Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery
Study Details
Study Description
Brief Summary
This phase II/III trial studies the usefulness of treatment with nivolumab and ipilimumab in addition to standard of care chemotherapy and radiation therapy in patients with esophageal and gastroesophageal junction adenocarcinoma who are undergoing surgery. Immunotherapy with antibodies, such as nivolumab and ipilimumab, may remove the brake on the body's immune system and may interfere with the ability of tumor cells to grow and spread. Chemotherapy and radiation therapy may reduce the tumor size and the amount of normal tissue that needs to be removed during surgery. A combined treatment with nivolumab and ipilimumab, chemotherapy, and radiation therapy might be more effective in patients with esophageal and gastroesophageal junction adenocarcinoma who are undergoing surgery.
Detailed Description
PRIMARY OBJECTIVES:
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To assess the pathologic complete response rate (pathCR) rate following administration of neoadjuvant carboplatin, paclitaxel and radiation therapy versus neoadjuvant carboplatin, paclitaxel, radiation therapy and nivolumab in patients with a resected locoregionally advanced esophageal or gastroesophageal junction adenocarcinoma.
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To assess the disease-free survival (DFS) following administration of adjuvant nivolumab and ipilimumab versus adjuvant nivolumab in patients with a resected locoregionally advanced esophageal or gastroesophageal junction adenocarcinoma who received neoadjuvant treatment with carboplatin, paclitaxel and radiation therapy with or without nivolumab.
SECONDARY OBJECTIVES:
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To assess the overall survival (OS) following administration of adjuvant nivolumab and ipilimumab versus nivolumab in patients with a resected locoregional esophageal or gastroesophageal junctional adenocarcinoma who received neoadjuvant treatment with carboplatin, paclitaxel and radiation therapy with or without nivolumab.
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To assess the disease free survival (DFS) following administration of neoadjuvant carboplatin, paclitaxel, and radiation therapy with or without nivolumab in patients with a locoregional esophageal or gastroesophageal junction adenocarcinoma III. To assess the toxicity associated with the administration of neoadjuvant nivolumab in combination with carboplatin, paclitaxel and radiation therapy in patients with a locoregional esophageal or gastroesophageal junction adenocarcinoma.
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To assess the toxicity associated with the administration of adjuvant nivolumab and ipilimumab versus adjuvant nivolumab in patients with a resected locoregional esophageal or gastroesophageal junction adenocarcinoma who received neoadjuvant treatment with carboplatin, paclitaxel and radiation therapy with or without nivolumab.
IMAGING OBJECTIVES:
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To determine if the percent change in mean volumetric apparent diffusion coefficient (ADC), measured from pre-treatment to mid-treatment, is predictive of pathCR in patients with a locoregional esophageal or gastroesophageal junctional adenocarcinoma undergoing chemo and chemoradiotherapy plus (+)/minus (-) nivolumab.
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To identify an optimal delta ADC cutoff in predicting pathCR.
OUTLINE:
STEP I: Patients are randomized to 1 of 2 arms.
ARM A: Patients receive carboplatin intravenously (IV) and paclitaxel IV once weekly and undergo radiation therapy once daily (Monday-Friday) beginning on day 1. Cycles repeat every week for up to 5 weeks in the absence of disease progression or unacceptable toxicity.
ARM B: Patients receive carboplatin, paclitaxel, and radiation therapy as in Arm A. Patients also receive nivolumab IV over 30 minutes on days 1 and 15. Cycles repeat every week for up to 5 weeks in the absence of disease progression or unacceptable toxicity.
STEP II: Patients are randomized to 1 of 2 arms following standard of care surgery.
ARM C: Patients receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 2 weeks for up to 12 cycles in the absence of disease progression or unacceptable toxicity.
ARM D: Patients receive nivolumab as in Arm C and receive ipilimumab IV over 90 minutes on day 1 of cycles 1, 4, 7, and 10. Treatment repeats every 2 weeks for up to 12 cycles in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for 2 years, and then every 6 months for up to 5 years.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Arm A (carboplatin, paclitaxel, radiation therapy) Patients receive carboplatin IV and paclitaxel IV once weekly and undergo radiation therapy once daily (Monday-Friday) beginning on day 1. Cycles repeat every week for up to 5 weeks in the absence of disease progression or unacceptable toxicity. |
Drug: Carboplatin
Given IV
Other Names:
Drug: Paclitaxel
Given IV
Other Names:
Radiation: Radiation Therapy
Undergo radiation therapy
Other Names:
|
Experimental: Arm B (carboplatin, paclitaxel, radiation therapy, nivolumab) Patients receive carboplatin, paclitaxel, and radiation therapy as in Arm A. Patients also receive nivolumab IV over 30 minutes on days 1 and 15. Cycles repeat every week for up to 5 weeks in the absence of disease progression or unacceptable toxicity. |
Drug: Carboplatin
Given IV
Other Names:
Biological: Nivolumab
Given IV
Other Names:
Drug: Paclitaxel
Given IV
Other Names:
Radiation: Radiation Therapy
Undergo radiation therapy
Other Names:
|
Experimental: Arm C (nivolumab) Patients receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 2 weeks for up to 12 cycles in the absence of disease progression or unacceptable toxicity. |
Biological: Nivolumab
Given IV
Other Names:
|
Experimental: Arm D (nivolumab, ipilimumab) Patients receive nivolumab as in Arm C and receive ipilimumab IV over 90 minutes on day 1 of cycles 1, 4, 7, and 10. Treatment repeats every 2 weeks for up to 12 cycles in the absence of disease progression or unacceptable toxicity. |
Biological: Ipilimumab
Given IV
Other Names:
Biological: Nivolumab
Given IV
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Pathologic complete response (Step I) [Up to 5 weeks]
The study with compare the pathologic complete response of Arm A and Arm B using a one-sided 0.10 level chi-squared test for proportions.
- Disease-free survival (DFS) (Step 2) [From the adjuvant treatment randomization assessed for up to 7 years]
DFS measured from the adjuvant treatment randomization will be the endpoint of the adjuvant portion of the study and to achieve the desired power it is expected that patients will be followed for an additional year post completion of accrual to the adjuvant portion. The DFS comparison will be between patients randomized to Arm C (nivolumab) versus Arm D (nivolumab plus ipilimumab) using a one-sided 0.10 level stratified log rank test.
Secondary Outcome Measures
- Incidence of adverse events [Up to 7 years]
Graded according to Common Terminology Criteria for Adverse Events version 5.0. Toxicity will be evaluated among all treated patients regardless of eligibility and interim analyses of toxicity are performed twice yearly. The study will have sufficient precision to provide 95% confidence intervals on toxicity
- Overall survival [From the time of first randomization up to 7 years]
Analyses will be descriptive in nature and will not follow any formal interim monitoring.
- DFS [From the time of first randomization up to 7 years]
The DFS comparison will be between patients randomized to Arm C (nivolumab) versus Arm D (nivolumab plus ipilimumab) using a one-sided 0.10 level stratified log rank test.
