The Effect of Circadian Rhytm on Postoperative Pain Undergoing Pediatric Surgery

Sponsor
Faruk Cicekci (Other)
Overall Status
Active, not recruiting
CT.gov ID
NCT05379192
Collaborator
(none)
200
2
12
100
8.4

Study Details

Study Description

Brief Summary

These circadian rhythms are self-sustained, endogenous oscillations generated by circadian clocks that persist with a period of around 24 -h under constant conditions. Multiple clinical and foundational science studies report that circadian rhythm disruption can directly alter pain thresholds. Altered circadian pain rhythms manifest inconsistently in various disease states. circadian differences exist in tolerability of administration as well as in effectiveness of analgesia during surgical, obstetric, and dental procedures, with the majority of studies demonstrating highest pain sensitivity during the overnight or early morning hours. Although the relationship between pain states and circadian rhythm has been studied in various surgical procedures and chronic pain syndromes, there is little literature examining the relationship between postoperative pain and circadian rhythm in pediatric surgical procedures. Therefore, it was aimed to evaluate the relationship between postoperative pain and circadian rhythm after pediatric acute appendicitis surgery.

Condition or Disease Intervention/Treatment Phase
  • Other: Group 1, Group 2, Group 3, Group 4

Detailed Description

This study will be conducted with the data to be obtained from the Anesthesiology Surgery Form and Pediatric Surgery Service Forms in 200 patients aged 6-18 years, after the approval of the Faculty Local Ethics Committee in the Department of Anesthesiology, Faculty of Medicine, Selcuk University. According to the time the patients were taken into the operation, Group 1; 01:01-07:00, Group 2; 07:01-13:00, Group 3; 13:01-20:00 and Group 4; 20:01-01:00, It will be divided into four groups between. The files of the patients will be examined and demographic data such as age (year), body weight (kg), height (cm), gender, ASA scores (I-III), anesthesia and surgery time, anesthesia and surgery time will be recorded. Intraoperative vital signs; systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), heart rate (HR) oxygen saturation (SpO2) Endtidal CO2 and temperature before operation (control) and 5, 10, 15, 20, 25 and 30 minutes (min) and at the end of the process (end) data will also be saved. Perioperative side effects such as nausea-vomiting, hypotension, bradycardia, tremor, respiratory distress, sore throat, headache, and dizziness symptoms will be noted if they occur. The routinely applied analgesic protocol and vital signs in the postoperative pediatric surgery service, the total amount of analgesic administered, the time to first analgesia requirement and VAS scores at 1, 2, 3, 6, 9, 12, 15, 18, 21 and 24th hours will also be recorded. There will be no interference with the routinely applied analgesic protocol.

Study Design

Study Type:
Observational [Patient Registry]
Anticipated Enrollment :
200 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
How Does Circadian Rhythm Affect Postoperative Pain After Pediatric Acute Appendicit Operation?
Actual Study Start Date :
Jan 1, 2022
Anticipated Primary Completion Date :
Aug 15, 2022
Anticipated Study Completion Date :
Dec 31, 2022

Arms and Interventions

Arm Intervention/Treatment
Group 1

Sociodemographic and clinical data of the patients who will be operated between 01:01-07:00 AM will be recorded. The total amount of antiemetic, the time of first antiemetic use, and the VAS scores at the postoperative 1, 2, 3, 6, 9, 12, 15, 18, 21 and 24th hours will also be recorded.

Other: Group 1, Group 2, Group 3, Group 4
The total amount of antiemetic,the time of first antiemetic use and VAS scores at 1, 2, 3, 6, 9, 12, 15, 18, 21 and 24th hours postoperatively will also be recorded according to circadian rhythm

Group 2

Patients who were operated between 07:01-13:00. Sociodemographic and clinical data of the patients who will be operated between 07:00 AM- 01:00 PM will be recorded. The total amount of antiemetic, the time of first antiemetic use, and the VAS scores at the postoperative 1, 2, 3, 6, 9, 12, 15, 18, 21 and 24th hours will also be recorded.

