RHD-CaSS: The Clinical Influence of Developing a Sustainable Cardiac Surgery Service to Reduce the Burden of Rheumatic Heart Disease in Sub-Saharan Africa
Study Details
Study Description
Brief Summary
In this bi-directional program of education, training and research activities based on sustainable development goals aim is to develop cardiac surgery service in Ethiopia.
The aim is to evaluate the short and long-term outcome of cardiac surgery for rheumatic heart disease in a low-income country compared to individuals not offered cardiac surgery due to limited availability of the service. Second aim is to evaluate the quality of anticoagulant therapy in patients after cardiac surgery for rheumatic heart disease in a low-income country .
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Our objectives are:
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To evaluate the 30- and 180-days outcome of cardiac surgery for rheumatic heart disease (RHD), and impact of gender, age, clinical findings and echocardiographic classification, during the time of development of cardiac surgery at Black Lion hospital, Ethiopia, in comparison with matched individuals (from the same waiting list) which had no offer of surgery due to limited availability.
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To evaluate the quality of anticoagulation therapy after cardiac surgery at Black Lion hospital, Ethiopia by evaluating the patients proportion of time in therapeutic INR-level, complications as valve dysfunction, bleeding and thrombosis compared to control patients undergoing valvular replacement due to RHD at Norwegian hospitals.
Population: Approximately 50 RHD patients operated by Our team at Addis Abeba University Hospital, Ethiopia.
Follow up for 180-days for objective 1 and continous follow-up for objective 2. Comparison With matched Controls. Outcome measures: Mortality, complications (heart failure, arrhythmias, thrombosis, bleedings, stroke, infections)
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Cases RHD patients undergoing Cardiac surgery at Addis Abeba University Hospital |
Procedure: Cardiac surgery
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RHD controls RHD patients not offered Cardiac surgery |
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Anticoagulation controls Norwegian patients on anticoagulant therapy due to mechanical valve implants |
Outcome Measures
Primary Outcome Measures
- Short term outcome [180 days]
Freedom from Death or complication
Other Outcome Measures
- Time in therapeutic INR [2 years]
Time in therapeutic window (anticoagulation)
- Mitral valve area by Doppler [14 days]
Influence of concomitant pathology for Echocardiographic assessment of mitral stenosis
- Mitral phenotype in rheumatic heart disease [0 days]
Influence of mitral valve phenotype with cardiac morphology and complications in untreated rheumatic heart disease patients
Eligibility Criteria
Criteria
Inclusion Criteria:
- Cardiac surgery due to rheumatic heart disease at the governmental Black Lion University Hospital during the bi-directional programme of education, training and Research to establish Cardiac surgery service
Exclusion Criteria:
- Not willing or able to provide written informed consent
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Black Lion University Hospital | Addis Ababa | Ethiopia | ||
2 | Haukeland University Hospital | Bergen | Norway | ||
3 | Oslo University Hospital | Oslo | Norway | ||
4 | St. Olav University Hospital | Trondheim | Norway | 7491 |
Sponsors and Collaborators
- Helse Nord-Trøndelag HF
- Haukeland University Hospital
- Addis Ababa University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- AISCaSS