Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery

Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Recruiting
CT.gov ID
NCT03604991
Collaborator
(none)
278
470
4
59.4
0.6
0

Study Details

Study Description

Brief Summary

This phase II/III trial studies the usefulness of treatment with nivolumab and ipilimumab in addition to standard of care chemotherapy and radiation therapy in patients with esophageal and gastroesophageal junction adenocarcinoma who are undergoing surgery. Immunotherapy with antibodies, such as nivolumab and ipilimumab, may remove the brake on the body's immune system and may interfere with the ability of tumor cells to grow and spread. Chemotherapy and radiation therapy may reduce the tumor size and the amount of normal tissue that needs to be removed during surgery. A combined treatment with nivolumab and ipilimumab, chemotherapy, and radiation therapy might be more effective in patients with esophageal and gastroesophageal junction adenocarcinoma who are undergoing surgery.

Condition or Disease Intervention/Treatment Phase
Phase 2/Phase 3

Detailed Description

PRIMARY OBJECTIVES:
  1. To assess the pathologic complete response rate (pathCR) rate following administration of neoadjuvant carboplatin, paclitaxel and radiation therapy versus neoadjuvant carboplatin, paclitaxel, radiation therapy and nivolumab in patients with a resected locoregionally advanced esophageal or gastroesophageal junction adenocarcinoma.

  2. To assess the disease-free survival (DFS) following administration of adjuvant nivolumab and ipilimumab versus adjuvant nivolumab in patients with a resected locoregionally advanced esophageal or gastroesophageal junction adenocarcinoma who received neoadjuvant treatment with carboplatin, paclitaxel and radiation therapy with or without nivolumab.

SECONDARY OBJECTIVES:
  1. To assess the overall survival (OS) following administration of adjuvant nivolumab and ipilimumab versus nivolumab in patients with a resected locoregional esophageal or gastroesophageal junctional adenocarcinoma who received neoadjuvant treatment with carboplatin, paclitaxel and radiation therapy with or without nivolumab.

  2. To assess the disease free survival (DFS) following administration of neoadjuvant carboplatin, paclitaxel, and radiation therapy with or without nivolumab in patients with a locoregional esophageal or gastroesophageal junction adenocarcinoma III. To assess the toxicity associated with the administration of neoadjuvant nivolumab in combination with carboplatin, paclitaxel and radiation therapy in patients with a locoregional esophageal or gastroesophageal junction adenocarcinoma.

  3. To assess the toxicity associated with the administration of adjuvant nivolumab and ipilimumab versus adjuvant nivolumab in patients with a resected locoregional esophageal or gastroesophageal junction adenocarcinoma who received neoadjuvant treatment with carboplatin, paclitaxel and radiation therapy with or without nivolumab.

IMAGING OBJECTIVES:
  1. To determine if the percent change in mean volumetric apparent diffusion coefficient (ADC), measured from pre-treatment to mid-treatment, is predictive of pathCR in patients with a locoregional esophageal or gastroesophageal junctional adenocarcinoma undergoing chemo and chemoradiotherapy plus (+)/minus (-) nivolumab.

  2. To identify an optimal delta ADC cutoff in predicting pathCR.

OUTLINE:

STEP I: Patients are randomized to 1 of 2 arms.

ARM A: Patients receive carboplatin intravenously (IV) and paclitaxel IV once weekly and undergo radiation therapy once daily (Monday-Friday) beginning on day 1. Cycles repeat every week for up to 5 weeks in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive carboplatin, paclitaxel, and radiation therapy as in Arm A. Patients also receive nivolumab IV over 30 minutes on days 1 and 15. Cycles repeat every week for up to 5 weeks in the absence of disease progression or unacceptable toxicity.

STEP II: Patients are randomized to 1 of 2 arms following standard of care surgery.

ARM C: Patients receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 2 weeks for up to 12 cycles in the absence of disease progression or unacceptable toxicity.

ARM D: Patients receive nivolumab as in Arm C and receive ipilimumab IV over 90 minutes on day 1 of cycles 1, 4, 7, and 10. Treatment repeats every 2 weeks for up to 12 cycles in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years, and then every 6 months for up to 5 years.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
278 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
A Phase II/III Study of Peri-Operative Nivolumab and Ipilimumab in Patients With Locoregional Esophageal and Gastroesophageal Junction Adenocarcinoma
Actual Study Start Date :
Jan 17, 2019
Anticipated Primary Completion Date :
Dec 31, 2023
Anticipated Study Completion Date :
Dec 31, 2023

Arms and Interventions

Arm Intervention/Treatment
Experimental: Arm A (carboplatin, paclitaxel, radiation therapy)

Patients receive carboplatin IV and paclitaxel IV once weekly and undergo radiation therapy once daily (Monday-Friday) beginning on day 1. Cycles repeat every week for up to 5 weeks in the absence of disease progression or unacceptable toxicity.

Drug: Carboplatin
Given IV
Other Names:
  • Blastocarb
  • Carboplat
  • Carboplatin Hexal
  • Carboplatino
  • Carboplatinum
  • Carbosin
  • Carbosol
  • Carbotec
  • CBDCA
  • Displata
  • Ercar
  • JM-8
  • Nealorin
  • Novoplatinum
  • Paraplatin
  • Paraplatin AQ
  • Paraplatine
  • Platinwas
  • Ribocarbo
  • Drug: Paclitaxel
    Given IV
    Other Names:
  • Anzatax
  • Asotax
  • Bristaxol
  • Praxel
  • Taxol
  • Taxol Konzentrat
  • Radiation: Radiation Therapy
    Undergo radiation therapy
    Other Names:
  • Cancer Radiotherapy
  • ENERGY_TYPE
  • Irradiate
  • Irradiated
  • Irradiation
  • Radiation
  • Radiation Therapy, NOS
  • Radiotherapeutics
  • Radiotherapy
  • RT
  • Therapy, Radiation
  • Experimental: Arm B (carboplatin, paclitaxel, radiation therapy, nivolumab)

    Patients receive carboplatin, paclitaxel, and radiation therapy as in Arm A. Patients also receive nivolumab IV over 30 minutes on days 1 and 15. Cycles repeat every week for up to 5 weeks in the absence of disease progression or unacceptable toxicity.