Other Outcome Measures
- Percent change in mean volumetric apparent diffusion coefficient (ADC) [Baseline to mid-treatment]
The study will assess the area under the receiver operating characteristic curve of the changes of ADC value.
Eligibility Criteria
Criteria
Inclusion Criteria:
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STEP 1: Patients must have histologically confirmed T1N1-3M0 or T2-3N0-2M0 esophageal or gastroesophageal junctional adenocarcinoma (Siewert I and II)
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STEP 1: Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1
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STEP 1: Patents must be deemed a surgical candidate by a thoracic surgeon, surgical oncologist, or surgeon who is qualified to perform an esophagectomy
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STEP 1: Absolute neutrophil count >= 1,500/mcL (within less than or equal to 14 days prior to randomization)
-
STEP 1: Platelets >= 100,000/mcL (within less than or equal to 14 days prior to randomization)
-
STEP 1: Total bilirubin =< institutional upper limit of normal (ULN) (within less than or equal to 14 days prior to randomization)
-
STEP 1: Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN (within less than or equal to 14 days prior to randomization)
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STEP 1: Serum creatinine =< 1.5 x institutional ULN (within less than or equal to 14 days prior to randomization)
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STEP 1: Hemoglobin (Hgb) >= 9 g/dL (within less than or equal to 14 days prior to randomization)
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STEP 1: Leukocytes >= 3,000/mm^3 (within less than or equal to 14 days prior to randomization)
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STEP 1: Patients may not have received prior chemotherapy or radiation therapy for management for this malignancy
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STEP 1: Patients may not have received prior immunotherapy for management of this malignancy or for any other past malignancy
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STEP 1: Patients must have no contraindication to receiving either carboplatin or paclitaxel chemotherapy
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STEP 1: Patients must have no contraindication to receiving radiation therapy
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STEP 1: Patients with active autoimmune disease or history of autoimmune disease that might recur, which may affect vital organ function or require immune suppressive treatment including systemic corticosteroids, should be excluded. These include but are not limited to patients with a history of immune related neurologic disease, multiple sclerosis, autoimmune (demyelinating) neuropathy, Guillain-Barre syndrome, myasthenia gravis; systemic autoimmune disease such as systemic lupus erythematosus (SLE), connective tissue disease, scleroderma, inflammatory bowel disease (IBD), Crohn's, ulcerative colitis, hepatitis; and patients with a history of toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome, or phospholipid syndrome should be excluded because of the risk of recurrence or exacerbation of disease. Patients with vitiligo, endocrine deficiencies including thyroiditis managed with replacement hormones including physiologic corticosteroids are eligible. Patients with rheumatoid arthritis and other arthropathies, Sjogren's syndrome and psoriasis controlled with topical medication and patients with positive serology, such as antinuclear antibodies (ANA), anti-thyroid antibodies should be evaluated for the presence of target organ involvement and potential need for systemic treatment but should otherwise be eligible
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STEP 1: Patients are permitted to enroll if they have vitiligo, type I diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger (precipitating event)
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STEP 1: Patient must NOT have previous or concurrent malignancy. Exceptions are made for patients who meet any of the following conditions:
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Non-melanoma skin cancer, in situ cervical cancer, superficial bladder cancer, or breast cancer in situ OR
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Prior malignancy completely excised or removed and patient has been continuously disease free for > 5 years OR
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Prior malignancy completely excised or removed and patient has been continuously disease free for > 5 years
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Date of last evidence of disease
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STEP 1: Patients must not have a condition requiring systemic treatment with either corticosteroids (> 10 mg/day prednisone equivalents) or other immunosuppressive medications within 14 days of study drug administration. Inhaled or topical steroids and adrenal replacement doses =< 10 mg/day prednisone equivalents are permitted in the absence of active autoimmune disease
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STEP 1: Adequate cardiac function including electrocardiogram (EKG) and echocardiogram for any patient with a history of congestive heart failure (CHF) or at risk because of underlying cardiovascular disease or exposure to cardiotoxic drugs
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STEP 1: For patients with evidence of CHF, myocardial infarction (MI), cardiomyopathy, or myositis, cardiac evaluation including lab tests and cardiology consultations including EKG, creatine phosphokinase (CPK), troponin, and echocardiogram
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STEP 1: Patients must not have a positive test result for hepatitis B virus surface antigen (HBV sAg) or hepatitis C virus ribonucleic acid (HCV RNA) indicating acute or chronic infection. Testing should be conducted to determine eligibility
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STEP 1: Patients with a known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) must have no detectable viral load on a stable anti-viral regimen
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STEP 1: Patients must not be receiving any other investigational agents
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STEP 1: Patients with an uncontrolled intercurrent illness such as ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia or psychiatric illness/social situations that would limit compliance with study requirements will be excluded
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STEP 1: Women must not be pregnant or breast-feeding due to potential harm to the fetus from carboplatin, paclitaxel, or nivolumab. All females of childbearing potential must have a blood test or urine study done within 2 weeks prior to registration to rule out pregnancy. Those enrolled on Arm B with nivolumab must agree to have a pregnancy test (minimum sensitivity 25 IU/L or equivalent units of human chorionic gonadotropin [HCG]) within 24 hours of starting nivolumab to rule out pregnancy. A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
