S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery

• Sponsor: Southwest Oncology Group (Other)
• Overall Status: Active, not recruiting
• CT.gov ID: NCT03365882
• Collaborator: National Cancer Institute (NCI) (NIH)
• Enrollment: 240
• Locations: 798
• Arms: 2
• Anticipated Duration (Months): 68.2
• Patients Per Site: 0.3
• Patients Per Site Per Month: 0

Study Details

Study Description

Brief Summary

This randomized phase II trial studies how well trastuzumab and pertuzumab work compared to cetuximab and irinotecan hydrochloride in treating patients with HER2/neu amplified colorectal cancer that has spread from where it started to other places in the body and cannot be removed by surgery. Monoclonal antibodies, such as trastuzumab and pertuzumab, may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as cetuximab and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving trastuzumab and pertuzumab may work better compared to cetuximab and irinotecan hydrochloride in treating patients with colorectal cancer.

Condition or Disease	Intervention/Treatment	Phase
Colon Adenocarcinoma; ERBB2 Gene Amplification; Rectal Adenocarcinoma; Recurrent Colon Carcinoma; Recurrent Rectal Carcinoma; Stage III Colon Cancer AJCC v7; Stage III Rectal Cancer AJCC v7; Stage IIIA Colon Cancer AJCC v7; Stage IIIA Rectal Cancer AJCC v7; Stage IIIB Colon Cancer AJCC v7; Stage IIIB Rectal Cancer AJCC v7; Stage IIIC Colon Cancer AJCC v7; Stage IIIC Rectal Cancer AJCC v7; Stage IV Colon Cancer AJCC v7; Stage IV Rectal Cancer AJCC v7; Stage IVA Colon Cancer AJCC v7; Stage IVA Rectal Cancer AJCC v7; Stage IVB Colon Cancer AJCC v7; Stage IVB Rectal Cancer AJCC v7	Biological: Cetuximab; Drug: Irinotecan Hydrochloride; Other: Laboratory Biomarker Analysis; Biological: Pertuzumab; Biological: Trastuzumab; Device: HER-2 testing	Phase 2

Detailed Description

PRIMARY OBJECTIVES:

1. To evaluate the efficacy of trastuzumab and pertuzumab (TP) (Arm 1) in HER-2 amplified metastatic colorectal cancer (mCRC) by comparing progression-free survival (PFS) on TP compared to control arm (Arm 2) of cetuximab and irinotecan hydrochloride (irinotecan) (CETIRI).

SECONDARY OBJECTIVES:

1. To evaluate the overall response rate (ORR), including confirmed complete and partial response per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1, in treatment Arms 1 and 2.

2. To evaluate the overall survival (OS) in treatment Arms 1 and 2. III. To evaluate the safety and toxicity of TP compared to CETIRI.

TERTIARY OBJECTIVES:

1. To estimate the rates of PFS, OS, and ORR in patients who crossover to TP (Arm 3) after disease progression on CETIRI.

2. To bank images for future retrospective analysis. III. To evaluate if HER-2/centromeric probe (CEP17) signal ratio and HER-2 gene copy number (GCN) are predictive of clinical efficacy for patients receiving TP versus CETIRI.

3. To bank tissue and blood samples for other future correlative studies from patients enrolled on the study.

OUTLINE: Patients with HER2 gene amplification are randomized to 1 of 2 arms.

ARM I: Patients receive pertuzumab intravenously (IV) over 30-60 minutes and trastuzumab IV over 30-120 minutes on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive cetuximab IV over 60-120 minutes and irinotecan hydrochloride IV over 90 minutes on day 1. Courses repeat every 14 days in the absence of disease progression or unacceptable toxicity. Patients with documented disease progression may optionally crossover to Arm I.

After completion of study treatment, patients are followed up for 3 years.

Study Design

• Study Type: Interventional
• Actual Enrollment: 240 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: S1613, A Randomized Phase II Study of Trastuzumab and Pertuzumab (TP) Compared to Cetuximab and Irinotecan (CETIRI) in Advanced/Metastatic Colorectal Cancer (mCRC) With HER-2 Amplification
• Actual Study Start Date: Oct 9, 2017
• Anticipated Primary Completion Date: Nov 1, 2022
• Anticipated Study Completion Date: Jun 15, 2023

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Arm I (pertuzumab, trastuzumab) Patients receive pertuzumab IV over 30-60 minutes and trastuzumab IV over 30-120 minutes on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.	Other: Laboratory Biomarker Analysis; Correlative studies; Biological: Pertuzumab; Given IV; Other Names: 2C4 2C4 Antibody MoAb 2C4 Monoclonal Antibody 2C4 Perjeta rhuMAb2C4 RO4368451 ; Biological: Trastuzumab; Given IV; Other Names: ABP 980 Anti-c-ERB-2 Anti-c-erbB2 Monoclonal Antibody Anti-ERB-2 Anti-erbB-2 Anti-erbB2 Monoclonal Antibody Anti-HER2/c-erbB2 Monoclonal Antibody Anti-p185-HER2 c-erb-2 Monoclonal Antibody HER2 Monoclonal Antibody Herceptin Herceptin Biosimilar PF-05280014 Herceptin Trastuzumab Biosimilar PF-05280014 MoAb HER2 Monoclonal Antibody c-erb-2 Monoclonal Antibody HER2 PF-05280014 rhuMAb HER2 RO0452317 Trastuzumab Biosimilar ABP 980 Trastuzumab Biosimilar PF-05280014 ; Device: HER-2 testing; Central testing of HER-2 for eligibility
Experimental: Arm II (cetuximab, irinotecan hydrochloride) Patients receive cetuximab IV over 60-120 minutes and irinotecan hydrochloride IV over 90 minutes on day 1. Courses repeat every 14 days in the absence of disease progression or unacceptable toxicity. Patients with documented disease progression may optionally crossover to Arm I.	Biological: Cetuximab; Given IV; Other Names: Chimeric Anti-EGFR Monoclonal Antibody Chimeric MoAb C225 Chimeric Monoclonal Antibody C225 Erbitux IMC-C225 ; Drug: Irinotecan Hydrochloride; Given IV; Other Names: Campto Camptosar Camptothecin 11 Camptothecin-11 CPT 11 CPT-11 Irinomedac U-101440E ; Other: Laboratory Biomarker Analysis; Correlative studies; Device: HER-2 testing; Central testing of HER-2 for eligibility

Outcome Measures

Primary Outcome Measures

1. Progression-free survival (PFS) [From date of registration to date of first documentation of progression or symptomatic deterioration, or death due to any cause, assessed up to 3 years]

   Analysis of PFS will be conducted using the stratified log rank test upon the observation of 115 PFS events. PFS among patients who register to Arm 3 will be summarized using descriptive statistics.

Secondary Outcome Measures

1. Incidence of adverse events [Up to 3 years]

   Evaluated according to National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0.

2. Overall response rate (ORR) [Up to 3 years]

   ORR including confirmed complete and partial responses per Response Evaluation Criteria in Solid Tumors 1.1 will be compared using using the Cochran-Mantel-Haenszel test. ORR among patients who register to Arm 3 will be summarized using descriptive statistics.

3. Overall survival (OS) [From date of registration to date of death due to any cause, assessed up to 3 years]

   Distributions of OS in each arm will be estimated using the method of Kaplan-Meier and compared using the stratified log-rank test. OS among patients who register to Arm 3 will be summarized using descriptive statistics.

Other Outcome Measures

1. Association between HER-2 gene copy number (GCN) and PFS [Up to 3 years]

   The associations between GCN and PFS will be explored via Kaplan-Meier curves and Cox regression.

2. Association between HER-2 gene copy number (GCN) and response [Up to 3 years]

   The associations between GCN and response will be explored via logistic regression.

3. Association between HER-2/CEP17 signal ratio and PFS [Up to 3 years]

   The associations between HER-2/CEP17 signal ratio and PFS will be explored via Kaplan-Meier curves and Cox regression.

4. Association between HER-2/CEP17 signal ratio and response [Up to 3 years]

   The associations between HER-2/CEP17 signal ratio and response will be explored via Logistic regression.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• STEP 1 INITIAL REGISTRATION: HER2 TESTING

• Patients must have histologically or cytologically documented adenocarcinoma of the colon or rectum that is metastatic or locally advanced and unresectable

• Mutation results:

• All patients must have molecular testing performed in a Clinical Laboratory Improvement Act (CLIA) certified lab which includes which includes KRAS and NRAS gene and exon 15 of BRAF gene (BRAF V600E mutation); patients with any known activating mutation in exon 2 [codons 12 and 13], exon 3 [codons 59 and 61] and exon 4 [codons 117 and 146]) of KRAS/NRAS genes and in exon 15 (BRAFV600E mutation) of BRAF gene are not eligible

• Patients must not have been treated with any of the following prior to step 1 initial registration:

• Cetuximab, panitumumab, or any other monoclonal antibody against EGFR or inhibitor of EGFR

• HER-2 targeting for treatment of colorectal cancer; patients who have received prior trastuzumab or pertuzumab for other indications such as prior history of adjuvant or neoadjuvant breast cancer treatment prior to the development of advanced colorectal cancer are eligible

• Patients must not have had history of severe toxicity and intolerance to or hypersensitivity to irinotecan or any other study drug; patients must not have had a severe infusion-related reaction during any prior therapy with pertuzumab or trastuzumab

• Patients must have tumor slides available for submission for HER-2 testing; HER-2 testing must be completed by the central lab prior to step 2 randomization

• Patients must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines; for step 1 initial registration, the appropriate consent form is the step 1 consent form

• As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

• STEP 2 RANDOMIZATION

• Patients must have HER-2 amplification as determined by central testing (3+ or 2+ by immunohistochemistry and HER-2 gene amplification by in situ hybridization with a ratio of HER-2 gene signals to centromere 17 signals >= 2.0)

• Patients must have measurable disease that is metastatic or locally advanced and unresectable; imaging used to assess all disease per RECIST 1.1 must have been completed within 28 days prior to step 2 randomization; all disease must be assessed and documented on the Baseline Tumor Assessment Form

