Collection and Storage of Tissue and Blood Samples From Patients With Cancer
Study Details
Study Description
Brief Summary
This research trial collects and stores tissue and blood samples from patients with cancer. Collecting and storing samples of tissue and blood from patients with cancer to study in the laboratory may help scientists create new and better models to learn about cancer and to test new cancer drugs.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
PRIMARY OBJECTIVE:
- To procure biologic tissues and materials to generate preclinical models of cancer.
OUTLINE:
Tumor tissue and blood samples are procured during procedures that are required for the patients' clinical management and will be stored via xenograft (transplant to another species) models or in vitro cell culture for future analysis.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Ancillary-correlative (tissue and blood procurement) Tumor tissue and blood samples are procured during procedures that are required for the patients' clinical management and stored via xenograft (transplant to another species) models or in vitro cell culture for future analysis. |
Other: Cytology Specimen Collection Procedure
Procurement of tissue and blood samples
Other Names:
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Outcome Measures
Primary Outcome Measures
- Procurement of tissue and blood specimens for research purposes [Up to 5 years]
Tissues and venous blood will be stored, implanted immediately to generate patient-derived xenografts (which require fresh, viable cells), or placed immediately into in vitro cell culture to generate patient-derived cell lines (which require fresh, viable cells).
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patients 18 year of age or older who are being evaluated, treated or enrolled in a clinical trial for cancer at participating sites
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Patients with a histologically or cytologically confirmed diagnosis of cancer
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Patients without histologically or cytologically confirmed diagnosis of cancer, but for whom approval has been requested and received from the coordinating site study coordinator
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Requests for coordinating site approval should only be made if the patient's existing work-up at the time of the request demonstrates a combination of two or more of the following indicating the greater likelihood of a cancerous process in the assessment of the treating physician:
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Radiographic imaging (computed tomography [CT], magnetic resonance imaging [MRI], etc.)
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Elevated tumor markers
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Clinical symptoms
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Documented risk factors, known genetic changes (mutation, deletion, fusion, etc.), and/or known familial cancer history or syndrome
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If the patient will be undergoing surgical resection at a later time and will be accessible to approach for study participation at that time, resected material following cancer diagnosis confirmation is preferred
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Important: Additional medical, genetic and/or demographic work-up should not be obtained solely for determination of eligibility for protocol 9846 by these criteria. Once available, final redacted pathology confirmation must be provided to the coordinating site detailing the confirmed cancer diagnosis for patients enrolled based on the above criteria
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Patients with a newly diagnosed primary and/or metastatic solid tumor, lymphoma or multiple myeloma malignancy for which they have not yet received treatment
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Patients with a solid tumor, lymphoma or multiple myeloma malignancy that is recurrent, newly metastasized, or progressing while on treatment indicated by:
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Radiographic evidence of tumor growth, re-growth, and/or new metastases, OR
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Documentation by the treating physician of clinical disease progression
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Patients currently undergoing treatment (adjuvant, neoadjuvant, etc.)
