ASSURE: Sunitinib Malate or Sorafenib Tosylate in Treating Patients With Kidney Cancer That Was Removed By Surgery

• Sponsor: National Cancer Institute (NCI) (NIH)
• Overall Status: Completed
• CT.gov ID: NCT00326898
• Collaborator: Cancer and Leukemia Group B (Other), NCIC Clinical Trials Group (Other), Southwest Oncology Group (Other)
• Enrollment: 1,943
• Locations: 987
• Arms: 3
• Actual Duration (Months): 184.3
• Patients Per Site: 2
• Patients Per Site Per Month: 0

Study Details

Study Description

Brief Summary

This randomized phase III trial studies sunitinib malate to see how well it works compared to sorafenib tosylate or placebo in treating patients with kidney cancer that has been removed by surgery. Sunitinib malate and sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Giving sunitinib malate or sorafenib tosylate after surgery may kill any tumor cells that remain after surgery. It is not yet known whether sunitinib malate is more effective than sorafenib tosylate or placebo in treating kidney cancer.

Condition or Disease	Intervention/Treatment	Phase
Clear Cell Renal Cell Carcinoma; Stage I Renal Cell Cancer AJCC v6 and v7; Stage II Renal Cell Cancer AJCC v7; Stage III Renal Cell Cancer AJCC v7	Other: Laboratory Biomarker Analysis; Other: Placebo; Other: Quality-of-Life Assessment; Drug: Sorafenib Tosylate; Drug: Sunitinib Malate	Phase 3

Detailed Description

PRIMARY OBJECTIVES:

1. To demonstrate an improvement in disease-free survival in locally advanced renal cell carcinoma patients randomly assigned to adjuvant sunitinib (sunitinib malate) (Arm A) or sorafenib (sorafenib tosylate) (Arm B) versus placebo (Arm C) after radical or partial nephrectomy.

SECONDARY OBJECTIVES:

1. To compare overall survival of patients randomized to each of the two regimens with placebo.

2. To further define the toxicity of prolonged administration of sunitinib or sorafenib in this patient population.

3. To prospectively collect tumor and biological specimens to assess their characteristics and associations: novel approaches to assess angiogenesis markers in tissue, blood and urine as predictors of disease-free survival and of therapeutic benefit.

4. To prospectively collect tumor and biological specimens to assess their characteristics and associations: the frequency of oncogene and tumor suppressor gene mutations as predictors of disease-free survival and therapeutic benefit.

5. To prospectively collect tumor and biological specimens to assess their characteristics and associations: tumor and genetic polymorphisms as predictors of disease-free survival and therapeutic benefit.

6. To prospectively collect tumor and biological specimens to assess their characteristics and associations: deoxyribonucleic acid (DNA) methylation profiles as predictors of outcome and of therapeutic benefit.

7. To prospectively collect tumor and biological specimens to assess their characteristics and associations: The relationship of polymorphisms in drug metabolizing enzymes with steady state concentrations of sorafenib and sunitinib in selected patients.

8. To study the effect of vascular endothelial growth factor (VEGF) targeted therapy on circulating endothelial cells and circulating endothelial progenitors.

9. To prospectively assess patient-reported fatigue in order to compare the magnitude and trajectory of fatigue among renal cell carcinoma (RCC) patients randomized to adjuvant sunitinib (Arm A) or sorafenib (Arm B) to placebo (Arm C). (Quality of life objectives) X. To evaluate the Patient Reported Outcomes Measurement Information System (PROMIS) Fatigue-Short Form (SF)1, a newly developed state-of-the-science PROMIS measure for fatigue and to calibrate the PROMIS Fatigue-SF1 with the established, validated FACIT-Fatigue scale. (Quality of life objectives)

OUTLINE: Patients are randomized to 1 of 3 treatment arms.

ARM A: Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sunitinib malate orally (PO) once daily (QD) for 4 weeks and placebo sorafenib tosylate PO QD or twice daily (BID) for 6 weeks.

ARM B: Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sorafenib tosylate PO QD or BID for 6 weeks and placebo sunitinib malate PO QD for 4 weeks followed.

ARM C: Beginning 4-12 weeks following radical or partial nephrectomy, patients receive placebo sorafenib tosylate as in Arm A and placebo sunitinib malate as in Arm B.

In all arms, treatment repeats every 6 weeks for 9 courses in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 3 years, and then every 12 months for 5 years.

Study Design

• Study Type: Interventional
• Actual Enrollment: 1943 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Double (Participant, Investigator)
• Primary Purpose: Treatment
• Official Title: ASSURE: Adjuvant Sorafenib or Sunitinib for Unfavorable Renal Carcinoma
• Actual Study Start Date: Apr 24, 2006
• Actual Primary Completion Date: Aug 27, 2015
• Actual Study Completion Date: Sep 1, 2021

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Arm A (sunitinib malate, placebo) Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sunitinib malate PO QD for 4 weeks and placebo sorafenib tosylate PO QD or BID for 6 weeks.	Other: Laboratory Biomarker Analysis; Correlative studies; Other: Placebo; Given PO; Other Names: placebo therapy PLCB sham therapy ; Other: Quality-of-Life Assessment; Ancillary studies; Other Names: Quality of Life Assessment ; Drug: Sunitinib Malate; Given PO; Other Names: SU011248 SU11248 sunitinib Sutent
Experimental: Arm B (sorafenib tosylate, placebo) Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sorafenib tosylate PO QD or BID for 6 weeks and placebo sunitinib malate PO QD for 4 weeks followed.	Other: Laboratory Biomarker Analysis; Correlative studies; Other: Placebo; Given PO; Other Names: placebo therapy PLCB sham therapy ; Other: Quality-of-Life Assessment; Ancillary studies; Other Names: Quality of Life Assessment ; Drug: Sorafenib Tosylate; Given PO; Other Names: BAY 43-9006 Tosylate BAY 54-9085 Nexavar sorafenib
Placebo Comparator: Arm C (placebo) Beginning 4-12 weeks following radical or partial nephrectomy, patients receive placebo sorafenib tosylate as in Arm A and placebo sunitinib malate as in Arm B.	Other: Laboratory Biomarker Analysis; Correlative studies; Other: Placebo; Given PO; Other Names: placebo therapy PLCB sham therapy ; Other: Quality-of-Life Assessment; Ancillary studies; Other Names: Quality of Life Assessment

Outcome Measures

Primary Outcome Measures

1. Disease-free Survival (DFS) [Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry; then annually if patient is 5 - 10 years from study entry]

   Disease-free survival (DFS) is defined as time from randomization to recurrence, development of second primary cancer (except localized breast or prostate cancer or nonmelanoma skin cancer), or death from any cause. Patients who were alive without recurrence or qualifying second primary cancer were censored at the date of last disease evaluation.

Secondary Outcome Measures

1. 5-year Overall Survival Rate [Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry]

   Overall survival is defined as the time from randomization to death from any cause. Patients without a date of death were censored at the date of last contact. Kaplan-Meier method was used to estimate 5-year survival rate.

2. Proportion of Patients With Cardiac Events [Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry]

   Cardiac event is defined as left ventricular ejection fraction (LVEF) below the institutional lower limit of normal, where the decrease was >15% absolute percentage points from baseline within 6 months.

3. 5-year Disease-free Survival (DFS) Rate Among Patients With Clear Cell Histology [Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry; then annually if patient is 5 - 10 years from study entry]

   Disease-free survival (DFS) is defined as time from randomization to recurrence, development of second primary cancer (except localized breast or prostate cancer or nonmelanoma skin cancer), or death from any cause. Patients who were alive without recurrence or qualifying second primary cancer were censored at the date of last disease evaluation. 5-year DFS rate is the proportion of patients who are alive and disease-free at 5 years based on the Kaplan-Meier estimate.

Other Outcome Measures

1. The Association Between Angiogenesis Markers and Disease-free Survival [Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry; then annually if patient is 5 - 10 years from study entry]

2. The Association Between Disease-free Survival and the Frequency of Oncogene as Well as Tumor Suppressor Gene Mutations [Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry; then annually if patient is 5 - 10 years from study entry]

3. The Association Between Tumor and Genetic Polymorphisms and Disease-free Survival [Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry; then annually if patient is 5 - 10 years from study entry]

4. The Association Between Deoxyribonucleic Acid (DNA) Methylation Profiles and Disease-free Survival [Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry; then annually if patient is 5 - 10 years from study entry]

5. The Relationship of Polymorphisms in Drug Metabolizing Enzymes With Steady State Concentrations of Sorafenib and Sunitinib in Selected Patients [Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry; then annually if patient is 5 - 10 years from study entry]

6. The Effect of Vascular Endothelial Growth Factor (VEGF) Targeted Therapy on Circulating Endothelial Cells and Circulating Endothelial Progenitors [Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry; then annually if patient is 5 - 10 years from study entry]

7. Patient-reported Fatigue Using Functional Assessment of Chronic Illness Therapy (FACIT) - Fatigue Scale [Assessed at baseline, 10 weeks and 22 weeks]

8. Patient-reported Fatigue Using the Patient-Reported Outcomes Measurement Information System (PROMIS) Fatigue Short Form [Assessed at baseline, 10 weeks and 22 weeks]

   PROMIS Fatigue short form is a newly developed state-of-the-science PROMIS measure for fatigue

9. The Association Between Scan Frequency and Development of Congestive Heart Failure [Assessed at 3, 6 and 12 months]

10. Frequency of Clinically Significant Congestive Heart Failure (CHF) Grade 3 or Higher Using the Common Terminology Criteria for Adverse Events Version 4.0 [Assessed every 6 weeks while on treatment and for 30 days after the end of treatment]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Pre-surgical criteria:

• Patients must have primary-intact renal cell carcinoma, eligible for nephrectomy with curative intent

• Tumors >= 4 cm AND/OR macroscopic fully resectable nodes AND/OR surgically resectable renal vein thrombus AND/OR surgically resectable inferior vena caval thrombus by radiologic criteria to be clinically >= pT1bNany (resectable) M0 disease

• Multifocal ipsilateral renal cell carcinoma is allowed provided fully resectable and does not exceed inclusion criteria

• Patients must have no history of distant metastases

• No prior anti-cancer therapy for renal cell carcinoma is permitted in either the adjuvant or neoadjuvant setting; this includes metastectomy for renal cell carcinoma, or radiation therapy to the renal bed

• Patients must not have other current malignancies, other than basal cell skin cancer, squamous cell skin cancer, in situ cervical cancer, ductal or lobular carcinoma in situ of the breast; patients with other malignancies are eligible if they have been continuously disease-free for >= 5 years prior to the time of registration

• Patients must have no serious intercurrent illness including, but not limited to, the following: clinically significant cardiovascular disease (e.g. uncontrolled hypertension, myocardial infarction, unstable angina); New York Heart Association grade II or greater congestive heart failure; serious cardiac arrhythmia requiring medication; grade II or greater peripheral vascular disease; or psychiatric illness/social situations that would limit compliance with study requirements

• Patients must not have any of the following within the 6 months prior to study drug administration: myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure, cerebrovascular accident or transient ischemic attack, or pulmonary embolism

• Patient must not have ongoing ventricular cardiac dysrhythmias of National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 4.0 grade

= 2; patients with a history of serious ventricular arrhythmia (ventricular tachycardia [VT] or ventricular fibrillation [VF] >= 3 beats in a row) are also excluded; additionally, patients with ongoing atrial fibrillation are not eligible

• Patients must have corrected QT (QTc) interval < 500 msec on baseline electrocardiogram (EKG)

• Patient must not have hypertension that cannot be controlled by medications (>= diastolic blood pressure 100 mm Hg despite optimal medical therapy)

• Patient must not have pre-existing thyroid abnormality with thyroid stimulating hormone that cannot be maintained in the normal range with medication

• If female, patient must not be pregnant or breastfeeding; all females of childbearing potential must have a blood test or urine study within 2 weeks prior to pre-registration to rule out pregnancy; if pre-registration occurs prior to surgery, the blood or urine study must be repeated within 2 weeks prior to randomization to rule out pregnancy; (note: should a woman become pregnant while participating in this study, she should inform her treating physician immediately)

• Women of child-bearing potential and men must agree to use an accepted and effective method of contraception prior to study entry and for the duration of study participation; should a woman become pregnant while participating in this study, she should inform her treating physician immediately; if a man impregnates a woman while participating in this study, he should inform his treating physician immediately as well

• Patients with known human immunodeficiency virus (HIV) are excluded

• ELIGIBILITY CRITERIA FOLLOWING RADICAL OR PARTIAL NEPHRECTOMY

• The date of randomization must be less than 12 weeks after the date of surgery; patients must have recovered from any surgical related complications

• Within 4 weeks prior to randomization, patients must meet preoperative eligibility requirements

• Patients must have histologically or cytologically confirmed renal cell carcinoma. Using 2002 (American Joint Committee on Cancer [AJCC] 6th edition) TNM Staging, patients must be one of the following:

• pT1b G3-4 N0 (or pNX where clinically N0) M0

• pT2 G (any) N0 (or pNX where clinically N0) M0

• pT3 G (any) N0 (or pNX where clinically N0) M0

• pT4 G (any) N0 (or pNX where clinically N0) M0 or

• T (any) G (any) N+ (fully resected) M0

• Patients with microvascular invasion of the renal vein of any grade or stage (as long as M0) are also eligible

• Patients must have undergone a full surgical resection (radical nephrectomy or partial nephrectomy) by either open or laparoscopic technique; clinical evidence of lymph node positivity requires removal of all clinically positive nodes; surgeons should designate extent of node dissection; all surgical specimens must have negative margins; patients with positive renal vein margins are eligible unless there is invasion of the renal vein wall at the margin (provided no other margins are positive)

• Patients must not have collecting duct carcinomas or medullary carcinomas

• Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1

• Patients must have an absolute baseline left ventricular ejection fraction (LVEF) of

= 50% by multigated acquisition (MUGA) scan within 4 weeks prior to randomization

• Patients must have paraffin-embedded tumor specimen available for central core review of tumor histology and other correlative studies; tumor samples will be shipped as specified

• Patients must have no evidence of residual or metastatic renal cell cancer as documented on computed tomography (CT) scans of the chest, abdomen, and pelvis, all with oral and intravenous (IV) contrast (magnetic resonance imaging [MRI] scans of the abdomen and pelvis with gadolinium and a non-contrast CT of the chest may be substituted if patient is not able to have CT scans with intravenous contrast); patients unable to tolerate either gadolinium or IV contrast should not participate in this study (limitations to a patient's renal function should be taken into consideration when screening for this study)

• Scans must be obtained within 4 weeks of randomization; changes on these scans that are felt to be post surgical must be documented

• Patients without reported lymph nodes in the resected surgical specimen and a reported pathologic stage (post-nephrectomy) of pNX MUST undergo a post-operative contrast-enhanced CT scan (or MRI with gadolinium) within 4 weeks of randomization to document that there is no evidence of residual disease

• Patients must not be taking cytochrome P450 enzyme-inducing antiepileptic drugs (phenytoin, carbamazepine or phenobarbital), St John's Wort, ketoconazole, dexamethasone, the dysrhythmic drugs (terfenadine, quinidine, procainamide, sotalol, probucol, bepridil, indapamide or flecainide), haloperidol, risperidone, rifampin, grapefruit, or grapefruit juice within two weeks of randomization and during the course of therapy; (medications are not prohibited unless listed above); topical and inhaled steroids are permitted

• Patients must not receive any other investigational anti-cancer agents during the period on study

• Patients must not have a serious intercurrent illness, including ongoing or active infection requiring parental antibiotics

• Absolute granulocyte count (AGC) >= 1,500/mm^3

• Platelet count >= 100,000/mm^3

• Serum creatinine =< 2.0 x upper limit of normal (ULN) or calculated creatinine clearance (CrCl) >= 30 mL/min (neither drug is cleared by the kidney)

