Collecting and Storing Malignant, Borderline Malignant Neoplasms, and Related Samples From Young Patients With Cancer
Sponsor
Children's Oncology Group (Other)
Overall Status
Completed
CT.gov ID
NCT00898079
Collaborator
National Cancer Institute (NCI) (NIH)
2,545
192
176.6
13.3
0.1
Study Details
Study Description
Brief Summary
This study is collecting and storing malignant, borderline malignant neoplasms, and related biological samples from young patients with cancer. Collecting and storing samples of tumor tissue, blood, and bone marrow from patients with cancer to study in the laboratory may help the study of cancer in the future.
Detailed Description
OBJECTIVES:
-
Collect malignant, borderline malignant neoplasms, and related biological specimens from Children's Oncology Group institutions for cases in which there is no disease-specific biologic protocol.
-
Provide a repository for long-term storage of malignant, borderline malignant neoplasms, and related biological specimens from these patients.
-
Make specimens available to qualified researchers to understand the biology of cancer in these patients.
OUTLINE:
Tumor tissue samples, blood, and bone marrow aspirates are collected and stored for future analysis.
Study Design
Study Type:
Observational
Actual Enrollment
:
2545 participants
Official Title:
A Children's Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens Including Rare Pediatric Tumors
Actual Study Start Date
:
Oct 13, 2003
Actual Primary Completion Date
:
Jun 30, 2018
Actual Study Completion Date
:
Jun 30, 2018
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Observational Tumor tissue samples, blood, and bone marrow aspirates are collected and stored for future analysis. |
Other: Cytology Specimen Collection Procedure
Correlative studies
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Repository of malignant, borderline malignant neoplasms, and related biological specimens [Baseline]
Eligibility Criteria
Criteria
Ages Eligible for Study:
N/A
to 30 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
Meets any of the following criteria:
-
Diagnosed with primary neoplasm
-
Developed a second malignant neoplasm
-
Any diagnoses having an ICD-O Morphology Code ending in 1, 2, or 3 as listed in the International Classification of Disease for Oncology, Third Edition
-
Must have biological specimens including solid tumors and leukemias available
-
Solid tumors meeting the following criteria:
-
Snap frozen primary tumor OR OCT embedded primary tumor OR formalin fixed (block or tissue in formalin) primary tumor AND at least 10 unstained paraffin slides for NIH Mandated QC (tumors that have undergone central pathology review are allowed)
-
Slides for pathology review (instead of slides for QC) are required for patients with rare tumors
-
Pleural fluid or cytologic specimens meeting the following criteria:
-
At least 1 mL of fluid and at least 2 unstained cytospin slides (or 2 unstained smears)
-
Slides for pathology review (instead of slides for QC) are required for patients with rare tumors
-
ALL/AML
-
3-6 mL of bone marrow aspirate and 10 mL of whole blood
-
Not eligible for disease-specific biology or banking protocol
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Children's Hospital of Alabama | Birmingham | Alabama | United States | 35233 |
| 2 | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | United States | 35233 |
| 3 | Phoenix Childrens Hospital | Phoenix | Arizona | United States | 85016 |
| 4 | Arkansas Children's Hospital | Little Rock | Arkansas | United States | 72202-3591 |
| 5 | University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
| 6 | Kaiser Permanente Downey Medical Center | Downey | California | United States | 90242 |
| 7 | City of Hope Comprehensive Cancer Center | Duarte | California | United States | 91010 |
| 8 | Loma Linda University Medical Center | Loma Linda | California | United States | 92354 |
| 9 | Miller Children's and Women's Hospital Long Beach | Long Beach | California | United States | 90806 |
| 10 | Children's Hospital Los Angeles | Los Angeles | California | United States | 90027 |
| 11 | Cedars Sinai Medical Center | Los Angeles | California | United States | 90048 |
