Collecting and Storing Tissue Samples From Patients With Rare or Cutaneous Non-Hodgkin Lymphoma

Sponsor
Children's Oncology Group (Other)
Overall Status
Active, not recruiting
CT.gov ID
NCT01000753
Collaborator
National Cancer Institute (NCI) (NIH)
174
Enrollment
130
Locations
1.3
Patients Per Site

Study Details

Study Description

Brief Summary

This research study is collecting and storing tissue samples from patients with rare or cutaneous non-Hodgkin lymphoma. Collecting and storing samples of tissue from patients with cancer to test in the laboratory may help the study of cancer in the future.

Condition or DiseaseIntervention/TreatmentPhase
  • Other: Cytology Specimen Collection Procedure

Detailed Description

OBJECTIVES:

  1. To determine the clinical features, treatment, and outcome of patients with rare or cutaneous pediatric non-Hodgkin lymphoma (NHL).

  2. To determine the pathologic and biologic features of these diseases, including molecular diagnostics and flow cytometry.

  3. To establish a bank of these pathologically reviewed diseases and make specimens of blood and tissue available to qualified researchers.

  4. To determine sub-groups of these diseases that could be targeted for future biologic, pathologic, or therapeutic studies.

OUTLINE:

On study data will include presenting symptoms and signs, physical description of the tumor if it is on the skin, results of metastatic evaluation, stage (if available), blood count, markers, and the results of viral serologies. Any existing underlying conditions that could predispose to lymphoma will also be noted. Demographic and outcomes data will be stored and maintained by the COG Research Data Center. Demographic data will be linked to the specimen data in the BPC database.

The approach of this study is prospective data collection, including central pathologic review, relevant biologic studies, submission of material to the Biopathology Center (BPC) and collection of diagnostic and outcome data. Participants will be registered with a standard COG registration form for documentation of age, gender, race, date of diagnosis, initial presentation, initial work-up, and stage according to the standard staging for the specific disease, initial diagnostic procedure, and institutional diagnosis. Tissue will be sent according to guidelines in Section 4.0. Follow-up data, including relapse or progression and vital status will be reported annually for 5 years.

Patients will be followed annually for 5 years and data will be collected including vital status, evidence/absence of disease, type of treatment received, progression/relapse and whether the patient continues on study.

Study Design

Study Type:
Observational
Actual Enrollment :
174 participants
Observational Model:
Case-Only
Time Perspective:
Prospective
Official Title:
Rare And Cutaneous Non-Hodgkin Lymphoma Registry
Actual Study Start Date :
May 30, 2005
Actual Primary Completion Date :
Jun 1, 2007

Arms and Interventions

ArmIntervention/Treatment
Observational (specimen collection)

See Detailed Description

Other: Cytology Specimen Collection Procedure
Correlative studies
Other Names:
  • Cytologic Sampling

    • Outcome Measures

    Primary Outcome Measures

    1. Clinical features, treatment, and outcomes [Up to 5 years]

    2. Pathologic and biologic features of these diseases, including molecular diagnostics and flow cytometry [Up to 5 years]

    3. Establishment of a bank of these pathologically reviewed diseases and make specimens of blood and tissue available to qualified researchers [Up to 5 years]

    4. Sub-groups of these diseases that could be targeted for future biologic, pathologic, or therapeutic studies [Up to 5 years]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    N/A to 21 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • Diagnosis of NHL

    • Any histology, except for Burkitt or Burkitt-like, diffuse large B-cell, anaplastic large cell, or lymphoblastic lymphoma

    • Primary CNS, primary cutaneous NHL, or lymphoproliferative diseases of any histology allowed