    Drug: Carboplatin
    Given IV
    Other Names:
  • Blastocarb
  • Carboplat
  • Carboplatin Hexal
  • Carboplatino
  • Carboplatinum
  • Carbosin
  • Carbosol
  • Carbotec
  • CBDCA
  • Displata
  • Ercar
  • JM-8
  • Nealorin
  • Novoplatinum
  • Paraplatin
  • Paraplatin AQ
  • Paraplatine
  • Platinwas
  • Ribocarbo
  • Biological: Nivolumab
    Given IV
    Other Names:
  • BMS-936558
  • CMAB819
  • MDX-1106
  • NIVO
  • Nivolumab Biosimilar CMAB819
  • ONO-4538
  • Opdivo
  • Drug: Paclitaxel
    Given IV
    Other Names:
  • Anzatax
  • Asotax
  • Bristaxol
  • Praxel
  • Taxol
  • Taxol Konzentrat
  • Radiation: Radiation Therapy
    Undergo radiation therapy
    Other Names:
  • Cancer Radiotherapy
  • ENERGY_TYPE
  • Irradiate
  • Irradiated
  • Irradiation
  • Radiation
  • Radiation Therapy, NOS
  • Radiotherapeutics
  • Radiotherapy
  • RT
  • Therapy, Radiation
  • Experimental: Arm C (nivolumab)

    Patients receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 2 weeks for up to 12 cycles in the absence of disease progression or unacceptable toxicity.

    Biological: Nivolumab
    Given IV
    Other Names:
  • BMS-936558
  • CMAB819
  • MDX-1106
  • NIVO
  • Nivolumab Biosimilar CMAB819
  • ONO-4538
  • Opdivo
  • Experimental: Arm D (nivolumab, ipilimumab)

    Patients receive nivolumab as in Arm C and receive ipilimumab IV over 90 minutes on day 1 of cycles 1, 4, 7, and 10. Treatment repeats every 2 weeks for up to 12 cycles in the absence of disease progression or unacceptable toxicity.

    Biological: Ipilimumab
    Given IV
    Other Names:
  • Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody
  • BMS-734016
  • Ipilimumab Biosimilar CS1002
  • MDX-010
  • MDX-CTLA4
  • Yervoy
  • Biological: Nivolumab
    Given IV
    Other Names:
  • BMS-936558
  • CMAB819
  • MDX-1106
  • NIVO
  • Nivolumab Biosimilar CMAB819
  • ONO-4538
  • Opdivo
  • Outcome Measures

    Primary Outcome Measures

    1. Pathologic complete response (Step I) [Up to 5 weeks]

      The study with compare the pathologic complete response of Arm A and Arm B using a one-sided 0.10 level chi-squared test for proportions.

    2. Disease-free survival (DFS) (Step 2) [From the adjuvant treatment randomization assessed for up to 7 years]

      DFS measured from the adjuvant treatment randomization will be the endpoint of the adjuvant portion of the study and to achieve the desired power it is expected that patients will be followed for an additional year post completion of accrual to the adjuvant portion. The DFS comparison will be between patients randomized to Arm C (nivolumab) versus Arm D (nivolumab plus ipilimumab) using a one-sided 0.10 level stratified log rank test.

    Secondary Outcome Measures

    1. Incidence of adverse events [Up to 7 years]

      Graded according to Common Terminology Criteria for Adverse Events version 5.0. Toxicity will be evaluated among all treated patients regardless of eligibility and interim analyses of toxicity are performed twice yearly. The study will have sufficient precision to provide 95% confidence intervals on toxicity

    2. Overall survival [From the time of first randomization up to 7 years]

      Analyses will be descriptive in nature and will not follow any formal interim monitoring.

    3. DFS [From the time of first randomization up to 7 years]

      The DFS comparison will be between patients randomized to Arm C (nivolumab) versus Arm D (nivolumab plus ipilimumab) using a one-sided 0.10 level stratified log rank test.

    Other Outcome Measures

    1. Percent change in mean volumetric apparent diffusion coefficient (ADC) [Baseline to mid-treatment]

      The study will assess the area under the receiver operating characteristic curve of the changes of ADC value.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • STEP 1: Patients must have histologically confirmed T1N1-3M0 or T2-3N0-2M0 esophageal or gastroesophageal junctional adenocarcinoma (Siewert I and II)

    • STEP 1: Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1

    • STEP 1: Patents must be deemed a surgical candidate by a thoracic surgeon, surgical oncologist, or surgeon who is qualified to perform an esophagectomy

    • STEP 1: Absolute neutrophil count >= 1,500/mcL (within less than or equal to 14 days prior to randomization)

    • STEP 1: Platelets >= 100,000/mcL (within less than or equal to 14 days prior to randomization)

    • STEP 1: Total bilirubin =< institutional upper limit of normal (ULN) (within less than or equal to 14 days prior to randomization)

    • STEP 1: Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN (within less than or equal to 14 days prior to randomization)

    • STEP 1: Serum creatinine =< 1.5 x institutional ULN (within less than or equal to 14 days prior to randomization)

    • STEP 1: Hemoglobin (Hgb) >= 9 g/dL (within less than or equal to 14 days prior to randomization)

    • STEP 1: Leukocytes >= 3,000/mm^3 (within less than or equal to 14 days prior to randomization)

    • STEP 1: Patients may not have received prior chemotherapy or radiation therapy for management for this malignancy

    • STEP 1: Patients may not have received prior immunotherapy for management of this malignancy or for any other past malignancy

    • STEP 1: Patients must have no contraindication to receiving either carboplatin or paclitaxel chemotherapy

    • STEP 1: Patients must have no contraindication to receiving radiation therapy

    • STEP 1: Patients with active autoimmune disease or history of autoimmune disease that might recur, which may affect vital organ function or require immune suppressive treatment including systemic corticosteroids, should be excluded. These include but are not limited to patients with a history of immune related neurologic disease, multiple sclerosis, autoimmune (demyelinating) neuropathy, Guillain-Barre syndrome, myasthenia gravis; systemic autoimmune disease such as systemic lupus erythematosus (SLE), connective tissue disease, scleroderma, inflammatory bowel disease (IBD), Crohn's, ulcerative colitis, hepatitis; and patients with a history of toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome, or phospholipid syndrome should be excluded because of the risk of recurrence or exacerbation of disease. Patients with vitiligo, endocrine deficiencies including thyroiditis managed with replacement hormones including physiologic corticosteroids are eligible. Patients with rheumatoid arthritis and other arthropathies, Sjogren's syndrome and psoriasis controlled with topical medication and patients with positive serology, such as antinuclear antibodies (ANA), anti-thyroid antibodies should be evaluated for the presence of target organ involvement and potential need for systemic treatment but should otherwise be eligible

    • STEP 1: Patients are permitted to enroll if they have vitiligo, type I diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger (precipitating event)

    • STEP 1: Patient must NOT have previous or concurrent malignancy. Exceptions are made for patients who meet any of the following conditions:

    • Non-melanoma skin cancer, in situ cervical cancer, superficial bladder cancer, or breast cancer in situ OR

    • Prior malignancy completely excised or removed and patient has been continuously disease free for > 5 years OR

    • Prior malignancy completely excised or removed and patient has been continuously disease free for > 5 years

    • Date of last evidence of disease

    • STEP 1: Patients must not have a condition requiring systemic treatment with either corticosteroids (> 10 mg/day prednisone equivalents) or other immunosuppressive medications within 14 days of study drug administration. Inhaled or topical steroids and adrenal replacement doses =< 10 mg/day prednisone equivalents are permitted in the absence of active autoimmune disease

