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Testing The Addition of a New Anti-cancer Drug, Venetoclax, to the Usual Treatment (Ibrutinib and Obinutuzumab) in Untreated, Older Patients With Chronic Lymphocytic Leukemia

Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Active, not recruiting
CT.gov ID
NCT03737981
Collaborator
(none)
454
Enrollment
867
Locations
2
Arms
100.9
Anticipated Duration (Months)
0.5
Patients Per Site
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This phase III trial compares adding a new anti-cancer drug (venetoclax) to the usual treatment (ibrutinib plus obinutuzumab) in older patients with chronic lymphocytic leukemia who have not received previous treatment. The addition of venetoclax to the usual treatment might prevent chronic lymphocytic leukemia from returning. This trial also will investigate whether patients who receive ibrutinib plus obinutuzumab plus venetoclax and have no detectable chronic lymphocytic leukemia after 1 year of treatment, can stop taking ibrutinib. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Immunotherapy with obinutuzumab may induce changes in body's immune system and may interfere with the ability of cancer cells to grow and spread. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Giving ibrutinib and obinutuzumab with venetoclax may work better at treating chronic lymphocytic leukemia compared to ibrutinib and obinutuzumab.

Condition or Disease Intervention/Treatment Phase
Phase 3

Detailed Description

PRIMARY OBJECTIVE:
  1. To compare the progression-free survival (PFS) between control treatment and experimental treatment strategies: ibrutinib/obinutuzumab (IO) with ibrutinib maintenance (IM) versus ibrutinib/venetoclax/obinutuzumab (IVO) regardless of IM or observation.
SECONDARY OBJECTIVES:

  1. To compare bone marrow (BM) minimal residual disease (MRD)- complete response (CR) rates, MRD- rates, and depth of response at cycle 15 day 1 between patients treated with IO versus IVO.

  2. To compare overall survival (OS) between the control and experimental treatment strategies: IO with IM versus IVO regardless of IM or observation.

  3. To compare the 5-year PFS and overall survival (OS) for the control and experimental treatment strategies: IO with IM versus IVO regardless of IM or observation.

  4. To describe the toxicity profile for each of the treatment strategies and by each treatment course.

CORRELATIVES SCIENCE OBJECTIVES:

  1. To compare MRD status between blood and bone marrow at the end of induction treatment/cycle 15 day 1 to determine whether blood MRD can be used as a surrogate to bone marrow MRD with these treatment regimens.

  2. To compare peripheral blood MRD status by standard central flow cytometry to next generation sequencing (NGS) using ClonoSeq technique to determine the agreement in MRD negativity of the two techniques.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM I: Patients receive ibrutinib orally (PO) once daily (QD) on days 1-28. Patients also receive obinutuzumab intravenously (IV) on days 1, 2, 8, and 15 of cycle 1, and on day 1 of cycles 2-6. Treatment repeats every 28 days for up to 14 cycles in the absence of disease progression or unacceptable toxicity. Beginning cycle 15, patients receive ibrutinib PO QD every 28 days in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive ibrutinib PO QD on days 1-28. Patients also receive obinutuzumab IV on days 1, 2, 8, and 15 of cycle 1, and on day 1 of cycles 2-6. Beginning cycle 3, patients also receive venetoclax PO QD on days 1-28. Treatment repeats every 28 days for 14 cycles in the absence of disease progression or unacceptable toxicity. All patients will then receive a 15th cycle of ibrutinib. Beginning cycle 16, patients who do not achieve a BM MRD negative CR, receive ibrutinib PO QD every 28 days in the absence of disease progression or unacceptable toxicity. Patients who achieve a BM MRD negative CR undergo observation every 3 cycles for 6 years, then every 6 cycles thereafter.

After completion of study treatment, patients are followed every 6 months until 10 years from registration.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
454 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
A Randomized Phase III Study of Ibrutinib Plus Obinutuzumab Versus Ibrutinib Plus Venetoclax and Obinutuzumab in Untreated Older Patients (>/= 65 Years of Age) With Chronic Lymphocytic Leukemia (CLL)
Actual Study Start Date :
Jan 4, 2019
Anticipated Primary Completion Date :
Jun 1, 2027
Anticipated Study Completion Date :
Jun 1, 2027

Arms and Interventions

Arm Intervention/Treatment
Active Comparator: Arm I (ibrutinib, obinutuzumab)

Patients receive ibrutinib PO QD on days 1-28. Patients also receive obinutuzumab IV on days 1, 2, 8, and 15 of cycle 1, and on day 1 of cycles 2-6. Treatment repeats every 28 days for up to 14 cycles in the absence of disease progression or unacceptable toxicity. Beginning cycle 15, patients receive ibrutinib PO QD every 28 days in the absence of disease progression or unacceptable toxicity.

Drug: Ibrutinib
Given PO
Other Names:
  • BTK Inhibitor PCI-32765
  • CRA-032765
  • Imbruvica
  • PCI-32765

    • Biological: Obinutuzumab
    Given IV
    Other Names:
  • Anti-CD20 Monoclonal Antibody R7159
  • GA-101
  • GA101
  • Gazyva
  • huMAB(CD20)
  • R7159
  • RO 5072759
  • RO-5072759
  • RO5072759

    		•
    Experimental: Arm II (ibrutinib, obinutuzumab, venetoclax)

    Patients receive ibrutinib PO QD on days 1-28. Patients also receive obinutuzumab IV on days 1, 2, 8, and 15 of cycle 1, and on day 1 of cycles 2-6. Beginning cycle 3, patients also receive venetoclax PO QD on days 1-28. Treatment repeats every 28 days for 14 cycles in the absence of disease progression or unacceptable toxicity. All patients will then receive a 15th cycle of ibrutinib. Beginning cycle 16, patients who do not achieve a BM MRD negative CR, receive ibrutinib PO QD every 28 days in the absence of disease progression or unacceptable toxicity. Patients who achieve a BM MRD negative CR undergo observation every 3 cycles for 6 years, then every 6 cycles thereafter.

    Drug: Ibrutinib
    Given PO
    Other Names:
  • BTK Inhibitor PCI-32765
  • CRA-032765
  • Imbruvica
  • PCI-32765

    • Biological: Obinutuzumab
    Given IV
    Other Names:
  • Anti-CD20 Monoclonal Antibody R7159
  • GA-101
  • GA101
  • Gazyva
  • huMAB(CD20)
  • R7159
  • RO 5072759
  • RO-5072759
  • RO5072759

    • Other: Observation
    Undergo observation
    Other Names:
  • Inspection
  • Visual Inspection

    • Drug: Venetoclax
    Given PO
    Other Names:
  • ABT-0199
  • ABT-199
  • ABT199
  • GDC-0199
  • RG7601
  • Venclexta
  • Venclyxto

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Progression-free survival (PFS) [From randomization date until the earlier of disease progression or death from any cause, assessed up to 10 years]

      PFS will be compared between the experimental and control treatment strategy groups using a stratified log-rank test (stratified on Rai stage, intermediate versus [vs.] high, and del(17p13.1) by fluorescence in situ hybridization [FISH], present vs. absent). The Kaplan-Meier method will be used to estimate PFS distributions. Five-year PFS estimates, medians, and corresponding hazard ratios will be provided with 95% confidence intervals for each treatment strategy.

    Secondary Outcome Measures

    1. Bone marrow (BM) minimal residual disease (MRD)- complete response (CR) rate [Up to 10 years]

      BM MRD- CR rate will be calculated and will be estimated using the number of patients meeting the BM MRD- CR criteria divided by the total number of patients randomized to each of the treatment arms. The stratified Cochran-Mantel-Haenszel test will be used to compare the BM MRD- CR rates between treatment arms (stratified on Rai stage, intermediate vs. high, and del(17p13.1) by FISH, present vs. absent).

    2. Overall survival (OS) [From randomization date until death from any cause, assessed up to 10 years]

      The Kaplan-Meier method will be used to estimate the OS distribution for each treatment strategy. Estimates at 5 years will be calculated with corresponding 95% confidence intervals, and differences in these estimates between the treatment strategies will be tested using a stratified chi-square test based on the complementary log-log transformation of the Kaplan-Meier estimates. Comparisons in OS curves between experimental and control treatment strategies will use a stratified log-rank test (stratified on Rai stage, intermediate vs. high, and del(17p13.1) by FISH, present vs. absent). Hazard ratios with 95% confidence intervals will be estimated from the corresponding, stratified proportional hazard model.

    3. Incidence of adverse events [Up to 10 years]

      Will be defined as adverse events that are classified as either possibly, probably, or definitely related to study treatment, graded per National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0. Frequency and severity of adverse events and tolerability for each treatment strategy group will be summarized using descriptive statistics. The maximum grade for each type of toxicity will be recorded for each patient, and frequency tables will be reviewed to determine toxicity patterns. The incidence of severe (grade 3+) adverse events or toxicities will be described.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    65 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • PRE-REGISTRATION ELIGIBILITY CRITERIA (STEP 0)

    • Patients must have been diagnosed with chronic lymphocytic leukemia (CLL) (> 5000 B-cells per uL of peripheral blood at any point during the course of their disease) or small lymphocytic lymphoma (SLL) with < 5000 B-cells per uL of blood but with disease-associated lymphadenopathy

    • This blood submission is mandatory prior to registration/randomization to perform fluorescence in situ hybridization (FISH) centrally that will be used for stratification. It should be obtained as soon after pre-registration as possible

    • REGISTRATION ELIGIBILITY CRITERIA (STEP 1)

    • Patients must be diagnosed with CLL or SLL in accordance with 2018 International Workshop on Chronic Lymphocytic Leukemia (IWCLL) criteria that includes all of the following:

    • = 5 x10^9 B lymphocytes (5000/uL) in the peripheral blood measured by flow cytometry at any point in the course of the disease or less peripheral blood involvement but disease-associated lymphadenopathy

    • On local morphologic review, the leukemic cells must be small mature lymphocytes, and prolymphocytes must not exceed 55% of the blood lymphocytes

    • Neoplastic cells on immunophenotype (performed locally) must reveal a clonal B-cell population, which express the B cell surface markers of CD19 and CD20, as well as the T-cell antigen CD5. Patients with bright surface immunoglobulin expression or lack of CD23 expression in >10% of cells must lack t(11;14) translocation by interphase cytogenetics