• Total bilirubin =< 1.5 x upper limit of normal (ULN)

• Serum glutamic oxaloacetic transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) =< 2.5 x ULN

• Patients must be able to swallow pills

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	United States	35233
2	Clearview Cancer Institute	Huntsville	Alabama	United States	35805
3	Mobile Infirmary Medical Center	Mobile	Alabama	United States	36607
4	Providence Hospital	Mobile	Alabama	United States	36608
5	University of South Alabama Mitchell Cancer Institute	Mobile	Alabama	United States	36688
6	Providence Alaska Medical Center	Anchorage	Alaska	United States	99508
7	Fairbanks Memorial Hospital	Fairbanks	Alaska	United States	99701
8	Banner Thunderbird Medical Center	Glendale	Arizona	United States	85306
9	Banner-University Medical Center Phoenix	Phoenix	Arizona	United States	85006
10	Western Regional CCOP	Phoenix	Arizona	United States	85006
11	Mayo Clinic in Arizona	Scottsdale	Arizona	United States	85259
12	Banner University Medical Center - Tucson	Tucson	Arizona	United States	85719
13	Sparks Regional Medical Center	Fort Smith	Arkansas	United States	72901
14	CHI Saint Vincent Cancer Center Hot Springs	Hot Springs	Arkansas	United States	71913
15	University of Arkansas for Medical Sciences	Little Rock	Arkansas	United States	72205
16	Highlands Oncology Group-Rogers	Rogers	Arkansas	United States	72758
17	Alta Bates Summit Medical Center-Herrick Campus	Berkeley	California	United States	94704
18	Providence Saint Joseph Medical Center/Disney Family Cancer Center	Burbank	California	United States	91505
19	Mills-Peninsula Medical Center	Burlingame	California	United States	94010
20	East Bay Radiation Oncology Center	Castro Valley	California	United States	94546
21	Eden Hospital Medical Center	Castro Valley	California	United States	94546
22	Valley Medical Oncology Consultants-Castro Valley	Castro Valley	California	United States	94546
23	John Muir Medical Center-Concord Campus	Concord	California	United States	94520
24	City of Hope Comprehensive Cancer Center	Duarte	California	United States	91010
25	Bay Area Breast Surgeons Inc	Emeryville	California	United States	94608
26	Kaiser Permanente-Fremont	Fremont	California	United States	94538
27	Valley Medical Oncology Consultants-Fremont	Fremont	California	United States	94538
28	Washington Hospital	Fremont	California	United States	94538
29	Saint Jude Medical Center	Fullerton	California	United States	92835
30	Glendale Memorial Hospital and Health Center	Glendale	California	United States	91204
31	Marin Cancer Care Inc	Greenbrae	California	United States	94904
32	Marin General Hospital	Greenbrae	California	United States	94904
33	Saint Rose Hospital	Hayward	California	United States	94545
34	Loma Linda University Medical Center	Loma Linda	California	United States	92354
35	Veterans Affairs Loma Linda Healthcare System	Loma Linda	California	United States	92357
36	USC / Norris Comprehensive Cancer Center	Los Angeles	California	United States	90033
37	Contra Costa Regional Medical Center	Martinez	California	United States	94553-3156
38	Fremont - Rideout Cancer Center	Marysville	California	United States	95901
39	Memorial Medical Center	Modesto	California	United States	95355
40	Community Hospital of Monterey Peninsula	Monterey	California	United States	93940
41	El Camino Hospital	Mountain View	California	United States	94040
42	Palo Alto Medical Foundation-Camino Division	Mountain View	California	United States	94040
43	Northridge Hospital Medical Center	Northridge	California	United States	91325
44	Sutter Cancer Research Consortium	Novato	California	United States	94945
45	Highland General Hospital	Oakland	California	United States	94602
46	Alta Bates Summit Medical Center - Summit Campus	Oakland	California	United States	94609
47	Bay Area Tumor Institute	Oakland	California	United States	94609
48	Hematology and Oncology Associates-Oakland	Oakland	California	United States	94609
49	Tom K Lee Inc	Oakland	California	United States	94609
50	Kaiser Permanente-Oakland	Oakland	California	United States	94611
51	Saint Joseph Hospital - Orange	Orange	California	United States	92868
52	UC Irvine Health/Chao Family Comprehensive Cancer Center	Orange	California	United States	92868
53	Palo Alto Medical Foundation Health Care	Palo Alto	California	United States	94301
54	Stanford Cancer Institute Palo Alto	Palo Alto	California	United States	94304
55	VA Palo Alto Health Care System	Palo Alto	California	United States	94304
56	Valley Care Health System - Pleasanton	Pleasanton	California	United States	94588
57	Valley Medical Oncology Consultants	Pleasanton	California	United States	94588
58	Eisenhower Medical Center	Rancho Mirage	California	United States	92270
59	Shasta Regional Medical Center	Redding	California	United States	96001
60	Kaiser Permanente-Redwood City	Redwood City	California	United States	94063
61	Kaiser Permanente-Richmond	Richmond	California	United States	94801
62	Kaiser Permanente-Roseville	Roseville	California	United States	95661
63	Sutter Roseville Medical Center	Roseville	California	United States	95661
64	Sutter Medical Center Sacramento	Sacramento	California	United States	95816
65	University of California Davis Comprehensive Cancer Center	Sacramento	California	United States	95817
66	Mercy General Hospital	Sacramento	California	United States	95819
67	Kaiser Permanente-South Sacramento	Sacramento	California	United States	95823
68	Kaiser Permanente - Sacramento	Sacramento	California	United States	95825
69	Salinas Valley Memorial	Salinas	California	United States	93901
70	University of California San Diego	San Diego	California	United States	92103
71	Kaiser Permanente-San Diego Mission	San Diego	California	United States	92108
72	Veterans Administration-San Diego Medical Center	San Diego	California	United States	92161
73	California Pacific Medical Center-Pacific Campus	San Francisco	California	United States	94115
74	Kaiser Permanente-San Francisco	San Francisco	California	United States	94115
75	UCSF Medical Center-Mount Zion	San Francisco	California	United States	94115
76	Kaiser Permanente-Santa Teresa-San Jose	San Jose	California	United States	95119
77	Kaiser Permanente San Leandro	San Leandro	California	United States	94577
78	Doctors Medical Center- JC Robinson Regional Cancer Center	San Pablo	California	United States	94806
79	Kaiser Permanente-San Rafael	San Rafael	California	United States	94903
80	Kaiser Permanente Medical Center - Santa Clara	Santa Clara	California	United States	95051
81	Kaiser Permanente-Santa Rosa	Santa Rosa	California	United States	95403
82	Kaiser Permanente-South San Francisco	South San Francisco	California	United States	94080
83	Kaiser Permanente-Stockton	Stockton	California	United States	95210
84	Gene Upshaw Memorial Tahoe Forest Cancer Center	Truckee	California	United States	96161
85	Northbay Cancer Center	Vacaville	California	United States	95687
86	Kaiser Permanente-Vallejo	Vallejo	California	United States	94589
87	Sutter Solano Medical Center/Cancer Center	Vallejo	California	United States	94589
88	Kaiser Permanente-Walnut Creek	Walnut Creek	California	United States	94596
89	John Muir Medical Center-Walnut Creek	Walnut Creek	California	United States	94598
90	The Medical Center of Aurora	Aurora	Colorado	United States	80012
91	Rocky Mountain Regional VA Medical Center	Aurora	Colorado	United States	80045
92	Boulder Community Hospital	Boulder	Colorado	United States	80301
93	Penrose-Saint Francis Healthcare	Colorado Springs	Colorado	United States	80907
94	UCHealth Memorial Hospital Central	Colorado Springs	Colorado	United States	80909
95	Denver Health Medical Center	Denver	Colorado	United States	80204
96	Kaiser Permanente-Franklin	Denver	Colorado	United States	80205
97	Porter Adventist Hospital	Denver	Colorado	United States	80210
98	University of Colorado	Denver	Colorado	United States	80217-3364
99	Presbyterian - Saint Lukes Medical Center - Health One	Denver	Colorado	United States	80218
100	SCL Health Saint Joseph Hospital	Denver	Colorado	United States	80218
101	Rose Medical Center	Denver	Colorado	United States	80220
102	Colorado Cancer Research Program NCORP	Denver	Colorado	United States	80222
103	Shaw Cancer Center	Edwards	Colorado	United States	81632
104	Swedish Medical Center	Englewood	Colorado	United States	80113
105	Poudre Valley Hospital	Fort Collins	Colorado	United States	80524
106	Valley View Hospital Cancer Center	Glenwood Springs	Colorado	United States	81601
107	Saint Mary's Hospital and Regional Medical Center	Grand Junction	Colorado	United States	81501
108	North Colorado Medical Center	Greeley	Colorado	United States	80631
109	Kaiser Permanente-Rock Creek	Lafayette	Colorado	United States	80026
110	Saint Anthony Hospital	Lakewood	Colorado	United States	80228
111	Sky Ridge Medical Center	Lone Tree	Colorado	United States	80124
112	Longmont United Hospital	Longmont	Colorado	United States	80501
113	McKee Medical Center	Loveland	Colorado	United States	80539
114	Montrose Memorial Hospital	Montrose	Colorado	United States	81401
115	Saint Mary Corwin Medical Center	Pueblo	Colorado	United States	81004
116	North Suburban Medical Center	Thornton	Colorado	United States	80229
117	SCL Health Lutheran Medical Center	Wheat Ridge	Colorado	United States	80033
118	Saint Vincent's Medical Center	Bridgeport	Connecticut	United States	06606
119	Danbury Hospital	Danbury	Connecticut	United States	06810
120	Hartford Hospital	Hartford	Connecticut	United States	06102
121	Smilow Cancer Hospital Care Center at Saint Francis	Hartford	Connecticut	United States	06105
122	Manchester Memorial Hospital	Manchester	Connecticut	United States	06040
123	Yale University	New Haven	Connecticut	United States	06520
124	Norwalk Hospital	Norwalk	Connecticut	United States	06856
125	Eastern Connecticut Hematology and Oncology Associates	Norwich	Connecticut	United States	06360
126	Bayhealth Hospital Kent Campus	Dover	Delaware	United States	19901
127	Beebe Medical Center	Lewes	Delaware	United States	19958
128	Christiana Care Health System-Christiana Hospital	Newark	Delaware	United States	19718
129	MedStar Georgetown University Hospital	Washington	District of Columbia	United States	20007
130	MedStar Washington Hospital Center	Washington	District of Columbia	United States	20010
131	Sibley Memorial Hospital	Washington	District of Columbia	United States	20016
132	George Washington University Medical Center	Washington	District of Columbia	United States	20037
133	Boca Raton Regional Hospital	Boca Raton	Florida	United States	33486
134	Holy Cross Hospital	Fort Lauderdale	Florida	United States	33308
135	Broward Health Medical Center	Fort Lauderdale	Florida	United States	33316
136	Lee Memorial Health System	Fort Myers	Florida	United States	33901
137	Southwest Florida Regional Medical Center	Fort Myers	Florida	United States	33901
138	Florida Cancer Specialists-Gainesville Cancer Center	Gainesville	Florida	United States	32605
139	University of Florida Health Science Center - Gainesville	Gainesville	Florida	United States	32610
140	Memorial Regional Hospital/Joe DiMaggio Children's Hospital	Hollywood	Florida	United States	33021
141	Baptist MD Anderson Cancer Center	Jacksonville	Florida	United States	32207
142	Mayo Clinic in Florida	Jacksonville	Florida	United States	32224-9980
143	Jupiter Medical Center	Jupiter	Florida	United States	33458
144	Lakeland Regional Health Hollis Cancer Center	Lakeland	Florida	United States	33805
145	Cancer Centers of Central Florida PA	Leesburg	Florida	United States	34788
146	Mount Sinai Medical Center	Miami Beach	Florida	United States	33140
147	University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	United States	33136
148	21st Century Oncology-Orange Park	Orange Park	Florida	United States	32073
149	AdventHealth Orlando	Orlando	Florida	United States	32803
150	UF Cancer Center at Orlando Health	Orlando	Florida	United States	32806
151	Sacred Heart Hospital	Pensacola	Florida	United States	32504
152	Florida Cancer Specialists - Sarasota Downtown	Sarasota	Florida	United States	34236
153	Moffitt Cancer Center	Tampa	Florida	United States	33612
154	Cleveland Clinic-Weston	Weston	Florida	United States	33331
155	Phoebe Putney Memorial Hospital	Albany	Georgia	United States	31701
156	University Cancer and Blood Center LLC	Athens	Georgia	United States	30607
157	Piedmont Hospital	Atlanta	Georgia	United States	30309
158	Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	United States	30322
159	Atlanta Regional CCOP	Atlanta	Georgia	United States	30342
160	Emory Saint Joseph's Hospital	Atlanta	Georgia	United States	30342
161	Northside Hospital	Atlanta	Georgia	United States	30342
162	Augusta University Medical Center	Augusta	Georgia	United States	30912
163	WellStar Cobb Hospital	Austell	Georgia	United States	30106
164	John B Amos Cancer Center	Columbus	Georgia	United States	31904
165	Atlanta VA Medical Center	Decatur	Georgia	United States	30033
166	Dekalb Medical Center	Decatur	Georgia	United States	30033
167	Northeast Georgia Medical Center-Gainesville	Gainesville	Georgia	United States	30501
168	Gwinnett Medical Center	Lawrenceville	Georgia	United States	30046
169	Medical Center of Central Georgia	Macon	Georgia	United States	31201
170	Wellstar Kennestone Hospital	Marietta	Georgia	United States	30060
171	Southern Regional Medical Center	Riverdale	Georgia	United States	30274
172	Harbin Clinic Medical Oncology and Clinical Research	Rome	Georgia	United States	30165
173	Memorial Health University Medical Center	Savannah	Georgia	United States	31404
174	Lewis Cancer and Research Pavilion at Saint Joseph's/Candler	Savannah	Georgia	United States	31405
175	South Georgia Medical Center/Pearlman Cancer Center	Valdosta	Georgia	United States	31602
176	Pali Momi Medical Center	'Aiea	Hawaii	United States	96701
177	Hawaii Cancer Care Inc-POB II	Honolulu	Hawaii	United States	96813
178	Queen's Medical Center	Honolulu	Hawaii	United States	96813
179	Straub Clinic and Hospital	Honolulu	Hawaii	United States	96813
180	University of Hawaii Cancer Center	Honolulu	Hawaii	United States	96813
181	Hawaii Oncology Inc-Kuakini	Honolulu	Hawaii	United States	96817
182	The Cancer Center of Hawaii-Liliha	Honolulu	Hawaii	United States	96817
183	Kaiser Permanente Moanalua Medical Center	Honolulu	Hawaii	United States	96819
184	Kapiolani Medical Center for Women and Children	Honolulu	Hawaii	United States	96826
185	Tripler Army Medical Center	Honolulu	Hawaii	United States	96859
186	Maui Memorial Medical Center	Wailuku	Hawaii	United States	96793
187	Pacific Cancer Institute of Maui	Wailuku	Hawaii	United States	96793
188	Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	United States	83706
189	Portneuf Medical Center	Pocatello	Idaho	United States	83201
190	Kootenai Cancer Center	Post Falls	Idaho	United States	83854
191	Saint Anthony's Health	Alton	Illinois	United States	62002
192	Rush - Copley Medical Center	Aurora	Illinois	United States	60504
193	Saint Joseph Medical Center	Bloomington	Illinois	United States	61701
194	Illinois CancerCare-Bloomington	Bloomington	Illinois	United States	61704
195	Graham Hospital Association	Canton	Illinois	United States	61520
196	Illinois CancerCare-Canton	Canton	Illinois	United States	61520
197	Illinois CancerCare-Carthage	Carthage	Illinois	United States	62321
