706
    76Saint Luke's Cancer Institute - BoiseBoiseIdahoUnited States83712
    77Saint Alphonsus Cancer Care Center-CaldwellCaldwellIdahoUnited States83605
    78Kootenai Health - Coeur d'AleneCoeur d'AleneIdahoUnited States83814
    79Walter Knox Memorial HospitalEmmettIdahoUnited States83617
    80Saint Luke's Cancer Institute - FruitlandFruitlandIdahoUnited States83619
    81Idaho Urologic Institute-MeridianMeridianIdahoUnited States83642
    82Saint Luke's Cancer Institute - MeridianMeridianIdahoUnited States83642
    83Saint Alphonsus Medical Center-NampaNampaIdahoUnited States83686
    84Saint Luke's Cancer Institute - NampaNampaIdahoUnited States83686
    85Kootenai Clinic Cancer Services - Post FallsPost FallsIdahoUnited States83854
    86Kootenai Cancer ClinicSandpointIdahoUnited States83864
    87Saint Luke's Cancer Institute - Twin FallsTwin FallsIdahoUnited States83301
    88Saint Anthony's HealthAltonIllinoisUnited States62002
    89Rush - Copley Medical CenterAuroraIllinoisUnited States60504
    90Illinois CancerCare-BloomingtonBloomingtonIllinoisUnited States61704
    91Loyola Center for Health at Burr RidgeBurr RidgeIllinoisUnited States60527
    92Illinois CancerCare-CantonCantonIllinoisUnited States61520
    93Memorial Hospital of CarbondaleCarbondaleIllinoisUnited States62902
    94SIH Cancer InstituteCartervilleIllinoisUnited States62918
    95Illinois CancerCare-CarthageCarthageIllinoisUnited States62321
    96Centralia Oncology ClinicCentraliaIllinoisUnited States62801
    97Northwestern UniversityChicagoIllinoisUnited States60611
    98University of Chicago Comprehensive Cancer CenterChicagoIllinoisUnited States60637
    99Carle on VermilionDanvilleIllinoisUnited States61832
    100Cancer Care Specialists of Illinois - DecaturDecaturIllinoisUnited States62526
    101Decatur Memorial HospitalDecaturIllinoisUnited States62526
    102Northwestern Medicine Cancer Center KishwaukeeDeKalbIllinoisUnited States60115
    103Illinois CancerCare-DixonDixonIllinoisUnited States61021
    104Carle Physician Group-EffinghamEffinghamIllinoisUnited States62401
    105Crossroads Cancer CenterEffinghamIllinoisUnited States62401
    106Illinois CancerCare-EurekaEurekaIllinoisUnited States61530
    107NorthShore University HealthSystem-Evanston HospitalEvanstonIllinoisUnited States60201
    108Illinois CancerCare-GalesburgGalesburgIllinoisUnited States61401
    109Western Illinois Cancer Treatment CenterGalesburgIllinoisUnited States61401
    110Northwestern Medicine Cancer Center DelnorGenevaIllinoisUnited States60134
    111NorthShore University HealthSystem-Glenbrook HospitalGlenviewIllinoisUnited States60026
    112Ingalls Memorial HospitalHarveyIllinoisUnited States60426
    113NorthShore University HealthSystem-Highland Park HospitalHighland ParkIllinoisUnited States60035
    114Loyola Medicine Homer GlenHomer GlenIllinoisUnited States60491
    115Illinois CancerCare-Kewanee ClinicKewaneeIllinoisUnited States61443
    116Northwestern Medicine Lake Forest HospitalLake ForestIllinoisUnited States60045
    117Illinois CancerCare-MacombMacombIllinoisUnited States61455
    118Carle Physician Group-Mattoon/CharlestonMattoonIllinoisUnited States61938
    119Loyola University Medical CenterMaywoodIllinoisUnited States60153
    120Marjorie Weinberg Cancer Center at Loyola-GottliebMelrose ParkIllinoisUnited States60160
    121Good Samaritan Regional Health CenterMount VernonIllinoisUnited States62864
    122UC Comprehensive Cancer Center at Silver CrossNew LenoxIllinoisUnited States60451
    123Cancer Care Center of O'FallonO'FallonIllinoisUnited States62269
    124University of Chicago Medicine-Orland ParkOrland ParkIllinoisUnited States60462