• Patients must have had at least one prior regimen of systemic chemotherapy for metastatic or locally advanced, unresectable disease; patients must have progressed following the most recent therapy; prior treatment with irinotecan is allowed; for patients that received adjuvant chemotherapy: prior treatment for metastatic disease is not required for patient who experienced disease recurrence during or within 6 months of completion of adjuvant chemotherapy; if the patient received one line of adjuvant treatment and had disease recurrence after 6 months of completing chemotherapy, patients will only be eligible after failing one additional line of chemotherapy used to treat the metastatic or locally advanced, unresectable disease; patients who have received >= 3 lines of systemic chemotherapy for metastatic or locally advanced, unresectable disease are not eligible

• Patients must have completed prior chemotherapy, immunotherapy, or radiation therapy at least 14 days prior to step 2 randomization and all toxicity must be resolved to Common Terminology Criteria for Adverse Events (CTCAE) version (v)4.0 grade 1 (with the exception of CTCAE v4.0 grade 2 neuropathy) prior to step 2 randomization

• Brain metastases are allowed if they have been adequately treated with radiotherapy or surgery and stable for at least 30 days prior to step 2 randomization; eligible patients must be neurologically asymptomatic and without corticosteroid treatment for at least 7 days prior to step 2 randomization

• Patients must have a Zubrod performance status of 0 or 1

• Patients must have a complete physical examination and medical history within 28 days prior to step 2 randomization

• Absolute neutrophil count (ANC) >= 1,500/mcL

• Platelets >= 75,000/mcL

• Hemoglobin >= 9 g/dL

• Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) both =< 5 x institutional upper limit of normal (IULN)

• Bilirubin =< 1.5 mg/dL

• Calculated creatinine clearance > 30 ml/min within 14 days prior to step 2 randomization

• Patients who have had an echocardiogram performed within 6 months prior to step 2 randomization must have ventricular ejection fraction (left ventricular ejection fraction [LVEF]) >= 50% or >= within normal limits for the institution

• Patients must not have an uncontrolled intercurrent illness including, but not limited to diabetes, hypertension, severe infection, severe malnutrition, unstable angina, class III-IV New York Heart Association (NYHA) congestive heart failure, ventricular arrhythmias, active ischemic heart disease, or myocardial infarction within 6 months prior to step 2 randomization

• Patients must not have any known previous or concurrent condition suggesting susceptibility to hypersensitivity or allergic reactions, including, but not limited to: known hypersensitivity to any of the study treatments or to excipients of recombinant human or humanized antibodies; patients with mild or seasonal allergies may be included after discussion with the study chairs

• Patients must not be planning treatment with other systemic anti-cancer agents (e.g., chemotherapy, hormonal therapy, immunotherapy) or other treatments not part of protocol-specified anti-cancer therapy including concurrent investigational agents of any type

• No prior malignancy is allowed except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, ductal carcinoma in situ, other low grade lesions such as incidental appendix carcinoid, or any other cancer from which the patient has been disease and treatment free for two years; prostate cancer patients on active surveillance are eligible

• Patients must not be pregnant or nursing; females of child-bearing potential must have a negative serum pregnancy test within 7 days prior to registration; women/men of reproductive potential must have agreed to use an effective contraceptive method while on study and for at least 7 months after the last dose of study treatment; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures

• Patients must be given the opportunity to consent to the optional submission of tissue for future research

• Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines; the appropriate consent form for this registration is the step 2 consent form

• STEP 2 RANDOMIZATION: As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

• STEP 3 CROSSOVER REGISTRATION (OPTIONAL): Patients must have documented disease progression while on CETIRI (Arm 2) on this protocol; the Follow-up Tumor Assessment Form documenting disease progression must be submitted to Southwest Oncology Group (SWOG) prior to step 3 crossover registration; registration to step 3 crossover must be within 28 days of discontinuation of CETIRI protocol treatment; patients going off treatment for any other reason are not eligible

• STEP 3 CROSSOVER REGISTRATION (OPTIONAL): Patients must have a Zubrod performance status of 0 or 1

• STEP 3 CROSSOVER REGISTRATION (OPTIONAL): ANC >= 1,500/mcL

• STEP 3 CROSSOVER REGISTRATION (OPTIONAL): Platelets >= 75,000/mcL

• STEP 3 CROSSOVER REGISTRATION (OPTIONAL): Hemoglobin >= 9 g/dL

• STEP 3 CROSSOVER REGISTRATION (OPTIONAL): AST and ALT both =< 5 x institutional upper limit of normal (IULN)

• STEP 3 CROSSOVER REGISTRATION (OPTIONAL): Bilirubin =< 1.5 mg/dL

• STEP 3 CROSSOVER REGISTRATION (OPTIONAL): Calculated creatinine clearance > 30 ml/min within 14 days prior to step 3 crossover registration

• STEP 3 CROSSOVER REGISTRATION (OPTIONAL): Patients must have left ventricular ejection fraction (LVEF) >= 50% or >= lower limit of normal for the institution by echocardiogram within 14 days prior to step 3 crossover registration

• STEP 3 CROSSOVER REGISTRATION (OPTIONAL): Patients must have a magnesium, potassium, calcium, sodium, bicarbonate, and chloride performed within 14 days prior to step 3 crossover registration

• STEP 3 CROSSOVER REGISTRATION (OPTIONAL): Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines; the appropriate consent form for this registration is the step 2 consent form