198	Memorial Hospital	Carthage	Illinois	United States	62321
199	Mount Sinai Hospital Medical Center	Chicago	Illinois	United States	60608
200	Hematology and Oncology Associates	Chicago	Illinois	United States	60611
201	Northwestern University	Chicago	Illinois	United States	60611
202	Jesse Brown Veterans Affairs Medical Center	Chicago	Illinois	United States	60612
203	John H Stroger Jr Hospital of Cook County	Chicago	Illinois	United States	60612
204	Rush University Medical Center	Chicago	Illinois	United States	60612
205	Mercy Hospital and Medical Center	Chicago	Illinois	United States	60616
206	Swedish Covenant Hospital	Chicago	Illinois	United States	60625
207	Presence Resurrection Medical Center	Chicago	Illinois	United States	60631
208	University of Chicago Comprehensive Cancer Center	Chicago	Illinois	United States	60637
209	Decatur Memorial Hospital	Decatur	Illinois	United States	62526
210	Heartland Cancer Research NCORP	Decatur	Illinois	United States	62526
211	Advocate Sherman Hospital	Elgin	Illinois	United States	60123
212	AMITA Health Alexian Brothers Medical Center	Elk Grove Village	Illinois	United States	60007
213	Elmhurst Memorial Hospital	Elmhurst	Illinois	United States	60126
214	Eureka Hospital	Eureka	Illinois	United States	61530
215	Illinois CancerCare-Eureka	Eureka	Illinois	United States	61530
216	NorthShore University HealthSystem-Evanston Hospital	Evanston	Illinois	United States	60201
217	Saint Francis Hospital	Evanston	Illinois	United States	60202
218	Galesburg Cottage Hospital	Galesburg	Illinois	United States	61401
219	Illinois CancerCare-Cottage	Galesburg	Illinois	United States	61401
220	Illinois CancerCare-Galesburg	Galesburg	Illinois	United States	61401
221	LaGrange Oncology Associates	Geneva	Illinois	United States	60134
222	Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	United States	60134
223	Ingalls Memorial Hospital	Harvey	Illinois	United States	60426
224	Illinois CancerCare-Havana	Havana	Illinois	United States	62644
225	Mason District Hospital	Havana	Illinois	United States	62644
226	Hematology Oncology Associates of Illinois-Highland Park	Highland Park	Illinois	United States	60035
227	Hinsdale Hematology Oncology Associates Incorporated	Hinsdale	Illinois	United States	60521
228	Hopedale Medical Complex - Hospital	Hopedale	Illinois	United States	61747
229	Midwest Center for Hematology Oncology	Joliet	Illinois	United States	60432
230	Joliet Oncology-Hematology Associates Limited	Joliet	Illinois	United States	60435
231	Presence Saint Mary's Hospital	Kankakee	Illinois	United States	60901
232	Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	United States	61443
233	Kewanee Hospital	Kewanee	Illinois	United States	61443
234	AMITA Health Adventist Medical Center	La Grange	Illinois	United States	60525
235	NorthShore Hematology Oncology-Libertyville	Libertyville	Illinois	United States	60048
236	Illinois CancerCare-Macomb	Macomb	Illinois	United States	61455
237	Mcdonough District Hospital	Macomb	Illinois	United States	61455
238	Loyola University Medical Center	Maywood	Illinois	United States	60153
239	Garneau, Stewart C MD (UIA Investigator)	Moline	Illinois	United States	61265
240	Porubcin, Michael MD (UIA Investigator)	Moline	Illinois	United States	61265
241	Sharis, Christine M MD (UIA Investigator)	Moline	Illinois	United States	61265
242	Spector, David MD (UIA Investigator)	Moline	Illinois	United States	61265
243	Stoffel, Thomas J MD (UIA Investigator)	Moline	Illinois	United States	61265
244	Trinity Medical Center	Moline	Illinois	United States	61265
245	Vigliotti, Antonio, P.G. M.D. (UIA Investigator)	Moline	Illinois	United States	61265
246	Holy Family Medical Center	Monmouth	Illinois	United States	61462
247	Illinois CancerCare-Monmouth	Monmouth	Illinois	United States	61462
248	Good Samaritan Regional Health Center	Mount Vernon	Illinois	United States	62864
249	Edward Hospital/Cancer Center	Naperville	Illinois	United States	60540
250	DuPage Medical Group-Ogden	Naperville	Illinois	United States	60563
251	Illinois Cancer Specialists-Niles	Niles	Illinois	United States	60714
252	Bromenn Regional Medical Center	Normal	Illinois	United States	61761
253	Community Cancer Center Foundation	Normal	Illinois	United States	61761
254	Illinois CancerCare-Community Cancer Center	Normal	Illinois	United States	61761
255	Advocate Christ Medical Center	Oak Lawn	Illinois	United States	60453-2699
256	Franciscan St. James Health-Olympia Fields Campus	Olympia Fields	Illinois	United States	60461
257	Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	United States	61350
258	Ottawa Regional Hospital and Healthcare Center	Ottawa	Illinois	United States	61350
259	Illinois CancerCare-Pekin	Pekin	Illinois	United States	61554
260	OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center	Pekin	Illinois	United States	61554
261	Pekin Hospital	Pekin	Illinois	United States	61554
262	Proctor Hospital	Peoria	Illinois	United States	61614
263	Illinois CancerCare-Peoria	Peoria	Illinois	United States	61615
264	Methodist Medical Center of Illinois	Peoria	Illinois	United States	61636
265	OSF Saint Francis Medical Center	Peoria	Illinois	United States	61637
266	Illinois CancerCare-Peru	Peru	Illinois	United States	61354
267	Illinois Valley Hospital	Peru	Illinois	United States	61354
268	Illinois CancerCare-Princeton	Princeton	Illinois	United States	61356
269	Perry Memorial Hospital	Princeton	Illinois	United States	61356
270	West Suburban Medical Center	River Forest	Illinois	United States	60305
271	Swedish American Hospital	Rockford	Illinois	United States	61104
272	OSF Saint Anthony Medical Center	Rockford	Illinois	United States	61108
273	Edward H Kaplan MD and Associates	Skokie	Illinois	United States	60076
274	Hematology Oncology Associates of Illinois - Skokie	Skokie	Illinois	United States	60076
275	Illinois CancerCare-Spring Valley	Spring Valley	Illinois	United States	61362
276	Saint Margaret's Hospital	Spring Valley	Illinois	United States	61362
277	Memorial Medical Center	Springfield	Illinois	United States	62781
278	Carle Cancer Center	Urbana	Illinois	United States	61801
279	Northwestern Medicine Central DuPage Hospital	Winfield	Illinois	United States	60190
280	Franciscan Saint Francis Health-Beech Grove	Beech Grove	Indiana	United States	46107
281	Elkhart Clinic	Elkhart	Indiana	United States	46514-2098
282	Elkhart General Hospital	Elkhart	Indiana	United States	46515
283	Fort Wayne Medical Oncology and Hematology Inc-Parkview	Fort Wayne	Indiana	United States	46845
284	Goshen Center for Cancer Care	Goshen	Indiana	United States	46526
285	Indiana University/Melvin and Bren Simon Cancer Center	Indianapolis	Indiana	United States	46202
286	Richard L. Roudebush Veterans Affairs Medical Center	Indianapolis	Indiana	United States	46202
287	Sidney and Lois Eskenazi Hospital	Indianapolis	Indiana	United States	46202
288	Saint Vincent Hospital and Health Care Center	Indianapolis	Indiana	United States	46260
289	Community Howard Regional Health	Kokomo	Indiana	United States	46904
290	IU Health La Porte Hospital	La Porte	Indiana	United States	46350
291	IU Health Arnett Cancer Care	Lafayette	Indiana	United States	47904
292	Horizon Oncology Research LLC	Lafayette	Indiana	United States	47905
293	Premier Oncology Hematology Associates	Merrillville	Indiana	United States	46410
294	Franciscan Saint Anthony Health-Michigan City	Michigan City	Indiana	United States	46360
295	Saint Joseph Regional Medical Center-Mishawaka	Mishawaka	Indiana	United States	46545
296	The Community Hospital	Munster	Indiana	United States	46321
297	Reid Health	Richmond	Indiana	United States	47374
298	Memorial Hospital of South Bend	South Bend	Indiana	United States	46601
299	Michiana Hematology Oncology PC-South Bend	South Bend	Indiana	United States	46601
300	South Bend Clinic	South Bend	Indiana	United States	46617
301	Northern Indiana Cancer Research Consortium	South Bend	Indiana	United States	46628
302	McFarland Clinic PC - Ames	Ames	Iowa	United States	50010
303	Constantinou, Costas L MD (UIA Investigator)	Bettendorf	Iowa	United States	52722
304	University of Iowa Healthcare Cancer Services Quad Cities	Bettendorf	Iowa	United States	52722
305	Saint Luke's Hospital	Cedar Rapids	Iowa	United States	52402
306	Mercy Hospital	Cedar Rapids	Iowa	United States	52403
307	Oncology Associates at Mercy Medical Center	Cedar Rapids	Iowa	United States	52403
308	Medical Oncology and Hematology Associates-West Des Moines	Clive	Iowa	United States	50325
309	Alegent Health Mercy Hospital	Council Bluffs	Iowa	United States	51503
310	Heartland Oncology and Hematology LLP	Council Bluffs	Iowa	United States	51503
311	Genesis Medical Center - East Campus	Davenport	Iowa	United States	52803
312	Genesis Cancer Care Institute	Davenport	Iowa	United States	52804
313	Mercy Capitol	Des Moines	Iowa	United States	50307
314	Iowa Methodist Medical Center	Des Moines	Iowa	United States	50309
315	Iowa-Wide Oncology Research Coalition NCORP	Des Moines	Iowa	United States	50309
316	Medical Oncology and Hematology Associates-Des Moines	Des Moines	Iowa	United States	50309
317	Medical Oncology and Hematology Associates-Laurel	Des Moines	Iowa	United States	50314
318	Mercy Medical Center - Des Moines	Des Moines	Iowa	United States	50314
319	Iowa Lutheran Hospital	Des Moines	Iowa	United States	50316
320	University of Iowa/Holden Comprehensive Cancer Center	Iowa City	Iowa	United States	52242
321	Mercy Medical Center - North Iowa	Mason City	Iowa	United States	50401
322	Ottumwa Regional Health Center	Ottumwa	Iowa	United States	52501
323	Siouxland Regional Cancer Center	Sioux City	Iowa	United States	51101
324	Mercy Medical Center-Sioux City	Sioux City	Iowa	United States	51102
325	Saint Luke's Regional Medical Center	Sioux City	Iowa	United States	51104
326	Cedar Valley Medical Specialists	Waterloo	Iowa	United States	50701
327	MercyOne Waterloo Medical Center	Waterloo	Iowa	United States	50702
328	Hospital District Sixth of Harper County	Anthony	Kansas	United States	67003
329	Cancer Center of Kansas - Chanute	Chanute	Kansas	United States	66720
330	Cancer Center of Kansas - Dodge City	Dodge City	Kansas	United States	67801
331	Cancer Center of Kansas - El Dorado	El Dorado	Kansas	United States	67042
332	Cancer Center of Kansas - Fort Scott	Fort Scott	Kansas	United States	66701
333	Hays Medical Center	Hays	Kansas	United States	67601
334	Hutchinson Regional Medical Center	Hutchinson	Kansas	United States	67502
335	Cancer Center of Kansas-Independence	Independence	Kansas	United States	67301
336	Providence Medical Center	Kansas City	Kansas	United States	66112
337	University of Kansas Cancer Center	Kansas City	Kansas	United States	66160
338	Cancer Center of Kansas-Kingman	Kingman	Kansas	United States	67068
339	Lawrence Memorial Hospital	Lawrence	Kansas	United States	66044
340	Southwest Medical Center	Liberal	Kansas	United States	67901
341	Cancer Center of Kansas - Newton	Newton	Kansas	United States	67114
342	Olathe Cancer Center	Olathe	Kansas	United States	66061
343	Menorah Medical Center	Overland Park	Kansas	United States	66209
344	Radiation Oncology Practice Corporation Southwest	Overland Park	Kansas	United States	66210
345	Saint Luke's South Hospital	Overland Park	Kansas	United States	66213
346	Cancer Center of Kansas - Parsons	Parsons	Kansas	United States	67357
347	Cancer Center of Kansas - Pratt	Pratt	Kansas	United States	67124
348	Cancer Center of Kansas - Salina	Salina	Kansas	United States	67401
349	Shawnee Mission Medical Center-KCCC	Shawnee Mission	Kansas	United States	66204
350	Cotton O'Neil Cancer Center / Stormont Vail Health	Topeka	Kansas	United States	66606
351	Saint Francis Hospital and Medical Center - Topeka	Topeka	Kansas	United States	66606
352	Cancer Center of Kansas - Wellington	Wellington	Kansas	United States	67152
353	Associates In Womens Health	Wichita	Kansas	United States	67208
354	Cancer Center of Kansas-Wichita Medical Arts Tower	Wichita	Kansas	United States	67208
355	Cancer Center of Kansas - Wichita	Wichita	Kansas	United States	67214
356	Via Christi Regional Medical Center	Wichita	Kansas	United States	67214
357	Wichita NCI Community Oncology Research Program	Wichita	Kansas	United States	67214
358	Cancer Center of Kansas - Winfield	Winfield	Kansas	United States	67156
359	University of Kentucky/Markey Cancer Center	Lexington	Kentucky	United States	40536
360	The James Graham Brown Cancer Center at University of Louisville	Louisville	Kentucky	United States	40202
361	Baptist Health Louisville	Louisville	Kentucky	United States	40207
362	Doctors Carrol, Sheth, Raghavan	Louisville	Kentucky	United States	40215
363	Baton Rouge General Medical Center	Baton Rouge	Louisiana	United States	70806
364	Mary Bird Perkins Cancer Center	Baton Rouge	Louisiana	United States	70809
365	Ochsner Health Center-Summa	Baton Rouge	Louisiana	United States	70809
366	University Health-Conway	Monroe	Louisiana	United States	71202
367	Louisiana State University Health Science Center	New Orleans	Louisiana	United States	70112
368	University Medical Center New Orleans	New Orleans	Louisiana	United States	70112
369	Ochsner Medical Center Jefferson	New Orleans	Louisiana	United States	70121
370	Louisiana State University Health Sciences Center Shreveport	Shreveport	Louisiana	United States	71103
371	Highland Clinic	Shreveport	Louisiana	United States	71105
372	Harold Alfond Center for Cancer Care	Augusta	Maine	United States	04330
373	Eastern Maine Medical Center	Bangor	Maine	United States	04401
374	Mercy Hospital	Portland	Maine	United States	04101
375	Maine Center for Cancer Medicine-Scarborough	Scarborough	Maine	United States	04074
376	Maine Medical Center- Scarborough Campus	Scarborough	Maine	United States	04074
377	Maine General Medical Center-Thayer	Waterville	Maine	United States	04901
378	York Hospital	York	Maine	United States	03909
379	Anne Arundel Medical Center	Annapolis	Maryland	United States	21401
380	University of Maryland/Greenebaum Cancer Center	Baltimore	Maryland	United States	21201
381	Greater Baltimore Medical Center	Baltimore	Maryland	United States	21204
382	Saint Agnes Hospital	Baltimore	Maryland	United States	21229
383	MedStar Franklin Square Medical Center/Weinberg Cancer Institute	Baltimore	Maryland	United States	21237
384	Johns Hopkins University/Sidney Kimmel Cancer Center	Baltimore	Maryland	United States	21287
385	Suburban Hospital	Bethesda	Maryland	United States	20814
386	Memorial Hospital at Easton - Shore Regional Cancer Center	Easton	Maryland	United States	21601
387	University of Maryland Shore Medical Center at Easton	Easton	Maryland	United States	21601
388	Union Hospital of Cecil County	Elkton	Maryland	United States	21921
389	Frederick Memorial Hospital	Frederick	Maryland	United States	21701
390	Peninsula Regional Medical Center	Salisbury	Maryland	United States	21801
391	UM Saint Joseph Medical Center	Towson	Maryland	United States	21204
392	Massachusetts General Hospital Cancer Center	Boston	Massachusetts	United States	02114
393	Boston Medical Center	Boston	Massachusetts	United States	02118
394	Beth Israel Deaconess Medical Center	Boston	Massachusetts	United States	02215
395	Dana-Farber Cancer Institute	Boston	Massachusetts	United States	02215
396	Steward Saint Elizabeth's Medical Center	Brighton	Massachusetts	United States	02135