    • Patients must be intermediate or high-risk Rai stage CLL or SLL

    • Intermediate risk (formerly stage I/II) is defined by lymphadenopathy and/or hepatomegaly or splenomegaly without anemia or thrombocytopenia

    • High risk (formerly stage III/IV) is defined by splenomegaly and/or anemia (hemoglobin < 11g/dL) not attributable to autoimmune hemolytic anemia and/or thrombocytopenia (platelets [plt] < 100 x10^9/L) not attributable to autoimmune thrombocytopenia

    • Patients must meet criteria for treatment as defined by 2018 IWCLL guidelines which includes at least one of the following criteria:

    • Evidence of marrow failure as manifested by the development or worsening of anemia or thrombocytopenia (not attributable to autoimmune hemolytic anemia or thrombocytopenia)

    • Massive (>= 6 cm below the costal margin), progressive or symptomatic splenomegaly

    • Massive nodes (>= 10 cm) or progressive or symptomatic lymphadenopathy

    • Progressive lymphocytosis with a lymphocyte doubling time < 6 months or an increase of >= 50% over a 2 month period

    • Autoimmune anemia and/or thrombocytopenia that is poorly responsive to standard therapy

    • Symptomatic or functional extranodal involvement (e.g. skin, kidney, lung, spine)

    • Constitutional symptoms, which include any of the following:

    • Unintentional weight loss of 10% or more within 6 months

    • Significant fatigue

    • Fevers > 100.5 degrees Fahrenheit (F) for 2 weeks or more without evidence of infection

    • Night sweats >= 1 month without evidence of infection

    • Treatment with rituximab and/or high dose corticosteroids for autoimmune complications of CLL/SLL must be complete at least 4 weeks prior to enrollment. Palliative steroids must be at a dose not higher than 20 mg/day of prednisone or equivalent corticosteroid at the time of registration

    • Age >= 65 years

    • Eastern Cooperative Oncology Group (ECOG) performance status 0-2

    • Absolute neutrophil count (ANC) >= 1,000/mm^3 except if due to bone marrow involvement

    • Platelet count (untransfused) >= 30,000/mm^3 except if due to bone marrow involvement

    • Calculated (Calc.) creatinine clearance >= 40 mL/min (by Cockcroft-Gault)

    • Bilirubin =< 1.5 x upper limit of normal (ULN) except if due to liver involvement, hemolysis, or Gilbert's disease

    • Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) except if due to liver involvement

    • If evidence of chronic hepatitis B virus (HBV) infection, HBV viral load must be undetectable on suppressive therapy if indicated

    • Please note: Intravenous immunoglobulin therapy (IVIG) can cause a false positive hepatitis B serology. If patients receiving routine IVIG have core antibody or surface antigen positivity without evidence of active viremia (negative hepatitis B deoxyribonucleic acid [DNA]) they may still participate in the study, must have hepatitis serologies and hepatitis B DNA monitored periodically by the treating physician

    • If history of hepatitis C virus (HCV) infection, must be treated with undetectable HCV viral load

    • Human immunodeficiency virus (HIV)-infected patients on effective antiretroviral therapy with undetectable viral load within 6 months are eligible for this trial

    • Central fluorescent in situ hybridization (FISH) blood results are mandatory prior to registration/randomization for it will be used for stratification

    • Patients must be able to swallow capsules and not have the following conditions: disease significantly affecting gastrointestinal absorption, resection of the stomach or small bowel, partial or complete bowel obstruction

    • Patients must be able to receive either a xanthine oxidase inhibitor or rasburicase for prophylaxis/treatment of tumor lysis syndrome (TLS)

    • RE-REGISTRATION ELIGIBILITY CRITERIA (STEP 2)

    • Completion of treatment through cycle 14 day 28, and remain on ibrutinib therapy

    • Receipt of central BM MRD results

    • Response assessment completed with CR determination

    Exclusion Criteria:

    • Patients must not have had prior therapy for CLL/SLL (except palliative steroids or treatment of autoimmune complications of CLL with rituximab or steroids)

    • Patients must not have any history of Richter's transformation or prolymphocytic leukemia (prolymphocytes in blood > 55%)

    • Patients with class III or class IV heart failure by New York Heart Association, those with unstable angina, and those with uncontrolled arrhythmia are not eligible

    • Patients who have had a myocardial infarction, intracranial bleed, or stroke within the past 6 months are not eligible

    • Patients must not be receiving active systemic anticoagulation with heparin or warfarin. Patients on warfarin must discontinue the drug for at least 10 days prior to registration on the study

    • Chronic concomitant treatment with strong inhibitors of CYP3A4/5 is not allowed on this study. Patients on strong CYP3A inhibitors must discontinue the drug for 14 days prior to registration on the study

    • Chronic concomitant treatment with strong CYP3A4/5 inducers is not allowed. Patients must discontinue the drug 14 days prior to registration on the study

    • Patients must not require more than 20 mg prednisone or equivalent corticosteroid daily

    • Patients must not have uncontrolled active systemic infection requiring intravenous antibiotics

    • Patients must not have a known allergy to mannitol

    • Patients must not have prior significant hypersensitivity to rituximab (not including infusion reactions)

    • Patients may not have had major surgery within 10 days prior to registration, or minor surgery within 7 days prior to registration. Examples of minor surgery include dental surgery, insertion of a venous access device, skin biopsy, or aspiration for a joint. The decision about whether a surgery is major or minor can be made at the discretion of the treating physician