| 12 | Mattel Children's Hospital UCLA | Los Angeles | California | United States | 90095 |
| 13 | UCLA / Jonsson Comprehensive Cancer Center | Los Angeles | California | United States | 90095 |
| 14 | Children's Hospital Central California | Madera | California | United States | 93636-8762 |
| 15 | Children's Hospital and Research Center at Oakland | Oakland | California | United States | 94609-1809 |
| 16 | Kaiser Permanente-Oakland | Oakland | California | United States | 94611 |
| 17 | Children's Hospital of Orange County | Orange | California | United States | 92868 |
| 18 | Lucile Packard Children's Hospital Stanford University | Palo Alto | California | United States | 94304 |
| 19 | Rady Children's Hospital - San Diego | San Diego | California | United States | 92123 |
| 20 | UCSF Medical Center-Parnassus | San Francisco | California | United States | 94143 |
| 21 | UCSF Medical Center-Mission Bay | San Francisco | California | United States | 94158 |
| 22 | Children's Hospital Colorado | Aurora | Colorado | United States | 80045 |
| 23 | Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center | Denver | Colorado | United States | 80218 |
| 24 | Connecticut Children's Medical Center | Hartford | Connecticut | United States | 06106 |
| 25 | Alfred I duPont Hospital for Children | Wilmington | Delaware | United States | 19803 |
| 26 | MedStar Georgetown University Hospital | Washington | District of Columbia | United States | 20007 |
| 27 | Children's National Medical Center | Washington | District of Columbia | United States | 20010 |
| 28 | Broward Health Medical Center | Fort Lauderdale | Florida | United States | 33316 |
| 29 | Lee Memorial Health System | Fort Myers | Florida | United States | 33901 |
| 30 | Golisano Children's Hospital of Southwest Florida | Fort Myers | Florida | United States | 33908 |
| 31 | University of Florida Health Science Center - Gainesville | Gainesville | Florida | United States | 32610 |
| 32 | Memorial Regional Hospital/Joe DiMaggio Children's Hospital | Hollywood | Florida | United States | 33021 |
| 33 | Nemours Children's Clinic-Jacksonville | Jacksonville | Florida | United States | 32207 |
| 34 | University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | United States | 33136 |
| 35 | Nicklaus Children's Hospital | Miami | Florida | United States | 33155 |
| 36 | Miami Cancer Institute | Miami | Florida | United States | 33176 |
| 37 | Florida Hospital Orlando | Orlando | Florida | United States | 32803 |
| 38 | Nemours Children's Clinic - Orlando | Orlando | Florida | United States | 32806 |
| 39 | Nemours Children's Hospital | Orlando | Florida | United States | 32827 |
| 40 | Nemours Children's Clinic - Pensacola | Pensacola | Florida | United States | 32504 |
| 41 | Johns Hopkins All Children's Hospital | Saint Petersburg | Florida | United States | 33701 |
| 42 | Tampa General Hospital | Tampa | Florida | United States | 33606 |
| 43 | Saint Joseph's Hospital/Children's Hospital-Tampa | Tampa | Florida | United States | 33607 |
| 44 | Saint Mary's Hospital | West Palm Beach | Florida | United States | 33407 |
| 45 | Children's Healthcare of Atlanta - Egleston | Atlanta | Georgia | United States | 30322 |
| 46 | Memorial Health University Medical Center | Savannah | Georgia | United States | 31404 |
| 47 | University of Hawaii Cancer Center | Honolulu | Hawaii | United States | 96813 |
| 48 | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | United States | 96826 |
| 49 | Saint Luke's Mountain States Tumor Institute | Boise | Idaho | United States | 83712 |
| 50 | Lurie Children's Hospital-Chicago | Chicago | Illinois | United States | 60611 |
| 51 | University of Illinois | Chicago | Illinois | United States | 60612 |
| 52 | University of Chicago Comprehensive Cancer Center | Chicago | Illinois | United States | 60637 |
| 53 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 54 | Advocate Children's Hospital-Park Ridge | Park Ridge | Illinois | United States | 60068 |
| 55 | Advocate Lutheran General Hospital | Park Ridge | Illinois | United States | 60068 |
| 56 | Saint Jude Midwest Affiliate | Peoria | Illinois | United States | 61637 |
| 57 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62702 |