    125Illinois CancerCare-Ottawa ClinicOttawaIllinoisUnited States61350
    126Illinois CancerCare-PekinPekinIllinoisUnited States61554
    127Illinois CancerCare-PeoriaPeoriaIllinoisUnited States61615
    128Methodist Medical Center of IllinoisPeoriaIllinoisUnited States61636
    129Illinois CancerCare-PeruPeruIllinoisUnited States61354
    130Valley Radiation OncologyPeruIllinoisUnited States61354
    131Illinois CancerCare-PrincetonPrincetonIllinoisUnited States61356
    132Southern Illinois University School of MedicineSpringfieldIllinoisUnited States62702
    133Springfield ClinicSpringfieldIllinoisUnited States62702
    134Memorial Medical CenterSpringfieldIllinoisUnited States62781
    135Carle Cancer CenterUrbanaIllinoisUnited States61801
    136The Carle Foundation HospitalUrbanaIllinoisUnited States61801
    137Northwestern Medicine Cancer Center WarrenvilleWarrenvilleIllinoisUnited States60555
    138Illinois CancerCare - WashingtonWashingtonIllinoisUnited States61571
    139Rush-Copley Healthcare CenterYorkvilleIllinoisUnited States60560
    140Reid HealthRichmondIndianaUnited States47374
    141Mary Greeley Medical CenterAmesIowaUnited States50010
    142McFarland Clinic PC - AmesAmesIowaUnited States50010
    143McFarland Clinic PC-BooneBooneIowaUnited States50036
    144Saint Anthony Regional HospitalCarrollIowaUnited States51401
    145Medical Oncology and Hematology Associates-West Des MoinesCliveIowaUnited States50325
    146Mercy Cancer Center-West LakesCliveIowaUnited States50325
    147Alegent Health Mercy HospitalCouncil BluffsIowaUnited States51503
    148Greater Regional Medical CenterCrestonIowaUnited States50801
    149Iowa Methodist Medical CenterDes MoinesIowaUnited States50309
    150Medical Oncology and Hematology Associates-Des MoinesDes MoinesIowaUnited States50309
    151Broadlawns Medical CenterDes MoinesIowaUnited States50314
    152Medical Oncology and Hematology Associates-LaurelDes MoinesIowaUnited States50314
    153Mercy Medical Center - Des MoinesDes MoinesIowaUnited States50314
    154Iowa Lutheran HospitalDes MoinesIowaUnited States50316
    155McFarland Clinic PC-Trinity Cancer CenterFort DodgeIowaUnited States50501
    156Trinity Regional Medical CenterFort DodgeIowaUnited States50501
    157McFarland Clinic PC-JeffersonJeffersonIowaUnited States50129
    158McFarland Clinic PC-MarshalltownMarshalltownIowaUnited States50158
    159Methodist West HospitalWest Des MoinesIowaUnited States50266-7700
    160Mercy Medical Center-West LakesWest Des MoinesIowaUnited States50266
    161Central Care Cancer Center - Garden CityGarden CityKansasUnited States67846
    162Central Care Cancer Center - Great BendGreat BendKansasUnited States67530
    163Flaget Memorial HospitalBardstownKentuckyUnited States40004
    164Commonwealth Cancer Center-CorbinCorbinKentuckyUnited States40701
    165Saint Joseph Radiation Oncology Resource CenterLexingtonKentuckyUnited States40504
    166Saint Joseph Hospital EastLexingtonKentuckyUnited States40509
    167Saint Joseph LondonLondonKentuckyUnited States40741
    168Jewish HospitalLouisvilleKentuckyUnited States40202
    169Saints Mary and Elizabeth HospitalLouisvilleKentuckyUnited States40215
    170Jewish Hospital Medical Center NortheastLouisvilleKentuckyUnited States40245
    171Jewish Hospital Medical Center SouthShepherdsvilleKentuckyUnited States40165
    172Hematology/Oncology Clinic PLLCBaton RougeLouisianaUnited States70809
    173Ochsner LSU Health Monroe Medical CenterMonroeLouisianaUnited States71202
    174Tulane University Health Sciences CenterNew OrleansLouisianaUnited States70112
    175Ochsner LSU Health Saint Mary's Medical CenterShreveportLouisianaUnited States71101