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 University of Alabama at Birmingham Cancer Center Birmingham Alabama United States 35233
    2 Anchorage Associates in Radiation Medicine Anchorage Alaska United States 98508
    3 Anchorage Radiation Therapy Center Anchorage Alaska United States 99504
    4 Alaska Breast Care and Surgery LLC Anchorage Alaska United States 99508
    5 Alaska Oncology and Hematology LLC Anchorage Alaska United States 99508
    6 Alaska Women's Cancer Care Anchorage Alaska United States 99508
    7 Anchorage Oncology Centre Anchorage Alaska United States 99508
    8 Katmai Oncology Group Anchorage Alaska United States 99508
    9 Providence Alaska Medical Center Anchorage Alaska United States 99508
    10 Fairbanks Memorial Hospital Fairbanks Alaska United States 99701
    11 Kingman Regional Medical Center Kingman Arizona United States 86401
    12 Cancer Center at Saint Joseph's Phoenix Arizona United States 85004
    13 Mayo Clinic Hospital in Arizona Phoenix Arizona United States 85054
    14 Mayo Clinic in Arizona Scottsdale Arizona United States 85259
    15 University of Arizona Cancer Center-Orange Grove Campus Tucson Arizona United States 85704
    16 Banner University Medical Center - Tucson Tucson Arizona United States 85719
    17 University of Arizona Cancer Center-North Campus Tucson Arizona United States 85719
    18 Mercy Hospital Fort Smith Fort Smith Arkansas United States 72903
    19 CHI Saint Vincent Cancer Center Hot Springs Hot Springs Arkansas United States 71913
    20 John L McClellan Memorial Veterans Hospital Little Rock Arkansas United States 72205
    21 Kaiser Permanente-Anaheim Anaheim California United States 92806
    22 Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande California United States 93420
    23 PCR Oncology Arroyo Grande California United States 93420
    24 Kaiser Permanente-Baldwin Park Baldwin Park California United States 91706
    25 Kaiser Permanente-Bellflower Bellflower California United States 90706
    26 Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California United States 91505
    27 Community Cancer Institute Clovis California United States 93611
    28 University Oncology Associates Clovis California United States 93611
    29 UC Irvine Health Cancer Center-Newport Costa Mesa California United States 92627
    30 City of Hope Comprehensive Cancer Center Duarte California United States 91010
    31 Kaiser Permanente-Fontana Fontana California United States 92335
    32 Kaiser Permanente - Harbor City Harbor City California United States 90710
    33 Kaiser Permanente-Irvine Irvine California United States 92618
    34 Tibor Rubin VA Medical Center Long Beach California United States 90822
    35 Kaiser Permanente Los Angeles Medical Center Los Angeles California United States 90027
    36 Kaiser Permanente West Los Angeles Los Angeles California United States 90034
    37 Kaiser Permanente-Ontario Ontario California United States 91761
    38 UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California United States 92868
    39 Desert Regional Medical Center Palm Springs California United States 92262
    40 Stanford Cancer Institute Palo Alto Palo Alto California United States 94304
    41 Kaiser Permanente - Panorama City Panorama City California United States 91402
    42 Kaiser Permanente-Riverside Riverside California United States 92505
    43 Kaiser Permanente-San Diego Mission San Diego California United States 92108
    44 Kaiser Permanente-San Diego Zion San Diego California United States 92120
    45 Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo California United States 93401
    46 Kaiser Permanente-San Marcos San Marcos California United States 92078
    47 Mission Hope Medical Oncology - Santa Maria Santa Maria California United States 93444
    48 Kaiser Permanente-Woodland Hills Woodland Hills California United States 91367
    49 Rocky Mountain Cancer Centers-Aurora Aurora Colorado United States 80012
    50 The Medical Center of Aurora Aurora Colorado United States 80012
    51 Rocky Mountain Regional VA Medical Center Aurora Colorado United States 80045
    52 Boulder Community Hospital Boulder Colorado United States 80301
    53 Boulder Community Foothills Hospital Boulder Colorado United States 80303
    54 Rocky Mountain Cancer Centers-Boulder Boulder Colorado United States 80304
    55 Rocky Mountain Cancer Centers - Centennial Centennial Colorado United States 80112
    56 Penrose-Saint Francis Healthcare Colorado Springs Colorado United States 80907
    57 Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado United States 80907
    58 Cancer Center of Colorado at Sloan's Lake Denver Colorado United States 80204
    59 Denver Health Medical Center Denver Colorado United States 80204
    60 Kaiser Permanente-Franklin Denver Colorado United States 80205
    61 National Jewish Health-Main Campus Denver Colorado United States 80206
    62 The Women's Imaging Center Denver Colorado United States 80209
    63 Porter Adventist Hospital Denver Colorado United States 80210
    64 Colorado Blood Cancer Institute Denver Colorado United States 80218
    65 Presbyterian - Saint Lukes Medical Center - Health One Denver Colorado United States 80218
    66 Rocky Mountain Cancer Centers-Midtown Denver Colorado United States 80218
    67 SCL Health Saint Joseph Hospital Denver Colorado United States 80218
    68 Rocky Mountain Cancer Centers-Rose Denver Colorado United States 80220
    69 Rose Medical Center Denver Colorado United States 80220
    70 Western Surgical Care Denver Colorado United States 80220
    71 Mercy Medical Center Durango Colorado United States 81301
    72 Southwest Oncology PC Durango Colorado United States 81301
    73 Mountain Blue Cancer Care Center - Swedish Englewood Colorado United States 80113
    74 Rocky Mountain Cancer Centers - Swedish Englewood Colorado United States 80113
    75 Swedish Medical Center Englewood Colorado United States 80113
    76 The Melanoma and Skin Cancer Institute Englewood Colorado United States 80113
    77 Mountain Blue Cancer Care Center Golden Colorado United States 80401
    78 National Jewish Health-Western Hematology Oncology Golden Colorado United States 80401
    79 Saint Mary's Hospital and Regional Medical Center Grand Junction Colorado United States 81501
    80 Grand Valley Oncology Grand Junction Colorado United States 81505
    81 North Colorado Medical Center Greeley Colorado United States 80631
    82 Good Samaritan Medical Center Lafayette Colorado United States 80026
    83 Kaiser Permanente-Rock Creek Lafayette Colorado United States 80026
    84 Rocky Mountain Cancer Centers-Lakewood Lakewood Colorado United States 80228
    85 Saint Anthony Hospital Lakewood Colorado United States 80228
    86 Rocky Mountain Cancer Centers-Littleton Littleton Colorado United States 80120
    87 Littleton Adventist Hospital Littleton Colorado United States 80122
    88 Kaiser Permanente-Lone Tree Lone Tree Colorado United States 80124
    89 Rocky Mountain Cancer Centers-Sky Ridge Lone Tree Colorado United States 80124
    90 Sky Ridge Medical Center Lone Tree Colorado United States 80124
    91 Longmont United Hospital Longmont Colorado United States 80501
    92 Rocky Mountain Cancer Centers-Longmont Longmont Colorado United States 80501
    93 McKee Medical Center Loveland Colorado United States 80539
    94 Parker Adventist Hospital Parker Colorado United States 80138
    95 Rocky Mountain Cancer Centers-Parker Parker Colorado United States 80138
    96 Saint Mary Corwin Medical Center Pueblo Colorado United States 81004
    97 Rocky Mountain Cancer Centers - Pueblo Pueblo Colorado United States 81008
    98 National Jewish Health-Northern Hematology Oncology Thornton Colorado United States 80260
    99 Rocky Mountain Cancer Centers-Thornton Thornton Colorado United States 80260
    100 SCL Health Lutheran Medical Center Wheat Ridge Colorado United States 80033
    101 Smilow Cancer Hospital-Derby Care Center Derby Connecticut United States 06418
    102 Smilow Cancer Hospital Care Center-Fairfield Fairfield Connecticut United States 06824
    103 Smilow Cancer Hospital Care Center at Glastonbury Glastonbury Connecticut United States 06033
    104 Smilow Cancer Hospital Care Center - Guiford Guilford Connecticut United States 06437
    105 Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut United States 06105
    106 Smilow Cancer Center/Yale-New Haven Hospital New Haven Connecticut United States 06510
    107 Yale University New Haven Connecticut United States 06520
    108 Yale-New Haven Hospital North Haven Medical Center North Haven Connecticut United States 06473
    109 Smilow Cancer Hospital-Orange Care Center Orange Connecticut United States 06477
    110 Smilow Cancer Hospital Care Center-Trumbull Trumbull Connecticut United States 06611
    111 Smilow Cancer Hospital-Waterbury Care Center Waterbury Connecticut United States 06708
    112 Smilow Cancer Hospital Care Center - Waterford Waterford Connecticut United States 06385
    113 Veterans Affairs Connecticut Healthcare System-West Haven Campus West Haven Connecticut United States 06516
    114 Beebe South Coastal Health Campus Frankford Delaware United States 19945
    115 Beebe Medical Center Lewes Delaware United States 19958
    116 Delaware Clinical and Laboratory Physicians PA Newark Delaware United States 19713
    117 Helen F Graham Cancer Center Newark Delaware United States 19713
    118 Medical Oncology Hematology Consultants PA Newark Delaware United States 19713
    119 Christiana Care Health System-Christiana Hospital Newark Delaware United States 19718
    120 Beebe Health Campus Rehoboth Beach Delaware United States 19971
    121 TidalHealth Nanticoke / Allen Cancer Center Seaford Delaware United States 19973
    122 Christiana Care Health System-Wilmington Hospital Wilmington Delaware United States 19801
    123 UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida United States 33146
    124 Broward Health North Deerfield Beach Florida United States 33064
    125 UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida United States 33442
    126 Holy Cross Hospital Fort Lauderdale Florida United States 33308
    127 Broward Health Medical Center Fort Lauderdale Florida United States 33316
    128 UM Sylvester Comprehensive Cancer Center at Hollywood Hollywood Florida United States 33021
    129 University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida United States 33136
    130 UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida United States 33324
    131 Cleveland Clinic-Weston Weston Florida United States 33331
    132 University Cancer and Blood Center LLC Athens Georgia United States 30607
    133 Augusta Oncology Associates PC-D'Antignac Augusta Georgia United States 30901
    134 Augusta Oncology Associates PC-Wheeler Augusta Georgia United States 30909
    135 Augusta University Medical Center Augusta Georgia United States 30912
    136 Atlanta VA Medical Center Decatur Georgia United States 30033
    137 Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah Georgia United States 31405
    138 Hawaii Cancer Care - Savio 'Aiea Hawaii United States 96701
    139 Pali Momi Medical Center 'Aiea Hawaii United States 96701
    140 Queen's Cancer Center - Pearlridge 'Aiea Hawaii United States 96701
    141 The Cancer Center of Hawaii-Pali Momi 'Aiea Hawaii United States 96701
    142 Island Urology-Hilo Hilo Hawaii United States 96720
    143 Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii United States 96813
    144 Island Urology Honolulu Hawaii United States 96813
    145 Queen's Cancer Cenrer - POB I Honolulu Hawaii United States 96813
    146 Queen's Medical Center Honolulu Hawaii United States 96813
    147 Straub Clinic and Hospital Honolulu Hawaii United States 96813