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STEP 1: Women of childbearing potential (WOCBP) and sexually active males must either abstain from sexual intercourse for the duration of their participation in the study or agree to use both double barrier contraception and birth control pills or implants for at least one month (female patients) or one week (male patients) prior to the start of the study drug and continuing for 5 months after the last dose of study drug (for female patients) and for 7 months after the last dose of study drug (for male patients who are sexually active with WOCBP). Investigators shall counsel WOCBP and male subjects who are sexually active with WOCBP on the importance of pregnancy prevention and the implications of an unexpected pregnancy
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STEP 1: If patient says 'Yes' to "I choose to take part in the imaging study and will have the diffusion weighted magnetic resonance imaging (MRI) scans": patients must be able to tolerate MRI scans:
-
No history of untreatable claustrophobia
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No magnetic resonance (MR) incompatible implants/devices or metallic foreign bodies
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Weight compatible with limits imposed by the MRI scanner table
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STEP 2: Patient registration must not exceed 12 weeks from time of esophagectomy
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STEP 2: Patients must have a post-operative ECOG performance status of 0-2
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STEP 2: Absolute neutrophil count >= 1,500/mcL (within less than or equal to 14 days prior to randomization)
-
STEP 2: Platelets >= 100,000/mcL (within less than or equal to 14 days prior to randomization)
-
STEP 2: Total bilirubin =< institutional upper limit of normal (ULN) (within less than or equal to 14 days prior to randomization)
-
STEP 2: AST (SGOT)/ ALT (SGPT) =< 2.5 x institutional ULN (within less than or equal to 14 days prior to randomization)
-
STEP 2: Serum creatinine =< 1.5 x institutional ULN (within less than or equal to 14 days prior to randomization)
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STEP 2: Patients must be disease free following esophagectomy as is demonstrated by having no evidence of disease on a post-surgical computed tomography (CT) scan. Patients must also have a negative surgical margin (R0 resection)
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STEP 2: Patients must not have an active, known or suspected autoimmune disease or a condition requiring treatment with steroids or immunosuppressive agents. Patients are permitted to enroll if they have vitiligo, type I diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger
-
STEP 2: Patients must not have a condition requiring systemic treatment with either corticosteroids (> 10 mg/day prednisone equivalents) or other immunosuppressive medications with 14 days of study drug administration. Inhaled or topical steroids and adrenal replacement doses > 10 mg/day prednisone equivalents are permitted in the absence of active autoimmune disease
-
STEP 2: Patients must not be receiving any other investigational agents
-
STEP 2: Patients with an uncontrolled intercurrent illness such as ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia or psychiatric illness/social situations that would limit compliance with study requirements will be excluded
-
STEP 2: Women must not be pregnant or breast-feeding due to potential harm to the fetus from nivolumab or ipilimumab. All females of childbearing potential must have a blood test or urine study done (minimum sensitivity 25 IU/L or equivalent units of HCG) within 2 weeks prior to registration to rule out pregnancy. All patients must also agree to have a pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 24 hours of starting nivolumab to rule out pregnancy. Those enrolled on Arm D with ipilimumab must agree to have pregnancy tests within 72 hours of each ipilimumab administration to rule out pregnancy
-
STEP 2: Women of childbearing potential (WOCBP) and sexually active males must either abstain from sexual intercourse for the duration of their participation in the study or agree to use both double barrier contraception and birth control pills or implants for at least one month (female patients) or one week (male patients) prior to the start of the study drug and continuing for 5 months after the last dose of study drug (for female patients) and for 7 months after the last dose of study drug (for male patients who are sexually active with WOCBP). Investigators shall counsel WOCBP and male subjects who are sexually active with WOCBP on the importance of pregnancy prevention and the implications of an unexpected pregnancy
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Anchorage Associates in Radiation Medicine | Anchorage | Alaska | United States | 98508 |
2 | Alaska Breast Care and Surgery LLC | Anchorage | Alaska | United States | 99508 |
3 | Alaska Oncology and Hematology LLC | Anchorage | Alaska | United States | 99508 |
4 | Alaska Women's Cancer Care | Anchorage | Alaska | United States | 99508 |
5 | Anchorage Oncology Centre | Anchorage | Alaska | United States | 99508 |
6 | Katmai Oncology Group | Anchorage | Alaska | United States | 99508 |
7 | Providence Alaska Medical Center | Anchorage | Alaska | United States | 99508 |
8 | Cancer Center at Saint Joseph's | Phoenix | Arizona | United States | 85004 |
9 | Mercy Hospital Fort Smith | Fort Smith | Arkansas | United States | 72903 |
10 | CHI Saint Vincent Cancer Center Hot Springs | Hot Springs | Arkansas | United States | 71913 |
11 | NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro | Arkansas | United States | 72401 |
12 | PCR Oncology | Arroyo Grande | California | United States | 93420 |
13 | Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | United States | 91505 |
14 | Community Cancer Institute | Clovis | California | United States | 93611 |
15 | University Oncology Associates | Clovis | California | United States | 93611 |
16 | Los Angeles County-USC Medical Center | Los Angeles | California | United States | 90033 |
17 | USC / Norris Comprehensive Cancer Center | Los Angeles | California | United States | 90033 |
18 | Stanford Cancer Institute Palo Alto | Palo Alto | California | United States | 94304 |
19 | VA Palo Alto Health Care System | Palo Alto | California | United States | 94304 |
20 | University of California Davis Comprehensive Cancer Center | Sacramento | California | United States | 95817 |
21 | Saint Helena Hospital | Saint Helena | California | United States | 94574 |
22 | Pacific Central Coast Health Center-San Luis Obispo | San Luis Obispo | California | United States | 93401 |
23 | Mission Hope Medical Oncology - Santa Maria | Santa Maria | California | United States | 93444 |
24 | Presbyterian Intercommunity Hospital | Whittier | California | United States | 90602 |
25 | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | United States | 80907 |
26 | Rocky Mountain Cancer Centers-Penrose | Colorado Springs | Colorado | United States | 80907 |
27 | Saint Francis Cancer Center | Colorado Springs | Colorado | United States | 80923 |
28 | Porter Adventist Hospital | Denver | Colorado | United States | 80210 |
29 | Saint Anthony Hospital | Lakewood | Colorado | United States | 80228 |
30 | Littleton Adventist Hospital | Littleton | Colorado | United States | 80122 |
31 | Longmont United Hospital | Longmont | Colorado | United States | 80501 |
32 | Parker Adventist Hospital | Parker | Colorado | United States | 80138 |
33 | Saint Mary Corwin Medical Center | Pueblo | Colorado | United States | 81004 |
34 | Beebe South Coastal Health Campus | Frankford | Delaware | United States | 19945 |
35 | Beebe Medical Center | Lewes | Delaware | United States | 19958 |