    176LSU Health Sciences Center at ShreveportShreveportLouisianaUnited States71103
    177Hickman Cancer CenterAdrianMichiganUnited States49221
    178Saint Joseph Mercy HospitalAnn ArborMichiganUnited States48106
    179Bronson Battle CreekBattle CreekMichiganUnited States49017
    180IHA Hematology Oncology Consultants-BrightonBrightonMichiganUnited States48114
    181Saint Joseph Mercy BrightonBrightonMichiganUnited States48114
    182Henry Ford Cancer Institute-DownriverBrownstownMichiganUnited States48183
    183IHA Hematology Oncology Consultants-CantonCantonMichiganUnited States48188
    184Saint Joseph Mercy CantonCantonMichiganUnited States48188
    185Caro Cancer CenterCaroMichiganUnited States48723
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    188Hematology Oncology Consultants-ClarkstonClarkstonMichiganUnited States48346
    189Newland Medical Associates-ClarkstonClarkstonMichiganUnited States48346
    190Henry Ford Macomb Hospital-Clinton TownshipClinton TownshipMichiganUnited States48038
    191Henry Ford Medical Center-FairlaneDearbornMichiganUnited States48126
    192Henry Ford HospitalDetroitMichiganUnited States48202
    193Ascension Saint John HospitalDetroitMichiganUnited States48236
    194Great Lakes Cancer Management Specialists-Doctors ParkEast China TownshipMichiganUnited States48054
    195Genesee Cancer and Blood Disease Treatment CenterFlintMichiganUnited States48503
    196Genesee Hematology Oncology PCFlintMichiganUnited States48503
    197Genesys Hurley Cancer InstituteFlintMichiganUnited States48503
    198Hurley Medical CenterFlintMichiganUnited States48503
    199Helen DeVos Children's Hospital at Spectrum HealthGrand RapidsMichiganUnited States49503
    200Mercy Health Saint Mary'sGrand RapidsMichiganUnited States49503
    201Spectrum Health at Butterworth CampusGrand RapidsMichiganUnited States49503
    202Academic Hematology Oncology SpecialistsGrosse Pointe WoodsMichiganUnited States48236
    203Great Lakes Cancer Management Specialists-Van Elslander Cancer CenterGrosse Pointe WoodsMichiganUnited States48236
    204Michigan Breast Specialists-Grosse Pointe WoodsGrosse Pointe WoodsMichiganUnited States48236
    205Allegiance HealthJacksonMichiganUnited States49201
    206Bronson Methodist HospitalKalamazooMichiganUnited States49007
    207West Michigan Cancer CenterKalamazooMichiganUnited States49007
    208Ascension Borgess Cancer CenterKalamazooMichiganUnited States49009
    209Borgess Medical CenterKalamazooMichiganUnited States49048
    210Sparrow HospitalLansingMichiganUnited States48912
    211Hope Cancer ClinicLivoniaMichiganUnited States48154
    212Saint Mary Mercy HospitalLivoniaMichiganUnited States48154
    213Great Lakes Cancer Management Specialists-Macomb Medical CampusMacombMichiganUnited States48044
    214Michigan Breast Specialists-Macomb TownshipMacombMichiganUnited States48044
    215Saint Mary's Oncology/Hematology Associates of MarletteMarletteMichiganUnited States48453
    216Toledo Clinic Cancer Centers-MonroeMonroeMichiganUnited States48162
    217Mercy Health Mercy CampusMuskegonMichiganUnited States49444
    218Lakeland Hospital NilesNilesMichiganUnited States49120
    219Cancer and Hematology Centers of Western Michigan - Norton ShoresNorton ShoresMichiganUnited States49444
    220Henry Ford Medical Center-ColumbusNoviMichiganUnited States48377
    22121st Century Oncology-PontiacPontiacMichiganUnited States48341
    222Hope Cancer CenterPontiacMichiganUnited States48341
    223Newland Medical Associates-PontiacPontiacMichiganUnited States48341
    224Saint Joseph Mercy OaklandPontiacMichiganUnited States48341
    225Spectrum Health Reed City HospitalReed CityMichiganUnited States49677