    148 University of Hawaii Cancer Center Honolulu Hawaii United States 96813
    149 Hawaii Cancer Care Inc-Liliha Honolulu Hawaii United States 96817
    150 Kuakini Medical Center Honolulu Hawaii United States 96817
    151 Queen's Cancer Center - Kuakini Honolulu Hawaii United States 96817
    152 The Cancer Center of Hawaii-Liliha Honolulu Hawaii United States 96817
    153 Kapiolani Medical Center for Women and Children Honolulu Hawaii United States 96826
    154 Wilcox Memorial Hospital and Kauai Medical Clinic Lihue Hawaii United States 96766
    155 Saint Alphonsus Cancer Care Center-Boise Boise Idaho United States 83706
    156 Saint Luke's Cancer Institute - Boise Boise Idaho United States 83712
    157 Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho United States 83605
    158 Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho United States 83814
    159 Walter Knox Memorial Hospital Emmett Idaho United States 83617
    160 Saint Luke's Cancer Institute - Fruitland Fruitland Idaho United States 83619
    161 Idaho Urologic Institute-Meridian Meridian Idaho United States 83642
    162 Saint Luke's Cancer Institute - Meridian Meridian Idaho United States 83642
    163 Saint Alphonsus Medical Center-Nampa Nampa Idaho United States 83686
    164 Saint Luke's Cancer Institute - Nampa Nampa Idaho United States 83686
    165 Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho United States 83854
    166 Kootenai Cancer Clinic Sandpoint Idaho United States 83864
    167 Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho United States 83301
    168 Saint Anthony's Health Alton Illinois United States 62002
    169 Rush - Copley Medical Center Aurora Illinois United States 60504
    170 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    171 Loyola Center for Health at Burr Ridge Burr Ridge Illinois United States 60527
    172 Illinois CancerCare-Canton Canton Illinois United States 61520
    173 Memorial Hospital of Carbondale Carbondale Illinois United States 62902
    174 SIH Cancer Institute Carterville Illinois United States 62918
    175 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    176 Centralia Oncology Clinic Centralia Illinois United States 62801
    177 Northwestern University Chicago Illinois United States 60611
    178 Rush University Medical Center Chicago Illinois United States 60612
    179 University of Illinois Chicago Illinois United States 60612
    180 University of Chicago Comprehensive Cancer Center Chicago Illinois United States 60637
    181 Carle on Vermilion Danville Illinois United States 61832
    182 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    183 Decatur Memorial Hospital Decatur Illinois United States 62526
    184 Northwestern Medicine Cancer Center Kishwaukee DeKalb Illinois United States 60115
    185 Illinois CancerCare-Dixon Dixon Illinois United States 61021
    186 Carle Physician Group-Effingham Effingham Illinois United States 62401
    187 Crossroads Cancer Center Effingham Illinois United States 62401
    188 Illinois CancerCare-Eureka Eureka Illinois United States 61530
    189 NorthShore University HealthSystem-Evanston Hospital Evanston Illinois United States 60201
    190 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    191 Western Illinois Cancer Treatment Center Galesburg Illinois United States 61401
    192 Northwestern Medicine Cancer Center Delnor Geneva Illinois United States 60134
    193 NorthShore University HealthSystem-Glenbrook Hospital Glenview Illinois United States 60026
    194 Ingalls Memorial Hospital Harvey Illinois United States 60426
    195 NorthShore University HealthSystem-Highland Park Hospital Highland Park Illinois United States 60035
    196 Loyola Medicine Homer Glen Homer Glen Illinois United States 60491
    197 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    198 Northwestern Medicine Lake Forest Hospital Lake Forest Illinois United States 60045
    199 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    200 Carle Physician Group-Mattoon/Charleston Mattoon Illinois United States 61938
    201 Loyola University Medical Center Maywood Illinois United States 60153
    202 Marjorie Weinberg Cancer Center at Loyola-Gottlieb Melrose Park Illinois United States 60160
    203 Good Samaritan Regional Health Center Mount Vernon Illinois United States 62864
    204 UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois United States 60451
    205 Cancer Care Center of O'Fallon O'Fallon Illinois United States 62269
    206 University of Chicago Medicine-Orland Park Orland Park Illinois United States 60462
    207 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    208 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    209 OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin Illinois United States 61554
    210 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    211 OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria Illinois United States 61615
    212 Methodist Medical Center of Illinois Peoria Illinois United States 61636
    213 OSF Saint Francis Medical Center Peoria Illinois United States 61637
    214 Illinois CancerCare-Peru Peru Illinois United States 61354
    215 Valley Radiation Oncology Peru Illinois United States 61354
    216 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    217 SwedishAmerican Regional Cancer Center/ACT Rockford Illinois United States 61114
    218 North Shore Medical Center Skokie Illinois United States 60076
    219 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    220 Springfield Clinic Springfield Illinois United States 62702
    221 Memorial Medical Center Springfield Illinois United States 62781
    222 Southwest Illinois Health Services LLP Swansea Illinois United States 62226
    223 Carle Cancer Center Urbana Illinois United States 61801
    224 The Carle Foundation Hospital Urbana Illinois United States 61801
    225 Northwestern Medicine Cancer Center Warrenville Warrenville Illinois United States 60555
    226 Illinois CancerCare - Washington Washington Illinois United States 61571
    227 Rush-Copley Healthcare Center Yorkville Illinois United States 60560
    228 Franciscan Health Indianapolis Indianapolis Indiana United States 46237
    229 Franciscan Health Mooresville Mooresville Indiana United States 46158
    230 Reid Health Richmond Indiana United States 47374
    231 Mary Greeley Medical Center Ames Iowa United States 50010
    232 McFarland Clinic PC - Ames Ames Iowa United States 50010
    233 University of Iowa Healthcare Cancer Services Quad Cities Bettendorf Iowa United States 52722
    234 McFarland Clinic PC-Boone Boone Iowa United States 50036
    235 Physicians' Clinic of Iowa PC Cedar Rapids Iowa United States 52402
    236 Medical Oncology and Hematology Associates-West Des Moines Clive Iowa United States 50325
    237 Mercy Cancer Center-West Lakes Clive Iowa United States 50325
    238 Alegent Health Mercy Hospital Council Bluffs Iowa United States 51503
    239 Greater Regional Medical Center Creston Iowa United States 50801
    240 Medical Oncology and Hematology Associates-Laurel Des Moines Iowa United States 50314
    241 Mercy Medical Center - Des Moines Des Moines Iowa United States 50314
    242 McFarland Clinic PC-Trinity Cancer Center Fort Dodge Iowa United States 50501
    243 University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa United States 52242
    244 McFarland Clinic PC-Jefferson Jefferson Iowa United States 50129
    245 McFarland Clinic PC-Marshalltown Marshalltown Iowa United States 50158
    246 Siouxland Regional Cancer Center Sioux City Iowa United States 51101
    247 MercyOne Waterloo Medical Center Waterloo Iowa United States 50702
    248 Mercy Medical Center-West Lakes West Des Moines Iowa United States 50266
    249 Coffeyville Regional Medical Center Coffeyville Kansas United States 67337
    250 Central Care Cancer Center - Garden City Garden City Kansas United States 67846
    251 Central Care Cancer Center - Great Bend Great Bend Kansas United States 67530
    252 HaysMed University of Kansas Health System Hays Kansas United States 67601
    253 Cancer Center of Kansas-Independence Independence Kansas United States 67301
    254 University of Kansas Cancer Center-West Kansas City Kansas United States 66112
    255 University of Kansas Cancer Center Kansas City Kansas United States 66160
    256 Lawrence Memorial Hospital Lawrence Kansas United States 66044
    257 Kansas Institute of Medicine Cancer and Blood Center Lenexa Kansas United States 66219
    258 Minimally Invasive Surgery Hospital Lenexa Kansas United States 66219
    259 Olathe Health Cancer Center Olathe Kansas United States 66061
    260 Menorah Medical Center Overland Park Kansas United States 66209
    261 University of Kansas Cancer Center-Overland Park Overland Park Kansas United States 66210
    262 Ascension Via Christi - Pittsburg Pittsburg Kansas United States 66762
    263 Salina Regional Health Center Salina Kansas United States 67401
    264 University of Kansas Health System Saint Francis Campus Topeka Kansas United States 66606
    265 University of Kansas Hospital-Westwood Cancer Center Westwood Kansas United States 66205
    266 Cancer Center of Kansas-Wichita Medical Arts Tower Wichita Kansas United States 67208
    267 Ascension Via Christi Hospitals Wichita Wichita Kansas United States 67214
    268 Cancer Center of Kansas - Wichita Wichita Kansas United States 67214
    269 Wesley Medical Center Wichita Kansas United States 67214
    270 Flaget Memorial Hospital Bardstown Kentucky United States 40004
    271 Commonwealth Cancer Center-Corbin Corbin Kentucky United States 40701
    272 Saint Joseph Radiation Oncology Resource Center Lexington Kentucky United States 40504
    273 Saint Joseph Hospital East Lexington Kentucky United States 40509
    274 Saint Joseph London London Kentucky United States 40741
    275 Jewish Hospital Louisville Kentucky United States 40202
    276 Saints Mary and Elizabeth Hospital Louisville Kentucky United States 40215
    277 UofL Health Medical Center Northeast Louisville Kentucky United States 40245
    278 Jewish Hospital Medical Center South Shepherdsville Kentucky United States 40165
    279 Christus Saint Frances Cabrini Hospital Alexandria Louisiana United States 71301
    280 Ochsner Medical Center Jefferson New Orleans Louisiana United States 70121
    281 Eastern Maine Medical Center Bangor Maine United States 04401
    282 Lafayette Family Cancer Center-EMMC Brewer Maine United States 04412
    283 University of Maryland/Greenebaum Cancer Center Baltimore Maryland United States 21201
    284 Saint Agnes Hospital Baltimore Maryland United States 21229
    285 Western Maryland Regional Medical Center Cumberland Maryland United States 21502
    286 Tufts Medical Center Boston Massachusetts United States 02111
    287 Lahey Hospital and Medical Center Burlington Massachusetts United States 01805
    288 Lowell General Hospital Lowell Massachusetts United States 01854
    289 Mercy Medical Center Springfield Massachusetts United States 01104
    290 Baystate Medical Center Springfield Massachusetts United States 01199
    291 Saint Joseph Mercy Hospital Ann Arbor Michigan United States 48106
    292 Bronson Battle Creek Battle Creek Michigan United States 49017
    293 Saint Joseph Mercy Brighton Brighton Michigan United States 48114
    294 Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan United States 48114
    295 Henry Ford Cancer Institute-Downriver Brownstown Michigan United States 48183
    296 Saint Joseph Mercy Canton Canton Michigan United States 48188
    297 Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan United States 48188
    298 Caro Cancer Center Caro Michigan United States 48723
    299 Saint Joseph Mercy Chelsea Chelsea Michigan United States 48118