397	Lahey Hospital and Medical Center	Burlington	Massachusetts	United States	01805
398	Addison Gilbert Hospital	Gloucester	Massachusetts	United States	01930
399	Cape Cod Hospital	Hyannis	Massachusetts	United States	02601
400	Holy Family Hospital	Methuen	Massachusetts	United States	01844
401	Milford Regional Medical Center	Milford	Massachusetts	United States	01757
402	Berkshire Medical Center - Cancer Center	Pittsfield	Massachusetts	United States	01201
403	Commonwealth Hematology Oncology PC-Worcester	Worcester	Massachusetts	United States	01605
404	University of Massachusetts Medical School	Worcester	Massachusetts	United States	01655
405	Bixby Medical Center	Adrian	Michigan	United States	49221
406	Hickman Cancer Center	Adrian	Michigan	United States	49221
407	Michigan Cancer Research Consortium NCORP	Ann Arbor	Michigan	United States	48106
408	Saint Joseph Mercy Hospital	Ann Arbor	Michigan	United States	48106
409	University of Michigan Comprehensive Cancer Center	Ann Arbor	Michigan	United States	48109
410	Bronson Battle Creek	Battle Creek	Michigan	United States	49017
411	Spectrum Health Big Rapids Hospital	Big Rapids	Michigan	United States	49307
412	Beaumont Hospital ? Dearborn	Dearborn	Michigan	United States	48124
413	Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	United States	48201
414	Henry Ford Hospital	Detroit	Michigan	United States	48202
415	Ascension Saint John Hospital	Detroit	Michigan	United States	48236
416	Green Bay Oncology - Escanaba	Escanaba	Michigan	United States	49829
417	Hurley Medical Center	Flint	Michigan	United States	48503
418	Genesys Regional Medical Center-West Flint Campus	Flint	Michigan	United States	48532
419	McLaren Cancer Institute-Flint	Flint	Michigan	United States	48532
420	Cancer Research Consortium of West Michigan NCORP	Grand Rapids	Michigan	United States	49503
421	Mercy Health Saint Mary's	Grand Rapids	Michigan	United States	49503
422	Spectrum Health at Butterworth Campus	Grand Rapids	Michigan	United States	49503
423	Holland Community Hospital	Holland	Michigan	United States	49423
424	Green Bay Oncology - Iron Mountain	Iron Mountain	Michigan	United States	49801
425	Allegiance Health	Jackson	Michigan	United States	49201
426	Bronson Methodist Hospital	Kalamazoo	Michigan	United States	49007
427	West Michigan Cancer Center	Kalamazoo	Michigan	United States	49007
428	Borgess Medical Center	Kalamazoo	Michigan	United States	49048
429	Sparrow Hospital	Lansing	Michigan	United States	48912
430	Saint Mary Mercy Hospital	Livonia	Michigan	United States	48154
431	Mercy Memorial Hospital	Monroe	Michigan	United States	48162
432	Toledo Clinic Cancer Centers-Monroe	Monroe	Michigan	United States	48162
433	Mercy Health Partners-Hackley Campus	Muskegon	Michigan	United States	49442
434	Mercy Health Mercy Campus	Muskegon	Michigan	United States	49444
435	Saint Joseph Mercy Oakland	Pontiac	Michigan	United States	48341
436	Lake Huron Medical Center	Port Huron	Michigan	United States	48060
437	William Beaumont Hospital-Royal Oak	Royal Oak	Michigan	United States	48073
438	Ascension Saint Mary's Hospital	Saginaw	Michigan	United States	48601
439	Lakeland Medical Center Saint Joseph	Saint Joseph	Michigan	United States	49085
440	Marie Yeager Cancer Center	Saint Joseph	Michigan	United States	49085
441	Oncology Care Associates PLLC	Saint Joseph	Michigan	United States	49085
442	Ascension Providence Hospitals - Southfield	Southfield	Michigan	United States	48075
443	Munson Medical Center	Traverse City	Michigan	United States	49684
444	Saint John Macomb-Oakland Hospital	Warren	Michigan	United States	48093
445	Metro Health Hospital	Wyoming	Michigan	United States	49519
446	Harris, John Gilbert MD (UIA Investigator)	Alexandria	Minnesota	United States	56308
447	Medini, Eitan MD (UIA Investigator)	Alexandria	Minnesota	United States	56308
448	Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	United States	56601
449	Brainerd Medical Center Inc	Brainerd	Minnesota	United States	56401
450	Essentia Health Saint Joseph's Medical Center	Brainerd	Minnesota	United States	56401
451	Fairview Ridges Hospital	Burnsville	Minnesota	United States	55337
452	Mercy Hospital	Coon Rapids	Minnesota	United States	55433
453	Essentia Health Cancer Center	Duluth	Minnesota	United States	55805
454	Essentia Health Saint Mary's Medical Center	Duluth	Minnesota	United States	55805
455	Miller-Dwan Hospital	Duluth	Minnesota	United States	55805
456	Fairview-Southdale Hospital	Edina	Minnesota	United States	55435
457	Etzell, Paul S MD (UIA Investigator)	Fergus Falls	Minnesota	United States	56537
458	Lake Region Healthcare Corporation-Cancer Care	Fergus Falls	Minnesota	United States	56537
459	Swenson, Wade II, MD (UIA Investigator)	Fergus Falls	Minnesota	United States	56537
460	Unity Hospital	Fridley	Minnesota	United States	55432
461	Hutchinson Area Health Care	Hutchinson	Minnesota	United States	55350
462	Meeker County Memorial Hospital	Litchfield	Minnesota	United States	55355
463	Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	United States	55109
464	Saint John's Hospital - Healtheast	Maplewood	Minnesota	United States	55109
465	Abbott-Northwestern Hospital	Minneapolis	Minnesota	United States	55407
466	Virginia Piper Cancer Institute	Minneapolis	Minnesota	United States	55407
467	Hennepin County Medical Center	Minneapolis	Minnesota	United States	55415
468	Minneapolis VA Medical Center	Minneapolis	Minnesota	United States	55417
469	University of Minnesota/Masonic Cancer Center	Minneapolis	Minnesota	United States	55455
470	Chippewa County - Montevideo Hospital	Montevideo	Minnesota	United States	56265
471	North Memorial Medical Health Center	Robbinsdale	Minnesota	United States	55422
472	Mayo Clinic	Rochester	Minnesota	United States	55905
473	Coborn Cancer Center at Saint Cloud Hospital	Saint Cloud	Minnesota	United States	56303
474	Saint Cloud Hospital	Saint Cloud	Minnesota	United States	56303
475	Metro Minnesota Community Oncology Research Consortium	Saint Louis Park	Minnesota	United States	55416
476	Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	United States	55416
477	Regions Hospital	Saint Paul	Minnesota	United States	55101
478	Saint Joseph's Hospital - Healtheast	Saint Paul	Minnesota	United States	55102
479	United Hospital	Saint Paul	Minnesota	United States	55102
480	Adult and Pediatric Urology PLLP	Sartell	Minnesota	United States	56377
481	Saint Francis Regional Medical Center	Shakopee	Minnesota	United States	55379
482	Ridgeview Medical Center	Waconia	Minnesota	United States	55387
483	Rice Memorial Hospital	Willmar	Minnesota	United States	56201
484	Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	United States	55125
485	Woodwinds Health Campus	Woodbury	Minnesota	United States	55125
486	University of Mississippi Medical Center	Jackson	Mississippi	United States	39216
487	Singing River Hospital	Pascagoula	Mississippi	United States	39581
488	Southeast Missouri Hospital	Cape Girardeau	Missouri	United States	63701
489	Saint Francis Medical Center	Cape Girardeau	Missouri	United States	63703
490	Saint Luke's Hospital	Chesterfield	Missouri	United States	63017
491	Missouri Cancer Associates	Columbia	Missouri	United States	65201
492	Veterans Administration	Columbia	Missouri	United States	65201
493	University of Missouri - Ellis Fischel	Columbia	Missouri	United States	65212
494	Centerpoint Medical Center LLC	Independence	Missouri	United States	64057
495	Freeman Health System	Joplin	Missouri	United States	64804
496	Truman Medical Center	Kansas City	Missouri	United States	64108
497	Saint Luke's Hospital of Kansas City	Kansas City	Missouri	United States	64111
498	Radiation Oncology Practice Corporation South	Kansas City	Missouri	United States	64114
499	Saint Joseph Health Center	Kansas City	Missouri	United States	64114
500	North Kansas City Hospital	Kansas City	Missouri	United States	64116
501	Heartland Hematology and Oncology Associates Incorporated	Kansas City	Missouri	United States	64118
502	Research Medical Center	Kansas City	Missouri	United States	64132
503	Radiation Oncology Practice Corporation - North	Kansas City	Missouri	United States	64154
504	Saint Luke's East - Lee's Summit	Lee's Summit	Missouri	United States	64086
505	Liberty Radiation Oncology Center	Liberty	Missouri	United States	64068
506	Heartland Regional Medical Center	Saint Joseph	Missouri	United States	64507
507	Saint Joseph Oncology Inc	Saint Joseph	Missouri	United States	64507
508	Saint Louis Cancer and Breast Institute-South City	Saint Louis	Missouri	United States	63109
509	Saint Louis University Hospital	Saint Louis	Missouri	United States	63110
510	Washington University School of Medicine	Saint Louis	Missouri	United States	63110
511	Mercy Hospital South	Saint Louis	Missouri	United States	63128
512	Missouri Baptist Medical Center	Saint Louis	Missouri	United States	63131
513	Siteman Cancer Center at Christian Hospital	Saint Louis	Missouri	United States	63136
514	Center for Cancer Care and Research	Saint Louis	Missouri	United States	63141
515	Mercy Hospital Saint Louis	Saint Louis	Missouri	United States	63141
516	Saint Louis-Cape Girardeau CCOP	Saint Louis	Missouri	United States	63141
517	Cancer Research for the Ozarks NCORP	Springfield	Missouri	United States	65804
518	Mercy Hospital Springfield	Springfield	Missouri	United States	65804
519	CoxHealth South Hospital	Springfield	Missouri	United States	65807
520	Billings Clinic Cancer Center	Billings	Montana	United States	59101
521	Northern Rockies Radiation Oncology Center	Billings	Montana	United States	59101
522	Saint Vincent Healthcare	Billings	Montana	United States	59101
523	Montana Cancer Consortium NCORP	Billings	Montana	United States	59102
524	Saint Vincent Frontier Cancer Center	Billings	Montana	United States	59102
525	Deaconess Medical Center	Billings	Montana	United States	59107
526	Bozeman Deaconess Hospital	Bozeman	Montana	United States	59715
527	Saint James Community Hospital and Cancer Treatment Center	Butte	Montana	United States	59701
528	Benefis Healthcare- Sletten Cancer Institute	Great Falls	Montana	United States	59405
529	Berdeaux, Donald MD (UIA Investigator)	Great Falls	Montana	United States	59405
530	Great Falls Clinic	Great Falls	Montana	United States	59405
531	Northern Montana Hospital	Havre	Montana	United States	59501
532	Saint Peter's Community Hospital	Helena	Montana	United States	59601
533	Glacier Oncology PLLC	Kalispell	Montana	United States	59901
534	Kalispell Medical Oncology	Kalispell	Montana	United States	59901
535	Kalispell Regional Medical Center	Kalispell	Montana	United States	59901
536	Montana Cancer Specialists	Missoula	Montana	United States	59802
537	Saint Patrick Hospital - Community Hospital	Missoula	Montana	United States	59802
538	Community Medical Hospital	Missoula	Montana	United States	59804
539	Guardian Oncology and Center for Wellness	Missoula	Montana	United States	59804
540	CHI Health Saint Francis	Grand Island	Nebraska	United States	68803
541	CHI Health Good Samaritan	Kearney	Nebraska	United States	68847
542	Nebraska Cancer Research Center	Lincoln	Nebraska	United States	68510
543	Great Plains Health Callahan Cancer Center	North Platte	Nebraska	United States	69101
544	Missouri Valley Cancer Consortium	Omaha	Nebraska	United States	68106
545	Nebraska Methodist Hospital	Omaha	Nebraska	United States	68114
546	Alegent Health Immanuel Medical Center	Omaha	Nebraska	United States	68122
547	Alegent Health Bergan Mercy Medical Center	Omaha	Nebraska	United States	68124
548	Alegent Health Lakeside Hospital	Omaha	Nebraska	United States	68130
549	Creighton University Medical Center	Omaha	Nebraska	United States	68131
550	University of Nebraska Medical Center	Omaha	Nebraska	United States	68198
551	Midlands Community Hospital	Papillion	Nebraska	United States	68046
552	Carson-Tahoe Specialty Medical Center	Carson City	Nevada	United States	89703
553	University Medical Center of Southern Nevada	Las Vegas	Nevada	United States	89102
554	Nevada Cancer Research Foundation CCOP	Las Vegas	Nevada	United States	89106
555	Renown Regional Medical Center	Reno	Nevada	United States	89502
556	Cheshire Medical Center-Dartmouth-Hitchcock Keene	Keene	New Hampshire	United States	03431
557	Dartmouth Hitchcock Medical Center	Lebanon	New Hampshire	United States	03756
558	Frisbie Hospital	Rochester	New Hampshire	United States	03867
559	Ocean Medical Center	Brick	New Jersey	United States	08724
560	Cooper Hospital University Medical Center	Camden	New Jersey	United States	08103
561	Veterans Adminstration New Jersey Health Care System	East Orange	New Jersey	United States	07018-1095
562	Hunterdon Medical Center	Flemington	New Jersey	United States	08822
563	CentraState Medical Center	Freehold	New Jersey	United States	07728
564	Hackensack University Medical Center	Hackensack	New Jersey	United States	07601
565	The Cancer Institute of New Jersey Hamilton	Hamilton	New Jersey	United States	08690
566	Saint Barnabas Medical Center	Livingston	New Jersey	United States	07039
567	Monmouth Medical Center	Long Branch	New Jersey	United States	07740
568	Mountainside Hospital	Montclair	New Jersey	United States	07042
569	Morristown Medical Center	Morristown	New Jersey	United States	07960
570	Virtua Memorial	Mount Holly	New Jersey	United States	08060
571	Saint Peter's University Hospital	New Brunswick	New Jersey	United States	08901
572	Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	United States	08903
573	Rutgers New Jersey Medical School	Newark	New Jersey	United States	07101
574	Capital Health Medical Center-Hopewell	Pennington	New Jersey	United States	08534
575	Riverview Medical Center/Booker Cancer Center	Red Bank	New Jersey	United States	07701
576	Valley Hospital	Ridgewood	New Jersey	United States	07450
577	Robert Wood Johnson University Hospital Somerset	Somerville	New Jersey	United States	08876
578	Overlook Hospital	Summit	New Jersey	United States	07902
579	Community Medical Center	Toms River	New Jersey	United States	08755
580	Inspira Medical Center Vineland	Vineland	New Jersey	United States	08360
581	Virtua Voorhees	Voorhees	New Jersey	United States	08043
582	University of New Mexico Cancer Center	Albuquerque	New Mexico	United States	87102
583	Hematology Oncology Associates	Albuquerque	New Mexico	United States	87106
584	Presbyterian Kaseman Hospital	Albuquerque	New Mexico	United States	87110
585	Memorial Medical Center - Las Cruces	Las Cruces	New Mexico	United States	88011
586	Christus Saint Vincent Regional Cancer Center	Santa Fe	New Mexico	United States	87505
587	Christus Saint Vincent Regional Medical Center	Santa Fe	New Mexico	United States	87505
588	New York Oncology Hematology PC - Albany	Albany	New York	United States	12206
589	New York Oncology Hematology PC -Albany Medical Center	Albany	New York	United States	12208
590	New York Oncology Hematology PC - Amsterdam	Amsterdam	New York	United States	12010
591	Montefiore Medical Center-Weiler Hospital	Bronx	New York	United States	10461
592	Montefiore Medical Center-Wakefield Campus	Bronx	New York	United States	10466
593	Montefiore Medical Center - Moses Campus	Bronx	New York	United States	10467
594	Kings County Hospital	Brooklyn	New York	United States	11203
595	State University of New York Downstate Medical Center	Brooklyn	New York	United States	11203
596	Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus	Brooklyn	New York	United States	11209