    226Ascension Saint Mary's HospitalSaginawMichiganUnited States48601
    227Oncology Hematology Associates of Saginaw Valley PCSaginawMichiganUnited States48604
    228Lakeland Medical Center Saint JosephSaint JosephMichiganUnited States49085
    229Marie Yeager Cancer CenterSaint JosephMichiganUnited States49085
    230Henry Ford Macomb Health Center - Shelby TownshipShelbyMichiganUnited States48315
    231Bhadresh Nayak MD PC-Sterling HeightsSterling HeightsMichiganUnited States48312
    232Ascension Saint Joseph HospitalTawas CityMichiganUnited States48764
    233Munson Medical CenterTraverse CityMichiganUnited States49684
    234Advanced Breast Care Center PLLCWarrenMichiganUnited States48088
    235Great Lakes Cancer Management Specialists-Macomb Professional BuildingWarrenMichiganUnited States48093
    236Macomb Hematology Oncology PCWarrenMichiganUnited States48093
    237Michigan Breast Specialists-WarrenWarrenMichiganUnited States48093
    238Saint John Macomb-Oakland HospitalWarrenMichiganUnited States48093
    239Henry Ford West Bloomfield HospitalWest BloomfieldMichiganUnited States48322
    240Saint Mary's Oncology/Hematology Associates of West BranchWest BranchMichiganUnited States48661
    241Metro Health HospitalWyomingMichiganUnited States49519
    242Huron Gastroenterology PCYpsilantiMichiganUnited States48106
    243IHA Hematology Oncology Consultants-Ann ArborYpsilantiMichiganUnited States48197
    244Fairview Ridges HospitalBurnsvilleMinnesotaUnited States55337
    245Minnesota Oncology - BurnsvilleBurnsvilleMinnesotaUnited States55337
    246Cambridge Medical CenterCambridgeMinnesotaUnited States55008
    247Mercy HospitalCoon RapidsMinnesotaUnited States55433
    248Fairview Southdale HospitalEdinaMinnesotaUnited States55435
    249Unity HospitalFridleyMinnesotaUnited States55432
    250Fairview Clinics and Surgery Center Maple GroveMaple GroveMinnesotaUnited States55369
    251Minnesota Oncology Hematology PA-MaplewoodMaplewoodMinnesotaUnited States55109
    252Saint John's Hospital - HealtheastMaplewoodMinnesotaUnited States55109
    253Abbott-Northwestern HospitalMinneapolisMinnesotaUnited States55407
    254Hennepin County Medical CenterMinneapolisMinnesotaUnited States55415
    255Minneapolis VA Medical CenterMinneapolisMinnesotaUnited States55417
    256Health Partners IncMinneapolisMinnesotaUnited States55454
    257Monticello Cancer CenterMonticelloMinnesotaUnited States55362
    258New Ulm Medical CenterNew UlmMinnesotaUnited States56073
    259Fairview Northland Medical CenterPrincetonMinnesotaUnited States55371
    260North Memorial Medical Health CenterRobbinsdaleMinnesotaUnited States55422
    261Park Nicollet Clinic - Saint Louis ParkSaint Louis ParkMinnesotaUnited States55416
    262Regions HospitalSaint PaulMinnesotaUnited States55101
    263United HospitalSaint PaulMinnesotaUnited States55102
    264Saint Francis Regional Medical CenterShakopeeMinnesotaUnited States55379
    265Lakeview HospitalStillwaterMinnesotaUnited States55082
    266Ridgeview Medical CenterWaconiaMinnesotaUnited States55387
    267Rice Memorial HospitalWillmarMinnesotaUnited States56201
    268Minnesota Oncology Hematology PA-WoodburyWoodburyMinnesotaUnited States55125
    269Fairview Lakes Medical CenterWyomingMinnesotaUnited States55092
    270Saint Louis Cancer and Breast Institute-BallwinBallwinMissouriUnited States63011
    271Central Care Cancer Center - BolivarBolivarMissouriUnited States65613
    272Saint Francis Medical CenterCape GirardeauMissouriUnited States63703
    273Southeast Cancer CenterCape GirardeauMissouriUnited States63703
    274Saint Luke's HospitalChesterfieldMissouriUnited States63017
    275Siteman Cancer Center at West County HospitalCreve CoeurMissouriUnited States63141