    300 Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan United States 48118
    301 Hematology Oncology Consultants-Clarkston Clarkston Michigan United States 48346
    302 Newland Medical Associates-Clarkston Clarkston Michigan United States 48346
    303 Henry Ford Macomb Hospital-Clinton Township Clinton Township Michigan United States 48038
    304 Beaumont Hospital - Dearborn Dearborn Michigan United States 48124
    305 Henry Ford Medical Center-Fairlane Dearborn Michigan United States 48126
    306 Wayne State University/Karmanos Cancer Institute Detroit Michigan United States 48201
    307 Henry Ford Hospital Detroit Michigan United States 48202
    308 Ascension Saint John Hospital Detroit Michigan United States 48236
    309 Great Lakes Cancer Management Specialists-Doctors Park East China Township Michigan United States 48054
    310 Green Bay Oncology - Escanaba Escanaba Michigan United States 49829
    311 Weisberg Cancer Treatment Center Farmington Hills Michigan United States 48334
    312 Beaumont Hospital - Farmington Hills Farmington Hills Michigan United States 48336
    313 Genesee Cancer and Blood Disease Treatment Center Flint Michigan United States 48503
    314 Genesee Hematology Oncology PC Flint Michigan United States 48503
    315 Genesys Hurley Cancer Institute Flint Michigan United States 48503
    316 Hurley Medical Center Flint Michigan United States 48503
    317 Helen DeVos Children's Hospital at Spectrum Health Grand Rapids Michigan United States 49503
    318 Mercy Health Saint Mary's Grand Rapids Michigan United States 49503
    319 Spectrum Health at Butterworth Campus Grand Rapids Michigan United States 49503
    320 Academic Hematology Oncology Specialists Grosse Pointe Woods Michigan United States 48236
    321 Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods Michigan United States 48236
    322 Michigan Breast Specialists-Grosse Pointe Woods Grosse Pointe Woods Michigan United States 48236
    323 William Beaumont Hospital-Grosse Pointe Grosse Pointe Michigan United States 48230
    324 Allegiance Health Jackson Michigan United States 49201
    325 Bronson Methodist Hospital Kalamazoo Michigan United States 49007
    326 West Michigan Cancer Center Kalamazoo Michigan United States 49007
    327 Ascension Borgess Cancer Center Kalamazoo Michigan United States 49009
    328 Borgess Medical Center Kalamazoo Michigan United States 49048
    329 Sparrow Hospital Lansing Michigan United States 48912
    330 Hope Cancer Clinic Livonia Michigan United States 48154
    331 Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan United States 48154
    332 Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb Michigan United States 48044
    333 Michigan Breast Specialists-Macomb Township Macomb Michigan United States 48044
    334 Saint Mary's Oncology/Hematology Associates of Marlette Marlette Michigan United States 48453
    335 Mercy Health Mercy Campus Muskegon Michigan United States 49444
    336 Lakeland Hospital Niles Niles Michigan United States 49120
    337 Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan United States 49444
    338 Henry Ford Medical Center-Columbus Novi Michigan United States 48377
    339 21st Century Oncology-Pontiac Pontiac Michigan United States 48341
    340 Hope Cancer Center Pontiac Michigan United States 48341
    341 Newland Medical Associates-Pontiac Pontiac Michigan United States 48341
    342 Saint Joseph Mercy Oakland Pontiac Michigan United States 48341
    343 Spectrum Health Reed City Hospital Reed City Michigan United States 49677
    344 Great Lakes Cancer Management Specialists-Rochester Hills Rochester Hills Michigan United States 48309
    345 Michigan Cancer Specialists Roseville Michigan United States 48066
    346 Oakland Colon Rectal Associates Royal Oak Michigan United States 48067
    347 Cancer Care Associates PC Royal Oak Michigan United States 48073
    348 Comprehensive Medical Center PLLC Royal Oak Michigan United States 48073
    349 Hematology Oncology Consultants PC Royal Oak Michigan United States 48073
    350 Oakland Medical Group Royal Oak Michigan United States 48073
    351 William Beaumont Hospital-Royal Oak Royal Oak Michigan United States 48073
    352 Ascension Saint Mary's Hospital Saginaw Michigan United States 48601
    353 Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan United States 48604
    354 Lakeland Medical Center Saint Joseph Saint Joseph Michigan United States 49085
    355 Marie Yeager Cancer Center Saint Joseph Michigan United States 49085
    356 Henry Ford Macomb Health Center - Shelby Township Shelby Michigan United States 48315
    357 Bhadresh Nayak MD PC-Sterling Heights Sterling Heights Michigan United States 48312
    358 Premier Hematology Oncology Care Sterling Heights Michigan United States 48312
    359 Ascension Saint Joseph Hospital Tawas City Michigan United States 48764
    360 Munson Medical Center Traverse City Michigan United States 49684
    361 Michigan Institute of Urology-Town Center Troy Michigan United States 48084
    362 William Beaumont Hospital - Troy Troy Michigan United States 48085
    363 Hematology Oncology Consultants PC-Troy Troy Michigan United States 48098
    364 Advanced Breast Care Center PLLC Warren Michigan United States 48088
    365 Great Lakes Cancer Management Specialists-Macomb Professional Building Warren Michigan United States 48093
    366 Macomb Hematology Oncology PC Warren Michigan United States 48093
    367 Michigan Breast Specialists-Warren Warren Michigan United States 48093
    368 Saint John Macomb-Oakland Hospital Warren Michigan United States 48093
    369 Henry Ford West Bloomfield Hospital West Bloomfield Michigan United States 48322
    370 Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan United States 48661
    371 Metro Health Hospital Wyoming Michigan United States 49519
    372 Huron Gastroenterology PC Ypsilanti Michigan United States 48106
    373 Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan United States 48197
    374 Riverwood Healthcare Center Aitkin Minnesota United States 56431
    375 Sanford Joe Lueken Cancer Center Bemidji Minnesota United States 56601
    376 Essentia Health Saint Joseph's Medical Center Brainerd Minnesota United States 56401
    377 Fairview Ridges Hospital Burnsville Minnesota United States 55337
    378 Minnesota Oncology - Burnsville Burnsville Minnesota United States 55337
    379 Cambridge Medical Center Cambridge Minnesota United States 55008
    380 Mercy Hospital Coon Rapids Minnesota United States 55433
    381 Essentia Health - Deer River Clinic Deer River Minnesota United States 56636
    382 Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes Minnesota United States 56501
    383 Essentia Health Cancer Center Duluth Minnesota United States 55805
    384 Essentia Health Saint Mary's Medical Center Duluth Minnesota United States 55805
    385 Miller-Dwan Hospital Duluth Minnesota United States 55805
    386 Fairview Southdale Hospital Edina Minnesota United States 55435
    387 Lake Region Healthcare Corporation-Cancer Care Fergus Falls Minnesota United States 56537
    388 Essentia Health - Fosston Fosston Minnesota United States 56542
    389 Unity Hospital Fridley Minnesota United States 55432
    390 Essentia Health Hibbing Clinic Hibbing Minnesota United States 55746
    391 Mayo Clinic Health Systems-Mankato Mankato Minnesota United States 56001
    392 Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota United States 55369
    393 Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota United States 55109
    394 Saint John's Hospital - Healtheast Maplewood Minnesota United States 55109
    395 Abbott-Northwestern Hospital Minneapolis Minnesota United States 55407
    396 Hennepin County Medical Center Minneapolis Minnesota United States 55415
    397 Minneapolis VA Medical Center Minneapolis Minnesota United States 55417
    398 Health Partners Inc Minneapolis Minnesota United States 55454
    399 Monticello Cancer Center Monticello Minnesota United States 55362
    400 New Ulm Medical Center New Ulm Minnesota United States 56073
    401 Essentia Health - Park Rapids Park Rapids Minnesota United States 56470
    402 Fairview Northland Medical Center Princeton Minnesota United States 55371
    403 North Memorial Medical Health Center Robbinsdale Minnesota United States 55422
    404 Mayo Clinic in Rochester Rochester Minnesota United States 55905
    405 Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota United States 56303
    406 Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota United States 55416
    407 Regions Hospital Saint Paul Minnesota United States 55101
    408 United Hospital Saint Paul Minnesota United States 55102
    409 Essentia Health Sandstone Sandstone Minnesota United States 55072
    410 Saint Francis Regional Medical Center Shakopee Minnesota United States 55379
    411 Lakeview Hospital Stillwater Minnesota United States 55082
    412 Sanford Thief River Falls Medical Center Thief River Falls Minnesota United States 56701
    413 Essentia Health Virginia Clinic Virginia Minnesota United States 55792
    414 Ridgeview Medical Center Waconia Minnesota United States 55387
    415 Rice Memorial Hospital Willmar Minnesota United States 56201
    416 Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota United States 55125
    417 Sanford Cancer Center Worthington Worthington Minnesota United States 56187
    418 Fairview Lakes Medical Center Wyoming Minnesota United States 55092
    419 Saint Louis Cancer and Breast Institute-Ballwin Ballwin Missouri United States 63011
    420 Central Care Cancer Center - Bolivar Bolivar Missouri United States 65613
    421 Parkland Health Center-Bonne Terre Bonne Terre Missouri United States 63628
    422 Cox Cancer Center Branson Branson Missouri United States 65616
    423 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    424 Southeast Cancer Center Cape Girardeau Missouri United States 63703
    425 Siteman Cancer Center at West County Hospital Creve Coeur Missouri United States 63141
    426 Parkland Health Center - Farmington Farmington Missouri United States 63640
    427 Centerpoint Medical Center LLC Independence Missouri United States 64057
    428 Capital Region Southwest Campus Jefferson City Missouri United States 65109
    429 Freeman Health System Joplin Missouri United States 64804
    430 Mercy Hospital Joplin Joplin Missouri United States 64804
    431 Truman Medical Centers Kansas City Missouri United States 64108
    432 Research Medical Center Kansas City Missouri United States 64132
    433 University of Kansas Cancer Center - North Kansas City Missouri United States 64154
    434 University of Kansas Cancer Center - Lee's Summit Lee's Summit Missouri United States 64064
    435 University of Kansas Cancer Center at North Kansas City Hospital North Kansas City Missouri United States 64116
    436 Delbert Day Cancer Institute at PCRMC Rolla Missouri United States 65401
    437 Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri United States 65401
    438 Heartland Regional Medical Center Saint Joseph Missouri United States 64506
    439 Saint Louis Cancer and Breast Institute-South City Saint Louis Missouri United States 63109
    440 Washington University School of Medicine Saint Louis Missouri United States 63110
    441 Mercy Hospital South Saint Louis Missouri United States 63128
    442 Siteman Cancer Center-South County Saint Louis Missouri United States 63129
    443 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    444 Siteman Cancer Center at Christian Hospital Saint Louis Missouri United States 63136
    445 Mercy Hospital Saint Louis Saint Louis Missouri United States 63141
    446 Siteman Cancer Center at Saint Peters Hospital Saint Peters Missouri United States 63376