36 | Delaware Clinical and Laboratory Physicians PA | Newark | Delaware | United States | 19713 |
37 | Helen F Graham Cancer Center | Newark | Delaware | United States | 19713 |
38 | Medical Oncology Hematology Consultants PA | Newark | Delaware | United States | 19713 |
39 | Christiana Care Health System-Christiana Hospital | Newark | Delaware | United States | 19718 |
40 | Beebe Health Campus | Rehoboth Beach | Delaware | United States | 19971 |
41 | TidalHealth Nanticoke / Allen Cancer Center | Seaford | Delaware | United States | 19973 |
42 | AdventHealth Altamonte | Altamonte Springs | Florida | United States | 32701 |
43 | Mount Sinai Comprehensive Cancer Center at Aventura | Aventura | Florida | United States | 33180 |
44 | Holy Cross Hospital | Fort Lauderdale | Florida | United States | 33308 |
45 | Regional Cancer Center-Lee Memorial Health System | Fort Myers | Florida | United States | 33905 |
46 | University of Florida Health Science Center - Gainesville | Gainesville | Florida | United States | 32610 |
47 | AdventHealth Kissimmee | Kissimmee | Florida | United States | 34744 |
48 | Mount Sinai Medical Center | Miami Beach | Florida | United States | 33140 |
49 | AdventHealth Orlando | Orlando | Florida | United States | 32803 |
50 | AdventHealth East Orlando | Orlando | Florida | United States | 32822 |
51 | Emory Proton Therapy Center | Atlanta | Georgia | United States | 30308 |
52 | Emory University Hospital Midtown | Atlanta | Georgia | United States | 30308 |
53 | Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | United States | 30322 |
54 | Emory Saint Joseph's Hospital | Atlanta | Georgia | United States | 30342 |
55 | Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | United States | 31405 |
56 | Hawaii Cancer Care - Savio | 'Aiea | Hawaii | United States | 96701 |
57 | Pali Momi Medical Center | 'Aiea | Hawaii | United States | 96701 |
58 | Queen's Cancer Center - Pearlridge | 'Aiea | Hawaii | United States | 96701 |
59 | The Cancer Center of Hawaii-Pali Momi | 'Aiea | Hawaii | United States | 96701 |
60 | Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii | United States | 96813 |
61 | Island Urology | Honolulu | Hawaii | United States | 96813 |
62 | Queen's Cancer Cenrer - POB I | Honolulu | Hawaii | United States | 96813 |
63 | Queen's Medical Center | Honolulu | Hawaii | United States | 96813 |
64 | Straub Clinic and Hospital | Honolulu | Hawaii | United States | 96813 |
65 | University of Hawaii Cancer Center | Honolulu | Hawaii | United States | 96813 |
66 | Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii | United States | 96817 |
67 | Kuakini Medical Center | Honolulu | Hawaii | United States | 96817 |
68 | Queen's Cancer Center - Kuakini | Honolulu | Hawaii | United States | 96817 |
69 | The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii | United States | 96817 |
70 | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | United States | 96826 |
71 | Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii | United States | 96766 |
72 | Saint Luke's Cancer Institute - Boise | Boise | Idaho | United States | 83712 |
73 | Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | United States | 83619 |
74 | Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | United States | 83642 |
75 | Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | United States | 83686 |
76 | Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho | United States | 83301 |
77 | Illinois CancerCare-Bloomington | Bloomington | Illinois | United States | 61704 |
78 | Illinois CancerCare-Canton | Canton | Illinois | United States | 61520 |
79 | Memorial Hospital of Carbondale | Carbondale | Illinois | United States | 62902 |
80 | SIH Cancer Institute | Carterville | Illinois | United States | 62918 |
81 | Illinois CancerCare-Carthage | Carthage | Illinois | United States | 62321 |
82 | Centralia Oncology Clinic | Centralia | Illinois | United States | 62801 |
83 | Northwestern University | Chicago | Illinois | United States | 60611 |
84 | University of Illinois | Chicago | Illinois | United States | 60612 |
85 | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | United States | 62526 |
86 | Decatur Memorial Hospital | Decatur | Illinois | United States | 62526 |
87 | Illinois CancerCare-Dixon | Dixon | Illinois | United States | 61021 |
88 | Crossroads Cancer Center | Effingham | Illinois | United States | 62401 |
89 | Illinois CancerCare-Eureka | Eureka | Illinois | United States | 61530 |
90 | Illinois CancerCare-Galesburg | Galesburg | Illinois | United States | 61401 |
91 | Western Illinois Cancer Treatment Center | Galesburg | Illinois | United States | 61401 |
92 | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | United States | 61443 |
93 | Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | United States | 60045 |
94 | Illinois CancerCare-Macomb | Macomb | Illinois | United States | 61455 |
95 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
96 | Good Samaritan Regional Health Center | Mount Vernon | Illinois | United States | 62864 |
97 | Cancer Care Center of O'Fallon | O'Fallon | Illinois | United States | 62269 |
98 | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | United States | 61350 |
99 | Illinois CancerCare-Pekin | Pekin | Illinois | United States | 61554 |
100 | OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin | Illinois | United States | 61554 |
101 | Illinois CancerCare-Peoria | Peoria | Illinois | United States | 61615 |
102 | OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois | United States | 61615 |
103 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
104 | OSF Saint Francis Medical Center | Peoria | Illinois | United States | 61637 |
105 | Illinois CancerCare-Peru | Peru | Illinois | United States | 61354 |
106 | Valley Radiation Oncology | Peru | Illinois | United States | 61354 |
107 | Illinois CancerCare-Princeton | Princeton | Illinois | United States | 61356 |
108 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62702 |
109 | Springfield Clinic | Springfield | Illinois | United States | 62702 |
110 | Memorial Medical Center | Springfield | Illinois | United States | 62781 |
111 | Illinois CancerCare - Washington | Washington | Illinois | United States | 61571 |
112 | IU Health North Hospital | Carmel | Indiana | United States | 46032 |
113 | Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | United States | 46202 |
114 | Reid Health | Richmond | Indiana | United States | 47374 |
115 | Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa | United States | 50325 |
116 | Mercy Cancer Center-West Lakes | Clive | Iowa | United States | 50325 |
117 | Greater Regional Medical Center | Creston | Iowa | United States | 50801 |
118 | Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa | United States | 50314 |
119 | Mercy Medical Center - Des Moines | Des Moines | Iowa | United States | 50314 |
120 | Mercy Medical Center-West Lakes | West Des Moines | Iowa | United States | 50266 |
121 | Central Care Cancer Center - Garden City | Garden City | Kansas | United States | 67846 |
122 | Central Care Cancer Center - Great Bend | Great Bend | Kansas | United States | 67530 |
123 | Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky | United States | 40504 |
124 | Saint Joseph Hospital East | Lexington | Kentucky | United States | 40509 |
125 | Jewish Hospital | Louisville | Kentucky | United States | 40202 |
126 | UofL Health Medical Center Northeast | Louisville | Kentucky | United States | 40245 |
127 | Ochsner Medical Center Kenner | Kenner | Louisiana | United States | 70065 |
128 | Ochsner Medical Center Jefferson | New Orleans | Louisiana | United States | 70121 |