    • Pathological specimen from site not treated within the past 6 months

    • Must have specimens available

    • At least 6 months since prior chemotherapy irradiation to study lesion

    • At least 2 weeks since prior steroids

    Contacts and Locations

    Locations

    SiteCityStateCountryPostal Code
    1Children's Hospital of AlabamaBirminghamAlabamaUnited States35233
    2University of Alabama at Birmingham Cancer CenterBirminghamAlabamaUnited States35233
    3Phoenix Childrens HospitalPhoenixArizonaUnited States85016
    4Arkansas Children's HospitalLittle RockArkansasUnited States72202-3591
    5University of Arkansas for Medical SciencesLittle RockArkansasUnited States72205
    6Kaiser Permanente Downey Medical CenterDowneyCaliforniaUnited States90242
    7Miller Children's and Women's Hospital Long BeachLong BeachCaliforniaUnited States90806
    8Children's Hospital Los AngelesLos AngelesCaliforniaUnited States90027
    9Children's Hospital and Research Center at OaklandOaklandCaliforniaUnited States94609-1809
    10Kaiser Permanente-OaklandOaklandCaliforniaUnited States94611
    11Lucile Packard Children's Hospital Stanford UniversityPalo AltoCaliforniaUnited States94304
    12UCSF Medical Center-ParnassusSan FranciscoCaliforniaUnited States94143
    13UCSF Medical Center-Mission BaySan FranciscoCaliforniaUnited States94158
    14Santa Barbara Cottage HospitalSanta BarbaraCaliforniaUnited States93102
    15Children's Hospital ColoradoAuroraColoradoUnited States80045
    16Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical CenterDenverColoradoUnited States80218
    17Connecticut Children's Medical CenterHartfordConnecticutUnited States06106
    18Alfred I duPont Hospital for ChildrenWilmingtonDelawareUnited States19803
    19MedStar Georgetown University HospitalWashingtonDistrict of ColumbiaUnited States20007
    20Children's National Medical CenterWashingtonDistrict of ColumbiaUnited States20010
    21Lee Memorial Health SystemFort MyersFloridaUnited States33901
    22Golisano Children's Hospital of Southwest FloridaFort MyersFloridaUnited States33908
    23Memorial Regional Hospital/Joe DiMaggio Children's HospitalHollywoodFloridaUnited States33021
    24Nemours Children's Clinic-JacksonvilleJacksonvilleFloridaUnited States32207
    25University of Miami Miller School of Medicine-Sylvester Cancer CenterMiamiFloridaUnited States33136
    26Nemours Children's Clinic - OrlandoOrlandoFloridaUnited States32806
    27Nemours Children's HospitalOrlandoFloridaUnited States32827
    28Nemours Children's Clinic - PensacolaPensacolaFloridaUnited States32504
    29Johns Hopkins All Children's HospitalSaint PetersburgFloridaUnited States33701
    30Tampa General HospitalTampaFloridaUnited States33606
    31Saint Joseph's Hospital/Children's Hospital-TampaTampaFloridaUnited States33607
    32Saint Mary's HospitalWest Palm BeachFloridaUnited States33407
    33Children's Healthcare of Atlanta - EglestonAtlantaGeorgiaUnited States30322
    34Memorial Health University Medical CenterSavannahGeorgiaUnited States31404
    35University of IllinoisChicagoIllinoisUnited States60612
    36Advocate Children's Hospital-Oak LawnOak LawnIllinoisUnited States60453
    37Advocate Children's Hospital-Park RidgePark RidgeIllinoisUnited States60068
    38Advocate Lutheran General HospitalPark RidgeIllinoisUnited States60068
    39Saint Jude Midwest AffiliatePeoriaIllinoisUnited States61637
    40Riley Hospital for ChildrenIndianapolisIndianaUnited States46202
    41Saint Vincent Hospital and Health Care CenterIndianapolisIndianaUnited States46260
    42Blank Children's HospitalDes MoinesIowaUnited States50309
    43University of Iowa/Holden Comprehensive Cancer CenterIowa CityIowaUnited States52242
    44University of Kansas Cancer CenterKansas CityKansasUnited States66160