    • STEP 1: Adequate cardiac function including electrocardiogram (EKG) and echocardiogram for any patient with a history of congestive heart failure (CHF) or at risk because of underlying cardiovascular disease or exposure to cardiotoxic drugs

    • STEP 1: For patients with evidence of CHF, myocardial infarction (MI), cardiomyopathy, or myositis, cardiac evaluation including lab tests and cardiology consultations including EKG, creatine phosphokinase (CPK), troponin, and echocardiogram

    • STEP 1: Patients must not have a positive test result for hepatitis B virus surface antigen (HBV sAg) or hepatitis C virus ribonucleic acid (HCV RNA) indicating acute or chronic infection. Testing should be conducted to determine eligibility

    • STEP 1: Patients with a known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) must have no detectable viral load on a stable anti-viral regimen

    • STEP 1: Patients must not be receiving any other investigational agents

    • STEP 1: Patients with an uncontrolled intercurrent illness such as ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia or psychiatric illness/social situations that would limit compliance with study requirements will be excluded

    • STEP 1: Women must not be pregnant or breast-feeding due to potential harm to the fetus from carboplatin, paclitaxel, or nivolumab. All females of childbearing potential must have a blood test or urine study done within 2 weeks prior to registration to rule out pregnancy. Those enrolled on Arm B with nivolumab must agree to have a pregnancy test (minimum sensitivity 25 IU/L or equivalent units of human chorionic gonadotropin [HCG]) within 24 hours of starting nivolumab to rule out pregnancy. A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

    • STEP 1: Women of childbearing potential (WOCBP) and sexually active males must either abstain from sexual intercourse for the duration of their participation in the study or agree to use both double barrier contraception and birth control pills or implants for at least one month (female patients) or one week (male patients) prior to the start of the study drug and continuing for 5 months after the last dose of study drug (for female patients) and for 7 months after the last dose of study drug (for male patients who are sexually active with WOCBP). Investigators shall counsel WOCBP and male subjects who are sexually active with WOCBP on the importance of pregnancy prevention and the implications of an unexpected pregnancy

    • STEP 1: If patient says 'Yes' to "I choose to take part in the imaging study and will have the diffusion weighted magnetic resonance imaging (MRI) scans": patients must be able to tolerate MRI scans:

    • No history of untreatable claustrophobia

    • No magnetic resonance (MR) incompatible implants/devices or metallic foreign bodies

    • Weight compatible with limits imposed by the MRI scanner table

    • STEP 2: Patient registration must not exceed 12 weeks from time of esophagectomy

    • STEP 2: Patients must have a post-operative ECOG performance status of 0-2

    • STEP 2: Absolute neutrophil count >= 1,500/mcL (within less than or equal to 14 days prior to randomization)

    • STEP 2: Platelets >= 100,000/mcL (within less than or equal to 14 days prior to randomization)

    • STEP 2: Total bilirubin =< institutional upper limit of normal (ULN) (within less than or equal to 14 days prior to randomization)

    • STEP 2: AST (SGOT)/ ALT (SGPT) =< 2.5 x institutional ULN (within less than or equal to 14 days prior to randomization)

    • STEP 2: Serum creatinine =< 1.5 x institutional ULN (within less than or equal to 14 days prior to randomization)

    • STEP 2: Patients must be disease free following esophagectomy as is demonstrated by having no evidence of disease on a post-surgical computed tomography (CT) scan. Patients must also have a negative surgical margin (R0 resection)

    • STEP 2: Patients must not have an active, known or suspected autoimmune disease or a condition requiring treatment with steroids or immunosuppressive agents. Patients are permitted to enroll if they have vitiligo, type I diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger

    • STEP 2: Patients must not have a condition requiring systemic treatment with either corticosteroids (> 10 mg/day prednisone equivalents) or other immunosuppressive medications with 14 days of study drug administration. Inhaled or topical steroids and adrenal replacement doses > 10 mg/day prednisone equivalents are permitted in the absence of active autoimmune disease

    • STEP 2: Patients must not be receiving any other investigational agents

    • STEP 2: Patients with an uncontrolled intercurrent illness such as ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia or psychiatric illness/social situations that would limit compliance with study requirements will be excluded

    • STEP 2: Women must not be pregnant or breast-feeding due to potential harm to the fetus from nivolumab or ipilimumab. All females of childbearing potential must have a blood test or urine study done (minimum sensitivity 25 IU/L or equivalent units of HCG) within 2 weeks prior to registration to rule out pregnancy. All patients must also agree to have a pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 24 hours of starting nivolumab to rule out pregnancy. Those enrolled on Arm D with ipilimumab must agree to have pregnancy tests within 72 hours of each ipilimumab administration to rule out pregnancy

    • STEP 2: Women of childbearing potential (WOCBP) and sexually active males must either abstain from sexual intercourse for the duration of their participation in the study or agree to use both double barrier contraception and birth control pills or implants for at least one month (female patients) or one week (male patients) prior to the start of the study drug and continuing for 5 months after the last dose of study drug (for female patients) and for 7 months after the last dose of study drug (for male patients who are sexually active with WOCBP). Investigators shall counsel WOCBP and male subjects who are sexually active with WOCBP on the importance of pregnancy prevention and the implications of an unexpected pregnancy