129 | Eastern Maine Medical Center | Bangor | Maine | United States | 04401 |
130 | MaineHealth Coastal Cancer Treatment Center | Bath | Maine | United States | 04530 |
131 | MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford | Biddeford | Maine | United States | 04005 |
132 | Lafayette Family Cancer Center-EMMC | Brewer | Maine | United States | 04412 |
133 | Maine Medical Center-Bramhall Campus | Portland | Maine | United States | 04102 |
134 | MaineHealth Cancer Care Center of York County | Sanford | Maine | United States | 04073 |
135 | MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford | Sanford | Maine | United States | 04073 |
136 | Maine Medical Center- Scarborough Campus | Scarborough | Maine | United States | 04074 |
137 | Maine Medical Partners - South Portland | South Portland | Maine | United States | 04106 |
138 | Tufts Medical Center | Boston | Massachusetts | United States | 02111 |
139 | Boston Medical Center | Boston | Massachusetts | United States | 02118 |
140 | Lowell General Hospital | Lowell | Massachusetts | United States | 01854 |
141 | Saint Joseph Mercy Hospital | Ann Arbor | Michigan | United States | 48106 |
142 | Saint Joseph Mercy Brighton | Brighton | Michigan | United States | 48114 |
143 | Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Michigan | United States | 48114 |
144 | Saint Joseph Mercy Canton | Canton | Michigan | United States | 48188 |
145 | Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Michigan | United States | 48188 |
146 | Caro Cancer Center | Caro | Michigan | United States | 48723 |
147 | Saint Joseph Mercy Chelsea | Chelsea | Michigan | United States | 48118 |
148 | Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Michigan | United States | 48118 |
149 | Ascension Saint John Hospital | Detroit | Michigan | United States | 48236 |
150 | Genesys Hurley Cancer Institute | Flint | Michigan | United States | 48503 |
151 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
152 | Sparrow Hospital | Lansing | Michigan | United States | 48912 |
153 | Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | United States | 48154 |
154 | Saint Mary's Oncology/Hematology Associates of Marlette | Marlette | Michigan | United States | 48453 |
155 | 21st Century Oncology-Pontiac | Pontiac | Michigan | United States | 48341 |
156 | Saint Joseph Mercy Oakland | Pontiac | Michigan | United States | 48341 |
157 | Ascension Saint Mary's Hospital | Saginaw | Michigan | United States | 48601 |
158 | Oncology Hematology Associates of Saginaw Valley PC | Saginaw | Michigan | United States | 48604 |
159 | Ascension Saint Joseph Hospital | Tawas City | Michigan | United States | 48764 |
160 | Saint John Macomb-Oakland Hospital | Warren | Michigan | United States | 48093 |
161 | Saint Mary's Oncology/Hematology Associates of West Branch | West Branch | Michigan | United States | 48661 |
162 | Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus | Ypsilanti | Michigan | United States | 48197 |
163 | Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | United States | 56601 |
164 | Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota | United States | 56401 |
165 | Fairview Ridges Hospital | Burnsville | Minnesota | United States | 55337 |
166 | Minnesota Oncology - Burnsville | Burnsville | Minnesota | United States | 55337 |
167 | Mercy Hospital | Coon Rapids | Minnesota | United States | 55433 |
168 | Essentia Health - Deer River Clinic | Deer River | Minnesota | United States | 56636 |
169 | Essentia Health Saint Mary's - Detroit Lakes Clinic | Detroit Lakes | Minnesota | United States | 56501 |
170 | Essentia Health Cancer Center | Duluth | Minnesota | United States | 55805 |
171 | Essentia Health Saint Mary's Medical Center | Duluth | Minnesota | United States | 55805 |
172 | Miller-Dwan Hospital | Duluth | Minnesota | United States | 55805 |
173 | Fairview Southdale Hospital | Edina | Minnesota | United States | 55435 |
174 | Lake Region Healthcare Corporation-Cancer Care | Fergus Falls | Minnesota | United States | 56537 |
175 | Essentia Health - Fosston | Fosston | Minnesota | United States | 56542 |
176 | Unity Hospital | Fridley | Minnesota | United States | 55432 |
177 | Essentia Health Hibbing Clinic | Hibbing | Minnesota | United States | 55746 |
178 | Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Minnesota | United States | 55369 |
179 | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | United States | 55109 |
180 | Saint John's Hospital - Healtheast | Maplewood | Minnesota | United States | 55109 |
181 | Abbott-Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
182 | Hennepin County Medical Center | Minneapolis | Minnesota | United States | 55415 |
183 | Health Partners Inc | Minneapolis | Minnesota | United States | 55454 |
184 | Monticello Cancer Center | Monticello | Minnesota | United States | 55362 |
185 | Essentia Health - Park Rapids | Park Rapids | Minnesota | United States | 56470 |
186 | North Memorial Medical Health Center | Robbinsdale | Minnesota | United States | 55422 |
187 | Mayo Clinic in Rochester | Rochester | Minnesota | United States | 55905 |
188 | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | United States | 55416 |
189 | Regions Hospital | Saint Paul | Minnesota | United States | 55101 |
190 | United Hospital | Saint Paul | Minnesota | United States | 55102 |
191 | Essentia Health Sandstone | Sandstone | Minnesota | United States | 55072 |
192 | Saint Francis Regional Medical Center | Shakopee | Minnesota | United States | 55379 |
193 | Lakeview Hospital | Stillwater | Minnesota | United States | 55082 |
194 | Essentia Health Virginia Clinic | Virginia | Minnesota | United States | 55792 |
195 | Ridgeview Medical Center | Waconia | Minnesota | United States | 55387 |
196 | Rice Memorial Hospital | Willmar | Minnesota | United States | 56201 |
197 | Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | United States | 55125 |
198 | Baptist Memorial Hospital and Cancer Center-Golden Triangle | Columbus | Mississippi | United States | 39705 |
199 | Baptist Cancer Center-Grenada | Grenada | Mississippi | United States | 38901 |
200 | Baptist Memorial Hospital and Cancer Center-Union County | New Albany | Mississippi | United States | 38652 |
201 | Baptist Memorial Hospital and Cancer Center-Oxford | Oxford | Mississippi | United States | 38655 |
202 | Baptist Memorial Hospital and Cancer Center-Desoto | Southhaven | Mississippi | United States | 38671 |
203 | Saint Louis Cancer and Breast Institute-Ballwin | Ballwin | Missouri | United States | 63011 |
204 | Central Care Cancer Center - Bolivar | Bolivar | Missouri | United States | 65613 |
205 | Saint Francis Medical Center | Cape Girardeau | Missouri | United States | 63703 |
206 | Southeast Cancer Center | Cape Girardeau | Missouri | United States | 63703 |
207 | Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | United States | 63141 |
208 | Parkland Health Center - Farmington | Farmington | Missouri | United States | 63640 |
209 | Capital Region Southwest Campus | Jefferson City | Missouri | United States | 65109 |
210 | Freeman Health System | Joplin | Missouri | United States | 64804 |
211 | Mercy Hospital Joplin | Joplin | Missouri | United States | 64804 |
212 | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | United States | 65401 |
213 | Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | United States | 65401 |
214 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64506 |
215 | Washington University School of Medicine | Saint Louis | Missouri | United States | 63110 |
216 | Mercy Hospital South | Saint Louis | Missouri | United States | 63128 |
217 | Siteman Cancer Center-South County | Saint Louis | Missouri | United States | 63129 |
218 | Missouri Baptist Medical Center | Saint Louis | Missouri | United States | 63131 |
219 | Siteman Cancer Center at Christian Hospital | Saint Louis | Missouri | United States | 63136 |
220 | Mercy Hospital Saint Louis | Saint Louis | Missouri | United States | 63141 |
221 | Siteman Cancer Center at Saint Peters Hospital | Saint Peters | Missouri | United States | 63376 |
222 | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | United States | 63670 |
223 | Mercy Hospital Springfield | Springfield | Missouri | United States | 65804 |
224 | CoxHealth South Hospital | Springfield | Missouri | United States | 65807 |
225 | Missouri Baptist Sullivan Hospital | Sullivan | Missouri | United States | 63080 |
226 | Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | United States | 63127 |
227 | Nebraska Medicine-Bellevue | Bellevue | Nebraska | United States | 68123 |
228 | CHI Health Saint Francis | Grand Island | Nebraska | United States | 68803 |
229 | CHI Health Good Samaritan | Kearney | Nebraska | United States | 68847 |
230 | Nebraska Medicine-Village Pointe | Omaha | Nebraska | United States | 68118 |
231 | Alegent Health Immanuel Medical Center | Omaha | Nebraska | United States | 68122 |
232 | Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska | United States | 68124 |
233 | Alegent Health Lakeside Hospital | Omaha | Nebraska | United States | 68130 |
234 | Creighton University Medical Center | Omaha | Nebraska | United States | 68131 |
235 | University of Nebraska Medical Center | Omaha | Nebraska | United States | 68198 |
236 | Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada | United States | 89052 |
237 | OptumCare Cancer Care at Seven Hills | Henderson | Nevada | United States | 89052 |
238 | OptumCare Cancer Care at Charleston | Las Vegas | Nevada | United States | 89102 |
239 | Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada | United States | 89106 |
240 | GenesisCare USA - Las Vegas | Las Vegas | Nevada | United States | 89109 |
241 | Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada | United States | 89119 |
242 | Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada | United States | 89128 |
243 | OptumCare Cancer Care at MountainView | Las Vegas | Nevada | United States | 89128 |
244 | Alliance for Childhood Diseases/Cure 4 the Kids Foundation | Las Vegas | Nevada | United States | 89135 |
245 | Comprehensive Cancer Centers of Nevada - Town Center | Las Vegas | Nevada | United States | 89144 |
246 | Comprehensive Cancer Centers of Nevada-Summerlin | Las Vegas | Nevada | United States | 89144 |
247 | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | United States | 89148 |
248 | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | United States | 89148 |
249 | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada | United States | 89169 |
250 | Renown Regional Medical Center | Reno | Nevada | United States | 89502 |
251 | Saint Mary's Regional Medical Center | Reno | Nevada | United States | 89503 |
252 | Radiation Oncology Associates | Reno | Nevada | United States | 89509 |
253 | Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | United States | 03756 |
254 | Ocean Medical Center | Brick | New Jersey | United States | 08724 |
255 | Monmouth Medical Center | Long Branch | New Jersey | United States | 07740 |
256 | Southern Ocean County Medical Center | Manahawkin | New Jersey | United States | 08050 |
257 | Jersey Shore Medical Center | Neptune | New Jersey | United States | 07753 |
258 | Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | United States | 08903 |
259 | Riverview Medical Center/Booker Cancer Center | Red Bank | New Jersey | United States | 07701 |
260 | Community Medical Center | Toms River | New Jersey | United States | 08755 |
261 | Lovelace Medical Center-Saint Joseph Square | Albuquerque | New Mexico | United States | 87102 |
262 | University of New Mexico Cancer Center | Albuquerque | New Mexico | United States | 87102 |
263 | New Mexico Oncology Hematology Consultants | Albuquerque | New Mexico | United States | 87109 |
264 | Presbyterian Kaseman Hospital | Albuquerque | New Mexico | United States | 87110 |
265 | Presbyterian Rust Medical Center/Jorgensen Cancer Center | Rio Rancho | New Mexico | United States | 87124 |
266 | Montefiore Medical Center-Einstein Campus | Bronx | New York | United States | 10461 |
267 | Montefiore Medical Center-Weiler Hospital | Bronx | New York | United States | 10461 |
268 | Montefiore Medical Center - Moses Campus | Bronx | New York | United States | 10467 |
269 | Sands Cancer Center | Canandaigua | New York | United States | 14424 |
270 | Noyes Memorial Hospital/Myers Cancer Center | Dansville | New York | United States | 14437 |
271 | Glens Falls Hospital | Glens Falls | New York | United States | 12801 |
272 | Northwell Health/Center for Advanced Medicine | Lake Success | New York | United States | 11042 |
273 | Garnet Health Medical Center | Middletown | New York | United States | 10940 |
274 | Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | United States | 10016 |
275 | NYP/Weill Cornell Medical Center | New York | New York | United States | 10065 |
276 | University of Rochester | Rochester | New York | United States | 14642 |
277 | State University of New York Upstate Medical University | Syracuse | New York | United States | 13210 |
278 | Novant Health Presbyterian Medical Center | Charlotte | North Carolina | United States | 28204 |
279 | Novant Health Presbyterian Medical Center Huntersville | Huntersville | North Carolina | United States | 28078 |
280 | Novant Health Cancer Institute - Kernersville | Kernersville | North Carolina | United States | 27284 |
281 | Matthews Radiation Oncology Center | Matthews | North Carolina | United States | 28105 |
282 | Novant Health Cancer Institute - Mount Airy | Mount Airy | North Carolina | United States | 27030 |
283 | Novant Health Cancer Institute - Statesville | Statesville | North Carolina | United States | 28625 |
284 | Novant Health Cancer Institute - Thomasville | Thomasville | North Carolina | United States | 27360 |
285 | Novant Health Cancer Institute - Wilkesboro | Wilkesboro | North Carolina | United States | 28659 |
286 | Novant Health Forsyth Medical Center | Winston-Salem | North Carolina | United States | 27103 |
287 | Sanford Bismarck Medical Center | Bismarck | North Dakota | United States | 58501 |
288 | Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota | United States | 58103 |
289 | Sanford Broadway Medical Center | Fargo | North Dakota | United States | 58122 |
290 | Sanford Roger Maris Cancer Center | Fargo | North Dakota | United States | 58122 |
291 | Essentia Health - Jamestown Clinic | Jamestown | North Dakota | United States | 58401 |
292 | Indu and Raj Soin Medical Center | Beavercreek | Ohio | United States | 45431 |
293 | Saint Elizabeth Boardman Hospital | Boardman | Ohio | United States | 44512 |
294 | Dayton Physicians LLC-Miami Valley South | Centerville | Ohio | United States | 45459 |
295 | Miami Valley Hospital South | Centerville | Ohio | United States | 45459 |
296 | University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | United States | 45219 |
297 | Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio | United States | 45220 |
298 | Oncology Hematology Care Inc-Kenwood | Cincinnati | Ohio | United States | 45236 |
299 | Bethesda North Hospital | Cincinnati | Ohio | United States | 45242 |
300 | MetroHealth Medical Center | Cleveland | Ohio | United States | 44109 |
301 | Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland | Ohio | United States | 44111 |
302 | Cleveland Clinic Foundation | Cleveland | Ohio | United States | 44195 |
303 | Ohio State University Comprehensive Cancer Center | Columbus | Ohio | United States | 43210 |
304 | Miami Valley Hospital | Dayton | Ohio | United States | 45409 |
305 | Dayton Physician LLC-Miami Valley Hospital North | Dayton | Ohio | United States | 45415 |
306 | Miami Valley Hospital North | Dayton | Ohio | United States | 45415 |
307 | Armes Family Cancer Center | Findlay | Ohio | United States | 45840 |
308 | Blanchard Valley Hospital | Findlay | Ohio | United States | 45840 |
309 | Orion Cancer Care | Findlay | Ohio | United States | 45840 |
310 | Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | United States | 45005-1066 |
311 | Dayton Physicians LLC-Atrium | Franklin | Ohio | United States | 45005 |
312 | Dayton Physicians LLC-Wayne | Greenville | Ohio | United States | 45331 |
313 | Wayne Hospital | Greenville | Ohio | United States | 45331 |
314 | Cleveland Clinic Cancer Center Independence | Independence | Ohio | United States | 44131 |
315 | Greater Dayton Cancer Center | Kettering | Ohio | United States | 45409 |
316 | Kettering Medical Center | Kettering | Ohio | United States | 45429 |
317 | Cleveland Clinic Cancer Center Mansfield | Mansfield | Ohio | United States | 44906 |
318 | Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio | United States | 44124 |
319 | North Coast Cancer Care | Sandusky | Ohio | United States | 44870 |
320 | Springfield Regional Cancer Center | Springfield | Ohio | United States | 45504 |
321 | Springfield Regional Medical Center | Springfield | Ohio | United States | 45505 |
322 | Cleveland Clinic Cancer Center Strongsville | Strongsville | Ohio | United States | 44136 |
323 | ProMedica Flower Hospital | Sylvania | Ohio | United States | 43560 |
324 | ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital | Toledo | Ohio | United States | 43606 |
325 | Dayton Physicians LLC-Upper Valley | Troy | Ohio | United States | 45373 |
326 | Upper Valley Medical Center | Troy | Ohio | United States | 45373 |
327 | South Pointe Hospital | Warrensville Heights | Ohio | United States | 44122 |
328 | Saint Joseph Warren Hospital | Warren | Ohio | United States | 44484 |
329 | University of Cincinnati Cancer Center-West Chester | West Chester | Ohio | United States | 45069 |
330 | Cleveland Clinic Wooster Family Health and Surgery Center | Wooster | Ohio | United States | 44691 |
331 | Saint Elizabeth Youngstown Hospital | Youngstown | Ohio | United States | 44501 |
332 | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | United States | 73120 |
333 | Saint Charles Health System | Bend | Oregon | United States | 97701 |
334 | Clackamas Radiation Oncology Center | Clackamas | Oregon | United States | 97015 |
335 | Providence Cancer Institute Clackamas Clinic | Clackamas | Oregon | United States | 97015 |
336 | Bay Area Hospital | Coos Bay | Oregon | United States | 97420 |
337 | Providence Newberg Medical Center | Newberg | Oregon | United States | 97132 |
338 | Providence Portland Medical Center | Portland | Oregon | United States | 97213 |
339 | Providence Saint Vincent Medical Center | Portland | Oregon | United States | 97225 |
340 | Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | United States | 18103 |
341 | UPMC Altoona | Altoona | Pennsylvania | United States | 16601 |
342 | UPMC-Heritage Valley Health System Beaver | Beaver | Pennsylvania | United States | 15009 |
343 | Saint Luke's University Hospital-Bethlehem Campus | Bethlehem | Pennsylvania | United States | 18015 |
344 | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | United States | 18017 |
345 | UPMC Camp Hill | Camp Hill | Pennsylvania | United States | 17011 |
346 | Carlisle Regional Cancer Center | Carlisle | Pennsylvania | United States | 17015 |
347 | Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | United States | 19317 |
348 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822 |
349 | Pocono Medical Center | East Stroudsburg | Pennsylvania | United States | 18301 |
350 | UPMC Hillman Cancer Center Erie | Erie | Pennsylvania | United States | 16505 |
351 | UPMC Cancer Center at UPMC Horizon | Farrell | Pennsylvania | United States | 16121 |
352 | UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania | United States | 15601 |
353 | UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Harrisburg | Pennsylvania | United States | 17109 |
354 | Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | United States | 17033-0850 |
355 | IRMC Cancer Center | Indiana | Pennsylvania | United States | 15701 |
356 | Jefferson Hospital | Jefferson Hills | Pennsylvania | United States | 15025 |
357 | UPMC-Johnstown/John P. Murtha Regional Cancer Center | Johnstown | Pennsylvania | United States | 15901 |
358 | Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | United States | 17837 |
359 | UPMC Cancer Center at UPMC McKeesport | McKeesport | Pennsylvania | United States | 15132 |
360 | Forbes Hospital | Monroeville | Pennsylvania | United States | 15146 |
361 | UPMC Cancer Center - Monroeville | Monroeville | Pennsylvania | United States | 15146 |
362 | UPMC-Coraopolis/Heritage Valley Radiation Oncology | Moon | Pennsylvania | United States | 15108 |
363 | UPMC Hillman Cancer Center - Part of Frick Hospital | Mount Pleasant | Pennsylvania | United States | 15666 |
364 | Arnold Palmer Cancer Center Medical Oncology Norwin | N. Huntingdon | Pennsylvania | United States | 15642 |
365 | Allegheny Valley Hospital | Natrona Heights | Pennsylvania | United States | 15065 |
366 | University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania | United States | 19104 |
367 | Allegheny General Hospital | Pittsburgh | Pennsylvania | United States | 15212 |
368 | UPMC-Magee Womens Hospital | Pittsburgh | Pennsylvania | United States | 15213 |
369 | UPMC-Saint Margaret | Pittsburgh | Pennsylvania | United States | 15215 |
370 | West Penn Hospital | Pittsburgh | Pennsylvania | United States | 15224 |
371 | University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | United States | 15232 |
372 | UPMC-Shadyside Hospital | Pittsburgh | Pennsylvania | United States | 15232 |
373 | UPMC-Passavant Hospital | Pittsburgh | Pennsylvania | United States | 15237 |
374 | UPMC-Saint Clair Hospital Cancer Center | Pittsburgh | Pennsylvania | United States | 15243 |
375 | Pottstown Hospital | Pottstown | Pennsylvania | United States | 19464 |
376 | UPMC Cancer Center at UPMC Northwest | Seneca | Pennsylvania | United States | 16346 |
377 | UPMC Cancer Center-Uniontown | Uniontown | Pennsylvania | United States | 15401 |
378 | UPMC Uniontown Hospital Radiation Oncology | Uniontown | Pennsylvania | United States | 15401 |
379 | UPMC Cancer Center-Washington | Washington | Pennsylvania | United States | 15301 |
380 | UPMC Washington Hospital Radiation Oncology | Washington | Pennsylvania | United States | 15301 |
381 | UPMC West Mifflin-Cancer Center Jefferson | West Mifflin | Pennsylvania | United States | 15122 |
382 | Reading Hospital | West Reading | Pennsylvania | United States | 19611 |
383 | Wexford Health and Wellness Pavilion | Wexford | Pennsylvania | United States | 15090 |
384 | UPMC Memorial | York | Pennsylvania | United States | 17408 |
385 | Newport Hospital | Newport | Rhode Island | United States | 02840 |
386 | Rhode Island Hospital | Providence | Rhode Island | United States | 02903 |
387 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425 |
388 | Saint Francis Hospital | Greenville | South Carolina | United States | 29601 |
389 | Saint Francis Cancer Center | Greenville | South Carolina | United States | 29607 |
390 | Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | United States | 57104 |
391 | Avera Cancer Institute | Sioux Falls | South Dakota | United States | 57105 |
392 | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | United States | 57117-5134 |
393 | Baptist Memorial Hospital and Cancer Center-Collierville | Collierville | Tennessee | United States | 38017 |
394 | Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee | United States | 38120 |
395 | Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | United States | 37232 |
396 | Saint Joseph Regional Cancer Center | Bryan | Texas | United States | 77802 |
397 | Parkland Memorial Hospital | Dallas | Texas | United States | 75235 |
398 | UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | United States | 75390 |
399 | UT Southwestern/Simmons Cancer Center-Fort Worth | Fort Worth | Texas | United States | 76104 |
400 | UT Southwestern Clinical Center at Richardson/Plano | Richardson | Texas | United States | 75080 |
401 | University of Utah Sugarhouse Health Center | Salt Lake City | Utah | United States | 84106 |
402 | Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | United States | 84112 |
403 | Central Vermont Medical Center/National Life Cancer Treatment | Berlin | Vermont | United States | 05602 |
404 | University of Vermont Medical Center | Burlington | Vermont | United States | 05401 |
405 | University of Vermont and State Agricultural College | Burlington | Vermont | United States | 05405 |
406 | Norris Cotton Cancer Center-North | Saint Johnsbury | Vermont | United States | 05819 |
407 | University of Virginia Cancer Center | Charlottesville | Virginia | United States | 22908 |
408 | Virginia Cancer Institute | Richmond | Virginia | United States | 23229 |
409 | Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia | United States | 23298 |
410 | VCU Community Memorial Health Center | South Hill | Virginia | United States | 23970 |
411 | Providence Regional Cancer System-Aberdeen | Aberdeen | Washington | United States | 98520 |
412 | Overlake Medical Center | Bellevue | Washington | United States | 98004 |
413 | PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | United States | 98225 |
414 | Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington | United States | 98310 |
415 | Harrison Medical Center | Bremerton | Washington | United States | 98310 |
416 | Highline Medical Center-Main Campus | Burien | Washington | United States | 98166 |
417 | Providence Regional Cancer System-Centralia | Centralia | Washington | United States | 98531 |
418 | Swedish Cancer Institute-Edmonds | Edmonds | Washington | United States | 98026 |
419 | Providence Regional Cancer Partnership | Everett | Washington | United States | 98201 |
420 | Swedish Cancer Institute-Issaquah | Issaquah | Washington | United States | 98029 |
421 | Providence Regional Cancer System-Lacey | Lacey | Washington | United States | 98503 |
422 | PeaceHealth Saint John Medical Center | Longview | Washington | United States | 98632 |
423 | Valley Medical Center | Renton | Washington | United States | 98055 |
424 | Swedish Medical Center-Ballard Campus | Seattle | Washington | United States | 98107 |
425 | Swedish Medical Center-First Hill | Seattle | Washington | United States | 98122-4307 |
426 | PeaceHealth United General Medical Center | Sedro-Woolley | Washington | United States | 98284 |
427 | Northwest Medical Specialties PLLC | Tacoma | Washington | United States | 98405 |
428 | PeaceHealth Southwest Medical Center | Vancouver | Washington | United States | 98664 |
429 | Providence Saint Mary Regional Cancer Center | Walla Walla | Washington | United States | 99362 |
430 | North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington | United States | 98902 |
431 | United Hospital Center | Bridgeport | West Virginia | United States | 26330 |
432 | West Virginia University Charleston Division | Charleston | West Virginia | United States | 25304 |
433 | West Virginia University Healthcare | Morgantown | West Virginia | United States | 26506 |
434 | Camden Clark Medical Center | Parkersburg | West Virginia | United States | 26101 |
435 | ThedaCare Regional Cancer Center | Appleton | Wisconsin | United States | 54911 |
436 | Duluth Clinic Ashland | Ashland | Wisconsin | United States | 54806 |
437 | Northwest Wisconsin Cancer Center | Ashland | Wisconsin | United States | 54806 |
438 | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin | United States | 53105 |
439 | Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | United States | 54701 |
440 | Aurora Health Center-Fond du Lac | Fond Du Lac | Wisconsin | United States | 54937 |
441 | Aurora Health Care Germantown Health Center | Germantown | Wisconsin | United States | 53022 |
442 | Aurora Cancer Care-Grafton | Grafton | Wisconsin | United States | 53024 |
443 | Bellin Memorial Hospital | Green Bay | Wisconsin | United States | 54301 |
444 | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin | United States | 54301 |
445 | Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin | United States | 54303 |
446 | Aurora BayCare Medical Center | Green Bay | Wisconsin | United States | 54311 |
447 | Essentia Health-Hayward Clinic | Hayward | Wisconsin | United States | 54843 |
448 | UW Cancer Center Johnson Creek | Johnson Creek | Wisconsin | United States | 53038 |
449 | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | United States | 53142 |
450 | University of Wisconsin Carbone Cancer Center | Madison | Wisconsin | United States | 53792 |
451 | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin | United States | 54143 |
452 | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | United States | 54449 |
453 | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin | United States | 53209 |
454 | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | United States | 53215 |
455 | Aurora Sinai Medical Center | Milwaukee | Wisconsin | United States | 53233 |
456 | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin | United States | 54548 |
457 | Cancer Center of Western Wisconsin | New Richmond | Wisconsin | United States | 54017 |
458 | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | United States | 54904 |
459 | Aurora Cancer Care-Racine | Racine | Wisconsin | United States | 53406 |
460 | Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | United States | 54868 |
461 | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | United States | 53081 |
462 | Essentia Health-Spooner Clinic | Spooner | Wisconsin | United States | 54801 |
463 | Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin | United States | 54482 |
464 | Saint Vincent Hospital Cancer Center at Sturgeon Bay | Sturgeon Bay | Wisconsin | United States | 54235-1495 |
465 | Aurora Medical Center in Summit | Summit | Wisconsin | United States | 53066 |
466 | Essentia Health Saint Mary's Hospital - Superior | Superior | Wisconsin | United States | 54880 |
467 | Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | United States | 54241 |
468 | Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin | United States | 53226 |
469 | Aurora West Allis Medical Center | West Allis | Wisconsin | United States | 53227 |
470 | Marshfield Medical Center - Weston | Weston | Wisconsin | United States | 54476 |
Sponsors and Collaborators
- National Cancer Institute (NCI)
Investigators
- Principal Investigator: Jennifer R Eads, ECOG-ACRIN Cancer Research Group
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NCI-2018-01575
- NCI-2018-01575
- EA2174
- EA2174
- U10CA180820