    45University of Kentucky/Markey Cancer CenterLexingtonKentuckyUnited States40536
    46Ochsner Medical Center JeffersonNew OrleansLouisianaUnited States70121
    47Eastern Maine Medical CenterBangorMaineUnited States04401
    48Sinai Hospital of BaltimoreBaltimoreMarylandUnited States21215
    49Johns Hopkins University/Sidney Kimmel Cancer CenterBaltimoreMarylandUnited States21287
    50Walter Reed National Military Medical CenterBethesdaMarylandUnited States20889-5600
    51Massachusetts General Hospital Cancer CenterBostonMassachusettsUnited States02114
    52Dana-Farber Cancer InstituteBostonMassachusettsUnited States02215
    53Wayne State University/Karmanos Cancer InstituteDetroitMichiganUnited States48201
    54Ascension Saint John HospitalDetroitMichiganUnited States48236
    55Michigan State University Clinical CenterEast LansingMichiganUnited States48824-7016
    56Hurley Medical CenterFlintMichiganUnited States48503
    57Helen DeVos Children's Hospital at Spectrum HealthGrand RapidsMichiganUnited States49503
    58Mayo ClinicRochesterMinnesotaUnited States55905
    59University of Mississippi Medical CenterJacksonMississippiUnited States39216
    60Columbia RegionalColumbiaMissouriUnited States65201
    61Children's Mercy Hospitals and ClinicsKansas CityMissouriUnited States64108
    62Washington University School of MedicineSaint LouisMissouriUnited States63110
    63Children's Hospital and Medical Center of OmahaOmahaNebraskaUnited States68114
    64University of Nebraska Medical CenterOmahaNebraskaUnited States68198
    65University Medical Center of Southern NevadaLas VegasNevadaUnited States89102
    66Nevada Cancer Research Foundation CCOPLas VegasNevadaUnited States89106
    67Sunrise Hospital and Medical CenterLas VegasNevadaUnited States89109
    68Alliance for Childhood Diseases/Cure 4 the Kids FoundationLas VegasNevadaUnited States89135
    69Summerlin Hospital Medical CenterLas VegasNevadaUnited States89144
    70Dartmouth Hitchcock Medical CenterLebanonNew HampshireUnited States03756
    71Hackensack University Medical CenterHackensackNew JerseyUnited States07601
    72Saint Barnabas Medical CenterLivingstonNew JerseyUnited States07039
    73Morristown Medical CenterMorristownNew JerseyUnited States07960
    74Saint Peter's University HospitalNew BrunswickNew JerseyUnited States08901
    75Newark Beth Israel Medical CenterNewarkNew JerseyUnited States07112
    76Saint Joseph's Regional Medical CenterPatersonNew JerseyUnited States07503
    77Overlook HospitalSummitNew JerseyUnited States07902
    78Montefiore Medical Center - Moses CampusBronxNew YorkUnited States10467
    79Brooklyn Hospital CenterBrooklynNew YorkUnited States11201
    80Roswell Park Cancer InstituteBuffaloNew YorkUnited States14263
    81Laura and Isaac Perlmutter Cancer Center at NYU LangoneNew YorkNew YorkUnited States10016
    82NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer CenterNew YorkNew YorkUnited States10032
    83State University of New York Upstate Medical UniversitySyracuseNew YorkUnited States13210
    84New York Medical CollegeValhallaNew YorkUnited States10595
    85Mission Hospital Inc-Memorial CampusAshevilleNorth CarolinaUnited States28801
    86Novant Health Presbyterian Medical CenterCharlotteNorth CarolinaUnited States28204
    87Duke University Medical CenterDurhamNorth CarolinaUnited States27710
    88Children's Hospital Medical Center of AkronAkronOhioUnited States44308
    89Rainbow Babies and Childrens HospitalClevelandOhioUnited States44106
    90Cleveland Clinic FoundationClevelandOhioUnited States44195
    91Nationwide Children's HospitalColumbusOhioUnited States43205
    92Dayton Children's HospitalDaytonOhioUnited States45404
    93University of Oklahoma Health Sciences CenterOklahoma CityOklahomaUnited States73104