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Anchorage Associates in Radiation Medicine Anchorage Alaska United States 98508
    2 Alaska Breast Care and Surgery LLC Anchorage Alaska United States 99508
    3 Alaska Oncology and Hematology LLC Anchorage Alaska United States 99508
    4 Alaska Women's Cancer Care Anchorage Alaska United States 99508
    5 Anchorage Oncology Centre Anchorage Alaska United States 99508
    6 Katmai Oncology Group Anchorage Alaska United States 99508
    7 Providence Alaska Medical Center Anchorage Alaska United States 99508
    8 Cancer Center at Saint Joseph's Phoenix Arizona United States 85004
    9 Mercy Hospital Fort Smith Fort Smith Arkansas United States 72903
    10 CHI Saint Vincent Cancer Center Hot Springs Hot Springs Arkansas United States 71913
    11 NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro Jonesboro Arkansas United States 72401
    12 PCR Oncology Arroyo Grande California United States 93420
    13 Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California United States 91505
    14 Community Cancer Institute Clovis California United States 93611
    15 University Oncology Associates Clovis California United States 93611
    16 Los Angeles County-USC Medical Center Los Angeles California United States 90033
    17 USC / Norris Comprehensive Cancer Center Los Angeles California United States 90033
    18 Stanford Cancer Institute Palo Alto Palo Alto California United States 94304
    19 VA Palo Alto Health Care System Palo Alto California United States 94304
    20 University of California Davis Comprehensive Cancer Center Sacramento California United States 95817
    21 Saint Helena Hospital Saint Helena California United States 94574
    22 Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo California United States 93401
    23 Mission Hope Medical Oncology - Santa Maria Santa Maria California United States 93444
    24 Presbyterian Intercommunity Hospital Whittier California United States 90602
    25 Penrose-Saint Francis Healthcare Colorado Springs Colorado United States 80907
    26 Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado United States 80907
    27 Saint Francis Cancer Center Colorado Springs Colorado United States 80923
    28 Porter Adventist Hospital Denver Colorado United States 80210
    29 Saint Anthony Hospital Lakewood Colorado United States 80228
    30 Littleton Adventist Hospital Littleton Colorado United States 80122
    31 Longmont United Hospital Longmont Colorado United States 80501
    32 Parker Adventist Hospital Parker Colorado United States 80138
    33 Saint Mary Corwin Medical Center Pueblo Colorado United States 81004
    34 Beebe South Coastal Health Campus Frankford Delaware United States 19945
    35 Beebe Medical Center Lewes Delaware United States 19958
    36 Delaware Clinical and Laboratory Physicians PA Newark Delaware United States 19713
    37 Helen F Graham Cancer Center Newark Delaware United States 19713
    38 Medical Oncology Hematology Consultants PA Newark Delaware United States 19713
    39 Christiana Care Health System-Christiana Hospital Newark Delaware United States 19718
    40 Beebe Health Campus Rehoboth Beach Delaware United States 19971
    41 TidalHealth Nanticoke / Allen Cancer Center Seaford Delaware United States 19973
    42 AdventHealth Altamonte Altamonte Springs Florida United States 32701
    43 Mount Sinai Comprehensive Cancer Center at Aventura Aventura Florida United States 33180
    44 Holy Cross Hospital Fort Lauderdale Florida United States 33308
    45 Regional Cancer Center-Lee Memorial Health System Fort Myers Florida United States 33905
    46 University of Florida Health Science Center - Gainesville Gainesville Florida United States 32610
    47 AdventHealth Kissimmee Kissimmee Florida United States 34744
    48 Mount Sinai Medical Center Miami Beach Florida United States 33140
    49 AdventHealth Orlando Orlando Florida United States 32803
    50 AdventHealth East Orlando Orlando Florida United States 32822
    51 Emory Proton Therapy Center Atlanta Georgia United States 30308
    52 Emory University Hospital Midtown Atlanta Georgia United States 30308
    53 Emory University Hospital/Winship Cancer Institute Atlanta Georgia United States 30322
    54 Emory Saint Joseph's Hospital Atlanta Georgia United States 30342
    55 Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah Georgia United States 31405
    56 Hawaii Cancer Care - Savio 'Aiea Hawaii United States 96701
    57 Pali Momi Medical Center 'Aiea Hawaii United States 96701
    58 Queen's Cancer Center - Pearlridge 'Aiea Hawaii United States 96701
    59 The Cancer Center of Hawaii-Pali Momi 'Aiea Hawaii United States 96701
    60 Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii United States 96813
    61 Island Urology Honolulu Hawaii United States 96813
    62 Queen's Cancer Cenrer - POB I Honolulu Hawaii United States 96813
    63 Queen's Medical Center Honolulu Hawaii United States 96813
    64 Straub Clinic and Hospital Honolulu Hawaii United States 96813
    65 University of Hawaii Cancer Center Honolulu Hawaii United States 96813
    66 Hawaii Cancer Care Inc-Liliha Honolulu Hawaii United States 96817
    67 Kuakini Medical Center Honolulu Hawaii United States 96817
    68 Queen's Cancer Center - Kuakini Honolulu Hawaii United States 96817
    69 The Cancer Center of Hawaii-Liliha Honolulu Hawaii United States 96817
    70 Kapiolani Medical Center for Women and Children Honolulu Hawaii United States 96826
    71 Wilcox Memorial Hospital and Kauai Medical Clinic Lihue Hawaii United States 96766
    72 Saint Luke's Cancer Institute - Boise Boise Idaho United States 83712
    73 Saint Luke's Cancer Institute - Fruitland Fruitland Idaho United States 83619
    74 Saint Luke's Cancer Institute - Meridian Meridian Idaho United States 83642
    75 Saint Luke's Cancer Institute - Nampa Nampa Idaho United States 83686
    76 Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho United States 83301
    77 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    78 Illinois CancerCare-Canton Canton Illinois United States 61520
    79 Memorial Hospital of Carbondale Carbondale Illinois United States 62902
    80 SIH Cancer Institute Carterville Illinois United States 62918
    81 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    82 Centralia Oncology Clinic Centralia Illinois United States 62801
    83 Northwestern University Chicago Illinois United States 60611
    84 University of Illinois Chicago Illinois United States 60612
    85 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    86 Decatur Memorial Hospital Decatur Illinois United States 62526
    87 Illinois CancerCare-Dixon Dixon Illinois United States 61021
    88 Crossroads Cancer Center Effingham Illinois United States 62401
    89 Illinois CancerCare-Eureka Eureka Illinois United States 61530
    90 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    91 Western Illinois Cancer Treatment Center Galesburg Illinois United States 61401
    92 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    93 Northwestern Medicine Lake Forest Hospital Lake Forest Illinois United States 60045
    94 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    95 Loyola University Medical Center Maywood Illinois United States 60153
    96 Good Samaritan Regional Health Center Mount Vernon Illinois United States 62864
    97 Cancer Care Center of O'Fallon O'Fallon Illinois United States 62269
    98 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    99 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    100 OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin Illinois United States 61554