    276Parkland Health Center - FarmingtonFarmingtonMissouriUnited States63640
    277Capital Region Southwest CampusJefferson CityMissouriUnited States65109
    278Freeman Health SystemJoplinMissouriUnited States64804
    279Mercy Hospital JoplinJoplinMissouriUnited States64804
    280Delbert Day Cancer Institute at PCRMCRollaMissouriUnited States65401
    281Mercy Clinic-Rolla-Cancer and HematologyRollaMissouriUnited States65401
    282Heartland Regional Medical CenterSaint JosephMissouriUnited States64506
    283Saint Louis Cancer and Breast Institute-South CitySaint LouisMissouriUnited States63109
    284Washington University School of MedicineSaint LouisMissouriUnited States63110
    285Mercy Hospital SouthSaint LouisMissouriUnited States63128
    286Siteman Cancer Center-South CountySaint LouisMissouriUnited States63129
    287Missouri Baptist Medical CenterSaint LouisMissouriUnited States63131
    288Siteman Cancer Center at Christian HospitalSaint LouisMissouriUnited States63136
    289Mercy Hospital Saint LouisSaint LouisMissouriUnited States63141
    290Siteman Cancer Center at Saint Peters HospitalSaint PetersMissouriUnited States63376
    291Sainte Genevieve County Memorial HospitalSainte GenevieveMissouriUnited States63670
    292Mercy Hospital SpringfieldSpringfieldMissouriUnited States65804
    293CoxHealth South HospitalSpringfieldMissouriUnited States65807
    294Missouri Baptist Sullivan HospitalSullivanMissouriUnited States63080
    295Missouri Baptist Outpatient Center-Sunset HillsSunset HillsMissouriUnited States63127
    296Mercy Hospital WashingtonWashingtonMissouriUnited States63090
    297Community Hospital of AnacondaAnacondaMontanaUnited States59711
    298Billings Clinic Cancer CenterBillingsMontanaUnited States59101
    299Saint Vincent HealthcareBillingsMontanaUnited States59101
    300Saint Vincent Frontier Cancer CenterBillingsMontanaUnited States59102
    301Bozeman Deaconess HospitalBozemanMontanaUnited States59715
    302Benefis Healthcare- Sletten Cancer InstituteGreat FallsMontanaUnited States59405
    303Great Falls ClinicGreat FallsMontanaUnited States59405
    304Kalispell Regional Medical CenterKalispellMontanaUnited States59901
    305Saint Patrick Hospital - Community HospitalMissoulaMontanaUnited States59802
    306Community Medical HospitalMissoulaMontanaUnited States59804
    307CHI Health Saint FrancisGrand IslandNebraskaUnited States68803
    308CHI Health Good SamaritanKearneyNebraskaUnited States68847
    309Saint Elizabeth Regional Medical CenterLincolnNebraskaUnited States68510
    310Cancer Partners of Nebraska - Pine LakeLincolnNebraskaUnited States68516
    311Southeast Nebraska Cancer Center - 68th Street PlaceLincolnNebraskaUnited States68516
    312Alegent Health Immanuel Medical CenterOmahaNebraskaUnited States68122
    313Alegent Health Bergan Mercy Medical CenterOmahaNebraskaUnited States68124
    314Alegent Health Lakeside HospitalOmahaNebraskaUnited States68130
    315Creighton University Medical CenterOmahaNebraskaUnited States68131
    316Midlands Community HospitalPapillionNebraskaUnited States68046
    317Memorial Sloan Kettering Basking RidgeBasking RidgeNew JerseyUnited States07920
    318Memorial Sloan Kettering MonmouthMiddletownNew JerseyUnited States07748
    319Memorial Sloan Kettering BergenMontvaleNew JerseyUnited States07645
    320Hematology Oncology Associates of Central New York-AuburnAuburnNew YorkUnited States13021
    321Memorial Sloan Kettering CommackCommackNew YorkUnited States11725
    322Hematology Oncology Associates of Central New York-East SyracuseEast SyracuseNew YorkUnited States13057
    323Glens Falls HospitalGlens FallsNew YorkUnited States12801
    324Memorial Sloan Kettering WestchesterHarrisonNew YorkUnited States10604
    325Memorial Sloan Kettering Cancer CenterNew YorkNew YorkUnited States10065
    326Rochester General HospitalRochesterNew YorkUnited States14621
    327University of RochesterRochesterNew YorkUnited States14642
    328Hematology Oncology Associates of Central New York-Onondaga HillSyracuseNew YorkUnited States13215
    329Memorial Sloan Kettering NassauUniondaleNew YorkUnited States11553
    330Southeastern Medical Oncology Center-ClintonClintonNorth CarolinaUnited States28328
    331Southeastern Medical Oncology Center-GoldsboroGoldsboroNorth CarolinaUnited States27534
    332Southeastern Medical Oncology Center-JacksonvilleJacksonvilleNorth CarolinaUnited States28546
    333Vidant Oncology-KenansvilleKenansvilleNorth CarolinaUnited States28349
    334Vidant Oncology-KinstonKinstonNorth CarolinaUnited States28501
    335Vidant Oncology-RichlandsRichlandsNorth CarolinaUnited States28574
    336Indu and Raj Soin Medical CenterBeavercreekOhioUnited States45431
    337Strecker Cancer Center-BelpreBelpreOhioUnited States45714
    338Saint Elizabeth Boardman HospitalBoardmanOhioUnited States44512
    339Cleveland Clinic Mercy HospitalCantonOhioUnited States44708
    340Mercy Hematology and Oncology Associates IncCantonOhioUnited States44708
    341Dayton Physicians LLC-Miami Valley SouthCentervilleOhioUnited States45459
    342Miami Valley Hospital SouthCentervilleOhioUnited States45459
    343Adena Regional Medical CenterChillicotheOhioUnited States45601
    344Good Samaritan Hospital - CincinnatiCincinnatiOhioUnited States45220
    345Oncology Hematology Care Inc-KenwoodCincinnatiOhioUnited States45236
    346Bethesda North HospitalCincinnatiOhioUnited States45242
    347TriHealth Cancer Institute-WestsideCincinnatiOhioUnited States45247
    348TriHealth Cancer Institute-AndersonCincinnatiOhioUnited States45255
    349Cleveland Clinic FoundationClevelandOhioUnited States44195
    350Ohio State University Comprehensive Cancer CenterColumbusOhioUnited States43210
    351Mount Carmel East HospitalColumbusOhioUnited States43213
    352Columbus Oncology and Hematology Associates IncColumbusOhioUnited States43214
    353Riverside Methodist HospitalColumbusOhioUnited States43214
    354Grant Medical CenterColumbusOhioUnited States43215
    355The Mark H Zangmeister CenterColumbusOhioUnited States43219
    356Mount Carmel Health Center WestColumbusOhioUnited States43222
    357Doctors HospitalColumbusOhioUnited States43228
    358Miami Valley HospitalDaytonOhioUnited States45409
    359Dayton Physician LLC-Miami Valley Hospital NorthDaytonOhioUnited States45415
    360Miami Valley Hospital NorthDaytonOhioUnited States45415
    361Delaware Health Center-Grady Cancer CenterDelawareOhioUnited States43015
    362Grady Memorial HospitalDelawareOhioUnited States43015
    363Dublin Methodist HospitalDublinOhioUnited States43016
    364Armes Family Cancer CenterFindlayOhioUnited States45840
    365Blanchard Valley HospitalFindlayOhioUnited States45840
    366Orion Cancer CareFindlayOhioUnited States45840
    367Atrium Medical Center-Middletown Regional HospitalFranklinOhioUnited States45005-1066
    368Dayton Physicians LLC-AtriumFranklinOhioUnited States45005
    369Central Ohio Breast and Endocrine SurgeryGahannaOhioUnited States43230
    370Dayton Physicians LLC-WayneGreenvilleOhioUnited States45331
    371Wayne HospitalGreenvilleOhioUnited States45331
    372Mount Carmel Grove City HospitalGrove CityOhioUnited States43123
    373Greater Dayton Cancer CenterKetteringOhioUnited States45409
    374Kettering Medical CenterKetteringOhioUnited States45429
    375Fairfield Medical CenterLancasterOhioUnited States43130