    94Legacy Emanuel Children's HospitalPortlandOregonUnited States97227
    95Legacy Emanuel Hospital and Health CenterPortlandOregonUnited States97227
    96Lehigh Valley Hospital - MuhlenbergBethlehemPennsylvaniaUnited States18017
    97Geisinger Medical CenterDanvillePennsylvaniaUnited States17822
    98Penn State Children's HospitalHersheyPennsylvaniaUnited States17033
    99Children's Hospital of PhiladelphiaPhiladelphiaPennsylvaniaUnited States19104
    100Childrens Oncology GroupPhiladelphiaPennsylvaniaUnited States19104
    101Children's Hospital of Pittsburgh of UPMCPittsburghPennsylvaniaUnited States15224
    102Prisma Health Richland HospitalColumbiaSouth CarolinaUnited States29203
    103East Tennessee Childrens HospitalKnoxvilleTennesseeUnited States37916
    104Vanderbilt University/Ingram Cancer CenterNashvilleTennesseeUnited States37232
    105Dell Children's Medical Center of Central TexasAustinTexasUnited States78723
    106Driscoll Children's HospitalCorpus ChristiTexasUnited States78411
    107Medical City Dallas HospitalDallasTexasUnited States75230
    108Brooke Army Medical CenterFort Sam HoustonTexasUnited States78234
    109Cook Children's Medical CenterFort WorthTexasUnited States76104
    110Baylor College of Medicine/Dan L Duncan Comprehensive Cancer CenterHoustonTexasUnited States77030
    111Methodist Children's Hospital of South TexasSan AntonioTexasUnited States78229
    112University of Texas Health Science Center at San AntonioSan AntonioTexasUnited States78229
    113Primary Children's HospitalSalt Lake CityUtahUnited States84113
    114Children's Hospital of The King's DaughtersNorfolkVirginiaUnited States23507
    115Seattle Children's HospitalSeattleWashingtonUnited States98105
    116Providence Sacred Heart Medical Center and Children's HospitalSpokaneWashingtonUnited States99204
    117West Virginia University Charleston DivisionCharlestonWest VirginiaUnited States25304
    118Marshfield Medical Center-MarshfieldMarshfieldWisconsinUnited States54449
    119Children's Hospital of WisconsinMilwaukeeWisconsinUnited States53226
    120Princess Margaret Hospital for ChildrenPerthWestern AustraliaAustralia6008
    121University of Alberta HospitalEdmontonAlbertaCanadaT6G 2B7
    122British Columbia Children's HospitalVancouverBritish ColumbiaCanadaV6H 3V4
    123CancerCare ManitobaWinnipegManitobaCanadaR3E 0V9
    124IWK Health CentreHalifaxNova ScotiaCanadaB3K 6R8
    125McMaster Children's Hospital at Hamilton Health SciencesHamiltonOntarioCanadaL8N 3Z5
    126Hospital for Sick ChildrenTorontoOntarioCanadaM5G 1X8
    127Centre Hospitalier Universitaire Sainte-JustineMontrealQuebecCanadaH3T 1C5
    128Saskatoon Cancer CentreSaskatoonSaskatchewanCanadaS7N 4H4
    129Centre Hospitalier Universitaire de QuebecQuebecCanadaG1V 4G2
    130San Jorge Children's HospitalSan JuanPuerto Rico00912

    Sponsors and Collaborators

    • Children's Oncology Group
    • National Cancer Institute (NCI)

    Investigators

    • Principal Investigator: Amanda M Termuhlen, Children's Oncology Group

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Children's Oncology Group
    ClinicalTrials.gov Identifier:
    NCT01000753
    Other Study ID Numbers:
    • ANHL04B1
    • NCI-2009-00406
    • COG-ANHL04B1
    • CDR0000404164
    • ANHL04B1
    • ANHL04B1
    • U10CA098543
    • UG1CA189958
    First Posted:
    Oct 23, 2009
    Last Update Posted:
    Mar 24, 2022
    Last Verified:
    Mar 1, 2022
    Additional relevant MeSH terms:
    Lymphoma
    Lymphoma, Follicular
    Lymphoma, Non-Hodgkin
    Lymphoma, Mantle-Cell
    Leukemia, Lymphocytic, Chronic, B-Cell
    Lymphoma, T-Cell
    Lymphoma, B-Cell
    Lymphoma, T-Cell, Cutaneous
    Plasmablastic Lymphoma
    Lymphoma, Large-Cell, Immunoblastic
    Lymphoproliferative Disorders

    Study Results

    No Results Posted as of Mar 24, 2022