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Specimen collection should occur as distant in time from the most recent drug administration as possible (e.g., after completion of a treatment cycle and immediately prior to initiation of the next cycle)
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Specimens should not be collected from patients between doses within a single treatment cycle
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Confirmation of viable malignancy and/or < 90% tumor necrosis must be confirmed to the National Cancer Institute (NCI) coordinating site, as indicated in the final post-operative/post-procedure pathology report
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Patients with ongoing partial response (PR) or stable disease (SD) are eligible
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Confirmation of viable malignancy and/or < 90% tumor necrosis must be confirmed to the NCI coordinating site, as indicated in the final post-operative/post-procedure pathology report
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Ability to understand and willingness to sign a written informed consent document indicating their willingness to have their tissue or biologic fluid specimens used for research as outlined in this protocol
Exclusion Criteria:
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Patients with invasive fungal infections
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Patients with active and/or uncontrolled infections or who are still recovering from an infection
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Actively febrile patients with uncertain etiology of febrile episode
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All antibiotics should be completed at least 1 week (7 days) prior to collection
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No recurrence of fever or other symptoms related to infection for at least 1 week (7 days) following completion of antibiotics
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Note: Use of antibiotics for pre-operative prophylaxis is not an exclusion
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Patients with human immunodeficiency virus (HIV), active or chronic hepatitis (i.e., quantifiable hepatitis B virus [HBV]-deoxyribonucleic acid [DNA] and/or positive hepatitis B surface antigen [HbsAg], quantifiable hepatitis C virus [HCV]-ribonucleic acid [RNA]) or known history of HCV, HBV, or HIV; testing for HBV, HCV, HIV or other infections for eligibility will be performed only if clinically indicated
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Patients with hepatitis A as indicated by anti-hepatitis A virus (HAV) IgM reactivity
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Patients that are anti-HAV IgG reactive only are eligible
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Specimen collections from patients with benign tumors including but not limited to desmoid tumors, carcinoma in situ, or ongoing evidence of complete disease response (CR) based on imaging
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | United States | 35233 |
2 | Mercy Hospital Fort Smith | Fort Smith | Arkansas | United States | 72903 |
3 | PCR Oncology | Arroyo Grande | California | United States | 93420 |
4 | City of Hope Comprehensive Cancer Center | Duarte | California | United States | 91010 |
5 | USC / Norris Comprehensive Cancer Center | Los Angeles | California | United States | 90033 |
6 | University of Colorado Hospital | Aurora | Colorado | United States | 80045 |
7 | Smilow Cancer Center/Yale-New Haven Hospital | New Haven | Connecticut | United States | 06510 |
8 | Yale University | New Haven | Connecticut | United States | 06520 |
9 | Delaware Clinical and Laboratory Physicians PA | Newark | Delaware | United States | 19713 |
10 | Helen F Graham Cancer Center | Newark | Delaware | United States | 19713 |
11 | Medical Oncology Hematology Consultants PA | Newark | Delaware | United States | 19713 |
12 | Christiana Care Health System-Christiana Hospital | Newark | Delaware | United States | 19718 |
13 | Christiana Care Health System-Wilmington Hospital | Wilmington | Delaware | United States | 19801 |
14 | Augusta University Medical Center | Augusta | Georgia | United States | 30912 |
15 | Saint Joseph Medical Center | Bloomington | Illinois | United States | 61701 |
16 | Illinois CancerCare-Bloomington | Bloomington | Illinois | United States | 61704 |
17 | Illinois CancerCare-Canton | Canton | Illinois | United States | 61520 |
18 | Memorial Hospital of Carbondale | Carbondale | Illinois | United States | 62902 |
19 | Illinois CancerCare-Carthage | Carthage | Illinois | United States | 62321 |
20 | Centralia Oncology Clinic | Centralia | Illinois | United States | 62801 |
21 | John H Stroger Jr Hospital of Cook County | Chicago | Illinois | United States | 60612 |
22 | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | United States | 62526 |
23 | Decatur Memorial Hospital | Decatur | Illinois | United States | 62526 |
24 | Crossroads Cancer Center | Effingham | Illinois | United States | 62401 |
25 | Illinois CancerCare-Eureka | Eureka | Illinois | United States | 61530 |
26 | Illinois CancerCare-Galesburg | Galesburg | Illinois | United States | 61401 |
27 | Western Illinois Cancer Treatment Center | Galesburg | Illinois | United States | 61401 |
28 | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | United States | 61443 |
29 | Illinois CancerCare-Macomb | Macomb | Illinois | United States | 61455 |
30 | Good Samaritan Regional Health Center | Mount Vernon | Illinois | United States | 62864 |
31 | Cancer Care Center of O'Fallon | O'Fallon | Illinois | United States | 62269 |
32 | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | United States | 61350 |
33 | Radiation Oncology of Northern Illinois | Ottawa | Illinois | United States | 61350 |
34 | Illinois CancerCare-Pekin | Pekin | Illinois | United States | 61554 |
35 | OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin | Illinois | United States | 61554 |
36 | Illinois CancerCare-Peoria | Peoria | Illinois | United States | 61615 |
37 | OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois | United States | 61615 |
38 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
39 | OSF Saint Francis Medical Center | Peoria | Illinois | United States | 61637 |
40 | Illinois CancerCare-Peru | Peru | Illinois | United States | 61354 |
41 | Valley Radiation Oncology | Peru | Illinois | United States | 61354 |
42 | Illinois CancerCare-Princeton | Princeton | Illinois | United States | 61356 |
43 | Central Illinois Hematology Oncology Center | Springfield | Illinois | United States | 62702 |
44 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62702 |
45 | Springfield Clinic | Springfield | Illinois | United States | 62702 |
46 | Memorial Medical Center | Springfield | Illinois | United States | 62781 |
47 | Cancer Center of Kansas - Chanute | Chanute | Kansas | United States | 66720 |
48 | Cancer Center of Kansas - Dodge City | Dodge City | Kansas | United States | 67801 |
49 | Cancer Center of Kansas - El Dorado | El Dorado | Kansas | United States | 67042 |
50 | Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas | United States | 66701 |
51 | Cancer Center of Kansas-Independence | Independence | Kansas | United States | 67301 |
52 | Cancer Center of Kansas-Kingman | Kingman | Kansas | United States | 67068 |
53 | Lawrence Memorial Hospital | Lawrence | Kansas | United States | 66044 |
54 | Cancer Center of Kansas-Liberal | Liberal | Kansas | United States | 67905 |
55 | Cancer Center of Kansas-Manhattan | Manhattan | Kansas | United States | 66502 |
56 | Cancer Center of Kansas - Newton | Newton | Kansas | United States | 67114 |
57 | Cancer Center of Kansas - Parsons | Parsons | Kansas | United States | 67357 |
58 | Cancer Center of Kansas - Pratt | Pratt | Kansas | United States | 67124 |
59 | Cancer Center of Kansas - Salina | Salina | Kansas | United States | 67401 |
60 | Cancer Center of Kansas - Wellington | Wellington | Kansas | United States | 67152 |
61 | Associates In Womens Health | Wichita | Kansas | United States | 67208 |
62 | Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | United States | 67208 |
63 | Ascension Via Christi Hospitals Wichita | Wichita | Kansas | United States | 67214 |
64 | Cancer Center of Kansas - Wichita | Wichita | Kansas | United States | 67214 |
65 | Wesley Medical Center | Wichita | Kansas | United States | 67214 |
66 | Cancer Center of Kansas - Winfield | Winfield | Kansas | United States | 67156 |
67 | Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | United States | 21287 |
68 | Dana-Farber Cancer Institute | Boston | Massachusetts | United States | 02215 |
69 | Saint Joseph Mercy Hospital | Ann Arbor | Michigan | United States | 48106 |
70 | Bronson Battle Creek | Battle Creek | Michigan | United States | 49017 |
71 | Mercy Health Saint Mary's | Grand Rapids | Michigan | United States | 49503 |
72 | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | United States | 49503 |
73 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 49007 |
74 | Borgess Medical Center | Kalamazoo | Michigan | United States | 49048 |
75 | Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | United States | 48154 |
76 | Mercy Health Mercy Campus | Muskegon | Michigan | United States | 49444 |
77 | Lakeland Hospital Niles | Niles | Michigan | United States | 49120 |
78 | Spectrum Health Reed City Hospital | Reed City | Michigan | United States | 49677 |
79 | Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan | United States | 49085 |
80 | Marie Yeager Cancer Center | Saint Joseph | Michigan | United States | 49085 |
81 | Munson Medical Center | Traverse City | Michigan | United States | 49684 |
82 | Mayo Clinic in Rochester | Rochester | Minnesota | United States | 55905 |
83 | Baptist Memorial Hospital and Cancer Center-Oxford | Oxford | Mississippi | United States | 38655 |
84 | Central Care Cancer Center - Bolivar | Bolivar | Missouri | United States | 65613 |
85 | Parkland Health Center-Bonne Terre | Bonne Terre | Missouri | United States | 63628 |
86 | Cox Cancer Center Branson | Branson | Missouri | United States | 65616 |