| 58 | Riley Hospital for Children | Indianapolis | Indiana | United States | 46202 |
| 59 | Saint Vincent Hospital and Health Care Center | Indianapolis | Indiana | United States | 46260 |
| 60 | Blank Children's Hospital | Des Moines | Iowa | United States | 50309 |
| 61 | University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | United States | 52242 |
| 62 | University of Kansas Cancer Center | Kansas City | Kansas | United States | 66160 |
| 63 | University of Kentucky/Markey Cancer Center | Lexington | Kentucky | United States | 40536 |
| 64 | Norton Children's Hospital | Louisville | Kentucky | United States | 40202 |
| 65 | Tulane University Health Sciences Center | New Orleans | Louisiana | United States | 70112 |
| 66 | Children's Hospital New Orleans | New Orleans | Louisiana | United States | 70118 |
| 67 | Ochsner Medical Center Jefferson | New Orleans | Louisiana | United States | 70121 |
| 68 | Maine Children's Cancer Program | Scarborough | Maine | United States | 04074 |
| 69 | Sinai Hospital of Baltimore | Baltimore | Maryland | United States | 21215 |
| 70 | Walter Reed National Military Medical Center | Bethesda | Maryland | United States | 20889-5600 |
| 71 | Dana-Farber Cancer Institute | Boston | Massachusetts | United States | 02215 |
| 72 | Baystate Medical Center | Springfield | Massachusetts | United States | 01199 |
| 73 | C S Mott Children's Hospital | Ann Arbor | Michigan | United States | 48109 |
| 74 | Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | United States | 48201 |
| 75 | Saint John Hospital and Medical Center | Detroit | Michigan | United States | 48236 |
| 76 | Michigan State University Clinical Center | East Lansing | Michigan | United States | 48824-7016 |
| 77 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
| 78 | Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids | Michigan | United States | 49503 |
| 79 | Bronson Methodist Hospital | Kalamazoo | Michigan | United States | 49007 |
| 80 | Kalamazoo Center for Medical Studies | Kalamazoo | Michigan | United States | 49008 |
| 81 | Children's Hospitals and Clinics of Minnesota - Minneapolis | Minneapolis | Minnesota | United States | 55404 |
| 82 | University of Minnesota/Masonic Cancer Center | Minneapolis | Minnesota | United States | 55455 |
| 83 | Mayo Clinic | Rochester | Minnesota | United States | 55905 |
| 84 | University of Mississippi Medical Center | Jackson | Mississippi | United States | 39216 |
| 85 | Columbia Regional | Columbia | Missouri | United States | 65201 |
| 86 | The Childrens Mercy Hospital | Kansas City | Missouri | United States | 64108 |
| 87 | Cardinal Glennon Children's Medical Center | Saint Louis | Missouri | United States | 63104 |
| 88 | Washington University School of Medicine | Saint Louis | Missouri | United States | 63110 |
| 89 | Children's Hospital and Medical Center of Omaha | Omaha | Nebraska | United States | 68114 |
| 90 | University of Nebraska Medical Center | Omaha | Nebraska | United States | 68198 |
| 91 | Nevada Cancer Research Foundation CCOP | Las Vegas | Nevada | United States | 89106 |
| 92 | Children's Specialty Center of Nevada II | Las Vegas | Nevada | United States | 89109 |
| 93 | Sunrise Hospital and Medical Center | Las Vegas | Nevada | United States | 89109 |
| 94 | Hackensack University Medical Center | Hackensack | New Jersey | United States | 07601 |
| 95 | Saint Barnabas Medical Center | Livingston | New Jersey | United States | 07039 |
| 96 | Morristown Medical Center | Morristown | New Jersey | United States | 07960 |
| 97 | Saint Peter's University Hospital | New Brunswick | New Jersey | United States | 08901 |
| 98 | Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital | New Brunswick | New Jersey | United States | 08903 |
| 99 | Newark Beth Israel Medical Center | Newark | New Jersey | United States | 07112 |
| 100 | Saint Joseph's Regional Medical Center | Paterson | New Jersey | United States | 07503 |
| 101 | Overlook Hospital | Summit | New Jersey | United States | 07902 |
| 102 | University of New Mexico Cancer Center | Albuquerque | New Mexico | United States | 87102 |
| 103 | Albany Medical Center | Albany | New York | United States | 12208 |
| 104 | Montefiore Medical Center - Moses Campus | Bronx | New York | United States | 10467 |