    101 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    102 OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria Illinois United States 61615
    103 Methodist Medical Center of Illinois Peoria Illinois United States 61636
    104 OSF Saint Francis Medical Center Peoria Illinois United States 61637
    105 Illinois CancerCare-Peru Peru Illinois United States 61354
    106 Valley Radiation Oncology Peru Illinois United States 61354
    107 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    108 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    109 Springfield Clinic Springfield Illinois United States 62702
    110 Memorial Medical Center Springfield Illinois United States 62781
    111 Illinois CancerCare - Washington Washington Illinois United States 61571
    112 IU Health North Hospital Carmel Indiana United States 46032
    113 Indiana University/Melvin and Bren Simon Cancer Center Indianapolis Indiana United States 46202
    114 Reid Health Richmond Indiana United States 47374
    115 Medical Oncology and Hematology Associates-West Des Moines Clive Iowa United States 50325
    116 Mercy Cancer Center-West Lakes Clive Iowa United States 50325
    117 Greater Regional Medical Center Creston Iowa United States 50801
    118 Medical Oncology and Hematology Associates-Laurel Des Moines Iowa United States 50314
    119 Mercy Medical Center - Des Moines Des Moines Iowa United States 50314
    120 Mercy Medical Center-West Lakes West Des Moines Iowa United States 50266
    121 Central Care Cancer Center - Garden City Garden City Kansas United States 67846
    122 Central Care Cancer Center - Great Bend Great Bend Kansas United States 67530
    123 Saint Joseph Radiation Oncology Resource Center Lexington Kentucky United States 40504
    124 Saint Joseph Hospital East Lexington Kentucky United States 40509
    125 Jewish Hospital Louisville Kentucky United States 40202
    126 UofL Health Medical Center Northeast Louisville Kentucky United States 40245
    127 Ochsner Medical Center Kenner Kenner Louisiana United States 70065
    128 Ochsner Medical Center Jefferson New Orleans Louisiana United States 70121
    129 Eastern Maine Medical Center Bangor Maine United States 04401
    130 MaineHealth Coastal Cancer Treatment Center Bath Maine United States 04530
    131 MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford Biddeford Maine United States 04005
    132 Lafayette Family Cancer Center-EMMC Brewer Maine United States 04412
    133 Maine Medical Center-Bramhall Campus Portland Maine United States 04102
    134 MaineHealth Cancer Care Center of York County Sanford Maine United States 04073
    135 MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford Sanford Maine United States 04073
    136 Maine Medical Center- Scarborough Campus Scarborough Maine United States 04074
    137 Maine Medical Partners - South Portland South Portland Maine United States 04106
    138 Tufts Medical Center Boston Massachusetts United States 02111
    139 Boston Medical Center Boston Massachusetts United States 02118
    140 Lowell General Hospital Lowell Massachusetts United States 01854
    141 Saint Joseph Mercy Hospital Ann Arbor Michigan United States 48106
    142 Saint Joseph Mercy Brighton Brighton Michigan United States 48114
    143 Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan United States 48114
    144 Saint Joseph Mercy Canton Canton Michigan United States 48188
    145 Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan United States 48188
    146 Caro Cancer Center Caro Michigan United States 48723
    147 Saint Joseph Mercy Chelsea Chelsea Michigan United States 48118
    148 Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan United States 48118
    149 Ascension Saint John Hospital Detroit Michigan United States 48236
    150 Genesys Hurley Cancer Institute Flint Michigan United States 48503
    151 Hurley Medical Center Flint Michigan United States 48503
    152 Sparrow Hospital Lansing Michigan United States 48912
    153 Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan United States 48154
    154 Saint Mary's Oncology/Hematology Associates of Marlette Marlette Michigan United States 48453
    155 21st Century Oncology-Pontiac Pontiac Michigan United States 48341
    156 Saint Joseph Mercy Oakland Pontiac Michigan United States 48341
    157 Ascension Saint Mary's Hospital Saginaw Michigan United States 48601
    158 Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan United States 48604
    159 Ascension Saint Joseph Hospital Tawas City Michigan United States 48764
    160 Saint John Macomb-Oakland Hospital Warren Michigan United States 48093
    161 Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan United States 48661
    162 Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan United States 48197
    163 Sanford Joe Lueken Cancer Center Bemidji Minnesota United States 56601
    164 Essentia Health Saint Joseph's Medical Center Brainerd Minnesota United States 56401
    165 Fairview Ridges Hospital Burnsville Minnesota United States 55337
    166 Minnesota Oncology - Burnsville Burnsville Minnesota United States 55337
    167 Mercy Hospital Coon Rapids Minnesota United States 55433
    168 Essentia Health - Deer River Clinic Deer River Minnesota United States 56636
    169 Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes Minnesota United States 56501
    170 Essentia Health Cancer Center Duluth Minnesota United States 55805
    171 Essentia Health Saint Mary's Medical Center Duluth Minnesota United States 55805
    172 Miller-Dwan Hospital Duluth Minnesota United States 55805
    173 Fairview Southdale Hospital Edina Minnesota United States 55435
    174 Lake Region Healthcare Corporation-Cancer Care Fergus Falls Minnesota United States 56537
    175 Essentia Health - Fosston Fosston Minnesota United States 56542
    176 Unity Hospital Fridley Minnesota United States 55432
    177 Essentia Health Hibbing Clinic Hibbing Minnesota United States 55746
    178 Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota United States 55369
    179 Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota United States 55109
    180 Saint John's Hospital - Healtheast Maplewood Minnesota United States 55109
    181 Abbott-Northwestern Hospital Minneapolis Minnesota United States 55407
    182 Hennepin County Medical Center Minneapolis Minnesota United States 55415
    183 Health Partners Inc Minneapolis Minnesota United States 55454
    184 Monticello Cancer Center Monticello Minnesota United States 55362
    185 Essentia Health - Park Rapids Park Rapids Minnesota United States 56470
    186 North Memorial Medical Health Center Robbinsdale Minnesota United States 55422
    187 Mayo Clinic in Rochester Rochester Minnesota United States 55905
    188 Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota United States 55416
    189 Regions Hospital Saint Paul Minnesota United States 55101
    190 United Hospital Saint Paul Minnesota United States 55102
    191 Essentia Health Sandstone Sandstone Minnesota United States 55072
    192 Saint Francis Regional Medical Center Shakopee Minnesota United States 55379
    193 Lakeview Hospital Stillwater Minnesota United States 55082
    194 Essentia Health Virginia Clinic Virginia Minnesota United States 55792
    195 Ridgeview Medical Center Waconia Minnesota United States 55387
    196 Rice Memorial Hospital Willmar Minnesota United States 56201
    197 Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota United States 55125
    198 Baptist Memorial Hospital and Cancer Center-Golden Triangle Columbus Mississippi United States 39705
    199 Baptist Cancer Center-Grenada Grenada Mississippi United States 38901
    200 Baptist Memorial Hospital and Cancer Center-Union County New Albany Mississippi United States 38652