• STEP 3 CROSSOVER REGISTRATION (OPTIONAL): As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Anchorage Associates in Radiation Medicine	Anchorage	Alaska	United States	98508
2	Anchorage Radiation Therapy Center	Anchorage	Alaska	United States	99504
3	Alaska Breast Care and Surgery LLC	Anchorage	Alaska	United States	99508
4	Alaska Oncology and Hematology LLC	Anchorage	Alaska	United States	99508
5	Alaska Women's Cancer Care	Anchorage	Alaska	United States	99508
6	Anchorage Oncology Centre	Anchorage	Alaska	United States	99508
7	Katmai Oncology Group	Anchorage	Alaska	United States	99508
8	Providence Alaska Medical Center	Anchorage	Alaska	United States	99508
9	Fairbanks Memorial Hospital	Fairbanks	Alaska	United States	99701
10	CTCA at Western Regional Medical Center	Goodyear	Arizona	United States	85338
11	Kingman Regional Medical Center	Kingman	Arizona	United States	86401
12	Mercy Hospital Fort Smith	Fort Smith	Arkansas	United States	72903
13	CHI Saint Vincent Cancer Center Hot Springs	Hot Springs	Arkansas	United States	71913
14	Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro	Jonesboro	Arkansas	United States	72401
15	Kaiser Permanente-Anaheim	Anaheim	California	United States	92806
16	Mission Hope Medical Oncology - Arroyo Grande	Arroyo Grande	California	United States	93420
17	PCR Oncology	Arroyo Grande	California	United States	93420
18	Sutter Auburn Faith Hospital	Auburn	California	United States	95602
19	Sutter Cancer Centers Radiation Oncology Services-Auburn	Auburn	California	United States	95603
20	Kaiser Permanente-Baldwin Park	Baldwin Park	California	United States	91706
21	Kaiser Permanente-Bellflower	Bellflower	California	United States	90706
22	Alta Bates Summit Medical Center-Herrick Campus	Berkeley	California	United States	94704
23	Providence Saint Joseph Medical Center/Disney Family Cancer Center	Burbank	California	United States	91505
24	Mills-Peninsula Medical Center	Burlingame	California	United States	94010
25	Sutter Cancer Centers Radiation Oncology Services-Cameron Park	Cameron Park	California	United States	95682
26	Eden Hospital Medical Center	Castro Valley	California	United States	94546
27	City of Hope Corona	Corona	California	United States	92879
28	UC Irvine Health Cancer Center-Newport	Costa Mesa	California	United States	92627
29	Sutter Davis Hospital	Davis	California	United States	95616
30	City of Hope Comprehensive Cancer Center	Duarte	California	United States	91010
31	Epic Care-Dublin	Dublin	California	United States	94568
32	Bay Area Breast Surgeons Inc	Emeryville	California	United States	94608
33	Epic Care Partners in Cancer Care	Emeryville	California	United States	94608
34	Kaiser Permanente-Fontana	Fontana	California	United States	92335
35	Palo Alto Medical Foundation-Fremont	Fremont	California	United States	94538
36	Kaiser Permanente - Harbor City	Harbor City	California	United States	90710
37	Kaiser Permanente-Irvine	Irvine	California	United States	92618
38	City of Hope Antelope Valley	Lancaster	California	United States	93534
39	Loma Linda University Medical Center	Loma Linda	California	United States	92354
40	Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	United States	90027
41	Los Angeles County-USC Medical Center	Los Angeles	California	United States	90033
42	USC / Norris Comprehensive Cancer Center	Los Angeles	California	United States	90033
43	Kaiser Permanente West Los Angeles	Los Angeles	California	United States	90034
44	Contra Costa Regional Medical Center	Martinez	California	United States	94553-3156
45	Fremont - Rideout Cancer Center	Marysville	California	United States	95901
46	City of Hope Mission Hills	Mission Hills	California	United States	91345
47	Memorial Medical Center	Modesto	California	United States	95355
48	Palo Alto Medical Foundation-Camino Division	Mountain View	California	United States	94040
49	Palo Alto Medical Foundation-Gynecologic Oncology	Mountain View	California	United States	94040
50	Sutter Cancer Research Consortium	Novato	California	United States	94945
51	Alta Bates Summit Medical Center - Summit Campus	Oakland	California	United States	94609
52	Bay Area Tumor Institute	Oakland	California	United States	94609
53	Kaiser Permanente-Ontario	Ontario	California	United States	91761
54	UC Irvine Health/Chao Family Comprehensive Cancer Center	Orange	California	United States	92868
55	Palo Alto Medical Foundation Health Care	Palo Alto	California	United States	94301
56	Kaiser Permanente - Panorama City	Panorama City	California	United States	91402
57	Kaiser Permanente-Riverside	Riverside	California	United States	92505
58	Sutter Cancer Centers Radiation Oncology Services-Roseville	Roseville	California	United States	95661
59	Sutter Roseville Medical Center	Roseville	California	United States	95661
60	Sutter Medical Center Sacramento	Sacramento	California	United States	95816
61	University of California Davis Comprehensive Cancer Center	Sacramento	California	United States	95817
62	Kaiser Permanente-San Diego Mission	San Diego	California	United States	92108
63	Kaiser Permanente-San Diego Zion	San Diego	California	United States	92120
64	California Pacific Medical Center-Pacific Campus	San Francisco	California	United States	94115
65	Pacific Central Coast Health Center-San Luis Obispo	San Luis Obispo	California	United States	93401
66	Kaiser Permanente-San Marcos	San Marcos	California	United States	92078
67	Mills Health Center	San Mateo	California	United States	94401
68	City of Hope - Santa Clarita	Santa Clarita	California	United States	91355
69	Palo Alto Medical Foundation-Santa Cruz	Santa Cruz	California	United States	95065
70	Mission Hope Medical Oncology - Santa Maria	Santa Maria	California	United States	93444
71	Sutter Pacific Medical Foundation	Santa Rosa	California	United States	95403
72	City of Hope South Pasadena	South Pasadena	California	United States	91030
73	Palo Alto Medical Foundation-Sunnyvale	Sunnyvale	California	United States	94086
74	City of Hope Upland	Upland	California	United States	91786
75	Sutter Cancer Centers Radiation Oncology Services-Vacaville	Vacaville	California	United States	95687
76	Sutter Solano Medical Center/Cancer Center	Vallejo	California	United States	94589
77	Epic Care Cyberknife Center	Walnut Creek	California	United States	94597
78	City of Hope West Covina	West Covina	California	United States	91790
79	Kaiser Permanente-Woodland Hills	Woodland Hills	California	United States	91367
80	Rocky Mountain Cancer Centers-Aurora	Aurora	Colorado	United States	80012
81	The Medical Center of Aurora	Aurora	Colorado	United States	80012
82	Children's Hospital Colorado	Aurora	Colorado	United States	80045
83	University of Colorado Hospital	Aurora	Colorado	United States	80045
84	Boulder Community Hospital	Boulder	Colorado	United States	80301
85	Boulder Community Foothills Hospital	Boulder	Colorado	United States	80303
86	Rocky Mountain Cancer Centers-Boulder	Boulder	Colorado	United States	80304
87	Rocky Mountain Cancer Centers - Centennial	Centennial	Colorado	United States	80112
88	Penrose-Saint Francis Healthcare	Colorado Springs	Colorado	United States	80907
89	Rocky Mountain Cancer Centers-Penrose	Colorado Springs	Colorado	United States	80907
90	UCHealth Memorial Hospital Central	Colorado Springs	Colorado	United States	80909
91	Memorial Hospital North	Colorado Springs	Colorado	United States	80920
92	Cancer Center of Colorado at Sloan's Lake	Denver	Colorado	United States	80204
93	Denver Health Medical Center	Denver	Colorado	United States	80204
94	National Jewish Health-Main Campus	Denver	Colorado	United States	80206
95	The Women's Imaging Center	Denver	Colorado	United States	80209
96	Porter Adventist Hospital	Denver	Colorado	United States	80210
97	Colorado Blood Cancer Institute	Denver	Colorado	United States	80218
98	Presbyterian - Saint Lukes Medical Center - Health One	Denver	Colorado	United States	80218
99	Rocky Mountain Cancer Centers-Midtown	Denver	Colorado	United States	80218
100	SCL Health Saint Joseph Hospital	Denver	Colorado	United States	80218
101	Rocky Mountain Cancer Centers-Rose	Denver	Colorado	United States	80220
102	Rose Medical Center	Denver	Colorado	United States	80220
103	Mercy Medical Center	Durango	Colorado	United States	81301
104	Southwest Oncology PC	Durango	Colorado	United States	81301
105	Mountain Blue Cancer Care Center - Swedish	Englewood	Colorado	United States	80113
106	Rocky Mountain Cancer Centers - Swedish	Englewood	Colorado	United States	80113
107	Swedish Medical Center	Englewood	Colorado	United States	80113
108	The Melanoma and Skin Cancer Institute	Englewood	Colorado	United States	80113
109	Poudre Valley Hospital	Fort Collins	Colorado	United States	80524
110	Cancer Care and Hematology-Fort Collins	Fort Collins	Colorado	United States	80528
111	Mountain Blue Cancer Care Center	Golden	Colorado	United States	80401
112	National Jewish Health-Western Hematology Oncology	Golden	Colorado	United States	80401
113	Saint Mary's Hospital and Regional Medical Center	Grand Junction	Colorado	United States	81501
114	Grand Valley Oncology	Grand Junction	Colorado	United States	81505
115	North Colorado Medical Center	Greeley	Colorado	United States	80631
116	UCHealth Greeley Hospital	Greeley	Colorado	United States	80631
117	UCHealth Highlands Ranch Hospital	Highlands Ranch	Colorado	United States	80129
118	Good Samaritan Medical Center	Lafayette	Colorado	United States	80026
119	Rocky Mountain Cancer Centers-Lakewood	Lakewood	Colorado	United States	80228
120	Saint Anthony Hospital	Lakewood	Colorado	United States	80228
121	Rocky Mountain Cancer Centers-Littleton	Littleton	Colorado	United States	80120
122	Littleton Adventist Hospital	Littleton	Colorado	United States	80122
123	Rocky Mountain Cancer Centers-Sky Ridge	Lone Tree	Colorado	United States	80124
124	Sky Ridge Medical Center	Lone Tree	Colorado	United States	80124
125	Longmont United Hospital	Longmont	Colorado	United States	80501
126	Rocky Mountain Cancer Centers-Longmont	Longmont	Colorado	United States	80501
127	Medical Center of the Rockies	Loveland	Colorado	United States	80538
128	McKee Medical Center	Loveland	Colorado	United States	80539
129	Parker Adventist Hospital	Parker	Colorado	United States	80138