Other: Group 1, Group 2, Group 3, Group 4
The total amount of antiemetic,the time of first antiemetic use and VAS scores at 1, 2, 3, 6, 9, 12, 15, 18, 21 and 24th hours postoperatively will also be recorded according to circadian rhythm

Group 3

Sociodemographic and clinical data of the patients who will be operated between 01:00 - 08:00 PM will be recorded. The total amount of antiemetic, the time of first antiemetic use and the VAS scores at the postoperative 1, 2, 3, 6, 9, 12, 15, 18, 21 and 24th hours will also be recorded.

Other: Group 1, Group 2, Group 3, Group 4
The total amount of antiemetic,the time of first antiemetic use and VAS scores at 1, 2, 3, 6, 9, 12, 15, 18, 21 and 24th hours postoperatively will also be recorded according to circadian rhythm

Group 4

Sociodemographic and clinical data of the patients who will be operated between 08:00 PM -01:00 AM will be recorded. The total amount of antiemetic,the time of first antiemetic use, and the VAS scores at the postoperative 1, 2, 3, 6, 9, 12, 15, 18, 21 and 24th hours will also be recorded.

Other: Group 1, Group 2, Group 3, Group 4
The total amount of antiemetic,the time of first antiemetic use and VAS scores at 1, 2, 3, 6, 9, 12, 15, 18, 21 and 24th hours postoperatively will also be recorded according to circadian rhythm

Outcome Measures

Primary Outcome Measures

  1. The postoperative VAS pain scores [1st hours , postoperatively]

    The VAS scores at 1st will be recorded.

  2. The postoperative VAS pain scores [2nd hours , postoperatively]

    The VAS scores at 2nd will be recorded.

  3. The postoperative VAS pain scores [3th hours , postoperatively]

    The VAS scores at 3th will be recorded.

  4. The postoperative VAS pain scores [6th hours , postoperatively]

    The VAS scores at 6th will be recorded.

  5. The postoperative VAS pain scores [9th hours , postoperatively]

    The VAS scores at 9th will be recorded.

  6. The postoperative VAS pain scores [12th hours , postoperatively]

    The VAS scores at 12th will be recorded.

  7. The postoperative VAS pain scores [15th hours , postoperatively]

    The VAS scores at 15th will be recorded.

  8. The postoperative VAS pain scores [18th hours , postoperatively]

    The VAS scores at 18th will be recorded.

  9. The postoperative VAS pain scores [21th hours , postoperatively]

    The VAS scores at 21th will be recorded.

  10. The postoperative VAS pain scores [24th hours , postoperatively]

    The VAS scores at 24th will be recorded.

Secondary Outcome Measures

  1. The total amount of analgesic [24 hours, postoperatively]

    The total amount of analgesic will be recorded postoperativly .

  2. the time to first analgesia requirement [24 hours, postoperatively]

    the time to first analgesia requirement will be recorded postoperativly .

Eligibility Criteria

Criteria

Ages Eligible for Study:
6 Years to 18 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • American Society of Anesthesiologists (ASA) physical condition I-II,

  • Undergoing acute appendicitis,

  • Patients aged 6-18 years

Exclusion Criteria:
  • ASA ≥ III,

  • Uncontrolled chronic, metabolic disease,

  • Opioid or analgesic use in the last 10 days,

  • Acute peritonitis or sepsis

  • History of abnormal operation or recovery from anesthesia,

  • Patients with parents who are unwilling to give informed consent

Contacts and Locations

Locations

Site City State Country Postal Code
1 Selcuk University, School of Medicine Konya Turkey 42080
2 Selcuk University, School of Medicine Konya Turkey 42250

Sponsors and Collaborators

  • Faruk Cicekci

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Faruk Cicekci, Associate Prof., Selcuk University
ClinicalTrials.gov Identifier:
NCT05379192
Other Study ID Numbers:
  • farukcicekci5
First Posted:
May 18, 2022
Last Update Posted:
May 18, 2022
Last Verified:
May 1, 2022
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of May 18, 2022