    201 Baptist Memorial Hospital and Cancer Center-Oxford Oxford Mississippi United States 38655
    202 Baptist Memorial Hospital and Cancer Center-Desoto Southhaven Mississippi United States 38671
    203 Saint Louis Cancer and Breast Institute-Ballwin Ballwin Missouri United States 63011
    204 Central Care Cancer Center - Bolivar Bolivar Missouri United States 65613
    205 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    206 Southeast Cancer Center Cape Girardeau Missouri United States 63703
    207 Siteman Cancer Center at West County Hospital Creve Coeur Missouri United States 63141
    208 Parkland Health Center - Farmington Farmington Missouri United States 63640
    209 Capital Region Southwest Campus Jefferson City Missouri United States 65109
    210 Freeman Health System Joplin Missouri United States 64804
    211 Mercy Hospital Joplin Joplin Missouri United States 64804
    212 Delbert Day Cancer Institute at PCRMC Rolla Missouri United States 65401
    213 Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri United States 65401
    214 Heartland Regional Medical Center Saint Joseph Missouri United States 64506
    215 Washington University School of Medicine Saint Louis Missouri United States 63110
    216 Mercy Hospital South Saint Louis Missouri United States 63128
    217 Siteman Cancer Center-South County Saint Louis Missouri United States 63129
    218 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    219 Siteman Cancer Center at Christian Hospital Saint Louis Missouri United States 63136
    220 Mercy Hospital Saint Louis Saint Louis Missouri United States 63141
    221 Siteman Cancer Center at Saint Peters Hospital Saint Peters Missouri United States 63376
    222 Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri United States 63670
    223 Mercy Hospital Springfield Springfield Missouri United States 65804
    224 CoxHealth South Hospital Springfield Missouri United States 65807
    225 Missouri Baptist Sullivan Hospital Sullivan Missouri United States 63080
    226 Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri United States 63127
    227 Nebraska Medicine-Bellevue Bellevue Nebraska United States 68123
    228 CHI Health Saint Francis Grand Island Nebraska United States 68803
    229 CHI Health Good Samaritan Kearney Nebraska United States 68847
    230 Nebraska Medicine-Village Pointe Omaha Nebraska United States 68118
    231 Alegent Health Immanuel Medical Center Omaha Nebraska United States 68122
    232 Alegent Health Bergan Mercy Medical Center Omaha Nebraska United States 68124
    233 Alegent Health Lakeside Hospital Omaha Nebraska United States 68130
    234 Creighton University Medical Center Omaha Nebraska United States 68131
    235 University of Nebraska Medical Center Omaha Nebraska United States 68198
    236 Comprehensive Cancer Centers of Nevada - Henderson Henderson Nevada United States 89052
    237 OptumCare Cancer Care at Seven Hills Henderson Nevada United States 89052
    238 OptumCare Cancer Care at Charleston Las Vegas Nevada United States 89102
    239 Radiation Oncology Centers of Nevada Central Las Vegas Nevada United States 89106
    240 GenesisCare USA - Las Vegas Las Vegas Nevada United States 89109
    241 Radiation Oncology Centers of Nevada Southeast Las Vegas Nevada United States 89119
    242 Comprehensive Cancer Centers of Nevada - Northwest Las Vegas Nevada United States 89128
    243 OptumCare Cancer Care at MountainView Las Vegas Nevada United States 89128
    244 Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas Nevada United States 89135
    245 Comprehensive Cancer Centers of Nevada - Town Center Las Vegas Nevada United States 89144
    246 Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas Nevada United States 89144
    247 Comprehensive Cancer Centers of Nevada Las Vegas Nevada United States 89148
    248 OptumCare Cancer Care at Fort Apache Las Vegas Nevada United States 89148
    249 Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas Nevada United States 89169
    250 Renown Regional Medical Center Reno Nevada United States 89502
    251 Saint Mary's Regional Medical Center Reno Nevada United States 89503
    252 Radiation Oncology Associates Reno Nevada United States 89509
    253 Dartmouth Hitchcock Medical Center Lebanon New Hampshire United States 03756
    254 Ocean Medical Center Brick New Jersey United States 08724
    255 Monmouth Medical Center Long Branch New Jersey United States 07740
    256 Southern Ocean County Medical Center Manahawkin New Jersey United States 08050
    257 Jersey Shore Medical Center Neptune New Jersey United States 07753
    258 Rutgers Cancer Institute of New Jersey New Brunswick New Jersey United States 08903
    259 Riverview Medical Center/Booker Cancer Center Red Bank New Jersey United States 07701
    260 Community Medical Center Toms River New Jersey United States 08755
    261 Lovelace Medical Center-Saint Joseph Square Albuquerque New Mexico United States 87102
    262 University of New Mexico Cancer Center Albuquerque New Mexico United States 87102
    263 New Mexico Oncology Hematology Consultants Albuquerque New Mexico United States 87109
    264 Presbyterian Kaseman Hospital Albuquerque New Mexico United States 87110
    265 Presbyterian Rust Medical Center/Jorgensen Cancer Center Rio Rancho New Mexico United States 87124
    266 Montefiore Medical Center-Einstein Campus Bronx New York United States 10461
    267 Montefiore Medical Center-Weiler Hospital Bronx New York United States 10461
    268 Montefiore Medical Center - Moses Campus Bronx New York United States 10467
    269 Sands Cancer Center Canandaigua New York United States 14424
    270 Noyes Memorial Hospital/Myers Cancer Center Dansville New York United States 14437
    271 Glens Falls Hospital Glens Falls New York United States 12801
    272 Northwell Health/Center for Advanced Medicine Lake Success New York United States 11042
    273 Garnet Health Medical Center Middletown New York United States 10940
    274 Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York United States 10016
    275 NYP/Weill Cornell Medical Center New York New York United States 10065
    276 University of Rochester Rochester New York United States 14642
    277 State University of New York Upstate Medical University Syracuse New York United States 13210
    278 Novant Health Presbyterian Medical Center Charlotte North Carolina United States 28204
    279 Novant Health Presbyterian Medical Center Huntersville Huntersville North Carolina United States 28078
    280 Novant Health Cancer Institute - Kernersville Kernersville North Carolina United States 27284
    281 Matthews Radiation Oncology Center Matthews North Carolina United States 28105
    282 Novant Health Cancer Institute - Mount Airy Mount Airy North Carolina United States 27030
    283 Novant Health Cancer Institute - Statesville Statesville North Carolina United States 28625
    284 Novant Health Cancer Institute - Thomasville Thomasville North Carolina United States 27360
    285 Novant Health Cancer Institute - Wilkesboro Wilkesboro North Carolina United States 28659
    286 Novant Health Forsyth Medical Center Winston-Salem North Carolina United States 27103
    287 Sanford Bismarck Medical Center Bismarck North Dakota United States 58501
    288 Essentia Health Cancer Center-South University Clinic Fargo North Dakota United States 58103
    289 Sanford Broadway Medical Center Fargo North Dakota United States 58122
    290 Sanford Roger Maris Cancer Center Fargo North Dakota United States 58122
    291 Essentia Health - Jamestown Clinic Jamestown North Dakota United States 58401