130	Rocky Mountain Cancer Centers-Parker	Parker	Colorado	United States	80138
131	Saint Mary Corwin Medical Center	Pueblo	Colorado	United States	81004
132	Rocky Mountain Cancer Centers - Pueblo	Pueblo	Colorado	United States	81008
133	National Jewish Health-Northern Hematology Oncology	Thornton	Colorado	United States	80260
134	Rocky Mountain Cancer Centers-Thornton	Thornton	Colorado	United States	80260
135	SCL Health Lutheran Medical Center	Wheat Ridge	Colorado	United States	80033
136	Smilow Cancer Hospital-Derby Care Center	Derby	Connecticut	United States	06418
137	Smilow Cancer Hospital Care Center-Fairfield	Fairfield	Connecticut	United States	06824
138	Smilow Cancer Hospital Care Center at Glastonbury	Glastonbury	Connecticut	United States	06033
139	Smilow Cancer Hospital Care Center - Guiford	Guilford	Connecticut	United States	06437
140	Smilow Cancer Hospital Care Center at Saint Francis	Hartford	Connecticut	United States	06105
141	Middlesex Hospital	Middletown	Connecticut	United States	06457
142	Smilow Cancer Center/Yale-New Haven Hospital	New Haven	Connecticut	United States	06510
143	Yale University	New Haven	Connecticut	United States	06520
144	Yale-New Haven Hospital North Haven Medical Center	North Haven	Connecticut	United States	06473
145	Smilow Cancer Hospital-Orange Care Center	Orange	Connecticut	United States	06477
146	Smilow Cancer Hospital-Torrington Care Center	Torrington	Connecticut	United States	06790
147	Smilow Cancer Hospital Care Center-Trumbull	Trumbull	Connecticut	United States	06611
148	Smilow Cancer Hospital-Waterbury Care Center	Waterbury	Connecticut	United States	06708
149	Smilow Cancer Hospital Care Center - Waterford	Waterford	Connecticut	United States	06385
150	Mount Sinai Comprehensive Cancer Center at Aventura	Aventura	Florida	United States	33180
151	Holy Cross Hospital	Fort Lauderdale	Florida	United States	33308
152	Lee Memorial Health System	Fort Myers	Florida	United States	33901
153	Regional Cancer Center-Lee Memorial Health System	Fort Myers	Florida	United States	33905
154	Memorial Regional Hospital/Joe DiMaggio Children's Hospital	Hollywood	Florida	United States	33021
155	Mount Sinai Medical Center	Miami Beach	Florida	United States	33140
156	Memorial Hospital West	Pembroke Pines	Florida	United States	33028
157	Low Country Cancer Care	Savannah	Georgia	United States	31404
158	Lewis Cancer and Research Pavilion at Saint Joseph's/Candler	Savannah	Georgia	United States	31405
159	Summit Cancer Care-Candler	Savannah	Georgia	United States	31405
160	Hawaii Cancer Care - Savio	'Aiea	Hawaii	United States	96701
161	Pali Momi Medical Center	'Aiea	Hawaii	United States	96701
162	Queen's Cancer Center - Pearlridge	'Aiea	Hawaii	United States	96701
163	The Cancer Center of Hawaii-Pali Momi	'Aiea	Hawaii	United States	96701
164	Hawaii Cancer Care Inc - Waterfront Plaza	Honolulu	Hawaii	United States	96813
165	Island Urology	Honolulu	Hawaii	United States	96813
166	Queen's Cancer Cenrer - POB I	Honolulu	Hawaii	United States	96813
167	Queen's Medical Center	Honolulu	Hawaii	United States	96813
168	Straub Clinic and Hospital	Honolulu	Hawaii	United States	96813
169	University of Hawaii Cancer Center	Honolulu	Hawaii	United States	96813
170	Hawaii Cancer Care Inc-Liliha	Honolulu	Hawaii	United States	96817
171	Kuakini Medical Center	Honolulu	Hawaii	United States	96817
172	Queen's Cancer Center - Kuakini	Honolulu	Hawaii	United States	96817
173	The Cancer Center of Hawaii-Liliha	Honolulu	Hawaii	United States	96817
174	Kapiolani Medical Center for Women and Children	Honolulu	Hawaii	United States	96826
175	Wilcox Memorial Hospital and Kauai Medical Clinic	Lihue	Hawaii	United States	96766
176	Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	United States	83706
177	Saint Luke's Cancer Institute - Boise	Boise	Idaho	United States	83712
178	Saint Alphonsus Cancer Care Center-Caldwell	Caldwell	Idaho	United States	83605
179	Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	United States	83814
180	Walter Knox Memorial Hospital	Emmett	Idaho	United States	83617
181	Saint Luke's Cancer Institute - Fruitland	Fruitland	Idaho	United States	83619
182	Idaho Urologic Institute-Meridian	Meridian	Idaho	United States	83642
183	Saint Luke's Cancer Institute - Meridian	Meridian	Idaho	United States	83642
184	Saint Alphonsus Medical Center-Nampa	Nampa	Idaho	United States	83686
185	Saint Luke's Cancer Institute - Nampa	Nampa	Idaho	United States	83686
186	Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	United States	83854
187	Kootenai Cancer Clinic	Sandpoint	Idaho	United States	83864
188	Saint Luke's Cancer Institute - Twin Falls	Twin Falls	Idaho	United States	83301
189	Saint Anthony's Health	Alton	Illinois	United States	62002
190	Rush - Copley Medical Center	Aurora	Illinois	United States	60504
191	Illinois CancerCare-Bloomington	Bloomington	Illinois	United States	61704
192	Loyola Center for Health at Burr Ridge	Burr Ridge	Illinois	United States	60527
193	Illinois CancerCare-Canton	Canton	Illinois	United States	61520
194	Memorial Hospital of Carbondale	Carbondale	Illinois	United States	62902
195	SIH Cancer Institute	Carterville	Illinois	United States	62918
196	Illinois CancerCare-Carthage	Carthage	Illinois	United States	62321
197	Centralia Oncology Clinic	Centralia	Illinois	United States	62801
198	Northwestern University	Chicago	Illinois	United States	60611
199	Carle on Vermilion	Danville	Illinois	United States	61832
200	Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	United States	62526
201	Decatur Memorial Hospital	Decatur	Illinois	United States	62526
202	Northwestern Medicine Cancer Center Kishwaukee	DeKalb	Illinois	United States	60115
203	Illinois CancerCare-Dixon	Dixon	Illinois	United States	61021
204	Carle Physician Group-Effingham	Effingham	Illinois	United States	62401
205	Crossroads Cancer Center	Effingham	Illinois	United States	62401
206	Illinois CancerCare-Eureka	Eureka	Illinois	United States	61530
207	Illinois CancerCare-Galesburg	Galesburg	Illinois	United States	61401
208	Western Illinois Cancer Treatment Center	Galesburg	Illinois	United States	61401
209	Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	United States	60134
210	Loyola Medicine Homer Glen	Homer Glen	Illinois	United States	60491
211	Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	United States	61443
212	Northwestern Medicine Lake Forest Hospital	Lake Forest	Illinois	United States	60045
213	Illinois CancerCare-Macomb	Macomb	Illinois	United States	61455
214	Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	United States	61938
215	Loyola University Medical Center	Maywood	Illinois	United States	60153
216	Marjorie Weinberg Cancer Center at Loyola-Gottlieb	Melrose Park	Illinois	United States	60160
217	Good Samaritan Regional Health Center	Mount Vernon	Illinois	United States	62864
218	Cancer Care Center of O'Fallon	O'Fallon	Illinois	United States	62269
219	Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	United States	61350
220	Illinois CancerCare-Pekin	Pekin	Illinois	United States	61554
221	OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center	Pekin	Illinois	United States	61554
222	Illinois CancerCare-Peoria	Peoria	Illinois	United States	61615
223	OSF Saint Francis Radiation Oncology at Peoria Cancer Center	Peoria	Illinois	United States	61615
224	Methodist Medical Center of Illinois	Peoria	Illinois	United States	61636
225	OSF Saint Francis Medical Center	Peoria	Illinois	United States	61637
226	Illinois CancerCare-Peru	Peru	Illinois	United States	61354
227	Valley Radiation Oncology	Peru	Illinois	United States	61354
228	Illinois CancerCare-Princeton	Princeton	Illinois	United States	61356
229	Southern Illinois University School of Medicine	Springfield	Illinois	United States	62702
230	Springfield Clinic	Springfield	Illinois	United States	62702
231	Memorial Medical Center	Springfield	Illinois	United States	62781
232	Southwest Illinois Health Services LLP	Swansea	Illinois	United States	62226
233	Carle Cancer Center	Urbana	Illinois	United States	61801
234	The Carle Foundation Hospital	Urbana	Illinois	United States	61801
235	Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	United States	60555
236	Illinois CancerCare - Washington	Washington	Illinois	United States	61571
237	Rush-Copley Healthcare Center	Yorkville	Illinois	United States	60560
238	Community Cancer Center East	Indianapolis	Indiana	United States	46219
239	Community Cancer Center South	Indianapolis	Indiana	United States	46227
240	Franciscan Health Indianapolis	Indianapolis	Indiana	United States	46237
241	Community Cancer Center North	Indianapolis	Indiana	United States	46256
242	Community Howard Regional Health	Kokomo	Indiana	United States	46904
243	Franciscan Saint Elizabeth Health - Lafayette East	Lafayette	Indiana	United States	47905
244	Woodland Cancer Care Center	Michigan City	Indiana	United States	46360
245	Memorial Regional Cancer Center Day Road	Mishawaka	Indiana	United States	46545
246	Franciscan Health Mooresville	Mooresville	Indiana	United States	46158
247	Baptist Health Floyd	New Albany	Indiana	United States	47150
248	Reid Health	Richmond	Indiana	United States	47374
249	Memorial Hospital of South Bend	South Bend	Indiana	United States	46601
250	Union Hospital	Terre Haute	Indiana	United States	47804
251	Saint Anthony Regional Hospital	Carroll	Iowa	United States	51401
252	Medical Oncology and Hematology Associates-West Des Moines	Clive	Iowa	United States	50325
253	Mercy Cancer Center-West Lakes	Clive	Iowa	United States	50325
254	Jennie Edmundson Memorial Hospital	Council Bluffs	Iowa	United States	51502
255	Alegent Health Mercy Hospital	Council Bluffs	Iowa	United States	51503
256	Heartland Oncology and Hematology LLP	Council Bluffs	Iowa	United States	51503
257	Greater Regional Medical Center	Creston	Iowa	United States	50801
258	Iowa Methodist Medical Center	Des Moines	Iowa	United States	50309
259	Medical Oncology and Hematology Associates-Des Moines	Des Moines	Iowa	United States	50309
260	Broadlawns Medical Center	Des Moines	Iowa	United States	50314
261	Medical Oncology and Hematology Associates-Laurel	Des Moines	Iowa	United States	50314
262	Mercy Medical Center - Des Moines	Des Moines	Iowa	United States	50314