597	Veterans Affairs Western New York Health Care System-Buffalo	Buffalo	New York	United States	14215
598	Roswell Park Cancer Institute	Buffalo	New York	United States	14263
599	New York Oncology Hematology PC - Clifton Park	Clifton Park	New York	United States	12065
600	Mary Imogene Bassett Hospital	Cooperstown	New York	United States	13326
601	Hematology Oncology Associates of Central New York-East Syracuse	East Syracuse	New York	United States	13057
602	Adirondack Cancer Center	Glens Falls	New York	United States	12801
603	Glens Falls Hospital	Glens Falls	New York	United States	12801
604	New York Oncology Hematology PC-Hudson	Hudson	New York	United States	12534
605	Northwell Health NCORP	Lake Success	New York	United States	11042
606	North Shore University Hospital	Manhasset	New York	United States	11030
607	Orange Regional Medical Center	Middletown	New York	United States	10940
608	Northern Westchester Hospital	Mount Kisco	New York	United States	10549
609	Long Island Jewish Medical Center	New Hyde Park	New York	United States	11040
610	Mount Sinai Union Square	New York	New York	United States	10003
611	Laura and Isaac Perlmutter Cancer Center at NYU Langone	New York	New York	United States	10016
612	Mount Sinai West	New York	New York	United States	10019
613	NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center	New York	New York	United States	10032
614	NYP/Weill Cornell Medical Center	New York	New York	United States	10065
615	Nyack Hospital	Nyack	New York	United States	10960
616	Champlain Valley Physicians Hospital Medical Center	Plattsburgh	New York	United States	12901
617	New York Oncology Hematology PC - Rexford	Rexford	New York	United States	12148
618	Interlakes Foundation Inc-Rochester	Rochester	New York	United States	14623
619	University of Rochester	Rochester	New York	United States	14642
620	Staten Island University Hospital	Staten Island	New York	United States	10305
621	State University of New York Upstate Medical University	Syracuse	New York	United States	13210
622	New York Oncology Hematology PC - Troy	Troy	New York	United States	12180
623	Faxton-Saint Luke's Healthcare	Utica	New York	United States	13502
624	Mission Hospital Inc-Memorial Campus	Asheville	North Carolina	United States	28801
625	Cone Health Cancer Center at Alamance Regional	Burlington	North Carolina	United States	27215
626	Waverly Hematology Oncology	Cary	North Carolina	United States	27518
627	Carolinas Medical Center/Levine Cancer Institute	Charlotte	North Carolina	United States	28203
628	Novant Health Presbyterian Medical Center	Charlotte	North Carolina	United States	28204
629	Atrium Health Cabarrus/LCI-Concord	Concord	North Carolina	United States	28025
630	CaroMont Regional Medical Center	Gastonia	North Carolina	United States	28054
631	Southeastern Medical Oncology Center-Goldsboro	Goldsboro	North Carolina	United States	27534
632	Wayne Memorial Hospital	Goldsboro	North Carolina	United States	27534
633	East Carolina University	Greenville	North Carolina	United States	27834
634	Margaret R Pardee Memorial Hospital	Hendersonville	North Carolina	United States	28791
635	High Point Regional Hospital	High Point	North Carolina	United States	27262
636	Vidant Oncology-Kinston	Kinston	North Carolina	United States	28501
637	FirstHealth of the Carolinas-Moore Regional Hospital	Pinehurst	North Carolina	United States	28374
638	Rex Cancer Center	Raleigh	North Carolina	United States	27607
639	Rutherford Hospital	Rutherfordton	North Carolina	United States	28139
640	Novant Health Forsyth Medical Center	Winston-Salem	North Carolina	United States	27103
641	Southeast Clinical Oncology Research (SCOR) Consortium NCORP	Winston-Salem	North Carolina	United States	27104
642	Mid Dakota Clinic	Bismarck	North Dakota	United States	58501
643	Saint Alexius Medical Center	Bismarck	North Dakota	United States	58501
644	Sanford Bismarck Medical Center	Bismarck	North Dakota	United States	58501
645	Essentia Health Cancer Center-South University Clinic	Fargo	North Dakota	United States	58103
646	Sanford Broadway Medical Center	Fargo	North Dakota	United States	58122
647	Sanford Clinic North-Fargo	Fargo	North Dakota	United States	58122
648	Trinity Cancer Care Center	Minot	North Dakota	United States	58701
649	Summa Akron City Hospital/Cooper Cancer Center	Akron	Ohio	United States	44304
650	Cleveland Clinic Akron General	Akron	Ohio	United States	44307
651	Summa Barberton Hospital	Barberton	Ohio	United States	44203
652	Cleveland Clinic Cancer Center Beachwood	Beachwood	Ohio	United States	44122
653	Mary Rutan Hospital	Bellefontaine	Ohio	United States	43311
654	Toledo Clinic Cancer Centers-Bowling Green	Bowling Green	Ohio	United States	43402
655	Mercy Medical Center	Canton	Ohio	United States	44708
656	Aultman Health Foundation	Canton	Ohio	United States	44710
657	Adena Regional Medical Center	Chillicothe	Ohio	United States	45601
658	The Christ Hospital	Cincinnati	Ohio	United States	45219
659	University of Cincinnati/Barrett Cancer Center	Cincinnati	Ohio	United States	45219
660	Oncology Hematology Care Inc-Blue Ash	Cincinnati	Ohio	United States	45242
661	Case Western Reserve University	Cleveland	Ohio	United States	44106
662	MetroHealth Medical Center	Cleveland	Ohio	United States	44109
663	Cleveland Clinic Cancer Center/Fairview Hospital	Cleveland	Ohio	United States	44111
664	Cleveland Clinic Foundation	Cleveland	Ohio	United States	44195
665	North Coast Cancer Care-Clyde	Clyde	Ohio	United States	43410
666	Ohio State University Comprehensive Cancer Center	Columbus	Ohio	United States	43210
667	Riverside Methodist Hospital	Columbus	Ohio	United States	43214
668	Columbus NCI Community Oncology Research Program	Columbus	Ohio	United States	43215
669	Grant Medical Center	Columbus	Ohio	United States	43215
670	Mount Carmel Health Center West	Columbus	Ohio	United States	43222
671	Doctors Hospital	Columbus	Ohio	United States	43228
672	Grandview Hospital	Dayton	Ohio	United States	45405
673	Good Samaritan Hospital - Dayton	Dayton	Ohio	United States	45406
674	Miami Valley Hospital	Dayton	Ohio	United States	45409
675	Miami Valley Hospital North	Dayton	Ohio	United States	45415
676	Dayton NCI Community Oncology Research Program	Dayton	Ohio	United States	45420
677	Veteran Affairs Medical Center	Dayton	Ohio	United States	45428
678	Grady Memorial Hospital	Delaware	Ohio	United States	43015
679	Hematology Oncology Center Incorporated	Elyria	Ohio	United States	44035
680	Mercy Cancer Center-Elyria	Elyria	Ohio	United States	44035
681	Blanchard Valley Hospital	Findlay	Ohio	United States	45840
682	Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	United States	45005-1066
683	Fremont Memorial Hospital	Fremont	Ohio	United States	43420
684	Wayne Hospital	Greenville	Ohio	United States	45331
685	Cleveland Clinic Cancer Center Independence	Independence	Ohio	United States	44131
686	Kettering Medical Center	Kettering	Ohio	United States	45429
687	Fairfield Medical Center	Lancaster	Ohio	United States	43130
688	Saint Rita's Medical Center	Lima	Ohio	United States	45801
689	Lima Memorial Hospital	Lima	Ohio	United States	45804
690	OhioHealth Mansfield Hospital	Mansfield	Ohio	United States	44903
691	Marietta Memorial Hospital	Marietta	Ohio	United States	45750
692	Saint Luke's Hospital	Maumee	Ohio	United States	43537
693	Toledo Clinic Cancer Centers-Maumee	Maumee	Ohio	United States	43537
694	Toledo Radiation Oncology at Northwest Ohio Onocolgy Center	Maumee	Ohio	United States	43537
695	Hillcrest Hospital Cancer Center	Mayfield Heights	Ohio	United States	44124
696	Licking Memorial Hospital	Newark	Ohio	United States	43055
697	Fisher-Titus Medical Center	Norwalk	Ohio	United States	44857
698	Saint Charles Hospital	Oregon	Ohio	United States	43616
699	Toledo Clinic Cancer Centers-Oregon	Oregon	Ohio	United States	43616
700	Firelands Regional Medical Center	Sandusky	Ohio	United States	44870
701	North Coast Cancer Care	Sandusky	Ohio	United States	44870
702	Springfield Regional Medical Center	Springfield	Ohio	United States	45505
703	ProMedica Flower Hospital	Sylvania	Ohio	United States	43560
704	Mercy Hospital of Tiffin	Tiffin	Ohio	United States	44883
705	The Toledo Hospital/Toledo Children's Hospital	Toledo	Ohio	United States	43606
706	Saint Vincent Mercy Medical Center	Toledo	Ohio	United States	43608
707	University of Toledo	Toledo	Ohio	United States	43614
708	Toledo Community Hospital Oncology Program CCOP	Toledo	Ohio	United States	43617
709	Mercy Saint Anne Hospital	Toledo	Ohio	United States	43623
710	Toledo Clinic Cancer Centers-Toledo	Toledo	Ohio	United States	43623
711	Upper Valley Medical Center	Troy	Ohio	United States	45373
712	Fulton County Health Center	Wauseon	Ohio	United States	43567
713	Saint Ann's Hospital	Westerville	Ohio	United States	43081
714	Clinton Memorial Hospital	Wilmington	Ohio	United States	45177
715	Cleveland Clinic Wooster Family Health and Surgery Center	Wooster	Ohio	United States	44691
716	Greene Memorial Hospital	Xenia	Ohio	United States	45385
717	Genesis Healthcare System Cancer Care Center	Zanesville	Ohio	United States	43701
718	Cancer Centers of Southwest Oklahoma Research	Lawton	Oklahoma	United States	73505
719	University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	United States	73104
720	Cancer Care Associates	Oklahoma City	Oklahoma	United States	73120
721	Natalie Warren Bryant Cancer Center at Saint Francis	Tulsa	Oklahoma	United States	74136
722	Bend Memorial Clinic	Bend	Oregon	United States	97701
723	Saint Charles Health System	Bend	Oregon	United States	97701
724	Bay Area Hospital	Coos Bay	Oregon	United States	97420
725	Legacy Mount Hood Medical Center	Gresham	Oregon	United States	97030
726	Providence Milwaukie Hospital	Milwaukie	Oregon	United States	97222
727	Legacy Good Samaritan Hospital and Medical Center	Portland	Oregon	United States	97210
728	Providence Portland Medical Center	Portland	Oregon	United States	97213
729	Adventist Medical Center	Portland	Oregon	United States	97216
730	Providence Saint Vincent Medical Center	Portland	Oregon	United States	97225
731	Compass Oncology Rose Quarter	Portland	Oregon	United States	97227
732	Kaiser Permanente Northwest	Portland	Oregon	United States	97227
733	Legacy Emanuel Hospital and Health Center	Portland	Oregon	United States	97227
734	Oregon Health and Science University	Portland	Oregon	United States	97239
735	Salem Hospital	Salem	Oregon	United States	97301
736	Mid-Columbia Medical Center/Celilo Cancer Center	The Dalles	Oregon	United States	97058
737	Legacy Meridian Park Hospital	Tualatin	Oregon	United States	97062
738	Abington Memorial Hospital	Abington	Pennsylvania	United States	19001
739	Lehigh Valley Hospital-Cedar Crest	Allentown	Pennsylvania	United States	18103
740	Saint Luke's University Hospital-Bethlehem Campus	Bethlehem	Pennsylvania	United States	18015
741	Bryn Mawr Hospital	Bryn Mawr	Pennsylvania	United States	19010
742	Geisinger Medical Center	Danville	Pennsylvania	United States	17822
743	Doylestown Hospital	Doylestown	Pennsylvania	United States	18901
744	Oncology Hematology Associates of Northern Pennsylvania	DuBois	Pennsylvania	United States	15801
745	Pocono Medical Center	East Stroudsburg	Pennsylvania	United States	18301
746	Ephrata Cancer Center	Ephrata	Pennsylvania	United States	17522
747	Adams Cancer Center	Gettysburg	Pennsylvania	United States	17325
748	UPMC Pinnacle Cancer Center/Community Osteopathic Campus	Harrisburg	Pennsylvania	United States	17109
749	Geisinger Medical Center-Cancer Center Hazleton	Hazleton	Pennsylvania	United States	18201
750	Penn State Milton S Hershey Medical Center	Hershey	Pennsylvania	United States	17033-0850
751	Armstrong Center for Medicine and Health	Kittanning	Pennsylvania	United States	16201
752	Lancaster General Hospital	Lancaster	Pennsylvania	United States	17604
753	Central PA Hematology-Medical Oncology Associates PC	Lemoyne	Pennsylvania	United States	17043
754	Lewistown Hospital	Lewistown	Pennsylvania	United States	17044
755	Riddle Memorial Hospital	Media	Pennsylvania	United States	19063
756	Paoli Memorial Hospital	Paoli	Pennsylvania	United States	19301
757	University of Pennsylvania/Abramson Cancer Center	Philadelphia	Pennsylvania	United States	19104
758	Pennsylvania Hospital	Philadelphia	Pennsylvania	United States	19107
759	Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	United States	19107
760	Fox Chase Cancer Center	Philadelphia	Pennsylvania	United States	19111
761	Aria Health-Torresdale Campus	Philadelphia	Pennsylvania	United States	19114
762	Einstein Medical Center Philadelphia	Philadelphia	Pennsylvania	United States	19141
763	Allegheny General Hospital	Pittsburgh	Pennsylvania	United States	15212
764	University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	United States	15232
765	Pottstown Hospital	Pottstown	Pennsylvania	United States	19464
766	Penn State Health Saint Joseph Medical Center	Reading	Pennsylvania	United States	19605
767	Guthrie Medical Group PC-Robert Packer Hospital	Sayre	Pennsylvania	United States	18840
768	Mercy Hospital	Scranton	Pennsylvania	United States	18501
769	Hematology and Oncology Associates of North East Pennsylvania	Scranton	Pennsylvania	United States	18508
770	Scranton Hematology Oncology	Scranton	Pennsylvania	United States	18510
771	Grand View Hospital	Sellersville	Pennsylvania	United States	18960
772	Geisinger Medical Group	State College	Pennsylvania	United States	16801
773	Mount Nittany Medical Center	State College	Pennsylvania	United States	16803
774	Associates In Hematology Oncology PC-Upland	Upland	Pennsylvania	United States	19013
775	Chester County Hospital	West Chester	Pennsylvania	United States	19380
776	Reading Hospital	West Reading	Pennsylvania	United States	19611
777	Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	United States	18711
778	UPMC Susquehanna	Williamsport	Pennsylvania	United States	17701
779	Lankenau Medical Center	Wynnewood	Pennsylvania	United States	19096
780	Main Line Health NCORP	Wynnewood	Pennsylvania	United States	19096
781	WellSpan Health-York Hospital	York	Pennsylvania	United States	17403
782	Hematology and Oncology Associates of Rhode Island Inc	Cranston	Rhode Island	United States	02920
783	Memorial Hospital of Rhode Island	Pawtucket	Rhode Island	United States	02860
784	Rhode Island Hospital	Providence	Rhode Island	United States	02903
785	Miriam Hospital	Providence	Rhode Island	United States	02906
786	Kent Hospital	Warwick	Rhode Island	United States	02886
787	AnMed Health Hospital	Anderson	South Carolina	United States	29621
788	Roper Hospital	Charleston	South Carolina	United States	29401
789	Medical University of South Carolina	Charleston	South Carolina	United States	29425
790	Greenville Health System Cancer Institute-Easley	Easley	South Carolina	United States	29640
791	McLeod Regional Medical Center	Florence	South Carolina	United States	29506
792	Greenville Health System Cancer Institute-Andrews	Greenville	South Carolina	United States	29601
793	Saint Francis Hospital	Greenville	South Carolina	United States	29601
794	Greenville Health System Cancer Institute-Butternut	Greenville	South Carolina	United States	29605
795	Greenville Health System Cancer Institute-Faris	Greenville	South Carolina	United States	29605
796	Greenville Memorial Hospital	Greenville	South Carolina	United States	29605