| 105 | Brooklyn Hospital Center | Brooklyn | New York | United States | 11201 |
| 106 | Maimonides Medical Center | Brooklyn | New York | United States | 11219 |
| 107 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263 |
| 108 | NYU Winthrop Hospital | Mineola | New York | United States | 11501 |
| 109 | The Steven and Alexandra Cohen Children's Medical Center of New York | New Hyde Park | New York | United States | 11040 |
| 110 | Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | United States | 10016 |
| 111 | Mount Sinai Hospital | New York | New York | United States | 10029 |
| 112 | Columbia University/Herbert Irving Cancer Center | New York | New York | United States | 10032 |
| 113 | University of Rochester | Rochester | New York | United States | 14642 |
| 114 | Stony Brook University Medical Center | Stony Brook | New York | United States | 11794 |
| 115 | State University of New York Upstate Medical University | Syracuse | New York | United States | 13210 |
| 116 | New York Medical College | Valhalla | New York | United States | 10595 |
| 117 | Mission Hospital Inc-Memorial Campus | Asheville | North Carolina | United States | 28801 |
| 118 | UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | United States | 27599 |
| 119 | Carolinas Medical Center/Levine Cancer Institute | Charlotte | North Carolina | United States | 28203 |
| 120 | Novant Health Presbyterian Medical Center | Charlotte | North Carolina | United States | 28204 |
| 121 | Duke University Medical Center | Durham | North Carolina | United States | 27710 |
| 122 | Wake Forest University Health Sciences | Winston-Salem | North Carolina | United States | 27157 |
| 123 | Sanford Broadway Medical Center | Fargo | North Dakota | United States | 58122 |
| 124 | Children's Hospital Medical Center of Akron | Akron | Ohio | United States | 44308 |
| 125 | Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | United States | 45229 |
| 126 | Rainbow Babies and Childrens Hospital | Cleveland | Ohio | United States | 44106 |
| 127 | Cleveland Clinic Foundation | Cleveland | Ohio | United States | 44195 |
| 128 | Nationwide Children's Hospital | Columbus | Ohio | United States | 43205 |
| 129 | Dayton Children's Hospital | Dayton | Ohio | United States | 45404 |
| 130 | Mercy Children's Hospital | Toledo | Ohio | United States | 43608 |
| 131 | Tod Children's Hospital - Forum Health | Youngstown | Ohio | United States | 44501 |
| 132 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 133 | Legacy Emanuel Children's Hospital | Portland | Oregon | United States | 97227 |
| 134 | Legacy Emanuel Hospital and Health Center | Portland | Oregon | United States | 97227 |
| 135 | Oregon Health and Science University | Portland | Oregon | United States | 97239 |
| 136 | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | United States | 18017 |
| 137 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822 |
| 138 | Penn State Children's Hospital | Hershey | Pennsylvania | United States | 17033 |
| 139 | Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | United States | 19104 |
| 140 | Saint Christopher's Hospital for Children | Philadelphia | Pennsylvania | United States | 19134 |
| 141 | Children's Hospital of Pittsburgh of UPMC | Pittsburgh | Pennsylvania | United States | 15224 |
| 142 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425 |
| 143 | Palmetto Health Richland | Columbia | South Carolina | United States | 29203 |
| 144 | BI-LO Charities Children's Cancer Center | Greenville | South Carolina | United States | 29605 |
| 145 | Greenville Cancer Treatment Center | Greenville | South Carolina | United States | 29605 |
| 146 | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | United States | 57117-5134 |
| 147 | T C Thompson Children's Hospital | Chattanooga | Tennessee | United States | 37403 |
| 148 | East Tennessee State University | Johnson City | Tennessee | United States | 37614-0054 |
| 149 | East Tennessee Childrens Hospital | Knoxville | Tennessee | United States | 37916 |
| 150 | Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | United States | 37232 |
| 151 | Texas Tech University Health Sciences Center-Amarillo | Amarillo | Texas | United States | 79106 |