263	Iowa Lutheran Hospital	Des Moines	Iowa	United States	50316
264	Trinity Regional Medical Center	Fort Dodge	Iowa	United States	50501
265	Methodist West Hospital	West Des Moines	Iowa	United States	50266-7700
266	Mercy Medical Center-West Lakes	West Des Moines	Iowa	United States	50266
267	Coffeyville Regional Medical Center	Coffeyville	Kansas	United States	67337
268	University of Kansas Clinical Research Center	Fairway	Kansas	United States	66205
269	Central Care Cancer Center - Garden City	Garden City	Kansas	United States	67846
270	Central Care Cancer Center - Great Bend	Great Bend	Kansas	United States	67530
271	HaysMed University of Kansas Health System	Hays	Kansas	United States	67601
272	University of Kansas Cancer Center-West	Kansas City	Kansas	United States	66112
273	University of Kansas Cancer Center	Kansas City	Kansas	United States	66160
274	Lawrence Memorial Hospital	Lawrence	Kansas	United States	66044
275	Kansas Institute of Medicine Cancer and Blood Center	Lenexa	Kansas	United States	66219
276	Minimally Invasive Surgery Hospital	Lenexa	Kansas	United States	66219
277	Olathe Health Cancer Center	Olathe	Kansas	United States	66061
278	Menorah Medical Center	Overland Park	Kansas	United States	66209
279	University of Kansas Cancer Center-Overland Park	Overland Park	Kansas	United States	66210
280	Ascension Via Christi - Pittsburg	Pittsburg	Kansas	United States	66762
281	Salina Regional Health Center	Salina	Kansas	United States	67401
282	University of Kansas Health System Saint Francis Campus	Topeka	Kansas	United States	66606
283	University of Kansas Hospital-Westwood Cancer Center	Westwood	Kansas	United States	66205
284	Cancer Center of Kansas-Wichita Medical Arts Tower	Wichita	Kansas	United States	67208
285	Cancer Center of Kansas - Wichita	Wichita	Kansas	United States	67214
286	Flaget Memorial Hospital	Bardstown	Kentucky	United States	40004
287	Baptist Health Corbin	Corbin	Kentucky	United States	40701
288	Commonwealth Cancer Center-Corbin	Corbin	Kentucky	United States	40701
289	Baptist Health Lexington	Lexington	Kentucky	United States	40503
290	Saint Joseph Radiation Oncology Resource Center	Lexington	Kentucky	United States	40504
291	Saint Joseph Hospital East	Lexington	Kentucky	United States	40509
292	University of Kentucky/Markey Cancer Center	Lexington	Kentucky	United States	40536
293	Saint Joseph London	London	Kentucky	United States	40741
294	Jewish Hospital	Louisville	Kentucky	United States	40202
295	Baptist Health Louisville	Louisville	Kentucky	United States	40207
296	Saints Mary and Elizabeth Hospital	Louisville	Kentucky	United States	40215
297	Jewish Hospital Medical Center Northeast	Louisville	Kentucky	United States	40245
298	Baptist Health Madisonville/Merle Mahr Cancer Center	Madisonville	Kentucky	United States	42431
299	Baptist Health Paducah	Paducah	Kentucky	United States	42003
300	Jewish Hospital Medical Center South	Shepherdsville	Kentucky	United States	40165
301	Ochsner Health Center-Summa	Baton Rouge	Louisiana	United States	70809
302	Medical Center of Baton Rouge	Baton Rouge	Louisiana	United States	70816
303	Ochsner High Grove	Baton Rouge	Louisiana	United States	70836
304	Ochsner Medical Center Jefferson	New Orleans	Louisiana	United States	70121
305	University of Maryland/Greenebaum Cancer Center	Baltimore	Maryland	United States	21201
306	Beverly Hospital	Beverly	Massachusetts	United States	01915
307	Lahey Hospital and Medical Center	Burlington	Massachusetts	United States	01805
308	Addison Gilbert Hospital	Gloucester	Massachusetts	United States	01930
309	Lahey Medical Center-Peabody	Peabody	Massachusetts	United States	01960
310	Mercy Medical Center	Springfield	Massachusetts	United States	01104
311	Winchester Hospital	Winchester	Massachusetts	United States	01890
312	Hickman Cancer Center	Adrian	Michigan	United States	49221
313	Saint Joseph Mercy Hospital	Ann Arbor	Michigan	United States	48106
314	University of Michigan Comprehensive Cancer Center	Ann Arbor	Michigan	United States	48109
315	Bronson Battle Creek	Battle Creek	Michigan	United States	49017
316	McLaren Cancer Institute-Bay City	Bay City	Michigan	United States	48706
317	McLaren Cancer Institute-Bloomfield	Bloomfield	Michigan	United States	48302
318	IHA Hematology Oncology Consultants-Brighton	Brighton	Michigan	United States	48114
319	Saint Joseph Mercy Brighton	Brighton	Michigan	United States	48114
320	Henry Ford Cancer Institute-Downriver	Brownstown	Michigan	United States	48183
321	IHA Hematology Oncology Consultants-Canton	Canton	Michigan	United States	48188
322	Saint Joseph Mercy Canton	Canton	Michigan	United States	48188
323	Caro Cancer Center	Caro	Michigan	United States	48723
324	IHA Hematology Oncology Consultants-Chelsea	Chelsea	Michigan	United States	48118
325	Saint Joseph Mercy Chelsea	Chelsea	Michigan	United States	48118
326	Hematology Oncology Consultants-Clarkston	Clarkston	Michigan	United States	48346
327	McLaren Cancer Institute-Clarkston	Clarkston	Michigan	United States	48346
328	Newland Medical Associates-Clarkston	Clarkston	Michigan	United States	48346
329	Henry Ford Macomb Hospital-Clinton Township	Clinton Township	Michigan	United States	48038
330	Beaumont Hospital - Dearborn	Dearborn	Michigan	United States	48124
331	Henry Ford Medical Center-Fairlane	Dearborn	Michigan	United States	48126
332	Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	United States	48201
333	Henry Ford Hospital	Detroit	Michigan	United States	48202
334	Ascension Saint John Hospital	Detroit	Michigan	United States	48236
335	Great Lakes Cancer Management Specialists-Doctors Park	East China Township	Michigan	United States	48054
336	Weisberg Cancer Treatment Center	Farmington Hills	Michigan	United States	48334
337	Genesee Cancer and Blood Disease Treatment Center	Flint	Michigan	United States	48503
338	Genesee Hematology Oncology PC	Flint	Michigan	United States	48503
339	Genesys Hurley Cancer Institute	Flint	Michigan	United States	48503
340	Hurley Medical Center	Flint	Michigan	United States	48503
341	Singh and Arora Hematology Oncology PC	Flint	Michigan	United States	48532
342	Helen DeVos Children's Hospital at Spectrum Health	Grand Rapids	Michigan	United States	49503
343	Mercy Health Saint Mary's	Grand Rapids	Michigan	United States	49503
344	Spectrum Health at Butterworth Campus	Grand Rapids	Michigan	United States	49503
345	Academic Hematology Oncology Specialists	Grosse Pointe Woods	Michigan	United States	48236
346	Great Lakes Cancer Management Specialists-Van Elslander Cancer Center	Grosse Pointe Woods	Michigan	United States	48236
347	Michigan Breast Specialists-Grosse Pointe Woods	Grosse Pointe Woods	Michigan	United States	48236
348	Allegiance Health	Jackson	Michigan	United States	49201
349	Bronson Methodist Hospital	Kalamazoo	Michigan	United States	49007
350	West Michigan Cancer Center	Kalamazoo	Michigan	United States	49007
351	Borgess Medical Center	Kalamazoo	Michigan	United States	49048
352	McLaren-Greater Lansing	Lansing	Michigan	United States	48910
353	Mid-Michigan Physicians-Lansing	Lansing	Michigan	United States	48912
354	Sparrow Hospital	Lansing	Michigan	United States	48912
355	Hope Cancer Clinic	Livonia	Michigan	United States	48154
356	Saint Mary Mercy Hospital	Livonia	Michigan	United States	48154
357	Great Lakes Cancer Management Specialists-Macomb Medical Campus	Macomb	Michigan	United States	48044
358	Michigan Breast Specialists-Macomb Township	Macomb	Michigan	United States	48044
359	Saint Mary's Oncology/Hematology Associates of Marlette	Marlette	Michigan	United States	48453
360	Toledo Clinic Cancer Centers-Monroe	Monroe	Michigan	United States	48162
361	McLaren Cancer Institute-Macomb	Mount Clemens	Michigan	United States	48043
362	McLaren Cancer Institute-Central Michigan	Mount Pleasant	Michigan	United States	48858
363	Mercy Health Mercy Campus	Muskegon	Michigan	United States	49444
364	Lakeland Hospital Niles	Niles	Michigan	United States	49120
365	Cancer and Hematology Centers of Western Michigan - Norton Shores	Norton Shores	Michigan	United States	49444
366	Henry Ford Medical Center-Columbus	Novi	Michigan	United States	48377
367	McLaren Cancer Institute-Northern Michigan	Petoskey	Michigan	United States	49770
368	21st Century Oncology-Pontiac	Pontiac	Michigan	United States	48341
369	Hope Cancer Center	Pontiac	Michigan	United States	48341
370	Newland Medical Associates-Pontiac	Pontiac	Michigan	United States	48341
371	Saint Joseph Mercy Oakland	Pontiac	Michigan	United States	48341
372	Huron Medical Center PC	Port Huron	Michigan	United States	48060
373	Lake Huron Medical Center	Port Huron	Michigan	United States	48060
374	McLaren-Port Huron	Port Huron	Michigan	United States	48060
375	Spectrum Health Reed City Hospital	Reed City	Michigan	United States	49677
376	Great Lakes Cancer Management Specialists-Rochester Hills	Rochester Hills	Michigan	United States	48309
377	Ascension Saint Mary's Hospital	Saginaw	Michigan	United States	48601
378	Oncology Hematology Associates of Saginaw Valley PC	Saginaw	Michigan	United States	48604
379	Lakeland Medical Center Saint Joseph	Saint Joseph	Michigan	United States	49085
380	Marie Yeager Cancer Center	Saint Joseph	Michigan	United States	49085
381	Henry Ford Macomb Health Center - Shelby Township	Shelby	Michigan	United States	48315
382	Bhadresh Nayak MD PC-Sterling Heights	Sterling Heights	Michigan	United States	48312
383	Ascension Saint Joseph Hospital	Tawas City	Michigan	United States	48764
384	Munson Medical Center	Traverse City	Michigan	United States	49684
385	Advanced Breast Care Center PLLC	Warren	Michigan	United States	48088
386	Great Lakes Cancer Management Specialists-Macomb Professional Building	Warren	Michigan	United States	48093
387	Macomb Hematology Oncology PC	Warren	Michigan	United States	48093
388	Michigan Breast Specialists-Warren	Warren	Michigan	United States	48093
389	Saint John Macomb-Oakland Hospital	Warren	Michigan	United States	48093
390	Henry Ford West Bloomfield Hospital	West Bloomfield	Michigan	United States	48322
391	Saint Mary's Oncology/Hematology Associates of West Branch	West Branch	Michigan	United States	48661
392	Metro Health Hospital	Wyoming	Michigan	United States	49519
393	Huron Gastroenterology PC	Ypsilanti	Michigan	United States	48106
394	IHA Hematology Oncology Consultants-Ann Arbor	Ypsilanti	Michigan	United States	48197
395	Riverwood Healthcare Center	Aitkin	Minnesota	United States	56431
396	Essentia Health Saint Joseph's Medical Center	Brainerd	Minnesota	United States	56401
397	Fairview Ridges Hospital	Burnsville	Minnesota	United States	55337
398	Minnesota Oncology - Burnsville	Burnsville	Minnesota	United States	55337
399	Cambridge Medical Center	Cambridge	Minnesota	United States	55008
400	Mercy Hospital	Coon Rapids	Minnesota	United States	55433
401	Essentia Health - Deer River Clinic	Deer River	Minnesota	United States	56636
402	Essentia Health Saint Mary's - Detroit Lakes Clinic	Detroit Lakes	Minnesota	United States	56501
403	Essentia Health Cancer Center	Duluth	Minnesota	United States	55805
404	Essentia Health Saint Mary's Medical Center	Duluth	Minnesota	United States	55805
405	Miller-Dwan Hospital	Duluth	Minnesota	United States	55805
406	Fairview Southdale Hospital	Edina	Minnesota	United States	55435
407	Lake Region Healthcare Corporation-Cancer Care	Fergus Falls	Minnesota	United States	56537
408	Essentia Health - Fosston	Fosston	Minnesota	United States	56542
409	Unity Hospital	Fridley	Minnesota	United States	55432
410	Essentia Health Hibbing Clinic	Hibbing	Minnesota	United States	55746
411	Fairview Clinics and Surgery Center Maple Grove	Maple Grove	Minnesota	United States	55369
412	Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	United States	55109
413	Saint John's Hospital - Healtheast	Maplewood	Minnesota	United States	55109
414	Abbott-Northwestern Hospital	Minneapolis	Minnesota	United States	55407
415	Hennepin County Medical Center	Minneapolis	Minnesota	United States	55415
416	Health Partners Inc	Minneapolis	Minnesota	United States	55454
417	Monticello Cancer Center	Monticello	Minnesota	United States	55362
418	New Ulm Medical Center	New Ulm	Minnesota	United States	56073
419	Essentia Health - Park Rapids	Park Rapids	Minnesota	United States	56470
420	Fairview Northland Medical Center	Princeton	Minnesota	United States	55371
421	North Memorial Medical Health Center	Robbinsdale	Minnesota	United States	55422
422	Coborn Cancer Center at Saint Cloud Hospital	Saint Cloud	Minnesota	United States	56303
423	Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	United States	55416
424	Regions Hospital	Saint Paul	Minnesota	United States	55101
425	United Hospital	Saint Paul	Minnesota	United States	55102
426	Essentia Health Sandstone	Sandstone	Minnesota	United States	55072
427	Saint Francis Regional Medical Center	Shakopee	Minnesota	United States	55379
428	Lakeview Hospital	Stillwater	Minnesota	United States	55082
429	Essentia Health Virginia Clinic	Virginia	Minnesota	United States	55792
430	Ridgeview Medical Center	Waconia	Minnesota	United States	55387
431	Rice Memorial Hospital	Willmar	Minnesota	United States	56201
432	Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	United States	55125
433	Fairview Lakes Medical Center	Wyoming	Minnesota	United States	55092
434	Singing River Hospital	Pascagoula	Mississippi	United States	39581
435	Saint Louis Cancer and Breast Institute-Ballwin	Ballwin	Missouri	United States	63011
436	Central Care Cancer Center - Bolivar	Bolivar	Missouri	United States	65613
437	Parkland Health Center-Bonne Terre	Bonne Terre	Missouri	United States	63628
438	Cox Cancer Center Branson	Branson	Missouri	United States	65616
439	Saint Francis Medical Center	Cape Girardeau	Missouri	United States	63703
440	Southeast Cancer Center	Cape Girardeau	Missouri	United States	63703
441	Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	United States	63141
442	Parkland Health Center - Farmington	Farmington	Missouri	United States	63640
443	Centerpoint Medical Center LLC	Independence	Missouri	United States	64057
444	Capital Region Southwest Campus	Jefferson City	Missouri	United States	65109
445	Freeman Health System	Joplin	Missouri	United States	64804
446	Mercy Hospital Joplin	Joplin	Missouri	United States	64804
447	Truman Medical Centers	Kansas City	Missouri	United States	64108
448	Kansas City Veterans Affairs Medical Center	Kansas City	Missouri	United States	64128
449	Research Medical Center	Kansas City	Missouri	United States	64132
450	University of Kansas Cancer Center - North	Kansas City	Missouri	United States	64154
451	University of Kansas Cancer Center - Lee's Summit	Lee's Summit	Missouri	United States	64064
452	Delbert Day Cancer Institute at PCRMC	Rolla	Missouri	United States	65401
453	Mercy Clinic-Rolla-Cancer and Hematology	Rolla	Missouri	United States	65401
454	Heartland Regional Medical Center	Saint Joseph	Missouri	United States	64506
455	Saint Louis Cancer and Breast Institute-South City	Saint Louis	Missouri	United States	63109
456	Washington University School of Medicine	Saint Louis	Missouri	United States	63110
457	Mercy Hospital South	Saint Louis	Missouri	United States	63128
458	Siteman Cancer Center-South County	Saint Louis	Missouri	United States	63129
459	Missouri Baptist Medical Center	Saint Louis	Missouri	United States	63131
460	Siteman Cancer Center at Christian Hospital	Saint Louis	Missouri	United States	63136
461	Mercy Hospital Saint Louis	Saint Louis	Missouri	United States	63141
462	Siteman Cancer Center at Saint Peters Hospital	Saint Peters	Missouri	United States	63376
463	Sainte Genevieve County Memorial Hospital	Sainte Genevieve	Missouri	United States	63670
464	Mercy Hospital Springfield	Springfield	Missouri	United States	65804
465	CoxHealth South Hospital	Springfield	Missouri	United States	65807
466	Missouri Baptist Sullivan Hospital	Sullivan	Missouri	United States	63080
467	Missouri Baptist Outpatient Center-Sunset Hills	Sunset Hills	Missouri	United States	63127
468	Mercy Hospital Washington	Washington	Missouri	United States	63090
469	Community Hospital of Anaconda	Anaconda	Montana	United States	59711
470	Billings Clinic Cancer Center	Billings	Montana	United States	59101
471	Saint Vincent Healthcare	Billings	Montana	United States	59101
472	Saint Vincent Frontier Cancer Center	Billings	Montana	United States	59102
473	Bozeman Deaconess Hospital	Bozeman	Montana	United States	59715
474	Saint James Community Hospital and Cancer Treatment Center	Butte	Montana	United States	59701
475	Benefis Healthcare- Sletten Cancer Institute	Great Falls	Montana	United States	59405
476	Great Falls Clinic	Great Falls	Montana	United States	59405
477	Saint Peter's Community Hospital	Helena	Montana	United States	59601
478	Kalispell Regional Medical Center	Kalispell	Montana	United States	59901
479	Saint Patrick Hospital - Community Hospital	Missoula	Montana	United States	59802
480	Community Medical Hospital	Missoula	Montana	United States	59804
481	CHI Health Saint Francis	Grand Island	Nebraska	United States	68803
482	Heartland Hematology and Oncology	Kearney	Nebraska	United States	68845
483	CHI Health Good Samaritan	Kearney	Nebraska	United States	68847
484	Saint Elizabeth Regional Medical Center	Lincoln	Nebraska	United States	68510
485	Nebraska Methodist Hospital	Omaha	Nebraska	United States	68114
486	Alegent Health Immanuel Medical Center	Omaha	Nebraska	United States	68122
487	Hematology and Oncology Consultants PC	Omaha	Nebraska	United States	68122
488	Alegent Health Bergan Mercy Medical Center	Omaha	Nebraska	United States	68124
489	Alegent Health Lakeside Hospital	Omaha	Nebraska	United States	68130
490	Creighton University Medical Center	Omaha	Nebraska	United States	68131
491	Midlands Community Hospital	Papillion	Nebraska	United States	68046
492	Carson Tahoe Regional Medical Center	Carson City	Nevada	United States	89703
493	Cancer and Blood Specialists-Henderson	Henderson	Nevada	United States	89052
494	Comprehensive Cancer Centers of Nevada - Henderson	Henderson	Nevada	United States	89052
495	Comprehensive Cancer Centers of Nevada-Horizon Ridge	Henderson	Nevada	United States	89052
496	Las Vegas Cancer Center-Henderson	Henderson	Nevada	United States	89052
497	OptumCare Cancer Care at Seven Hills	Henderson	Nevada	United States	89052
498	21st Century Oncology-Henderson	Henderson	Nevada	United States	89074
499	Comprehensive Cancer Centers of Nevada-Southeast Henderson	Henderson	Nevada	United States	89074
500	Las Vegas Urology - Green Valley	Henderson	Nevada	United States	89074
501	Las Vegas Urology - Pebble	Henderson	Nevada	United States	89074
502	Urology Specialists of Nevada - Green Valley	Henderson	Nevada	United States	89074
503	Las Vegas Urology - Pecos	Las Vegas	Nevada	United States	89074
504	Desert West Surgery	Las Vegas	Nevada	United States	89102
505	OptumCare Cancer Care at Charleston	Las Vegas	Nevada	United States	89102
506	University Medical Center of Southern Nevada	Las Vegas	Nevada	United States	89102
507	Hope Cancer Care of Nevada	Las Vegas	Nevada	United States	89103
508	Cancer and Blood Specialists-Shadow	Las Vegas	Nevada	United States	89106
509	Radiation Oncology Centers of Nevada Central	Las Vegas	Nevada	United States	89106
510	Urology Specialists of Nevada - Central	Las Vegas	Nevada	United States	89106
511	21st Century Oncology	Las Vegas	Nevada	United States	89109
512	HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway	Las Vegas	Nevada	United States	89109
513	Sunrise Hospital and Medical Center	Las Vegas	Nevada	United States	89109
514	HealthCare Partners Medical Group Oncology/Hematology-San Martin	Las Vegas	Nevada	United States	89113
515	Las Vegas Prostate Cancer Center	Las Vegas	Nevada	United States	89113
516	Las Vegas Urology - Sunset	Las Vegas	Nevada	United States	89113
517	Radiation Oncology Centers of Nevada Southeast	Las Vegas	Nevada	United States	89119
518	Cancer Therapy and Integrative Medicine	Las Vegas	Nevada	United States	89121
519	21st Century Oncology-Vegas Tenaya	Las Vegas	Nevada	United States	89128
520	Ann M Wierman MD LTD	Las Vegas	Nevada	United States	89128
521	Cancer and Blood Specialists-Tenaya	Las Vegas	Nevada	United States	89128
522	Comprehensive Cancer Centers of Nevada - Northwest	Las Vegas	Nevada	United States	89128
523	HealthCare Partners Medical Group Oncology/Hematology-Tenaya	Las Vegas	Nevada	United States	89128
524	Las Vegas Urology - Cathedral Rock	Las Vegas	Nevada	United States	89128
525	Las Vegas Urology - Smoke Ranch	Las Vegas	Nevada	United States	89128
526	OptumCare Cancer Care at MountainView	Las Vegas	Nevada	United States	89128
527	Urology Specialists of Nevada - Northwest	Las Vegas	Nevada	United States	89128
528	Alliance for Childhood Diseases/Cure 4 the Kids Foundation	Las Vegas	Nevada	United States	89135
529	Comprehensive Cancer Centers of Nevada - Town Center	Las Vegas	Nevada	United States	89144
530	Comprehensive Cancer Centers of Nevada-Summerlin	Las Vegas	Nevada	United States	89144
531	Summerlin Hospital Medical Center	Las Vegas	Nevada	United States	89144
532	Las Vegas Cancer Center-Medical Center	Las Vegas	Nevada	United States	89148-2405
533	21st Century Oncology-Fort Apache	Las Vegas	Nevada	United States	89148
534	Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	United States	89148
535	OptumCare Cancer Care at Fort Apache	Las Vegas	Nevada	United States	89148
536	Urology Specialists of Nevada - Southwest	Las Vegas	Nevada	United States	89148
537	HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills	Las Vegas	Nevada	United States	89149
538	Comprehensive Cancer Centers of Nevada - Central Valley	Las Vegas	Nevada	United States	89169
539	University Cancer Center	Las Vegas	Nevada	United States	89169
540	Hope Cancer Care of Nevada-Pahrump	Pahrump	Nevada	United States	89048
541	Renown Regional Medical Center	Reno	Nevada	United States	89502
542	Saint Mary's Regional Medical Center	Reno	Nevada	United States	89503
543	Radiation Oncology Associates	Reno	Nevada	United States	89509
544	Dartmouth Hitchcock Medical Center	Lebanon	New Hampshire	United States	03756
545	Norris Cotton Cancer Center-Manchester	Manchester	New Hampshire	United States	03102
546	Norris Cotton Cancer Center-Nashua	Nashua	New Hampshire	United States	03063
547	AtlantiCare Health Park-Cape May Court House	Cape May Court House	New Jersey	United States	08210
548	AtlantiCare Surgery Center	Egg Harbor Township	New Jersey	United States	08234
549	Inspira Medical Center Mullica Hill	Mullica Hill	New Jersey	United States	08062
550	Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	United States	08903
551	Newark Beth Israel Medical Center	Newark	New Jersey	United States	07112
552	Inspira Medical Center Vineland	Vineland	New Jersey	United States	08360
553	Lovelace Medical Center-Saint Joseph Square	Albuquerque	New Mexico	United States	87102
554	University of New Mexico Cancer Center	Albuquerque	New Mexico	United States	87102
555	New Mexico Cancer Care Alliance	Albuquerque	New Mexico	United States	87106
556	New Mexico Oncology Hematology Consultants	Albuquerque	New Mexico	United States	87109
557	Presbyterian Kaseman Hospital	Albuquerque	New Mexico	United States	87110
558	Memorial Medical Center - Las Cruces	Las Cruces	New Mexico	United States	88011
559	Presbyterian Rust Medical Center/Jorgensen Cancer Center	Rio Rancho	New Mexico	United States	87124
560	Atrium Health Stanly/LCI-Albemarle	Albemarle	North Carolina	United States	28002
561	AdventHealth Infusion Center Asheville	Asheville	North Carolina	United States	28803
562	Carolinas Medical Center/Levine Cancer Institute	Charlotte	North Carolina	United States	28203
563	Atrium Health Pineville/LCI-Pineville	Charlotte	North Carolina	United States	28210
564	Levine Cancer Institute-SouthPark	Charlotte	North Carolina	United States	28211
565	Atrium Health University City/LCI-University	Charlotte	North Carolina	United States	28262
566	Levine Cancer Institute-Ballantyne	Charlotte	North Carolina	United States	28277
567	Southeastern Medical Oncology Center-Clinton	Clinton	North Carolina	United States	28328
568	AdventHealth Infusion Center Haywood	Clyde	North Carolina	United States	28721
569	Atrium Health Cabarrus/LCI-Concord	Concord	North Carolina	United States	28025
570	Levine Cancer Institute - Rutherford	Forest City	North Carolina	United States	28043
571	CaroMont Regional Medical Center	Gastonia	North Carolina	United States	28054
572	Levine Cancer Institute-Gaston	Gastonia	North Carolina	United States	28054
573	Southeastern Medical Oncology Center-Goldsboro	Goldsboro	North Carolina	United States	27534
574	Wayne Memorial Hospital	Goldsboro	North Carolina	United States	27534
575	AdventHealth Hendersonville	Hendersonville	North Carolina	United States	28792
576	Onslow Memorial Hospital	Jacksonville	North Carolina	United States	28546
577	Southeastern Medical Oncology Center-Jacksonville	Jacksonville	North Carolina	United States	28546
578	Vidant Oncology-Kenansville	Kenansville	North Carolina	United States	28349
579	Vidant Oncology-Kinston	Kinston	North Carolina	United States	28501
580	Atrium Health Lincoln/LCI-Lincolnton	Lincolnton	North Carolina	United States	28092
581	Atrium Health Union/LCI-Union	Monroe	North Carolina	United States	28112
582	Vidant Oncology-Richlands	Richlands	North Carolina	United States	28574
583	Atrium Health Cleveland/LCI-Cleveland	Shelby	North Carolina	United States	28150
584	Johnston Memorial Hospital	Smithfield	North Carolina	United States	27577
585	AdventHealth Infusion Center Weaverville	Weaverville	North Carolina	United States	28787
586	Essentia Health Cancer Center-South University Clinic	Fargo	North Dakota	United States	58103
587	Altru Cancer Center	Grand Forks	North Dakota	United States	58201
588	Essentia Health - Jamestown Clinic	Jamestown	North Dakota	United States	58401
589	Cleveland Clinic Akron General	Akron	Ohio	United States	44307
590	Indu and Raj Soin Medical Center	Beavercreek	Ohio	United States	45431
591	Strecker Cancer Center-Belpre	Belpre	Ohio	United States	45714
592	Saint Elizabeth Boardman Hospital	Boardman	Ohio	United States	44512
593	Dayton Physicians LLC-Miami Valley South	Centerville	Ohio	United States	45459
594	Miami Valley Hospital South	Centerville	Ohio	United States	45459
595	Adena Regional Medical Center	Chillicothe	Ohio	United States	45601
596	Good Samaritan Hospital - Cincinnati	Cincinnati	Ohio	United States	45220
597	Oncology Hematology Care Inc-Kenwood	Cincinnati	Ohio	United States	45236
598	Bethesda North Hospital	Cincinnati	Ohio	United States	45242
599	TriHealth Cancer Institute-Westside	Cincinnati	Ohio	United States	45247
600	TriHealth Cancer Institute-Anderson	Cincinnati	Ohio	United States	45255
601	Ohio State University Comprehensive Cancer Center	Columbus	Ohio	United States	43210
602	Mount Carmel East Hospital	Columbus	Ohio	United States	43213
603	Columbus Oncology and Hematology Associates Inc	Columbus	Ohio	United States	43214
604	Riverside Methodist Hospital	Columbus	Ohio	United States	43214
605	Grant Medical Center	Columbus	Ohio	United States	43215
606	The Mark H Zangmeister Center	Columbus	Ohio	United States	43219
607	Mount Carmel Health Center West	Columbus	Ohio	United States	43222
608	Doctors Hospital	Columbus	Ohio	United States	43228
609	Good Samaritan Hospital - Dayton	Dayton	Ohio	United States	45406
610	Miami Valley Hospital	Dayton	Ohio	United States	45409
611	Dayton Physician LLC-Miami Valley Hospital North	Dayton	Ohio	United States	45415
612	Miami Valley Hospital North	Dayton	Ohio	United States	45415
613	Delaware Health Center-Grady Cancer Center	Delaware	Ohio	United States	43015
614	Delaware Radiation Oncology	Delaware	Ohio	United States	43015
615	Grady Memorial Hospital	Delaware	Ohio	United States	43015
616	Dublin Methodist Hospital	Dublin	Ohio	United States	43016
617	Armes Family Cancer Center	Findlay	Ohio	United States	45840
618	Blanchard Valley Hospital	Findlay	Ohio	United States	45840
619	Orion Cancer Care	Findlay	Ohio	United States	45840
620	Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	United States	45005-1066
621	Dayton Physicians LLC-Atrium	Franklin	Ohio	United States	45005
622	Dayton Physicians LLC-Wayne	Greenville	Ohio	United States	45331
623	Wayne Hospital	Greenville	Ohio	United States	45331
624	Mount Carmel Grove City Hospital	Grove City	Ohio	United States	43123
625	Greater Dayton Cancer Center	Kettering	Ohio	United States	45409
626	First Dayton Cancer Care	Kettering	Ohio	United States	45420
627	Kettering Medical Center	Kettering	Ohio	United States	45429
628	Fairfield Medical Center	Lancaster	Ohio	United States	43130
629	Saint Rita's Medical Center	Lima	Ohio	United States	45801
630	OhioHealth Mansfield Hospital	Mansfield	Ohio	United States	44903
631	Marietta Memorial Hospital	Marietta	Ohio	United States	45750
632	OhioHealth Marion General Hospital	Marion	Ohio	United States	43302
633	Toledo Clinic Cancer Centers-Maumee	Maumee	Ohio	United States	43537
634	Toledo Radiation Oncology at Northwest Ohio Onocolgy Center	Maumee	Ohio	United States	43537
635	Knox Community Hospital	Mount Vernon	Ohio	United States	43050
636	Licking Memorial Hospital	Newark	Ohio	United States	43055
637	Newark Radiation Oncology	Newark	Ohio	United States	43055
638	Mercy Health Perrysburg Cancer Center	Perrysburg	Ohio	United States	43551
639	Southern Ohio Medical Center	Portsmouth	Ohio	United States	45662
640	Springfield Regional Cancer Center	Springfield	Ohio	United States	45504
641	Springfield Regional Medical Center	Springfield	Ohio	United States	45505
642	Saint Vincent Mercy Medical Center	Toledo	Ohio	United States	43608
643	Mercy Health - Saint Anne Hospital	Toledo	Ohio	United States	43623
644	Toledo Clinic Cancer Centers-Toledo	Toledo	Ohio	United States	43623
645	Dayton Physicians LLC-Upper Valley	Troy	Ohio	United States	45373
646	Upper Valley Medical Center	Troy	Ohio	United States	45373
647	Saint Joseph Warren Hospital	Warren	Ohio	United States	44484
648	Saint Ann's Hospital	Westerville	Ohio	United States	43081
649	Saint Elizabeth Youngstown Hospital	Youngstown	Ohio	United States	44501
650	Genesis Healthcare System Cancer Care Center	Zanesville	Ohio	United States	43701
651	Cancer Centers of Southwest Oklahoma Research	Lawton	Oklahoma	United States	73505
652	University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	United States	73104
653	Integris Southwest Medical Center	Oklahoma City	Oklahoma	United States	73109
654	Mercy Hospital Oklahoma City	Oklahoma City	Oklahoma	United States	73120
655	Integris Cancer Institute of Oklahoma	Oklahoma City	Oklahoma	United States	73142