    376Saint Rita's Medical CenterLimaOhioUnited States45801
    377OhioHealth Mansfield HospitalMansfieldOhioUnited States44903
    378Marietta Memorial HospitalMariettaOhioUnited States45750
    379OhioHealth Marion General HospitalMarionOhioUnited States43302
    380Knox Community HospitalMount VernonOhioUnited States43050
    381Licking Memorial HospitalNewarkOhioUnited States43055
    382Newark Radiation OncologyNewarkOhioUnited States43055
    383Mercy Health Perrysburg Cancer CenterPerrysburgOhioUnited States43551
    384Southern Ohio Medical CenterPortsmouthOhioUnited States45662
    385Springfield Regional Cancer CenterSpringfieldOhioUnited States45504
    386Springfield Regional Medical CenterSpringfieldOhioUnited States45505
    387Saint Vincent Mercy Medical CenterToledoOhioUnited States43608
    388Mercy Health - Saint Anne HospitalToledoOhioUnited States43623
    389Toledo Clinic Cancer Centers-ToledoToledoOhioUnited States43623
    390Dayton Physicians LLC-Upper ValleyTroyOhioUnited States45373
    391Upper Valley Medical CenterTroyOhioUnited States45373
    392Saint Joseph Warren HospitalWarrenOhioUnited States44484
    393Saint Ann's HospitalWestervilleOhioUnited States43081
    394Wright-Patterson Medical CenterWright-Patterson Air Force BaseOhioUnited States45433
    395Saint Elizabeth Youngstown HospitalYoungstownOhioUnited States44501
    396Genesis Healthcare System Cancer Care CenterZanesvilleOhioUnited States43701
    397University of Oklahoma Health Sciences CenterOklahoma CityOklahomaUnited States73104
    398Mercy Hospital Oklahoma CityOklahoma CityOklahomaUnited States73120
    399Saint Alphonsus Medical Center-Baker CityBaker CityOregonUnited States97814
    400Saint Charles Health SystemBendOregonUnited States97701
    401Clackamas Radiation Oncology CenterClackamasOregonUnited States97015
    402Providence Cancer Institute Clackamas ClinicClackamasOregonUnited States97015
    403Bay Area HospitalCoos BayOregonUnited States97420
    404Providence Newberg Medical CenterNewbergOregonUnited States97132
    405Saint Alphonsus Medical Center-OntarioOntarioOregonUnited States97914
    406Providence Portland Medical CenterPortlandOregonUnited States97213
    407Providence Saint Vincent Medical CenterPortlandOregonUnited States97225
    408Saint Charles Health System-RedmondRedmondOregonUnited States97756
    409Lehigh Valley Hospital-Cedar CrestAllentownPennsylvaniaUnited States18103
    410Lehigh Valley Hospital - MuhlenbergBethlehemPennsylvaniaUnited States18017
    411Christiana Care Health System-Concord Health CenterChadds FordPennsylvaniaUnited States19317
    412Pocono Medical CenterEast StroudsburgPennsylvaniaUnited States18301
    413Lehigh Valley Hospital-HazletonHazletonPennsylvaniaUnited States18201
    414University of Pittsburgh Cancer Institute (UPCI)PittsburghPennsylvaniaUnited States15232
    415Medical University of South CarolinaCharlestonSouth CarolinaUnited States29425
    416Wellmont Bristol Regional Medical CenterBristolTennesseeUnited States37620
    417Regional Cancer Center at Indian Path Community HospitalKingsportTennesseeUnited States37660
    418Wellmont Holston Valley Hospital and Medical CenterKingsportTennesseeUnited States37660
    419Vanderbilt University/Ingram Cancer CenterNashvilleTennesseeUnited States37232
    420Saint Joseph Regional Cancer CenterBryanTexasUnited States77802
    421Huntsman Cancer Institute/University of UtahSalt Lake CityUtahUnited States84112
    422Wellmont Medical Associates-BristolBristolVirginiaUnited States24201
    423Southwest VA Regional Cancer CenterNortonVirginiaUnited States24273
    424Providence Regional Cancer System-AberdeenAberdeenWashingtonUnited States98520