    447 Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri United States 63670
    448 Mercy Hospital Springfield Springfield Missouri United States 65804
    449 CoxHealth South Hospital Springfield Missouri United States 65807
    450 Missouri Baptist Sullivan Hospital Sullivan Missouri United States 63080
    451 Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri United States 63127
    452 Mercy Hospital Washington Washington Missouri United States 63090
    453 Community Hospital of Anaconda Anaconda Montana United States 59711
    454 Billings Clinic Cancer Center Billings Montana United States 59101
    455 Saint Vincent Healthcare Billings Montana United States 59101
    456 Saint Vincent Frontier Cancer Center Billings Montana United States 59102
    457 Bozeman Deaconess Hospital Bozeman Montana United States 59715
    458 Saint James Community Hospital and Cancer Treatment Center Butte Montana United States 59701
    459 Benefis Healthcare- Sletten Cancer Institute Great Falls Montana United States 59405
    460 Great Falls Clinic Great Falls Montana United States 59405
    461 Saint Peter's Community Hospital Helena Montana United States 59601
    462 Kalispell Regional Medical Center Kalispell Montana United States 59901
    463 Saint Patrick Hospital - Community Hospital Missoula Montana United States 59802
    464 Community Medical Hospital Missoula Montana United States 59804
    465 Nebraska Medicine-Bellevue Bellevue Nebraska United States 68123
    466 CHI Health Saint Francis Grand Island Nebraska United States 68803
    467 Heartland Hematology and Oncology Kearney Nebraska United States 68845
    468 CHI Health Good Samaritan Kearney Nebraska United States 68847
    469 Saint Elizabeth Regional Medical Center Lincoln Nebraska United States 68510
    470 Nebraska Methodist Hospital Omaha Nebraska United States 68114
    471 Nebraska Medicine-Village Pointe Omaha Nebraska United States 68118
    472 Alegent Health Immanuel Medical Center Omaha Nebraska United States 68122
    473 Hematology and Oncology Consultants PC Omaha Nebraska United States 68122
    474 Alegent Health Bergan Mercy Medical Center Omaha Nebraska United States 68124
    475 Alegent Health Lakeside Hospital Omaha Nebraska United States 68130
    476 Creighton University Medical Center Omaha Nebraska United States 68131
    477 University of Nebraska Medical Center Omaha Nebraska United States 68198
    478 Midlands Community Hospital Papillion Nebraska United States 68046
    479 Carson Tahoe Regional Medical Center Carson City Nevada United States 89703
    480 Cancer and Blood Specialists-Henderson Henderson Nevada United States 89052
    481 Comprehensive Cancer Centers of Nevada - Henderson Henderson Nevada United States 89052
    482 Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson Nevada United States 89052
    483 Las Vegas Cancer Center-Henderson Henderson Nevada United States 89052
    484 OptumCare Cancer Care at Seven Hills Henderson Nevada United States 89052
    485 Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson Nevada United States 89074
    486 GenesisCare USA - Henderson Henderson Nevada United States 89074
    487 Las Vegas Urology - Green Valley Henderson Nevada United States 89074
    488 Las Vegas Urology - Pebble Henderson Nevada United States 89074
    489 Urology Specialists of Nevada - Green Valley Henderson Nevada United States 89074
    490 Las Vegas Urology - Pecos Las Vegas Nevada United States 89074
    491 Desert West Surgery Las Vegas Nevada United States 89102
    492 OptumCare Cancer Care at Charleston Las Vegas Nevada United States 89102
    493 University Medical Center of Southern Nevada Las Vegas Nevada United States 89102
    494 Hope Cancer Care of Nevada Las Vegas Nevada United States 89103
    495 Radiation Oncology Centers of Nevada Central Las Vegas Nevada United States 89106
    496 Urology Specialists of Nevada - Central Las Vegas Nevada United States 89106
    497 GenesisCare USA - Las Vegas Las Vegas Nevada United States 89109
    498 Sunrise Hospital and Medical Center Las Vegas Nevada United States 89109
    499 Las Vegas Prostate Cancer Center Las Vegas Nevada United States 89113
    500 Las Vegas Urology - Sunset Las Vegas Nevada United States 89113
    501 Urology Specialists of Nevada - Southwest Las Vegas Nevada United States 89113
    502 Radiation Oncology Centers of Nevada Southeast Las Vegas Nevada United States 89119
    503 Ann M Wierman MD LTD Las Vegas Nevada United States 89128
    504 Comprehensive Cancer Centers of Nevada - Northwest Las Vegas Nevada United States 89128
    505 GenesisCare USA - Vegas Tenaya Las Vegas Nevada United States 89128
    506 Las Vegas Urology - Cathedral Rock Las Vegas Nevada United States 89128
    507 Las Vegas Urology - Smoke Ranch Las Vegas Nevada United States 89128
    508 OptumCare Cancer Care at MountainView Las Vegas Nevada United States 89128
    509 Urology Specialists of Nevada - Northwest Las Vegas Nevada United States 89128
    510 Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas Nevada United States 89135
    511 Comprehensive Cancer Centers of Nevada - Town Center Las Vegas Nevada United States 89144
    512 Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas Nevada United States 89144
    513 Summerlin Hospital Medical Center Las Vegas Nevada United States 89144
    514 Las Vegas Cancer Center-Medical Center Las Vegas Nevada United States 89148-2405
    515 Comprehensive Cancer Centers of Nevada Las Vegas Nevada United States 89148
    516 GenesisCare USA - Fort Apache Las Vegas Nevada United States 89148
    517 OptumCare Cancer Care at Fort Apache Las Vegas Nevada United States 89148
    518 Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas Nevada United States 89169
    519 University Cancer Center Las Vegas Nevada United States 89169
    520 Hope Cancer Care of Nevada-Pahrump Pahrump Nevada United States 89048
    521 Renown Regional Medical Center Reno Nevada United States 89502
    522 Saint Mary's Regional Medical Center Reno Nevada United States 89503
    523 Radiation Oncology Associates Reno Nevada United States 89509
    524 New Hampshire Oncology Hematology PA-Concord Concord New Hampshire United States 03301
    525 Solinsky Center for Cancer Care Manchester New Hampshire United States 03103
    526 Monmouth Medical Center Southern Campus Lakewood New Jersey United States 08701
    527 Monmouth Medical Center Long Branch New Jersey United States 07740
    528 Morristown Medical Center Morristown New Jersey United States 07960
    529 Rutgers Cancer Institute of New Jersey New Brunswick New Jersey United States 08903
    530 The Valley Hospital-Luckow Pavilion Paramus New Jersey United States 07652
    531 Neurosurgeons of New Jersey-Ridgewood Ridgewood New Jersey United States 07450
    532 Valley Hospital Ridgewood New Jersey United States 07450
    533 Overlook Hospital Summit New Jersey United States 07902
    534 Valley Health System-Hematology/Oncology Westwood New Jersey United States 07675
    535 University of New Mexico Cancer Center Albuquerque New Mexico United States 87102
    536 Memorial Medical Center - Las Cruces Las Cruces New Mexico United States 88011
    537 Hematology Oncology Associates of Central New York-Auburn Auburn New York United States 13021
    538 Roswell Park Cancer Institute Buffalo New York United States 14263
    539 Cancer Institute at Saint Francis Hospital East Hills New York United States 11548
    540 Hematology Oncology Associates of Central New York-East Syracuse East Syracuse New York United States 13057
    541 Glens Falls Hospital Glens Falls New York United States 12801
    542 Northwell Health/Center for Advanced Medicine Lake Success New York United States 11042
    543 North Shore University Hospital Manhasset New York United States 11030
    544 Long Island Jewish Medical Center New Hyde Park New York United States 11040
    545 NYP/Weill Cornell Medical Center New York New York United States 10065
    546 Upstate Cancer Center at Oneida Oneida New York United States 13421
    547 University of Rochester Rochester New York United States 14642
    548 State University of New York Upstate Medical University Syracuse New York United States 13210
    549 Hematology Oncology Associates of Central New York-Onondaga Hill Syracuse New York United States 13215
    550 Good Samaritan Hospital Medical Center West Islip New York United States 11795
    551 Mission Hospital Asheville North Carolina United States 28801
    552 Messino Cancer Centers Asheville North Carolina United States 28806
    553 Waverly Hematology Oncology Cary North Carolina United States 27518
    554 UNC Lineberger Comprehensive Cancer Center Chapel Hill North Carolina United States 27599
    555 Wake Forest University at Clemmons Clemmons North Carolina United States 27012
    556 Southeastern Medical Oncology Center-Clinton Clinton North Carolina United States 28328
    557 Duke University Medical Center Durham North Carolina United States 27710
    558 Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina United States 27534
    559 Wayne Memorial Hospital Goldsboro North Carolina United States 27534
    560 East Carolina University Greenville North Carolina United States 27834
    561 Margaret R Pardee Memorial Hospital Hendersonville North Carolina United States 28791
    562 Onslow Memorial Hospital Jacksonville North Carolina United States 28546
    563 Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina United States 28546
    564 Vidant Oncology-Kenansville Kenansville North Carolina United States 28349
    565 Novant Health Cancer Institute - Kernersville Kernersville North Carolina United States 27284
    566 Vidant Oncology-Kinston Kinston North Carolina United States 28501
    567 Novant Health Cancer Institute - Mount Airy Mount Airy North Carolina United States 27030
    568 FirstHealth of the Carolinas-Moore Regional Hospital Pinehurst North Carolina United States 28374
    569 Vidant Oncology-Richlands Richlands North Carolina United States 28574
    570 Novant Health Cancer Institute - Statesville Statesville North Carolina United States 28625
    571 Novant Health Cancer Institute - Thomasville Thomasville North Carolina United States 27360
    572 Novant Health Cancer Institute - Wilkesboro Wilkesboro North Carolina United States 28659
    573 Wake Forest Baptist Health - Wilkes Medical Center Wilkesboro North Carolina United States 28659
    574 Novant Health Forsyth Medical Center Winston-Salem North Carolina United States 27103
    575 Novant Health Oncology Specialists Winston-Salem North Carolina United States 27103
    576 Wake Forest University Health Sciences Winston-Salem North Carolina United States 27157
    577 Sanford Bismarck Medical Center Bismarck North Dakota United States 58501
    578 Essentia Health Cancer Center-South University Clinic Fargo North Dakota United States 58103
    579 Sanford South University Medical Center Fargo North Dakota United States 58103
    580 Sanford Medical Center Fargo Fargo North Dakota United States 58104
    581 Sanford Broadway Medical Center Fargo North Dakota United States 58122
    582 Sanford Roger Maris Cancer Center Fargo North Dakota United States 58122
    583 Essentia Health - Jamestown Clinic Jamestown North Dakota United States 58401
    584 Indu and Raj Soin Medical Center Beavercreek Ohio United States 45431
    585 Strecker Cancer Center-Belpre Belpre Ohio United States 45714
    586 Saint Elizabeth Boardman Hospital Boardman Ohio United States 44512
    587 Dayton Physicians LLC-Miami Valley South Centerville Ohio United States 45459
    588 Miami Valley Hospital South Centerville Ohio United States 45459
    589 Geauga Hospital Chardon Ohio United States 44024
    590 Adena Regional Medical Center Chillicothe Ohio United States 45601
    591 Good Samaritan Hospital - Cincinnati Cincinnati Ohio United States 45220
    592 Oncology Hematology Care Inc-Kenwood Cincinnati Ohio United States 45236
    593 Bethesda North Hospital Cincinnati Ohio United States 45242
    594 TriHealth Cancer Institute-Westside Cincinnati Ohio United States 45247
    595 TriHealth Cancer Institute-Anderson Cincinnati Ohio United States 45255
    596 Case Western Reserve University Cleveland Ohio United States 44106
    597 Cleveland Clinic Cancer Center/Fairview Hospital Cleveland Ohio United States 44111
    598 Cleveland Clinic Foundation Cleveland Ohio United States 44195
    599 Ohio State University Comprehensive Cancer Center Columbus Ohio United States 43210
    600 Mount Carmel East Hospital Columbus Ohio United States 43213
    601 Columbus Oncology and Hematology Associates Inc Columbus Ohio United States 43214
    602 Riverside Methodist Hospital Columbus Ohio United States 43214
    603 Grant Medical Center Columbus Ohio United States 43215
    604 The Mark H Zangmeister Center Columbus Ohio United States 43219
    605 Mount Carmel Health Center West Columbus Ohio United States 43222
    606 Doctors Hospital Columbus Ohio United States 43228
    607 Good Samaritan Hospital - Dayton Dayton Ohio United States 45406
    608 Miami Valley Hospital Dayton Ohio United States 45409
    609 Dayton Physician LLC-Miami Valley Hospital North Dayton Ohio United States 45415
    610 Miami Valley Hospital North Dayton Ohio United States 45415
    611 Dayton Veterans Affairs Medical Center Dayton Ohio United States 45428
    612 Delaware Health Center-Grady Cancer Center Delaware Ohio United States 43015
    613 Grady Memorial Hospital Delaware Ohio United States 43015
    614 Dublin Methodist Hospital Dublin Ohio United States 43016
    615 Armes Family Cancer Center Findlay Ohio United States 45840
    616 Blanchard Valley Hospital Findlay Ohio United States 45840
    617 Orion Cancer Care Findlay Ohio United States 45840
    618 Atrium Medical Center-Middletown Regional Hospital Franklin Ohio United States 45005-1066
    619 Dayton Physicians LLC-Atrium Franklin Ohio United States 45005
    620 Central Ohio Breast and Endocrine Surgery Gahanna Ohio United States 43230
    621 Dayton Physicians LLC-Wayne Greenville Ohio United States 45331
    622 Wayne Hospital Greenville Ohio United States 45331
    623 Mount Carmel Grove City Hospital Grove City Ohio United States 43123
    624 Greater Dayton Cancer Center Kettering Ohio United States 45409
    625 First Dayton Cancer Care Kettering Ohio United States 45420
    626 Kettering Medical Center Kettering Ohio United States 45429
    627 Fairfield Medical Center Lancaster Ohio United States 43130
    628 Saint Rita's Medical Center Lima Ohio United States 45801
    629 OhioHealth Mansfield Hospital Mansfield Ohio United States 44903
    630 Cleveland Clinic Cancer Center Mansfield Mansfield Ohio United States 44906
    631 Marietta Memorial Hospital Marietta Ohio United States 45750
    632 OhioHealth Marion General Hospital Marion Ohio United States 43302
    633 Hillcrest Hospital Cancer Center Mayfield Heights Ohio United States 44124
    634 UH Seidman Cancer Center at Lake Health Mentor Campus Mentor Ohio United States 44060
    635 UH Seidman Cancer Center at Southwest General Hospital Middleburg Heights Ohio United States 44130
    636 Knox Community Hospital Mount Vernon Ohio United States 43050
    637 Licking Memorial Hospital Newark Ohio United States 43055
    638 Newark Radiation Oncology Newark Ohio United States 43055
    639 University Hospitals Parma Medical Center Parma Ohio United States 44129
    640 Mercy Health Perrysburg Cancer Center Perrysburg Ohio United States 43551
    641 Southern Ohio Medical Center Portsmouth Ohio United States 45662
    642 University Hospitals Portage Medical Center Ravenna Ohio United States 44266
    643 North Coast Cancer Care Sandusky Ohio United States 44870
    644 UH Seidman Cancer Center at Firelands Regional Medical Center Sandusky Ohio United States 44870
    645 Springfield Regional Cancer Center Springfield Ohio United States 45504
    646 Springfield Regional Medical Center Springfield Ohio United States 45505
    647 Cleveland Clinic Cancer Center Strongsville Strongsville Ohio United States 44136
    648 Saint Vincent Mercy Medical Center Toledo Ohio United States 43608
    649 Mercy Health - Saint Anne Hospital Toledo Ohio United States 43623
    650 Dayton Physicians LLC-Upper Valley Troy Ohio United States 45373
    651 Upper Valley Medical Center Troy Ohio United States 45373
    652 University Hospitals Sharon Health Center Wadsworth Ohio United States 44281
    653 South Pointe Hospital Warrensville Heights Ohio United States 44122
    654 Saint Joseph Warren Hospital Warren Ohio United States 44484
    655 Saint Ann's Hospital Westerville Ohio United States 43081
    656 UH Seidman Cancer Center at Saint John Medical Center Westlake Ohio United States 44145
    657 Cleveland Clinic Wooster Family Health and Surgery Center Wooster Ohio United States 44691
    658 Wright-Patterson Medical Center Wright-Patterson Air Force Base Ohio United States 45433
    659 Saint Elizabeth Youngstown Hospital Youngstown Ohio United States 44501
    660 Genesis Healthcare System Cancer Care Center Zanesville Ohio United States 43701
    661 Cancer Centers of Southwest Oklahoma Research Lawton Oklahoma United States 73505
    662 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
    663 Mercy Hospital Oklahoma City Oklahoma City Oklahoma United States 73120
    664 Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa Oklahoma United States 74146
    665 Saint Alphonsus Medical Center-Baker City Baker City Oregon United States 97814
    666 Saint Charles Health System Bend Oregon United States 97701
    667 Clackamas Radiation Oncology Center Clackamas Oregon United States 97015
    668 Providence Cancer Institute Clackamas Clinic Clackamas Oregon United States 97015
    669 Bay Area Hospital Coos Bay Oregon United States 97420
    670 Providence Newberg Medical Center Newberg Oregon United States 97132
    671 Saint Alphonsus Medical Center-Ontario Ontario Oregon United States 97914
    672 Providence Portland Medical Center Portland Oregon United States 97213
    673 Providence Saint Vincent Medical Center Portland Oregon United States 97225
    674 Oregon Health and Science University Portland Oregon United States 97239
    675 Saint Charles Health System-Redmond Redmond Oregon United States 97756
    676 Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania United States 18103
    677 Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania United States 18017
    678 Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania United States 19317
    679 Chambersburg Hospital Chambersburg Pennsylvania United States 17201
    680 Geisinger Medical Center Danville Pennsylvania United States 17822
    681 Pocono Medical Center East Stroudsburg Pennsylvania United States 18301
    682 Ephrata Cancer Center Ephrata Pennsylvania United States 17522
    683 Ephrata Community Hospital Ephrata Pennsylvania United States 17522
    684 Adams Cancer Center Gettysburg Pennsylvania United States 17325
    685 Cherry Tree Cancer Center Hanover Pennsylvania United States 17331
    686 Geisinger Medical Center-Cancer Center Hazleton Hazleton Pennsylvania United States 18201
    687 Lehigh Valley Hospital-Hazleton Hazleton Pennsylvania United States 18201
    688 Sechler Family Cancer Center Lebanon Pennsylvania United States 17042
    689 Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania United States 17837
    690 Lewistown Hospital Lewistown Pennsylvania United States 17044
    691 Geisinger Cancer Services-Pottsville Pottsville Pennsylvania United States 17901
    692 Community Medical Center Scranton Pennsylvania United States 18510
    693 Geisinger Medical Oncology-Selinsgrove Selinsgrove Pennsylvania United States 17870
    694 Geisinger Medical Group State College Pennsylvania United States 16801
    695 Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania United States 18711
    696 WellSpan Health-York Cancer Center York Pennsylvania United States 17403
    697 WellSpan Health-York Hospital York Pennsylvania United States 17403
    698 Smilow Cancer Hospital Care Center - Westerly Westerly Rhode Island United States 02891
    699 Saint Joseph's/Candler - Bluffton Campus Bluffton South Carolina United States 29910
    700 Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina United States 29316
    701 Medical University of South Carolina Charleston South Carolina United States 29425
    702 Prisma Health Cancer Institute - Laurens Clinton South Carolina United States 29325
    703 Prisma Health Cancer Institute - Easley Easley South Carolina United States 29640
    704 Gibbs Cancer Center-Gaffney Gaffney South Carolina United States 29341
    705 Saint Francis Hospital Greenville South Carolina United States 29601
    706 BI-LO Charities Children's Cancer Center Greenville South Carolina United States 29605
    707 Prisma Health Cancer Institute - Butternut Greenville South Carolina United States 29605
    708 Prisma Health Cancer Institute - Faris Greenville South Carolina United States 29605
    709 Prisma Health Greenville Memorial Hospital Greenville South Carolina United States 29605
    710 Saint Francis Cancer Center Greenville South Carolina United States 29607
    711 Prisma Health Cancer Institute - Eastside Greenville South Carolina United States 29615
    712 Prisma Health Cancer Institute - Greer Greer South Carolina United States 29650
    713 Gibbs Cancer Center-Pelham Greer South Carolina United States 29651
    714 South Carolina Cancer Specialists PC Hilton Head Island South Carolina United States 29926-3827
    715 Prisma Health Cancer Institute - Seneca Seneca South Carolina United States 29672
    716 Spartanburg Medical Center Spartanburg South Carolina United States 29303
    717 MGC Hematology Oncology-Union Union South Carolina United States 29379
    718 Avera Cancer Institute-Aberdeen Aberdeen South Dakota United States 57401
    719 Avera Cancer Institute at Pierre Pierre South Dakota United States 57501
    720 Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota United States 57104
    721 Avera Cancer Institute Sioux Falls South Dakota United States 57105
    722 Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota United States 57117-5134
    723 Memorial Hospital Chattanooga Tennessee United States 37404
    724 Cookeville Regional Medical Center Cookeville Tennessee United States 38501
    725 Pulmonary Medicine Center of Chattanooga-Hixson Hixson Tennessee United States 37343
    726 Memorial GYN Plus Ooltewah Tennessee United States 37363
    727 The Don and Sybil Harrington Cancer Center Amarillo Texas United States 79106
    728 Saint Joseph Regional Cancer Center Bryan Texas United States 77802
    729 UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas United States 75390
    730 STCC at DHR Health Institute for Research and Development Edinburg Texas United States 78539
    731 UT Southwestern/Simmons Cancer Center-Fort Worth Fort Worth Texas United States 76104
    732 UT Southwestern Clinical Center at Richardson/Plano Richardson Texas United States 75080
    733 American Fork Hospital / Huntsman Intermountain Cancer Center American Fork Utah United States 84003
    734 Sandra L Maxwell Cancer Center Cedar City Utah United States 84720
    735 Logan Regional Hospital Logan Utah United States 84321
    736 Intermountain Medical Center Murray Utah United States 84107
    737 McKay-Dee Hospital Center Ogden Utah United States 84403
    738 Utah Valley Regional Medical Center Provo Utah United States 84604
    739 Riverton Hospital Riverton Utah United States 84065