87 | Saint Francis Medical Center | Cape Girardeau | Missouri | United States | 63703 |
88 | Southeast Cancer Center | Cape Girardeau | Missouri | United States | 63703 |
89 | Capital Region Southwest Campus | Jefferson City | Missouri | United States | 65109 |
90 | Freeman Health System | Joplin | Missouri | United States | 64804 |
91 | Mercy Hospital Joplin | Joplin | Missouri | United States | 64804 |
92 | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | United States | 65401 |
93 | Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | United States | 65401 |
94 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64506 |
95 | Saint Louis Cancer and Breast Institute-South City | Saint Louis | Missouri | United States | 63109 |
96 | Washington University School of Medicine | Saint Louis | Missouri | United States | 63110 |
97 | Mercy Hospital South | Saint Louis | Missouri | United States | 63128 |
98 | Missouri Baptist Medical Center | Saint Louis | Missouri | United States | 63131 |
99 | Mercy Hospital Saint Louis | Saint Louis | Missouri | United States | 63141 |
100 | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | United States | 63670 |
101 | Mercy Hospital Springfield | Springfield | Missouri | United States | 65804 |
102 | CoxHealth South Hospital | Springfield | Missouri | United States | 65807 |
103 | Missouri Baptist Sullivan Hospital | Sullivan | Missouri | United States | 63080 |
104 | Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | United States | 63127 |
105 | Cancer and Blood Specialists-Henderson | Henderson | Nevada | United States | 89052 |
106 | Cancer and Blood Specialists-Shadow | Las Vegas | Nevada | United States | 89106 |
107 | HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway | Las Vegas | Nevada | United States | 89109 |
108 | HealthCare Partners Medical Group Oncology/Hematology-San Martin | Las Vegas | Nevada | United States | 89113 |
109 | Cancer Therapy and Integrative Medicine | Las Vegas | Nevada | United States | 89121 |
110 | Cancer and Blood Specialists-Tenaya | Las Vegas | Nevada | United States | 89128 |
111 | HealthCare Partners Medical Group Oncology/Hematology-Tenaya | Las Vegas | Nevada | United States | 89128 |
112 | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | United States | 89148 |
113 | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | United States | 89148 |
114 | HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills | Las Vegas | Nevada | United States | 89149 |
115 | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada | United States | 89169 |
116 | Montefiore Medical Center-Einstein Campus | Bronx | New York | United States | 10461 |
117 | Montefiore Medical Center-Weiler Hospital | Bronx | New York | United States | 10461 |
118 | Montefiore Medical Center - Moses Campus | Bronx | New York | United States | 10467 |
119 | NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York | United States | 10032 |
120 | UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | United States | 27599 |
121 | Duke University Medical Center | Durham | North Carolina | United States | 27710 |
122 | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | United States | 73120 |
123 | Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee | United States | 38120 |
124 | M D Anderson Cancer Center | Houston | Texas | United States | 77030 |
125 | MultiCare Auburn Medical Center | Auburn | Washington | United States | 98001 |
126 | Virginia Mason Bainbridge Island Medical Center | Bainbridge Island | Washington | United States | 98110 |
127 | Virginia Mason Federal Way Medical Center | Federal Way | Washington | United States | 98002 |
128 | MultiCare Gig Harbor Medical Park | Gig Harbor | Washington | United States | 98335 |
129 | Virginia Mason Lynnwood Medical Center | Lynnwood | Washington | United States | 98036 |
130 | MultiCare Good Samaritan Hospital | Puyallup | Washington | United States | 98372 |
131 | Virginia Mason Medical Center | Seattle | Washington | United States | 98101 |
132 | Marshfield Clinic-Chippewa Center | Chippewa Falls | Wisconsin | United States | 54729 |
133 | Marshfield Clinic Cancer Center at Sacred Heart | Eau Claire | Wisconsin | United States | 54701 |
134 | Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States | 54601 |
135 | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | United States | 54449 |
136 | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin | United States | 54548 |
137 | Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | United States | 54868 |
138 | Ascension Saint Michael's Hospital | Stevens Point | Wisconsin | United States | 54481 |
139 | Marshfield Clinic-Wausau Center | Wausau | Wisconsin | United States | 54401 |
140 | Marshfield Medical Center - Weston | Weston | Wisconsin | United States | 54476 |
Sponsors and Collaborators
- National Cancer Institute (NCI)
Investigators
- Principal Investigator: James H Doroshow, National Cancer Institute (NCI)
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NCI-2015-00863
- NCI-2015-00863
- P9846
- P9846_R02PAPPHOLD01
- 9846
- 9846
- UM1CA186689
- UM1CA186691
- UM1CA186704
- UM1CA186709
- UM1CA186717
- ZIABC011078