    425PeaceHealth Saint Joseph Medical CenterBellinghamWashingtonUnited States98225
    426Harrison HealthPartners Hematology and Oncology-BremertonBremertonWashingtonUnited States98310
    427Harrison Medical CenterBremertonWashingtonUnited States98310
    428Highline Medical Center-Main CampusBurienWashingtonUnited States98166
    429Providence Regional Cancer System-CentraliaCentraliaWashingtonUnited States98531
    430Swedish Cancer Institute-EdmondsEdmondsWashingtonUnited States98026
    431Saint Elizabeth HospitalEnumclawWashingtonUnited States98022
    432Providence Regional Cancer PartnershipEverettWashingtonUnited States98201
    433Saint Francis HospitalFederal WayWashingtonUnited States98003
    434Swedish Cancer Institute-IssaquahIssaquahWashingtonUnited States98029
    435Kadlec Clinic Hematology and OncologyKennewickWashingtonUnited States99336
    436Providence Regional Cancer System-LaceyLaceyWashingtonUnited States98503
    437Saint Clare HospitalLakewoodWashingtonUnited States98499
    438PeaceHealth Saint John Medical CenterLongviewWashingtonUnited States98632
    439Jefferson HealthcarePort TownsendWashingtonUnited States98368
    440Harrison HealthPartners Hematology and Oncology-PoulsboPoulsboWashingtonUnited States98370
    441Pacific Gynecology SpecialistsSeattleWashingtonUnited States98104
    442Swedish Medical Center-Ballard CampusSeattleWashingtonUnited States98107
    443Swedish Medical Center-First HillSeattleWashingtonUnited States98122-4307
    444Swedish Medical Center-Cherry HillSeattleWashingtonUnited States98122-5711
    445PeaceHealth United General Medical CenterSedro-WoolleyWashingtonUnited States98284
    446Providence Regional Cancer System-SheltonSheltonWashingtonUnited States98584
    447Franciscan Research Center-Northwest Medical PlazaTacomaWashingtonUnited States98405
    448Northwest Medical Specialties PLLCTacomaWashingtonUnited States98405
    449PeaceHealth Southwest Medical CenterVancouverWashingtonUnited States98664
    450Providence Saint Mary Regional Cancer CenterWalla WallaWashingtonUnited States99362
    451Providence Regional Cancer System-YelmYelmWashingtonUnited States98597
    452Marshfield Medical Center-EC Cancer CenterEau ClaireWisconsinUnited States54701
    453Marshfield Medical Center-MarshfieldMarshfieldWisconsinUnited States54449
    454Marshfield Clinic-Minocqua CenterMinocquaWisconsinUnited States54548
    455Cancer Center of Western WisconsinNew RichmondWisconsinUnited States54017
    456Marshfield Medical Center-Rice LakeRice LakeWisconsinUnited States54868
    457Marshfield Clinic Stevens Point CenterStevens PointWisconsinUnited States54482
    458Marshfield Medical Center - WestonWestonWisconsinUnited States54476
    459Cheyenne Regional Medical Center-WestCheyenneWyomingUnited States82001
    460Billings Clinic-CodyCodyWyomingUnited States82414
    461Welch Cancer CenterSheridanWyomingUnited States82801

    Sponsors and Collaborators

    • National Cancer Institute (NCI)


    • Principal Investigator: Deborah M Stephens, Southwest Oncology Group

    Study Documents (Full-Text)

    None provided.

    More Information


    None provided.
    Responsible Party:
    National Cancer Institute (NCI)
    ClinicalTrials.gov Identifier:
    Other Study ID Numbers:
    • NCI-2020-00752
    • NCI-2020-00752
    • S1925
    • S1925
    • U10CA180888
    First Posted:
    Feb 17, 2020
    Last Update Posted:
    Nov 29, 2021
    Last Verified:
    Oct 1, 2021
    Individual Participant Data (IPD) Sharing Statement:
    Plan to Share IPD:
    Studies a U.S. FDA-regulated Drug Product:
    Studies a U.S. FDA-regulated Device Product:
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Nov 29, 2021