797	Greenville Health System Cancer Institute-Eastside	Greenville	South Carolina	United States	29615
798	Self Regional Healthcare	Greenwood	South Carolina	United States	29646
799	Greenville Health System Cancer Institute-Greer	Greer	South Carolina	United States	29650
800	Greenville Health System Cancer Institute-Seneca	Seneca	South Carolina	United States	29672
801	Spartanburg Medical Center	Spartanburg	South Carolina	United States	29303
802	Greenville Health System Cancer Institute-Spartanburg	Spartanburg	South Carolina	United States	29307
803	Avera Cancer Institute-Aberdeen	Aberdeen	South Dakota	United States	57401
804	Rapid City Regional Hospital	Rapid City	South Dakota	United States	57701
805	Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	United States	57104
806	Avera Cancer Institute	Sioux Falls	South Dakota	United States	57105
807	Avera McKennan Hospital and University Health Center	Sioux Falls	South Dakota	United States	57105
808	Medical X-Ray Center	Sioux Falls	South Dakota	United States	57105
809	Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	United States	57117-5134
810	Erlanger Medical Center	Chattanooga	Tennessee	United States	37403
811	Vanderbilt-Ingram Cancer Center Cool Springs	Franklin	Tennessee	United States	37067
812	Jones Clinic	Germantown	Tennessee	United States	38138
813	Jackson-Madison County General Hospital	Jackson	Tennessee	United States	38301
814	Wellmont Holston Valley Hospital and Medical Center	Kingsport	Tennessee	United States	37660
815	Thompson Cancer Survival Center	Knoxville	Tennessee	United States	37916
816	East Tennessee Baptist Hospital-Mercy Health Partners	Knoxville	Tennessee	United States	37920
817	University of Tennessee - Knoxville	Knoxville	Tennessee	United States	37920
818	University of Tennessee Health Science Center	Memphis	Tennessee	United States	38163
819	Nashville Oncology Associates PC	Nashville	Tennessee	United States	37203
820	Meharry Medical College	Nashville	Tennessee	United States	37208
821	Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	United States	37232
822	The Don and Sybil Harrington Cancer Center	Amarillo	Texas	United States	79106
823	Texas Oncology-Austin Midtown	Austin	Texas	United States	78705
824	Texas Oncology - Central Austin Cancer Center	Austin	Texas	United States	78731
825	Texas Oncology - South Austin Cancer Center	Austin	Texas	United States	78745
826	Texas Oncology-Austin North	Austin	Texas	United States	78758
827	Texas Oncology Seton Northwest	Austin	Texas	United States	78759
828	Medical City Dallas Hospital	Dallas	Texas	United States	75230
829	Texas Health Presbyterian Hospital Dallas	Dallas	Texas	United States	75231
830	Parkland Memorial Hospital	Dallas	Texas	United States	75235
831	Clements University Hospital	Dallas	Texas	United States	75390
832	UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	United States	75390
833	Dallas Oncology Consultants PA	Duncanville	Texas	United States	75137
834	The Center for Integrative Cancer Medicine	El Paso	Texas	United States	79902
835	Brooke Army Medical Center	Fort Sam Houston	Texas	United States	78234
836	Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center	Houston	Texas	United States	77030
837	Baylor Saint Luke's Medical Center	Houston	Texas	United States	77030
838	Ben Taub General Hospital	Houston	Texas	United States	77030
839	M D Anderson Cancer Center	Houston	Texas	United States	77030
840	Michael E DeBakey VA Medical Center	Houston	Texas	United States	77030
841	The Methodist Hospital System	Houston	Texas	United States	77030
842	Wilford Hall Medical Center	Lackland Air Force Base	Texas	United States	78236
843	Texas Tech University Health Sciences Center-Lubbock	Lubbock	Texas	United States	79430
844	Texas Oncology-Seton Williamson	Round Rock	Texas	United States	78665
845	Texas Oncology - Round Rock Cancer Center	Round Rock	Texas	United States	78681
846	Audie L Murphy VA Hospital	San Antonio	Texas	United States	78229
847	Cancer Therapy and Research Center at The UT Health Science Center at San Antonio	San Antonio	Texas	United States	78229
848	University Hospital	San Antonio	Texas	United States	78229
849	University of Texas Health Science Center at San Antonio	San Antonio	Texas	United States	78229
850	Texas Oncology- San Marcos	San Marcos	Texas	United States	78666
851	Scott and White Memorial Hospital	Temple	Texas	United States	76508
852	American Fork Hospital / Huntsman Intermountain Cancer Center	American Fork	Utah	United States	84003
853	Sandra L Maxwell Cancer Center	Cedar City	Utah	United States	84720
854	Logan Regional Hospital	Logan	Utah	United States	84321
855	Cottonwood Hospital Medical Center	Murray	Utah	United States	84107
856	Intermountain Medical Center	Murray	Utah	United States	84107
857	McKay-Dee Hospital Center	Ogden	Utah	United States	84403
858	Utah Valley Regional Medical Center	Provo	Utah	United States	84604
859	Dixie Medical Center Regional Cancer Center	Saint George	Utah	United States	84770
860	Intermountain Health Care	Salt Lake City	Utah	United States	84103
861	Utah Cancer Specialists-Salt Lake City	Salt Lake City	Utah	United States	84106
862	Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	United States	84112
863	LDS Hospital	Salt Lake City	Utah	United States	84143
864	Southwestern Vermont Medical Center	Bennington	Vermont	United States	05201
865	Central Vermont Medical Center/National Life Cancer Treatment	Berlin	Vermont	United States	05602
866	University of Vermont and State Agricultural College	Burlington	Vermont	United States	05405
867	University of Virginia Cancer Center	Charlottesville	Virginia	United States	22908
868	Danville Regional Medical Center	Danville	Virginia	United States	24541
869	Fredericksburg Oncology Inc	Fredericksburg	Virginia	United States	22401
870	Peninsula Cancer Institute-Gloucester	Gloucester	Virginia	United States	23061
871	Centra Lynchburg Hematology-Oncology Clinic Inc	Lynchburg	Virginia	United States	24501
872	Peninsula Cancer Institute-Newport News	Newport News	Virginia	United States	23601
873	Southwest VA Regional Cancer Center	Norton	Virginia	United States	24273
874	Virginia Commonwealth University/Massey Cancer Center	Richmond	Virginia	United States	23298
875	Peninsula Cancer Institute-Williamsburg	Williamsburg	Virginia	United States	23185
876	MultiCare Auburn Medical Center	Auburn	Washington	United States	98001
877	PeaceHealth Saint Joseph Medical Center	Bellingham	Washington	United States	98225
878	Harrison HealthPartners Hematology and Oncology-Bremerton	Bremerton	Washington	United States	98310
879	Providence Regional Cancer System-Centralia	Centralia	Washington	United States	98531
880	Saint Francis Hospital	Federal Way	Washington	United States	98003
881	Kadlec Clinic Hematology and Oncology	Kennewick	Washington	United States	99336
882	EvergreenHealth Medical Center	Kirkland	Washington	United States	98033
883	Saint Clare Hospital	Lakewood	Washington	United States	98499
884	Skagit Valley Hospital	Mount Vernon	Washington	United States	98274
885	Providence - Saint Peter Hospital	Olympia	Washington	United States	98506-5166
886	Olympic Medical Center	Port Angeles	Washington	United States	98362
887	Harrison HealthPartners Hematology and Oncology-Poulsbo	Poulsbo	Washington	United States	98370
888	MultiCare Good Samaritan Hospital	Puyallup	Washington	United States	98372
889	Valley Medical Center	Renton	Washington	United States	98055
890	Virginia Mason Medical Center	Seattle	Washington	United States	98101
891	Minor and James Medical PLLC	Seattle	Washington	United States	98104
892	Pacific Medical Center-First Hill	Seattle	Washington	United States	98104
893	Kaiser Permanente Washington	Seattle	Washington	United States	98112
894	Swedish Medical Center-First Hill	Seattle	Washington	United States	98122-4307
895	University of Washington Medical Center	Seattle	Washington	United States	98195
896	Cancer Care Northwest - Spokane South	Spokane	Washington	United States	99202
897	Providence Sacred Heart Medical Center and Children's Hospital	Spokane	Washington	United States	99204
898	Providence Holy Family Hospital	Spokane	Washington	United States	99208
899	Rockwood Clinic	Spokane	Washington	United States	99220
900	MultiCare Allenmore Hospital	Tacoma	Washington	United States	98405
901	MultiCare Tacoma General Hospital	Tacoma	Washington	United States	98405
902	Northwest NCI Community Oncology Research Program	Tacoma	Washington	United States	98405
903	Saint Joseph Medical Center	Tacoma	Washington	United States	98405
904	Madigan Army Medical Center	Tacoma	Washington	United States	98431
905	PeaceHealth Southwest Medical Center	Vancouver	Washington	United States	98664
906	Compass Oncology Vancouver	Vancouver	Washington	United States	98684
907	Legacy Salmon Creek Hospital	Vancouver	Washington	United States	98686
908	Wenatchee Valley Hospital and Clinics	Wenatchee	Washington	United States	98801
909	Cancer Institutes of Washington PLLC	Yakima	Washington	United States	98902
910	North Star Lodge Cancer Center at Yakima Valley Memorial Hospital	Yakima	Washington	United States	98902
911	West Virginia University Charleston Division	Charleston	West Virginia	United States	25304
912	Edwards Comprehensive Cancer Center	Huntington	West Virginia	United States	25701
913	Saint Mary's Medical Center	Huntington	West Virginia	United States	25702
914	West Virginia University Healthcare	Morgantown	West Virginia	United States	26506
915	Camden Clark Medical Center	Parkersburg	West Virginia	United States	26101
916	Wheeling Hospital/Schiffler Cancer Center	Wheeling	West Virginia	United States	26003
917	Langlade Hospital and Cancer Center	Antigo	Wisconsin	United States	54409
918	Fox Valley Hematology and Oncology SC-Appleton	Appleton	Wisconsin	United States	54913
919	Aurora Cancer Care-Southern Lakes VLCC	Burlington	Wisconsin	United States	53105
920	Marshfield Clinic-Chippewa Center	Chippewa Falls	Wisconsin	United States	54729
921	HSHS Sacred Heart Hospital	Eau Claire	Wisconsin	United States	54701
922	Marshfield Clinic Cancer Center at Sacred Heart	Eau Claire	Wisconsin	United States	54701
923	Aurora Cancer Care-Franklin	Franklin	Wisconsin	United States	53132
924	Aurora Health Care Germantown Health Center	Germantown	Wisconsin	United States	53022
925	Aurora Cancer Care-Glendale	Glendale	Wisconsin	United States	53212
926	Green Bay Oncology at Saint Vincent Hospital	Green Bay	Wisconsin	United States	54301-3526
927	Saint Vincent Hospital Cancer Center Green Bay	Green Bay	Wisconsin	United States	54301
928	Green Bay Oncology Limited at Saint Mary's Hospital	Green Bay	Wisconsin	United States	54303
929	Saint Vincent Hospital Cancer Center at Saint Mary's	Green Bay	Wisconsin	United States	54303
930	Aurora BayCare Medical Center	Green Bay	Wisconsin	United States	54311
931	UW Cancer Center Johnson Creek	Johnson Creek	Wisconsin	United States	53038
932	Aurora Cancer Care-Kenosha South	Kenosha	Wisconsin	United States	53142
933	Gundersen Lutheran Medical Center	La Crosse	Wisconsin	United States	54601
934	Mayo Clinic Health System-Franciscan Healthcare	La Crosse	Wisconsin	United States	54601
935	UW Health Oncology-One South Park	Madison	Wisconsin	United States	53715
936	Dean Hematology and Oncology Clinic	Madison	Wisconsin	United States	53717
937	University of Wisconsin Hospital and Clinics	Madison	Wisconsin	United States	53792
938	Holy Family Memorial Hospital	Manitowoc	Wisconsin	United States	54221
939	Aurora Bay Area Medical Group-Marinette	Marinette	Wisconsin	United States	54143
940	Bay Area Medical Center	Marinette	Wisconsin	United States	54143
941	Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	United States	54449
942	Marshfield Medical Center	Marshfield	Wisconsin	United States	54449
943	Aurora Saint Luke's Medical Center	Milwaukee	Wisconsin	United States	53215
944	Froedtert and the Medical College of Wisconsin	Milwaukee	Wisconsin	United States	53226
945	Aurora Sinai Medical Center	Milwaukee	Wisconsin	United States	53233
946	Marshfield Clinic-Minocqua Center	Minocqua	Wisconsin	United States	54548
947	Saint Vincent Hospital Cancer Center at Oconto Falls	Oconto Falls	Wisconsin	United States	54154
948	Vince Lombardi Cancer Clinic - Oshkosh	Oshkosh	Wisconsin	United States	54904
949	Aurora Cancer Care-Racine	Racine	Wisconsin	United States	53406
950	Ascension Saint Mary's Hospital	Rhinelander	Wisconsin	United States	54501
951	Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	United States	54868
952	Vince Lombardi Cancer Clinic-Sheboygan	Sheboygan	Wisconsin	United States	53081
953	Ascension Saint Michael's Hospital	Stevens Point	Wisconsin	United States	54481
954	Saint Michael's Hospital	Stevens Point	Wisconsin	United States	54481
955	Green Bay Oncology - Sturgeon Bay	Sturgeon Bay	Wisconsin	United States	54235
956	Aurora Medical Center in Summit	Summit	Wisconsin	United States	53066
957	Vince Lombardi Cancer Clinic-Two Rivers	Two Rivers	Wisconsin	United States	54241
958	Aurora Cancer Care-Waukesha	Waukesha	Wisconsin	United States	53188
959	Aspirus Regional Cancer Center	Wausau	Wisconsin	United States	54401
960	Marshfield Clinic-Wausau Center	Wausau	Wisconsin	United States	54401
961	Aurora Cancer Care-Milwaukee West	Wauwatosa	Wisconsin	United States	53226
962	Marshfield Clinic - Weston Center	Weston	Wisconsin	United States	54476
963	Aspirus UW Cancer Center	Wisconsin Rapids	Wisconsin	United States	54494
964	Marshfield Clinic - Wisconsin Rapids Center	Wisconsin Rapids	Wisconsin	United States	54494
965	Rocky Mountain Oncology	Casper	Wyoming	United States	82609
966	Welch Cancer Center	Sheridan	Wyoming	United States	82801
967	Tom Baker Cancer Centre	Calgary	Alberta	Canada	T2N 4N2
968	Cross Cancer Institute	Edmonton	Alberta	Canada	T6G 1Z2
969	Clinical Research Unit at Vancouver Coastal Health Authority	Vancouver	British Columbia	Canada	V5Z 3P1
970	CancerCare Manitoba	Winnipeg	Manitoba	Canada	R3E 0V9
971	The Moncton Hospital	Moncton	New Brunswick	Canada	E1C 6Z8
972	Atlantic Health Sciences Corporation-Saint John Regional Hospital	Saint John	New Brunswick	Canada	E2L 4L2
973	QEII Health Sciences Centre/Nova Scotia Health Authority	Halifax	Nova Scotia	Canada	B3H 2Y9
974	Juravinski Cancer Centre at Hamilton Health Sciences	Hamilton	Ontario	Canada	L8V 5C2
975	Grand River Regional Cancer Centre at Grand River Hospital	Kitchener	Ontario	Canada	N2G 1G3
976	London Regional Cancer Program	London	Ontario	Canada	N6A 4L6
977	Lakeridge Health Oshawa	Oshawa	Ontario	Canada	L1G 2B9
978	Ottawa Hospital and Cancer Center-General Campus	Ottawa	Ontario	Canada	K1H 8L6
979	Algoma District Cancer Program Sault Area Hospital	Sault Ste Marie	Ontario	Canada	P6B 0A8
980	Thunder Bay Regional Health Science Centre	Thunder Bay	Ontario	Canada	P7B 6V4
981	Odette Cancer Centre- Sunnybrook Health Sciences Centre	Toronto	Ontario	Canada	M4N 3M5
982	University Health Network-Princess Margaret Hospital	Toronto	Ontario	Canada	M5G 2M9
983	PEI Cancer Treatment Centre-Queen Elizabeth Hospital	Charlottetown	Prince Edward Island	Canada	C1A 8T5
984	CHUM - Hopital Notre-Dame	Montreal	Quebec	Canada	H2L 4M1
985	McGill University Department of Oncology	Montreal	Quebec	Canada	H2W 1S6
986	CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)	Quebec City	Quebec	Canada	G1R 2J6
987	San Juan City Hospital	San Juan		Puerto Rico	00936

Sponsors and Collaborators

• National Cancer Institute (NCI)
• Cancer and Leukemia Group B
• NCIC Clinical Trials Group
• Southwest Oncology Group

Investigators

• Principal Investigator: Naomi S Balzer-Haas, ECOG-ACRIN Cancer Research Group

Study Documents (Full-Text)

None provided.

More Information

Additional Information:

• Data Available: Select individual patient-level data from this trial can be requested from the NCTN/NCORP Data Archive

Publications

None provided.

• Responsible Party: National Cancer Institute (NCI)
• ClinicalTrials.gov Identifier: NCT00326898
• Other Study ID Numbers: NCI-2009-00534; NCI-2009-00534; CAN-NCIC-E2805; SWOG-E2805; ECOG-E2805; CDR0000478976; CALGB-E2805; E2805; E2805; U10CA180820; U10CA021115
• First Posted: May 17, 2006
• Last Update Posted: Feb 8, 2022
• Last Verified: Jan 1, 2022

• Additional relevant MeSH terms: Carcinoma; Carcinoma, Renal Cell; Sorafenib; Sunitinib

Study Results

Participant Flow

Recruitment Details	The study was activated on April 24, 2006 and closed to accrual on September 1, 2010, after accrual of 1943 patients.

Arm/Group Title	Arm A (Sunitinib + Sorafenib Placebo)	Arm B (Sorafenib + Sunitinib Placebo)	Arm C (Sunitinib Placebo + Sorafenib Placebo)
Arm/Group Description	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sunitinib malate 37.5mg PO QD for 4 weeks and placebo sorafenib tosylate 400mg PO QD or BID for 6 weeks.	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sorafenib tosylate 400mg PO QD or BID for 6 weeks and placebo sunitinib malate 37.5mg PO QD for 4 weeks followed.	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive placebo sorafenib tosylate 400mg as in Arm A and placebo sunitinib malate 37.5mg as in Arm B.
Period Title: Overall Study
STARTED	647	649	647
Patients With Toxicity Data	625	628	626
Patients With Clear Cell Histology	542	540	540
Patients With >=1 Follow-up MUGA Scan	513	510	580
COMPLETED	296	306	444
NOT COMPLETED	351	343	203

Baseline Characteristics

Arm/Group Title	Arm A (Sunitinib + Sorafenib Placebo)	Arm B (Sorafenib + Sunitinib Placebo)	Arm C (Sunitinib Placebo + Sorafenib Placebo)	Total
Arm/Group Description	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sunitinib malate 37.5mg PO QD for 4 weeks and placebo sorafenib tosylate 400mg PO QD or BID for 6 weeks.	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sorafenib tosylate 400mg PO QD or BID for 6 weeks and placebo sunitinib malate 37.5mg PO QD for 4 weeks followed.	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive placebo sorafenib tosylate 400mg as in Arm A and placebo sunitinib malate 37.5mg as in Arm B.	Total of all reporting groups
Overall Participants	647	649	647	1943
Age (Count of Participants)
<=18 years	0 0%	0 0%	0 0%	0 0%
Between 18 and 65 years	489 75.6%	507 78.1%	500 77.3%	1496 77%
>=65 years	158 24.4%	142 21.9%	147 22.7%	447 23%
Sex: Female, Male (Count of Participants)
Female	218 33.7%	212 32.7%	204 31.5%	634 32.6%
Male	429 66.3%	437 67.3%	443 68.5%	1309 67.4%

Outcome Measures

1. Primary Outcome

Title	Disease-free Survival (DFS)
Description	Disease-free survival (DFS) is defined as time from randomization to recurrence, development of second primary cancer (except localized breast or prostate cancer or nonmelanoma skin cancer), or death from any cause. Patients who were alive without recurrence or qualifying second primary cancer were censored at the date of last disease evaluation.
Time Frame	Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry; then annually if patient is 5 - 10 years from study entry

Outcome Measure Data

Analysis Population Description

All randomized patients

Arm/Group Title	Arm A (Sunitinib + Sorafenib Placebo)	Arm B (Sorafenib + Sunitinib Placebo)	Arm C (Sunitinib Placebo + Sorafenib Placebo)
Arm/Group Description	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sunitinib malate 37.5mg PO QD for 4 weeks and placebo sorafenib tosylate 400mg PO QD or BID for 6 weeks.	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sorafenib tosylate 400mg PO QD or BID for 6 weeks and placebo sunitinib malate 37.5mg PO QD for 4 weeks followed.	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive placebo sorafenib tosylate 400mg as in Arm A and placebo sunitinib malate 37.5mg as in Arm B.
Measure Participants	647	649	647
Median (97.5% Confidence Interval) [years]	5.8	6.1	6.6

Statistical Analysis 1

Statistical Analysis Overview	Comparison Group Selection	Arm A (Sunitinib + Sorafenib Placebo), Arm C (Sunitinib Placebo + Sorafenib Placebo)
	Comments
	Type of Statistical Test	Superiority or Other (legacy)
	Comments
Statistical Test of Hypothesis	p-Value	0.80
	Comments
	Method	Stratified logrank test
	Comments	Stratified logrank test was performed. Stratification factors include basis of risk group, histologic subtype, performance status and type of surgery.
Method of Estimation	Estimation Parameter	Hazard Ratio (HR)
	Estimated Value	1.02
	Confidence Interval	(2-Sided) 97.5%; 0.85 to 1.23
	Parameter Dispersion	Type: Value:
	Estimation Comments

Statistical Analysis 2

Statistical Analysis Overview	Comparison Group Selection	Arm B (Sorafenib + Sunitinib Placebo), Arm C (Sunitinib Placebo + Sorafenib Placebo)
	Comments
	Type of Statistical Test	Superiority or Other (legacy)
	Comments
Statistical Test of Hypothesis	p-Value	0.72
	Comments
	Method	Stratified logrank test
	Comments	Stratified logrank test was performed. Stratification factors include basis of risk group, histologic subtype, performance status and type of surgery.
Method of Estimation	Estimation Parameter	Hazard Ratio (HR)
	Estimated Value	0.97
	Confidence Interval	(2-Sided) 97.5%; 0.80 to 1.17
	Parameter Dispersion	Type: Value:
	Estimation Comments

2. Secondary Outcome

Title	5-year Overall Survival Rate
Description	Overall survival is defined as the time from randomization to death from any cause. Patients without a date of death were censored at the date of last contact. Kaplan-Meier method was used to estimate 5-year survival rate.
Time Frame	Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry

Outcome Measure Data

Analysis Population Description

All randomized patients

Arm/Group Title	Arm A (Sunitinib + Sorafenib Placebo)	Arm B (Sorafenib + Sunitinib Placebo)	Arm C (Sunitinib Placebo + Sorafenib Placebo)
Arm/Group Description	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sunitinib malate 37.5mg PO QD for 4 weeks and placebo sorafenib tosylate 400mg PO QD or BID for 6 weeks.	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sorafenib tosylate 400mg PO QD or BID for 6 weeks and placebo sunitinib malate 37.5mg PO QD for 4 weeks followed.	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive placebo sorafenib tosylate 400mg as in Arm A and placebo sunitinib malate 37.5mg as in Arm B.
Measure Participants	647	649	647
Number (97.5% Confidence Interval) [proportion of participants]	0.779 0.1%	0.805 0.1%	0.803 0.1%

Statistical Analysis 1

Statistical Analysis Overview	Comparison Group Selection	Arm A (Sunitinib + Sorafenib Placebo), Arm C (Sunitinib Placebo + Sorafenib Placebo)
	Comments
	Type of Statistical Test	Superiority or Other (legacy)
	Comments
Statistical Test of Hypothesis	p-Value
	Comments
	Method
	Comments
Method of Estimation	Estimation Parameter	Hazard Ratio (HR)
	Estimated Value	1.17
	Confidence Interval	(2-Sided) 97.5%; 0.90 to 1.52
	Parameter Dispersion	Type: Value:
	Estimation Comments	Hazard ratio was estimated using stratified proportional hazards model with Arm C (placebo arm) as the reference group.

Statistical Analysis 2

Statistical Analysis Overview	Comparison Group Selection	Arm B (Sorafenib + Sunitinib Placebo), Arm C (Sunitinib Placebo + Sorafenib Placebo)
	Comments
	Type of Statistical Test	Superiority or Other (legacy)
	Comments
Statistical Test of Hypothesis	p-Value
	Comments
	Method
	Comments
Method of Estimation	Estimation Parameter	Hazard Ratio (HR)
	Estimated Value	0.98
	Confidence Interval	(2-Sided) 97.5%; 0.75 to 1.28
	Parameter Dispersion	Type: Value:
	Estimation Comments	Hazard ratio was estimated using stratified proportional hazards model with Arm C (placebo arm) as the reference group.

3. Secondary Outcome

Title	Proportion of Patients With Cardiac Events
Description	Cardiac event is defined as left ventricular ejection fraction (LVEF) below the institutional lower limit of normal, where the decrease was >15% absolute percentage points from baseline within 6 months.
Time Frame	Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry

Outcome Measure Data

Analysis Population Description

Patients with at least 1 follow-up MUGA scan were included in this analysis.

Arm/Group Title	Arm A (Sunitinib + Sorafenib Placebo)	Arm B (Sorafenib + Sunitinib Placebo)	Arm C (Sunitinib Placebo + Sorafenib Placebo)
Arm/Group Description	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sunitinib malate 37.5mg PO QD for 4 weeks and placebo sorafenib tosylate 400mg PO QD or BID for 6 weeks.	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sorafenib tosylate 400mg PO QD or BID for 6 weeks and placebo sunitinib malate 37.5mg PO QD for 4 weeks followed.	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive placebo sorafenib tosylate 400mg as in Arm A and placebo sunitinib malate 37.5mg as in Arm B.
Measure Participants	513	510	580
Number (90% Confidence Interval) [Proportion of participants]	0.017 0%	0.013 0%	0.008 0%

4. Secondary Outcome

Title	5-year Disease-free Survival (DFS) Rate Among Patients With Clear Cell Histology
Description	Disease-free survival (DFS) is defined as time from randomization to recurrence, development of second primary cancer (except localized breast or prostate cancer or nonmelanoma skin cancer), or death from any cause. Patients who were alive without recurrence or qualifying second primary cancer were censored at the date of last disease evaluation. 5-year DFS rate is the proportion of patients who are alive and disease-free at 5 years based on the Kaplan-Meier estimate.
Time Frame	Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry; then annually if patient is 5 - 10 years from study entry

Outcome Measure Data

Analysis Population Description

Patients with clear cell histology were included in this analysis.

Arm/Group Title	Arm A (Sunitinib + Sorafenib Placebo)	Arm B (Sorafenib + Sunitinib Placebo)	Arm C (Sunitinib Placebo + Sorafenib Placebo)
Arm/Group Description	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sunitinib malate 37.5mg PO QD for 4 weeks and placebo sorafenib tosylate 400mg PO QD or BID for 6 weeks.	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sorafenib tosylate 400mg PO QD or BID for 6 weeks and placebo sunitinib malate 37.5mg PO QD for 4 weeks followed.	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive placebo sorafenib tosylate 400mg as in Arm A and placebo sunitinib malate 37.5mg as in Arm B.
Measure Participants	542	540	540
Number (97.5% Confidence Interval) [proportion of participants]	0.534 0.1%	0.527 0.1%	0.560 0.1%

5. Other Pre-specified Outcome

Title	The Association Between Angiogenesis Markers and Disease-free Survival
Time Frame	Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry; then annually if patient is 5 - 10 years from study entry

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title

Arm/Group Description

6. Other Pre-specified Outcome

Title	The Association Between Disease-free Survival and the Frequency of Oncogene as Well as Tumor Suppressor Gene Mutations
Time Frame	Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry; then annually if patient is 5 - 10 years from study entry

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title

Arm/Group Description

7. Other Pre-specified Outcome

Title	The Association Between Tumor and Genetic Polymorphisms and Disease-free Survival
Time Frame	Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry; then annually if patient is 5 - 10 years from study entry

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title

Arm/Group Description

8. Other Pre-specified Outcome

Title	The Association Between Deoxyribonucleic Acid (DNA) Methylation Profiles and Disease-free Survival
Time Frame	Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry; then annually if patient is 5 - 10 years from study entry

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title

Arm/Group Description

9. Other Pre-specified Outcome

Title	The Relationship of Polymorphisms in Drug Metabolizing Enzymes With Steady State Concentrations of Sorafenib and Sunitinib in Selected Patients
Time Frame	Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry; then annually if patient is 5 - 10 years from study entry

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title

Arm/Group Description

10. Other Pre-specified Outcome

Title	The Effect of Vascular Endothelial Growth Factor (VEGF) Targeted Therapy on Circulating Endothelial Cells and Circulating Endothelial Progenitors
Time Frame	Assessed every 3 months if patient is < 2 years from study entry; every 6 months if patient is 2 - 5 years from study entry; then annually if patient is 5 - 10 years from study entry

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title

Arm/Group Description

11. Other Pre-specified Outcome

Title	Patient-reported Fatigue Using Functional Assessment of Chronic Illness Therapy (FACIT) - Fatigue Scale
Time Frame	Assessed at baseline, 10 weeks and 22 weeks

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title

Arm/Group Description

12. Other Pre-specified Outcome

Title	Patient-reported Fatigue Using the Patient-Reported Outcomes Measurement Information System (PROMIS) Fatigue Short Form
Description	PROMIS Fatigue short form is a newly developed state-of-the-science PROMIS measure for fatigue
Time Frame	Assessed at baseline, 10 weeks and 22 weeks

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title

Arm/Group Description

13. Other Pre-specified Outcome

Title	The Association Between Scan Frequency and Development of Congestive Heart Failure
Time Frame	Assessed at 3, 6 and 12 months

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title

Arm/Group Description

14. Other Pre-specified Outcome

Title	Frequency of Clinically Significant Congestive Heart Failure (CHF) Grade 3 or Higher Using the Common Terminology Criteria for Adverse Events Version 4.0
Time Frame	Assessed every 6 weeks while on treatment and for 30 days after the end of treatment

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title

Arm/Group Description

Adverse Events

Time Frame	Assessed every 6 weeks while on treatment and for 30 days after the end of treatment
Adverse Event Reporting Description	Only adverse events that are possibly, probably, or definitely related to protocol therapy are reported.
Arm/Group Title	Arm A (Sunitinib + Sorafenib Placebo)		Arm B (Sorafenib + Sunitinib Placebo)		Arm C (Sunitinib Placebo + Sorafenib Placebo)
Arm/Group Description	Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sunitinib malate 37.5mg PO QD for 4 weeks and placebo sorafenib tosylate 400mg PO QD or BID for 6 weeks.		Beginning 4-12 weeks following radical or partial nephrectomy, patients receive sorafenib tosylate 400mg PO QD or BID for 6 weeks and placebo sunitinib malate 37.5mg PO QD for 4 weeks followed.		Beginning 4-12 weeks following radical or partial nephrectomy, patients receive placebo sorafenib tosylate 400mg as in Arm A and placebo sunitinib malate 37.5mg as in Arm B.
All Cause Mortality
	Arm A (Sunitinib + Sorafenib Placebo)		Arm B (Sorafenib + Sunitinib Placebo)		Arm C (Sunitinib Placebo + Sorafenib Placebo)
	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events
Total	/ (NaN)		/ (NaN)		/ (NaN)
Serious Adverse Events
	Arm A (Sunitinib + Sorafenib Placebo)		Arm B (Sorafenib + Sunitinib Placebo)		Arm C (Sunitinib Placebo + Sorafenib Placebo)
	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events
Total	368/625 (58.9%)		424/628 (67.5%)		81/626 (12.9%)
Blood and lymphatic system disorders
Anemia	2/625 (0.3%)		1/628 (0.2%)		0/626 (0%)
Thrombotic microangiopathy	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Febrile neutropenia	2/625 (0.3%)		0/628 (0%)		0/626 (0%)
Cardiac disorders
Heart block abnormality NOS	0/625 (0%)		0/628 (0%)		1/626 (0.2%)
Atrial fibrillation	1/625 (0.2%)		0/628 (0%)		2/626 (0.3%)
Atrial flutter	0/625 (0%)		0/628 (0%)		2/626 (0.3%)
Sinus bradycardia	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Supraventricular tachycardia	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Bigeminy	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Cardiac-ischemia	1/625 (0.2%)		3/628 (0.5%)		4/626 (0.6%)
Left ventricular systolic dysfunction	4/625 (0.6%)		4/628 (0.6%)		2/626 (0.3%)
Cor Pulmonale	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
cardiac-other	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Cardiac/heart, pain	2/625 (0.3%)		3/628 (0.5%)		0/626 (0%)
Ear and labyrinth disorders
Hearing w/o audiogr not in monitor prg	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Endocrine disorders
Adrenal insufficiency	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Hyopthyroidism	2/625 (0.3%)		0/628 (0%)		0/626 (0%)
Eye disorders
Cataract	0/625 (0%)		0/628 (0%)		1/626 (0.2%)
Double vision	0/625 (0%)		0/628 (0%)		1/626 (0.2%)
Retinal detachment	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Ocular-other	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Gastrointestinal disorders
Colitis	0/625 (0%)		3/628 (0.5%)		0/626 (0%)
Constipation	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Diarrhea w/o prior colostomy	57/625 (9.1%)		55/628 (8.8%)		2/626 (0.3%)
Distention/bloating, abdominal	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Esophagitis	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Gastritis	1/625 (0.2%)		1/628 (0.2%)		0/626 (0%)
Dyspepsia	14/625 (2.2%)		4/628 (0.6%)		1/626 (0.2%)
Ileus	0/625 (0%)		0/628 (0%)		1/626 (0.2%)
Muco/stomatitis by exam, oral cavity	2/625 (0.3%)		0/628 (0%)		0/626 (0%)
Muco/stomatitis (symptom) oral cavity	3/625 (0.5%)		1/628 (0.2%)		0/626 (0%)
Nausea	22/625 (3.5%)		5/628 (0.8%)		0/626 (0%)
Perforation, colon	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Vomiting	11/625 (1.8%)		3/628 (0.5%)		1/626 (0.2%)
Colon, hemorrhage	2/625 (0.3%)		0/628 (0%)		0/626 (0%)
Lower GI, hemorrhage NOS	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Stomach, hemorrhage	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Pancreatitis	3/625 (0.5%)		1/628 (0.2%)		0/626 (0%)
Abdomen, pain	4/625 (0.6%)		8/628 (1.3%)		2/626 (0.3%)
Esophagus, pain	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Oral cavity, pain	1/625 (0.2%)		1/628 (0.2%)		0/626 (0%)
Stomach, pain	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
General disorders
Fatigue	108/625 (17.3%)		41/628 (6.5%)		15/626 (2.4%)
Fever w/o neutropenia	1/625 (0.2%)		2/628 (0.3%)		0/626 (0%)
Edema head and neck	3/625 (0.5%)		1/628 (0.2%)		0/626 (0%)
Edema limb	2/625 (0.3%)		0/628 (0%)		0/626 (0%)
Chest/thoracic pain NOS	4/625 (0.6%)		4/628 (0.6%)		0/626 (0%)
Pain-other	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Flu-like syndrome	3/625 (0.5%)		0/628 (0%)		0/626 (0%)
Hepatobiliary disorders
Cholecystitis	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Liver dysfunction/failure	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Hepatic-other	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Immune system disorders
Allergic reaction	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Infections and infestations
Infection w/ gr3-4 neut, ileum	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Infection Gr0-2 neut, appendix	0/625 (0%)		0/628 (0%)		1/626 (0.2%)
Infection Gr0-2 neut, colon	0/625 (0%)		2/628 (0.3%)		0/626 (0%)
Infection Gr0-2 neut, kidney	1/625 (0.2%)		1/628 (0.2%)		0/626 (0%)
Infection Gr0-2 neut, lung	2/625 (0.3%)		3/628 (0.5%)		2/626 (0.3%)
Infection Gr0-2 neut, mediastinm	0/625 (0%)		0/628 (0%)		1/626 (0.2%)
Infection Gr0-2 neut, mucosa	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Infection Gr0-2 neut, muscle	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Infection Gr0-2 neut, nerve-cranial	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Infection Gr0-2 neut, skin	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Infection Gr0-2 neut, urinary tract	1/625 (0.2%)		0/628 (0%)		1/626 (0.2%)
Infection Gr0-2 neut, vagina	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Infection Gr0-2 neut, wound	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Infection w/ unk ANC skin (cellulitis)	0/625 (0%)		2/628 (0.3%)		0/626 (0%)
Infection w/ unk ANC urinary tract NOS	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Infection Gr0-2 neut, blood	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Infection-other	1/625 (0.2%)		1/628 (0.2%)		0/626 (0%)
Injury, poisoning and procedural complications
Wound - non-infectious	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Vascular access,Thrombosis/embolism	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Investigations
Leukocytes decreased	3/625 (0.5%)		0/628 (0%)		0/626 (0%)
Neutrophils decreased	7/625 (1.1%)		2/628 (0.3%)		0/626 (0%)
Platelets decreased	13/625 (2.1%)		2/628 (0.3%)		1/626 (0.2%)
Weight gain	0/625 (0%)		0/628 (0%)		2/626 (0.3%)
Alanine aminotransferase increased	4/625 (0.6%)		4/628 (0.6%)		0/626 (0%)
Serum amylase increased	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Aspartate aminotransferase increased	6/625 (1%)		4/628 (0.6%)		0/626 (0%)
Blood bilirubin increased	1/625 (0.2%)		1/628 (0.2%)		1/626 (0.2%)
Hypercholesterolemia	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
CPK increased	1/625 (0.2%)		1/628 (0.2%)		0/626 (0%)
Creatinine increased	1/625 (0.2%)		3/628 (0.5%)		0/626 (0%)
Lipase increased	4/625 (0.6%)		3/628 (0.5%)		1/626 (0.2%)
Metabolism and nutrition disorders
Anorexia	11/625 (1.8%)		5/628 (0.8%)		0/626 (0%)
Dehydration	10/625 (1.6%)		3/628 (0.5%)		0/626 (0%)
Hypoalbuminemia	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Hypocalcemia	1/625 (0.2%)		1/628 (0.2%)		0/626 (0%)
Hyperglycemia	0/625 (0%)		1/628 (0.2%)		1/626 (0.2%)
Hypophosphatemia	1/625 (0.2%)		1/628 (0.2%)		0/626 (0%)
Hyperkalemia	3/625 (0.5%)		1/628 (0.2%)		0/626 (0%)
Hypokalemia	2/625 (0.3%)		1/628 (0.2%)		0/626 (0%)
Hypernatremia	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Hyponatremia	1/625 (0.2%)		5/628 (0.8%)		4/626 (0.6%)
Hypertriglyceridemia	2/625 (0.3%)		0/628 (0%)		0/626 (0%)
Hyperuricemia	0/625 (0%)		1/628 (0.2%)		3/626 (0.5%)
Musculoskeletal and connective tissue disorders
Nonneuropathic upper extr muscle weak	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Nonneuropathic left-side muscle weak	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Nonneuropathic right-side muscle weak	0/625 (0%)		0/628 (0%)		1/626 (0.2%)
Nonneuropathic generalized weakness	1/625 (0.2%)		1/628 (0.2%)		1/626 (0.2%)
Myositis	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Musculoskeletal/soft tissue-other	0/625 (0%)		2/628 (0.3%)		0/626 (0%)
Back, pain	1/625 (0.2%)		3/628 (0.5%)		0/626 (0%)
Bone, pain	2/625 (0.3%)		1/628 (0.2%)		0/626 (0%)
Extremity-limb, pain	4/625 (0.6%)		3/628 (0.5%)		0/626 (0%)
Joint, pain	8/625 (1.3%)		8/628 (1.3%)		3/626 (0.5%)
Muscle, pain	2/625 (0.3%)		8/628 (1.3%)		1/626 (0.2%)
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Secondary malignancy	0/625 (0%)		1/628 (0.2%)		1/626 (0.2%)
Nervous system disorders
Vasovagal episode	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Ataxia	0/625 (0%)		0/628 (0%)		1/626 (0.2%)
CNS cerebrovascular ischemia	4/625 (0.6%)		0/628 (0%)		1/626 (0.2%)
Cognitive disturbance	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Dizziness	4/625 (0.6%)		2/628 (0.3%)		2/626 (0.3%)
Memory impairment	1/625 (0.2%)		0/628 (0%)		1/626 (0.2%)
Neuropathy-motor	3/625 (0.5%)		1/628 (0.2%)		0/626 (0%)
Neuropathy-sensory	3/625 (0.5%)		12/628 (1.9%)		3/626 (0.5%)
Syncope	4/625 (0.6%)		2/628 (0.3%)		0/626 (0%)
Head/headache	6/625 (1%)		4/628 (0.6%)		0/626 (0%)
Psychiatric disorders
Insomnia	0/625 (0%)		4/628 (0.6%)		0/626 (0%)
Confusion	2/625 (0.3%)		0/628 (0%)		1/626 (0.2%)
Anxiety	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Depression	1/625 (0.2%)		2/628 (0.3%)		2/626 (0.3%)
Renal and urinary disorders
Kidney, hemorrhage	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Proteinuria	2/625 (0.3%)		2/628 (0.3%)		0/626 (0%)
Renal failure	6/625 (1%)		4/628 (0.6%)		0/626 (0%)
Renal/GU-other	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Reproductive system and breast disorders
Sexual/Reproductive function-Other	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Respiratory, thoracic and mediastinal disorders
Pulmonary hypertension	0/625 (0%)		0/628 (0%)		1/626 (0.2%)
Muco/stomatitis (symptom) pharynx	24/625 (3.8%)		14/628 (2.2%)		0/626 (0%)
Nose, hemorrhage	3/625 (0.5%)		0/628 (0%)		0/626 (0%)
Dyspnea	4/625 (0.6%)		4/628 (0.6%)		2/626 (0.3%)
Pleural effusion (non-malignant)	1/625 (0.2%)		1/628 (0.2%)		0/626 (0%)
Voice changes/dysarthria	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Skin and subcutaneous tissue disorders
Dry skin	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Nail changes	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Pruritus/itching	1/625 (0.2%)		11/628 (1.8%)		1/626 (0.2%)
Rash/desquamation	15/625 (2.4%)		93/628 (14.8%)		3/626 (0.5%)
Rash: acne/acneiform	0/625 (0%)		2/628 (0.3%)		0/626 (0%)
Erythema multiforme	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Hand-foot reaction	94/625 (15%)		208/628 (33.1%)		7/626 (1.1%)
Urticaria	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Scalp, pain	0/625 (0%)		2/628 (0.3%)		0/626 (0%)
Skin, pain	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Vascular disorders
Hypertension	104/625 (16.6%)		96/628 (15.3%)		15/626 (2.4%)
Hypotension	1/625 (0.2%)		0/628 (0%)		0/626 (0%)
Thrombosis/thrombus/embolism	3/625 (0.5%)		5/628 (0.8%)		1/626 (0.2%)
Vascular-Other (Specify)	0/625 (0%)		1/628 (0.2%)		0/626 (0%)
Other (Not Including Serious) Adverse Events
	Arm A (Sunitinib + Sorafenib Placebo)		Arm B (Sorafenib + Sunitinib Placebo)		Arm C (Sunitinib Placebo + Sorafenib Placebo)
	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events
Total	116/625 (18.6%)		117/628 (18.6%)		57/626 (9.1%)
Gastrointestinal disorders
Diarrhea w/o prior colostomy	41/625 (6.6%)		40/628 (6.4%)		13/626 (2.1%)
Nausea	33/625 (5.3%)		21/628 (3.3%)		11/626 (1.8%)
General disorders
Fatigue	62/625 (9.9%)		58/628 (9.2%)		31/626 (5%)
Skin and subcutaneous tissue disorders
Rash/desquamation	17/625 (2.7%)		43/628 (6.8%)		15/626 (2.4%)
Hand-foot reaction	36/625 (5.8%)		52/628 (8.3%)		7/626 (1.1%)
Vascular disorders
Hypertension	38/625 (6.1%)		38/628 (6.1%)		10/626 (1.6%)

Limitations/Caveats

[Not Specified]

More Information

Certain Agreements

Principal Investigators are NOT employed by the organization sponsoring the study.

The only disclosure restriction on the PI is that the sponsor can review results communications prior to public release and can embargo communications regarding trial results for a period that is less than or equal to 60 days. The sponsor cannot require changes to the communication and cannot extend the embargo.