    740 Saint George Regional Medical Center Saint George Utah United States 84770
    741 Utah Cancer Specialists-Salt Lake City Salt Lake City Utah United States 84106
    742 Huntsman Cancer Institute/University of Utah Salt Lake City Utah United States 84112
    743 LDS Hospital Salt Lake City Utah United States 84143
    744 University of Virginia Cancer Center Charlottesville Virginia United States 22908
    745 Centra Lynchburg Hematology-Oncology Clinic Inc Lynchburg Virginia United States 24501
    746 Virginia Cancer Institute Richmond Virginia United States 23229
    747 Virginia Commonwealth University/Massey Cancer Center Richmond Virginia United States 23298
    748 VCU Community Memorial Health Center South Hill Virginia United States 23970
    749 Providence Regional Cancer System-Aberdeen Aberdeen Washington United States 98520
    750 MultiCare Auburn Medical Center Auburn Washington United States 98001
    751 Virginia Mason Bainbridge Island Medical Center Bainbridge Island Washington United States 98110
    752 Overlake Medical Center Bellevue Washington United States 98004
    753 PeaceHealth Saint Joseph Medical Center Bellingham Washington United States 98225
    754 Harrison HealthPartners Hematology and Oncology-Bremerton Bremerton Washington United States 98310
    755 Harrison Medical Center Bremerton Washington United States 98310
    756 Highline Medical Center-Main Campus Burien Washington United States 98166
    757 Providence Regional Cancer System-Centralia Centralia Washington United States 98531
    758 Swedish Cancer Institute-Edmonds Edmonds Washington United States 98026
    759 Saint Elizabeth Hospital Enumclaw Washington United States 98022
    760 Providence Regional Cancer Partnership Everett Washington United States 98201
    761 Virginia Mason Federal Way Medical Center Federal Way Washington United States 98002
    762 Saint Francis Hospital Federal Way Washington United States 98003
    763 Tacoma/Valley Radiation Oncology Centers-Gig Harbor Gig Harbor Washington United States 98332
    764 MultiCare Gig Harbor Medical Park Gig Harbor Washington United States 98335
    765 Swedish Cancer Institute-Issaquah Issaquah Washington United States 98029
    766 Kadlec Clinic Hematology and Oncology Kennewick Washington United States 99336
    767 Northwest Cancer Clinic Kennewick Washington United States 99336
    768 Providence Regional Cancer System-Lacey Lacey Washington United States 98503
    769 Saint Clare Hospital Lakewood Washington United States 98499
    770 PeaceHealth Saint John Medical Center Longview Washington United States 98632
    771 Virginia Mason Lynnwood Medical Center Lynnwood Washington United States 98036
    772 Jefferson Healthcare Port Townsend Washington United States 98368
    773 Harrison HealthPartners Hematology and Oncology-Poulsbo Poulsbo Washington United States 98370
    774 MultiCare Good Samaritan Hospital Puyallup Washington United States 98372
    775 Tacoma/Valley Radiation Oncology Centers-Puyallup Puyallup Washington United States 98372
    776 Valley Medical Center Renton Washington United States 98055
    777 Virginia Mason Medical Center Seattle Washington United States 98101
    778 Pacific Gynecology Specialists Seattle Washington United States 98104
    779 Swedish Medical Center-Ballard Campus Seattle Washington United States 98107
    780 Kaiser Permanente Washington Seattle Washington United States 98112
    781 Swedish Medical Center-First Hill Seattle Washington United States 98122-4307
    782 Swedish Medical Center-Cherry Hill Seattle Washington United States 98122-5711
    783 PeaceHealth United General Medical Center Sedro-Woolley Washington United States 98284
    784 Providence Regional Cancer System-Shelton Shelton Washington United States 98584
    785 MultiCare Deaconess Cancer and Blood Specialty Center - Valley Spokane Valley Washington United States 99216
    786 MultiCare Deaconess Cancer and Blood Specialty Center - Downtown Spokane Washington United States 99204
    787 MultiCare Deaconess Cancer and Blood Specialty Center - North Spokane Washington United States 99218
    788 Tacoma/Valley Radiation Oncology Centers-Jackson Hall Tacoma Washington United States 97405
    789 Franciscan Research Center-Northwest Medical Plaza Tacoma Washington United States 98405
    790 Mary Bridge Children's Hospital and Health Center Tacoma Washington United States 98405
    791 MultiCare Tacoma General Hospital Tacoma Washington United States 98405
    792 Northwest Medical Specialties PLLC Tacoma Washington United States 98405
    793 Tacoma/Valley Radiation Oncology Centers-Saint Joe's Tacoma Washington United States 98405
    794 PeaceHealth Southwest Medical Center Vancouver Washington United States 98664
    795 Providence Saint Mary Regional Cancer Center Walla Walla Washington United States 99362
    796 North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima Washington United States 98902
    797 Providence Regional Cancer System-Yelm Yelm Washington United States 98597
    798 Langlade Hospital and Cancer Center Antigo Wisconsin United States 54409
    799 ThedaCare Regional Cancer Center Appleton Wisconsin United States 54911
    800 Ascension Saint Elizabeth Hospital Appleton Wisconsin United States 54915
    801 Duluth Clinic Ashland Ashland Wisconsin United States 54806
    802 Northwest Wisconsin Cancer Center Ashland Wisconsin United States 54806
    803 Ascension Southeast Wisconsin Hospital - Elmbrook Campus Brookfield Wisconsin United States 53045
    804 Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin United States 53105
    805 Ascension Calumet Hospital Chilton Wisconsin United States 53014
    806 HSHS Sacred Heart Hospital Eau Claire Wisconsin United States 54701
    807 Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin United States 54701
    808 Mayo Clinic Health System-Eau Claire Clinic Eau Claire Wisconsin United States 54701
    809 Aurora Health Center-Fond du Lac Fond Du Lac Wisconsin United States 54937
    810 Ascension Saint Francis - Reiman Cancer Center Franklin Wisconsin United States 53132
    811 Ascension Southeast Wisconsin Hospital - Franklin Franklin Wisconsin United States 53132
    812 Aurora Health Care Germantown Health Center Germantown Wisconsin United States 53022
    813 Aurora Cancer Care-Grafton Grafton Wisconsin United States 53024
    814 Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin United States 54301
    815 Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay Wisconsin United States 54303
    816 Aurora BayCare Medical Center Green Bay Wisconsin United States 54311
    817 Aurora Cancer Care-Kenosha South Kenosha Wisconsin United States 53142
    818 Gundersen Lutheran Medical Center La Crosse Wisconsin United States 54601
    819 Mayo Clinic Health System-Franciscan Healthcare La Crosse Wisconsin United States 54601
    820 William S Middleton VA Medical Center Madison Wisconsin United States 53705
    821 Dean Hematology and Oncology Clinic Madison Wisconsin United States 53717
    822 University of Wisconsin Carbone Cancer Center Madison Wisconsin United States 53792
    823 Holy Family Memorial Hospital Manitowoc Wisconsin United States 54221
    824 Aurora Bay Area Medical Group-Marinette Marinette Wisconsin United States 54143
    825 Saint Vincent Hospital Cancer Center at Marinette Marinette Wisconsin United States 54143
    826 Marshfield Medical Center-Marshfield Marshfield Wisconsin United States 54449
    827 Aspirus Medford Hospital Medford Wisconsin United States 54451
    828 Ascension Columbia Saint Mary's Hospital Ozaukee Mequon Wisconsin United States 53097
    829 Aurora Cancer Care-Milwaukee Milwaukee Wisconsin United States 53209
    830 Ascension Southeast Wisconsin Hospital - Saint Joseph Campus Milwaukee Wisconsin United States 53210
    831 Ascension Columbia Saint Mary's Hospital - Milwaukee Milwaukee Wisconsin United States 53211
    832 Ascension Saint Francis Hospital Milwaukee Wisconsin United States 53215
    833 Aurora Saint Luke's Medical Center Milwaukee Wisconsin United States 53215
    834 Medical College of Wisconsin Milwaukee Wisconsin United States 53226
    835 Aurora Sinai Medical Center Milwaukee Wisconsin United States 53233
    836 Marshfield Clinic-Minocqua Center Minocqua Wisconsin United States 54548
    837 ProHealth D N Greenwald Center Mukwonago Wisconsin United States 53149
    838 Froedtert and MCW Moorland Reserve Health Center New Berlin Wisconsin United States 53151
    839 Cancer Center of Western Wisconsin New Richmond Wisconsin United States 54017
    840 ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin United States 53066
    841 Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls Wisconsin United States 54154
    842 Ascension Mercy Hospital Oshkosh Wisconsin United States 54904
    843 Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin United States 54904
    844 Ascension All Saints Hospital Racine Wisconsin United States 53405
    845 Aurora Cancer Care-Racine Racine Wisconsin United States 53406
    846 Ascension Saint Mary's Hospital Rhinelander Wisconsin United States 54501
    847 Marshfield Medical Center-Rice Lake Rice Lake Wisconsin United States 54868
    848 HSHS Saint Nicholas Hospital Sheboygan Wisconsin United States 53081
    849 Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin United States 53081
    850 Ascension Saint Michael's Hospital Stevens Point Wisconsin United States 54481
    851 Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin United States 54482
    852 Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay Wisconsin United States 54235-1495
    853 Aurora Medical Center in Summit Summit Wisconsin United States 53066
    854 Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin United States 54241
    855 ProHealth Waukesha Memorial Hospital Waukesha Wisconsin United States 53188
    856 UW Cancer Center at ProHealth Care Waukesha Wisconsin United States 53188
    857 ThedaCare Cancer Care - Waupaca Waupaca Wisconsin United States 54981
    858 Aspirus Regional Cancer Center Wausau Wisconsin United States 54401
    859 Ascension Medical Group Southeast Wisconsin - Mayfair Road Wauwatosa Wisconsin United States 53226
    860 Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin United States 53226
    861 Aurora West Allis Medical Center West Allis Wisconsin United States 53227
    862 Marshfield Medical Center - Weston Weston Wisconsin United States 54476
    863 Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids Wisconsin United States 54494
    864 Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids Wisconsin United States 54494
    865 Cheyenne Regional Medical Center-West Cheyenne Wyoming United States 82001
    866 Billings Clinic-Cody Cody Wyoming United States 82414
    867 Welch Cancer Center Sheridan Wyoming United States 82801

    Sponsors and Collaborators

    • National Cancer Institute (NCI)

    Investigators

    • Principal Investigator: Jennifer A Woyach, Alliance for Clinical Trials in Oncology

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    National Cancer Institute (NCI)
    ClinicalTrials.gov Identifier:
    NCT03737981
    Other Study ID Numbers:
    • NCI-2018-02485
    • NCI-2018-02485
    • A041702
    • A041702
    • U10CA180821
    First Posted:
    Nov 13, 2018
    Last Update Posted:
    Jul 20, 2022
    Last Verified:
    Jul 1, 2022
    Individual Participant Data (IPD) Sharing Statement:
    Yes
    Plan to Share IPD:
    Yes
    Studies a U.S. FDA-regulated Drug Product:
    Yes
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Leukemia
    Leukemia, Lymphoid
    Leukemia, Lymphocytic, Chronic, B-Cell
    Venetoclax
    Obinutuzumab

    Study Results

    No Results Posted as of Jul 20, 2022