    292 Indu and Raj Soin Medical Center Beavercreek Ohio United States 45431
    293 Saint Elizabeth Boardman Hospital Boardman Ohio United States 44512
    294 Dayton Physicians LLC-Miami Valley South Centerville Ohio United States 45459
    295 Miami Valley Hospital South Centerville Ohio United States 45459
    296 University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio United States 45219
    297 Good Samaritan Hospital - Cincinnati Cincinnati Ohio United States 45220
    298 Oncology Hematology Care Inc-Kenwood Cincinnati Ohio United States 45236
    299 Bethesda North Hospital Cincinnati Ohio United States 45242
    300 MetroHealth Medical Center Cleveland Ohio United States 44109
    301 Cleveland Clinic Cancer Center/Fairview Hospital Cleveland Ohio United States 44111
    302 Cleveland Clinic Foundation Cleveland Ohio United States 44195
    303 Ohio State University Comprehensive Cancer Center Columbus Ohio United States 43210
    304 Miami Valley Hospital Dayton Ohio United States 45409
    305 Dayton Physician LLC-Miami Valley Hospital North Dayton Ohio United States 45415
    306 Miami Valley Hospital North Dayton Ohio United States 45415
    307 Armes Family Cancer Center Findlay Ohio United States 45840
    308 Blanchard Valley Hospital Findlay Ohio United States 45840
    309 Orion Cancer Care Findlay Ohio United States 45840
    310 Atrium Medical Center-Middletown Regional Hospital Franklin Ohio United States 45005-1066
    311 Dayton Physicians LLC-Atrium Franklin Ohio United States 45005
    312 Dayton Physicians LLC-Wayne Greenville Ohio United States 45331
    313 Wayne Hospital Greenville Ohio United States 45331
    314 Cleveland Clinic Cancer Center Independence Independence Ohio United States 44131
    315 Greater Dayton Cancer Center Kettering Ohio United States 45409
    316 Kettering Medical Center Kettering Ohio United States 45429
    317 Cleveland Clinic Cancer Center Mansfield Mansfield Ohio United States 44906
    318 Hillcrest Hospital Cancer Center Mayfield Heights Ohio United States 44124
    319 North Coast Cancer Care Sandusky Ohio United States 44870
    320 Springfield Regional Cancer Center Springfield Ohio United States 45504
    321 Springfield Regional Medical Center Springfield Ohio United States 45505
    322 Cleveland Clinic Cancer Center Strongsville Strongsville Ohio United States 44136
    323 ProMedica Flower Hospital Sylvania Ohio United States 43560
    324 ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital Toledo Ohio United States 43606
    325 Dayton Physicians LLC-Upper Valley Troy Ohio United States 45373
    326 Upper Valley Medical Center Troy Ohio United States 45373
    327 South Pointe Hospital Warrensville Heights Ohio United States 44122
    328 Saint Joseph Warren Hospital Warren Ohio United States 44484
    329 University of Cincinnati Cancer Center-West Chester West Chester Ohio United States 45069
    330 Cleveland Clinic Wooster Family Health and Surgery Center Wooster Ohio United States 44691
    331 Saint Elizabeth Youngstown Hospital Youngstown Ohio United States 44501
    332 Mercy Hospital Oklahoma City Oklahoma City Oklahoma United States 73120
    333 Saint Charles Health System Bend Oregon United States 97701
    334 Clackamas Radiation Oncology Center Clackamas Oregon United States 97015
    335 Providence Cancer Institute Clackamas Clinic Clackamas Oregon United States 97015
    336 Bay Area Hospital Coos Bay Oregon United States 97420
    337 Providence Newberg Medical Center Newberg Oregon United States 97132
    338 Providence Portland Medical Center Portland Oregon United States 97213
    339 Providence Saint Vincent Medical Center Portland Oregon United States 97225
    340 Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania United States 18103
    341 UPMC Altoona Altoona Pennsylvania United States 16601
    342 UPMC-Heritage Valley Health System Beaver Beaver Pennsylvania United States 15009
    343 Saint Luke's University Hospital-Bethlehem Campus Bethlehem Pennsylvania United States 18015
    344 Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania United States 18017
    345 UPMC Camp Hill Camp Hill Pennsylvania United States 17011
    346 Carlisle Regional Cancer Center Carlisle Pennsylvania United States 17015
    347 Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania United States 19317
    348 Geisinger Medical Center Danville Pennsylvania United States 17822
    349 Pocono Medical Center East Stroudsburg Pennsylvania United States 18301
    350 UPMC Hillman Cancer Center Erie Erie Pennsylvania United States 16505
    351 UPMC Cancer Center at UPMC Horizon Farrell Pennsylvania United States 16121
    352 UPMC Cancer Centers - Arnold Palmer Pavilion Greensburg Pennsylvania United States 15601
    353 UPMC Pinnacle Cancer Center/Community Osteopathic Campus Harrisburg Pennsylvania United States 17109
    354 Penn State Milton S Hershey Medical Center Hershey Pennsylvania United States 17033-0850
    355 IRMC Cancer Center Indiana Pennsylvania United States 15701
    356 Jefferson Hospital Jefferson Hills Pennsylvania United States 15025
    357 UPMC-Johnstown/John P. Murtha Regional Cancer Center Johnstown Pennsylvania United States 15901
    358 Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania United States 17837
    359 UPMC Cancer Center at UPMC McKeesport McKeesport Pennsylvania United States 15132
    360 Forbes Hospital Monroeville Pennsylvania United States 15146
    361 UPMC Cancer Center - Monroeville Monroeville Pennsylvania United States 15146
    362 UPMC-Coraopolis/Heritage Valley Radiation Oncology Moon Pennsylvania United States 15108
    363 UPMC Hillman Cancer Center - Part of Frick Hospital Mount Pleasant Pennsylvania United States 15666
    364 Arnold Palmer Cancer Center Medical Oncology Norwin N. Huntingdon Pennsylvania United States 15642
    365 Allegheny Valley Hospital Natrona Heights Pennsylvania United States 15065
    366 University of Pennsylvania/Abramson Cancer Center Philadelphia Pennsylvania United States 19104
    367 Allegheny General Hospital Pittsburgh Pennsylvania United States 15212
    368 UPMC-Magee Womens Hospital Pittsburgh Pennsylvania United States 15213
    369 UPMC-Saint Margaret Pittsburgh Pennsylvania United States 15215
    370 West Penn Hospital Pittsburgh Pennsylvania United States 15224
    371 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh Pennsylvania United States 15232
    372 UPMC-Shadyside Hospital Pittsburgh Pennsylvania United States 15232
    373 UPMC-Passavant Hospital Pittsburgh Pennsylvania United States 15237
    374 UPMC-Saint Clair Hospital Cancer Center Pittsburgh Pennsylvania United States 15243
    375 Pottstown Hospital Pottstown Pennsylvania United States 19464
    376 UPMC Cancer Center at UPMC Northwest Seneca Pennsylvania United States 16346
    377 UPMC Cancer Center-Uniontown Uniontown Pennsylvania United States 15401
    378 UPMC Uniontown Hospital Radiation Oncology Uniontown Pennsylvania United States 15401
    379 UPMC Cancer Center-Washington Washington Pennsylvania United States 15301
    380 UPMC Washington Hospital Radiation Oncology Washington Pennsylvania United States 15301
    381 UPMC West Mifflin-Cancer Center Jefferson West Mifflin Pennsylvania United States 15122
    382 Reading Hospital West Reading Pennsylvania United States 19611
    383 Wexford Health and Wellness Pavilion Wexford Pennsylvania United States 15090
    384 UPMC Memorial York Pennsylvania United States 17408
    385 Newport Hospital Newport Rhode Island United States 02840
    386 Rhode Island Hospital Providence Rhode Island United States 02903
    387 Medical University of South Carolina Charleston South Carolina United States 29425
    388 Saint Francis Hospital Greenville South Carolina United States 29601