| 152 | Dell Children's Medical Center of Central Texas | Austin | Texas | United States | 78723 |
| 153 | Driscoll Children's Hospital | Corpus Christi | Texas | United States | 78411 |
| 154 | Medical City Dallas Hospital | Dallas | Texas | United States | 75230 |
| 155 | Brooke Army Medical Center | Fort Sam Houston | Texas | United States | 78234 |
| 156 | Cook Children's Medical Center | Fort Worth | Texas | United States | 76104 |
| 157 | Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas | United States | 77030 |
| 158 | Covenant Children's Hospital | Lubbock | Texas | United States | 79410 |
| 159 | Methodist Children's Hospital of South Texas | San Antonio | Texas | United States | 78229 |
| 160 | University of Texas Health Science Center at San Antonio | San Antonio | Texas | United States | 78229 |
| 161 | Scott and White Memorial Hospital | Temple | Texas | United States | 76508 |
| 162 | Primary Children's Hospital | Salt Lake City | Utah | United States | 84113 |
| 163 | University of Vermont College of Medicine | Burlington | Vermont | United States | 05405 |
| 164 | Inova Fairfax Hospital | Falls Church | Virginia | United States | 22042 |
| 165 | Children's Hospital of The King's Daughters | Norfolk | Virginia | United States | 23507 |
| 166 | Carilion Clinic Children's Hospital | Roanoke | Virginia | United States | 24014 |
| 167 | Seattle Children's Hospital | Seattle | Washington | United States | 98105 |
| 168 | Providence Sacred Heart Medical Center and Children's Hospital | Spokane | Washington | United States | 99204 |
| 169 | Mary Bridge Children's Hospital and Health Center | Tacoma | Washington | United States | 98405 |
| 170 | Madigan Army Medical Center | Tacoma | Washington | United States | 98431 |
| 171 | West Virginia University Charleston Division | Charleston | West Virginia | United States | 25304 |
| 172 | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin | United States | 54301 |
| 173 | University of Wisconsin Hospital and Clinics | Madison | Wisconsin | United States | 53792 |
| 174 | Marshfield Clinic | Marshfield | Wisconsin | United States | 54449 |
| 175 | Children's Hospital of Wisconsin | Milwaukee | Wisconsin | United States | 53226 |
| 176 | Women's and Children's Hospital-Adelaide | North Adelaide | South Australia | Australia | 5006 |
| 177 | Princess Margaret Hospital for Children | Perth | Western Australia | Australia | 6008 |
| 178 | University of Alberta Hospital | Edmonton | Alberta | Canada | T6G 2B7 |
| 179 | British Columbia Children's Hospital | Vancouver | British Columbia | Canada | V6H 3V4 |
| 180 | CancerCare Manitoba | Winnipeg | Manitoba | Canada | R3E 0V9 |
| 181 | IWK Health Centre | Halifax | Nova Scotia | Canada | B3K 6R8 |
| 182 | McMaster Children's Hospital at Hamilton Health Sciences | Hamilton | Ontario | Canada | L8N 3Z5 |
| 183 | Kingston Health Sciences Centre | Kingston | Ontario | Canada | K7L 2V7 |
| 184 | Children's Hospital of Eastern Ontario | Ottawa | Ontario | Canada | K1H 8L1 |
| 185 | Hospital for Sick Children | Toronto | Ontario | Canada | M5G 1X8 |
| 186 | The Montreal Children's Hospital of the MUHC | Montreal | Quebec | Canada | H3H 1P3 |
| 187 | Centre Hospitalier Universitaire Sainte-Justine | Montreal | Quebec | Canada | H3T 1C5 |
| 188 | Allan Blair Cancer Centre | Regina | Saskatchewan | Canada | S4T 7T1 |
| 189 | Saskatoon Cancer Centre | Saskatoon | Saskatchewan | Canada | S7N 4H4 |
| 190 | Starship Children's Hospital | Grafton | Auckland | New Zealand | 1145 |
| 191 | San Jorge Children's Hospital | San Juan | Puerto Rico | 00912 | |
| 192 | Swiss Pediatric Oncology Group - Geneva | Geneva | Switzerland | 1205 |
Sponsors and Collaborators
- Children's Oncology Group
- National Cancer Institute (NCI)
Investigators
- Principal Investigator: Nilsa Ramirez, Children's Oncology Group
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Children's Oncology Group
ClinicalTrials.gov Identifier:
NCT00898079
Other Study ID Numbers:
- ABTR01B1
- NCI-2009-00324
- CDR0000271415
- COG-ABTR01B1
- ABTR01B1
- ABTR01B1
- U10CA098543
- UG1CA189958
- NCT00228735
First Posted:
May 12, 2009
Last Update Posted:
Jul 19, 2018
Last Verified:
Jul 1, 2018
Additional relevant MeSH terms: