Effects of Altitude Hypoxia and Hypoxia on Cognitive Function in Acute Patients
Study Details
Study Description
Brief Summary
By observing the changes of cognitive function of subjects after moving from plain to plateau, this study aims to find out the main types of impaired cognitive function and explore the indicators related to impaired cognitive function in the EEG.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
This study intends to recruit healthy subjects from plain area to 3000 m altitude group (N=40) and 4000 m altitude group (N=40).
First, subjects completed baseline cognitive function tests and information collection in the plain area.
Second, the tests were repeated on day 1, day 3 and day 7 after the two groups of subjects entered the area at different altitudes.
Finally, analyze and find out the main types of cognitive impairment, and explore the related indicators of cognitive impairment in EEG.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Group A People travelling from the plains to areas at altitudes of 3000-3500 meters |
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| Group B People travelling from the plains to areas at altitudes of 4000-4500 meters |
Outcome Measures
Primary Outcome Measures
- Major impairment of cognitive function types [7 days]
To assess cognitive function, we used CNS Vital Signs Neurocognitive test. The core CNS Vital Signs "BRIEF-CORE" neurocognitive assessment battery consists of seven subtests: Verbal Memory (VBM), Visual Memory (VIM), Finger Tapping (FTT), Symbol Digit Coding (SDC), Stroop Test (ST), Rat Attention Test (SAT) and the Continuous Performance Test (CPT). Based on the above 7 test results, the quantitative evaluation results of 11 cognitive functions, including complex memory, graphic memory, vocabulary memory, psychomotor speed, motor speed, processing speed, reaction time, cognitive flexibility, executive function, complex attention and simple attention, were generated. By comparing the cognitive function at different stages before and after entering the plateau, we will find out the impaired cognitive function.
Secondary Outcome Measures
- Changes of the relative power values of five different EEG band [7 days]
To collect the EEG data, we used the ZhenTec's 32-conductivity EEG monitoring device. 32 electrodes ( Fp1、Fp2、F3、F4、Fz、FT7、FT8、FC3、FC4、FCz、Cz、TP7、TP8、CP3、CP4、Pz、Oz、C3、C4、P3、P4、O1、O2、 F7、F8、T3、T4、T5、T6) were placed according to the international 10/20 system electrode placement method, and EEG data of the subjects were collected in the quiet state for 20 min. By analyzing the collected EEG data, we can calculate the relative power values of five different EEG band (δ wave, θ wave, α wave, β wave and γ wave) under different leads. By comparing the relative power values at different stages before and after entering the plateau, we tried to look for significantly altered EEG signatures, to find its association with the impaired cognitive function.
- Changes of the percentage of each EEG band in the total monitoring time [7 days]
To collect the EEG data, we used the ZhenTec's 32-conductivity EEG monitoring device. 32 electrodes ( Fp1、Fp2、F3、F4、Fz、FT7、FT8、FC3、FC4、FCz、Cz、TP7、TP8、CP3、CP4、Pz、Oz、C3、C4、P3、P4、O1、O2、 F7、F8、T3、T4、T5、T6) were placed according to the international 10/20 system electrode placement method, and EEG data of the subjects were collected in the quiet state for 20 min. By analyzing the collected EEG data, we can calculate the percentage of each EEG band (δ wave, θ wave, α wave, β wave and γ wave) in the total monitoring time. By comparing the percentage of each EEG band in the total monitoring time at different stages before and after entering the plateau, we tried to look for significantly altered EEG signatures, to find its association with the impaired cognitive function.
Eligibility Criteria
Criteria
Inclusion Criteria:
- Lived in plain, never entered the plateau
Exclusion Criteria:
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patients with epilepsy, migraine, brain injury, stroke and other neuropsychiatric diseases;
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central nervous system drugs;
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history of heart or head surgery;
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MMSE score < 25;
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patients suffering from pulmonary heart disease, chronic obstructive pulmonary disease, emphysema, pulmonary embolism and other serious respiratory diseases;
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patients with negative resistance to the study and poor compliance.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Fourth Military Medical University | Xi'an | Shaanxi | China | 710032 |
Sponsors and Collaborators
- Xijing Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Ciarlone GE, Dean JB. Acute hypercapnic hyperoxia stimulates reactive species production in the caudal solitary complex of rat brain slices but does not induce oxidative stress. Am J Physiol Cell Physiol. 2016 Dec 1;311(6):C1027-C1039. doi: 10.1152/ajpcell.00161.2016. Epub 2016 Oct 12.
- Davranche K, Casini L, Arnal PJ, Rupp T, Perrey S, Verges S. Cognitive functions and cerebral oxygenation changes during acute and prolonged hypoxic exposure. Physiol Behav. 2016 Oct 1;164(Pt A):189-97. doi: 10.1016/j.physbeh.2016.06.001. Epub 2016 Jun 2.
- Eide RP 3rd, Asplund CA. Altitude illness: update on prevention and treatment. Curr Sports Med Rep. 2012 May-Jun;11(3):124-30. doi: 10.1249/JSR.0b013e3182563e7a. Review.
- Falla M, Papagno C, Dal Cappello T, Vögele A, Hüfner K, Kim J, Weiss EM, Weber B, Palma M, Mrakic-Sposta S, Brugger H, Strapazzon G. A Prospective Evaluation of the Acute Effects of High Altitude on Cognitive and Physiological Functions in Lowlanders. Front Physiol. 2021 Apr 28;12:670278. doi: 10.3389/fphys.2021.670278. eCollection 2021.
- Turner CE, Barker-Collo SL, Connell CJ, Gant N. Acute hypoxic gas breathing severely impairs cognition and task learning in humans. Physiol Behav. 2015 Apr 1;142:104-10. doi: 10.1016/j.physbeh.2015.02.006. Epub 2015 Feb 4.
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