    389 Saint Francis Cancer Center Greenville South Carolina United States 29607
    390 Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota United States 57104
    391 Avera Cancer Institute Sioux Falls South Dakota United States 57105
    392 Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota United States 57117-5134
    393 Baptist Memorial Hospital and Cancer Center-Collierville Collierville Tennessee United States 38017
    394 Baptist Memorial Hospital and Cancer Center-Memphis Memphis Tennessee United States 38120
    395 Vanderbilt University/Ingram Cancer Center Nashville Tennessee United States 37232
    396 Saint Joseph Regional Cancer Center Bryan Texas United States 77802
    397 Parkland Memorial Hospital Dallas Texas United States 75235
    398 UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas United States 75390
    399 UT Southwestern/Simmons Cancer Center-Fort Worth Fort Worth Texas United States 76104
    400 UT Southwestern Clinical Center at Richardson/Plano Richardson Texas United States 75080
    401 University of Utah Sugarhouse Health Center Salt Lake City Utah United States 84106
    402 Huntsman Cancer Institute/University of Utah Salt Lake City Utah United States 84112
    403 Central Vermont Medical Center/National Life Cancer Treatment Berlin Vermont United States 05602
    404 University of Vermont Medical Center Burlington Vermont United States 05401
    405 University of Vermont and State Agricultural College Burlington Vermont United States 05405
    406 Norris Cotton Cancer Center-North Saint Johnsbury Vermont United States 05819
    407 University of Virginia Cancer Center Charlottesville Virginia United States 22908
    408 Virginia Cancer Institute Richmond Virginia United States 23229
    409 Virginia Commonwealth University/Massey Cancer Center Richmond Virginia United States 23298
    410 VCU Community Memorial Health Center South Hill Virginia United States 23970
    411 Providence Regional Cancer System-Aberdeen Aberdeen Washington United States 98520
    412 Overlake Medical Center Bellevue Washington United States 98004
    413 PeaceHealth Saint Joseph Medical Center Bellingham Washington United States 98225
    414 Harrison HealthPartners Hematology and Oncology-Bremerton Bremerton Washington United States 98310
    415 Harrison Medical Center Bremerton Washington United States 98310
    416 Highline Medical Center-Main Campus Burien Washington United States 98166
    417 Providence Regional Cancer System-Centralia Centralia Washington United States 98531
    418 Swedish Cancer Institute-Edmonds Edmonds Washington United States 98026
    419 Providence Regional Cancer Partnership Everett Washington United States 98201
    420 Swedish Cancer Institute-Issaquah Issaquah Washington United States 98029
    421 Providence Regional Cancer System-Lacey Lacey Washington United States 98503
    422 PeaceHealth Saint John Medical Center Longview Washington United States 98632
    423 Valley Medical Center Renton Washington United States 98055
    424 Swedish Medical Center-Ballard Campus Seattle Washington United States 98107
    425 Swedish Medical Center-First Hill Seattle Washington United States 98122-4307
    426 PeaceHealth United General Medical Center Sedro-Woolley Washington United States 98284
    427 Northwest Medical Specialties PLLC Tacoma Washington United States 98405
    428 PeaceHealth Southwest Medical Center Vancouver Washington United States 98664
    429 Providence Saint Mary Regional Cancer Center Walla Walla Washington United States 99362
    430 North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima Washington United States 98902
    431 United Hospital Center Bridgeport West Virginia United States 26330
    432 West Virginia University Charleston Division Charleston West Virginia United States 25304
    433 West Virginia University Healthcare Morgantown West Virginia United States 26506
    434 Camden Clark Medical Center Parkersburg West Virginia United States 26101
    435 ThedaCare Regional Cancer Center Appleton Wisconsin United States 54911
    436 Duluth Clinic Ashland Ashland Wisconsin United States 54806
    437 Northwest Wisconsin Cancer Center Ashland Wisconsin United States 54806
    438 Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin United States 53105
    439 Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin United States 54701
    440 Aurora Health Center-Fond du Lac Fond Du Lac Wisconsin United States 54937
    441 Aurora Health Care Germantown Health Center Germantown Wisconsin United States 53022
    442 Aurora Cancer Care-Grafton Grafton Wisconsin United States 53024
    443 Bellin Memorial Hospital Green Bay Wisconsin United States 54301
    444 Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin United States 54301
    445 Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay Wisconsin United States 54303
    446 Aurora BayCare Medical Center Green Bay Wisconsin United States 54311
    447 Essentia Health-Hayward Clinic Hayward Wisconsin United States 54843
    448 UW Cancer Center Johnson Creek Johnson Creek Wisconsin United States 53038
    449 Aurora Cancer Care-Kenosha South Kenosha Wisconsin United States 53142
    450 University of Wisconsin Carbone Cancer Center Madison Wisconsin United States 53792
    451 Aurora Bay Area Medical Group-Marinette Marinette Wisconsin United States 54143
    452 Marshfield Medical Center-Marshfield Marshfield Wisconsin United States 54449
    453 Aurora Cancer Care-Milwaukee Milwaukee Wisconsin United States 53209
    454 Aurora Saint Luke's Medical Center Milwaukee Wisconsin United States 53215
    455 Aurora Sinai Medical Center Milwaukee Wisconsin United States 53233
    456 Marshfield Clinic-Minocqua Center Minocqua Wisconsin United States 54548
    457 Cancer Center of Western Wisconsin New Richmond Wisconsin United States 54017
    458 Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin United States 54904
    459 Aurora Cancer Care-Racine Racine Wisconsin United States 53406
    460 Marshfield Medical Center-Rice Lake Rice Lake Wisconsin United States 54868
    461 Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin United States 53081
    462 Essentia Health-Spooner Clinic Spooner Wisconsin United States 54801
    463 Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin United States 54482
    464 Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay Wisconsin United States 54235-1495
    465 Aurora Medical Center in Summit Summit Wisconsin United States 53066
    466 Essentia Health Saint Mary's Hospital - Superior Superior Wisconsin United States 54880
    467 Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin United States 54241
    468 Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin United States 53226
    469 Aurora West Allis Medical Center West Allis Wisconsin United States 53227
    470 Marshfield Medical Center - Weston Weston Wisconsin United States 54476

    Sponsors and Collaborators

    • National Cancer Institute (NCI)

    Investigators

    • Principal Investigator: Jennifer R Eads, ECOG-ACRIN Cancer Research Group

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    National Cancer Institute (NCI)
    ClinicalTrials.gov Identifier:
    NCT03604991
    Other Study ID Numbers:
    • NCI-2018-01575
    • NCI-2018-01575
    • EA2174
    • EA2174
    • U10CA180820
    First Posted:
    Jul 30, 2018
    Last Update Posted:
    Aug 25, 2022
    Last Verified:
    Apr 1, 2022
    Individual Participant Data (IPD) Sharing Statement:
    Yes
    Plan to Share IPD:
    Yes
    Studies a U.S. FDA-regulated Drug Product:
    Yes
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Aug 25, 2022