656	Oklahoma Cancer Specialists and Research Institute-Tulsa	Tulsa	Oklahoma	United States	74146
657	Saint Alphonsus Medical Center-Baker City	Baker City	Oregon	United States	97814
658	Saint Charles Health System	Bend	Oregon	United States	97701
659	Clackamas Radiation Oncology Center	Clackamas	Oregon	United States	97015
660	Providence Cancer Institute Clackamas Clinic	Clackamas	Oregon	United States	97015
661	Bay Area Hospital	Coos Bay	Oregon	United States	97420
662	Providence Newberg Medical Center	Newberg	Oregon	United States	97132
663	Saint Alphonsus Medical Center-Ontario	Ontario	Oregon	United States	97914
664	Providence Portland Medical Center	Portland	Oregon	United States	97213
665	Providence Saint Vincent Medical Center	Portland	Oregon	United States	97225
666	Saint Charles Health System-Redmond	Redmond	Oregon	United States	97756
667	Lehigh Valley Hospital-Cedar Crest	Allentown	Pennsylvania	United States	18103
668	Lehigh Valley Hospital - Muhlenberg	Bethlehem	Pennsylvania	United States	18017
669	Bryn Mawr Hospital	Bryn Mawr	Pennsylvania	United States	19010
670	Main Line Health Center-Collegeville	Collegeville	Pennsylvania	United States	19426
671	Geisinger Medical Center	Danville	Pennsylvania	United States	17822
672	Pocono Medical Center	East Stroudsburg	Pennsylvania	United States	18301
673	Main Line Health Center-Exton	Exton	Pennsylvania	United States	19341
674	Geisinger Medical Center-Cancer Center Hazleton	Hazleton	Pennsylvania	United States	18201
675	Lehigh Valley Hospital-Hazleton	Hazleton	Pennsylvania	United States	18201
676	Geisinger Medical Oncology-Lewisburg	Lewisburg	Pennsylvania	United States	17837
677	Lewistown Hospital	Lewistown	Pennsylvania	United States	17044
678	Riddle Memorial Hospital	Media	Pennsylvania	United States	19063
679	Bryn Mawr Health Center	Newtown Square	Pennsylvania	United States	19073
680	Paoli Memorial Hospital	Paoli	Pennsylvania	United States	19301
681	Fox Chase Cancer Center	Philadelphia	Pennsylvania	United States	19111
682	Temple University Hospital	Philadelphia	Pennsylvania	United States	19140
683	Pottstown Hospital	Pottstown	Pennsylvania	United States	19464
684	Geisinger Cancer Services-Pottsville	Pottsville	Pennsylvania	United States	17901
685	Community Medical Center	Scranton	Pennsylvania	United States	18510
686	Geisinger Medical Oncology-Selinsgrove	Selinsgrove	Pennsylvania	United States	17870
687	Geisinger Medical Group	State College	Pennsylvania	United States	16801
688	Reading Hospital	West Reading	Pennsylvania	United States	19611
689	Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	United States	18711
690	Lankenau Medical Center	Wynnewood	Pennsylvania	United States	19096
691	Kent Hospital	Warwick	Rhode Island	United States	02886
692	Saint Joseph's/Candler - Bluffton Campus	Bluffton	South Carolina	United States	29910
693	South Carolina Cancer Specialists PC	Hilton Head Island	South Carolina	United States	29926-3827
694	Levine Cancer Institute-Rock Hill	Rock Hill	South Carolina	United States	29732
695	Memorial Hospital	Chattanooga	Tennessee	United States	37404
696	Pulmonary Medicine Center of Chattanooga-Hixson	Hixson	Tennessee	United States	37343
697	Memorial GYN Plus	Ooltewah	Tennessee	United States	37363
698	Houston Methodist San Jacinto Hospital	Baytown	Texas	United States	77521
699	Saint Joseph Regional Cancer Center	Bryan	Texas	United States	77802
700	Parkland Memorial Hospital	Dallas	Texas	United States	75235
701	UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	United States	75390
702	UT Southwestern/Simmons Cancer Center-Fort Worth	Fort Worth	Texas	United States	76104
703	Houston Methodist Hospital	Houston	Texas	United States	77030
704	M D Anderson Cancer Center	Houston	Texas	United States	77030
705	Methodist Willowbrook Hospital	Houston	Texas	United States	77070
706	UT Southwestern Clinical Center at Richardson/Plano	Richardson	Texas	United States	75080
707	Scott and White Healthcare Round Rock	Round Rock	Texas	United States	78665
708	Houston Methodist Sugar Land Hospital	Sugar Land	Texas	United States	77479
709	Scott and White Memorial Hospital	Temple	Texas	United States	76508
710	American Fork Hospital / Huntsman Intermountain Cancer Center	American Fork	Utah	United States	84003
711	Sandra L Maxwell Cancer Center	Cedar City	Utah	United States	84720
712	Farmington Health Center	Farmington	Utah	United States	84025
713	Logan Regional Hospital	Logan	Utah	United States	84321
714	Intermountain Medical Center	Murray	Utah	United States	84107
715	McKay-Dee Hospital Center	Ogden	Utah	United States	84403
716	Utah Valley Regional Medical Center	Provo	Utah	United States	84604
717	Riverton Hospital	Riverton	Utah	United States	84065
718	Dixie Medical Center Regional Cancer Center	Saint George	Utah	United States	84770
719	Utah Cancer Specialists-Salt Lake City	Salt Lake City	Utah	United States	84106
720	Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	United States	84112
721	LDS Hospital	Salt Lake City	Utah	United States	84143
722	South Jordan Health Center	South Jordan	Utah	United States	84009
723	Norris Cotton Cancer Center-North	Saint Johnsbury	Vermont	United States	05819
724	Providence Regional Cancer System-Aberdeen	Aberdeen	Washington	United States	98520
725	MultiCare Auburn Medical Center	Auburn	Washington	United States	98001
726	Overlake Medical Center	Bellevue	Washington	United States	98004
727	PeaceHealth Saint Joseph Medical Center	Bellingham	Washington	United States	98225
728	Harrison HealthPartners Hematology and Oncology-Bremerton	Bremerton	Washington	United States	98310
729	Harrison Medical Center	Bremerton	Washington	United States	98310
730	Highline Medical Center-Main Campus	Burien	Washington	United States	98166
731	Providence Regional Cancer System-Centralia	Centralia	Washington	United States	98531
732	Swedish Cancer Institute-Edmonds	Edmonds	Washington	United States	98026
733	Saint Elizabeth Hospital	Enumclaw	Washington	United States	98022
734	Providence Regional Cancer Partnership	Everett	Washington	United States	98201
735	Saint Francis Hospital	Federal Way	Washington	United States	98003
736	MultiCare Gig Harbor Medical Park	Gig Harbor	Washington	United States	98335
737	Swedish Cancer Institute-Issaquah	Issaquah	Washington	United States	98029
738	Kadlec Clinic Hematology and Oncology	Kennewick	Washington	United States	99336
739	Providence Regional Cancer System-Lacey	Lacey	Washington	United States	98503
740	Saint Clare Hospital	Lakewood	Washington	United States	98499
741	PeaceHealth Saint John Medical Center	Longview	Washington	United States	98632
742	Jefferson Healthcare	Port Townsend	Washington	United States	98368
743	Harrison HealthPartners Hematology and Oncology-Poulsbo	Poulsbo	Washington	United States	98370
744	MultiCare Good Samaritan Hospital	Puyallup	Washington	United States	98372
745	Valley Medical Center	Renton	Washington	United States	98055
746	Pacific Gynecology Specialists	Seattle	Washington	United States	98104
747	Swedish Medical Center-Ballard Campus	Seattle	Washington	United States	98107
748	Kaiser Permanente Washington	Seattle	Washington	United States	98112
749	Swedish Medical Center-First Hill	Seattle	Washington	United States	98122-4307
750	Swedish Medical Center-Cherry Hill	Seattle	Washington	United States	98122-5711
751	PeaceHealth United General Medical Center	Sedro-Woolley	Washington	United States	98284
752	Providence Regional Cancer System-Shelton	Shelton	Washington	United States	98584
753	MultiCare Deaconess Cancer and Blood Specialty Center - Valley	Spokane Valley	Washington	United States	99216
754	MultiCare Deaconess Cancer and Blood Specialty Center - Downtown	Spokane	Washington	United States	99204
755	MultiCare Deaconess Cancer and Blood Specialty Center - North	Spokane	Washington	United States	99218
756	Franciscan Research Center-Northwest Medical Plaza	Tacoma	Washington	United States	98405
757	Mary Bridge Children's Hospital and Health Center	Tacoma	Washington	United States	98405
758	MultiCare Tacoma General Hospital	Tacoma	Washington	United States	98405
759	Northwest Medical Specialties PLLC	Tacoma	Washington	United States	98405
760	PeaceHealth Southwest Medical Center	Vancouver	Washington	United States	98664
761	Providence Saint Mary Regional Cancer Center	Walla Walla	Washington	United States	99362
762	North Star Lodge Cancer Center at Yakima Valley Memorial Hospital	Yakima	Washington	United States	98902
763	Providence Regional Cancer System-Yelm	Yelm	Washington	United States	98597
764	United Hospital Center	Bridgeport	West Virginia	United States	26330
765	Edwards Comprehensive Cancer Center	Huntington	West Virginia	United States	25701
766	WVUH-Berkely Medical Center	Martinsburg	West Virginia	United States	25401
767	West Virginia University Healthcare	Morgantown	West Virginia	United States	26506
768	Camden Clark Medical Center	Parkersburg	West Virginia	United States	26101
769	Duluth Clinic Ashland	Ashland	Wisconsin	United States	54806
770	Northwest Wisconsin Cancer Center	Ashland	Wisconsin	United States	54806
771	Marshfield Clinic-Chippewa Center	Chippewa Falls	Wisconsin	United States	54729
772	Marshfield Medical Center-EC Cancer Center	Eau Claire	Wisconsin	United States	54701
773	Mercyhealth Hospital and Cancer Center - Janesville	Janesville	Wisconsin	United States	53548
774	Gundersen Lutheran Medical Center	La Crosse	Wisconsin	United States	54601
775	Marshfield Clinic - Ladysmith Center	Ladysmith	Wisconsin	United States	54848
776	Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	United States	54449
777	Marshfield Clinic-Minocqua Center	Minocqua	Wisconsin	United States	54548
778	Cancer Center of Western Wisconsin	New Richmond	Wisconsin	United States	54017
779	Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	United States	54868
780	Marshfield Clinic Stevens Point Center	Stevens Point	Wisconsin	United States	54482
781	Marshfield Clinic-Wausau Center	Wausau	Wisconsin	United States	54401
782	Marshfield Medical Center - Weston	Weston	Wisconsin	United States	54476
783	Marshfield Clinic - Wisconsin Rapids Center	Wisconsin Rapids	Wisconsin	United States	54494
784	Cheyenne Regional Medical Center-West	Cheyenne	Wyoming	United States	82001
785	Billings Clinic-Cody	Cody	Wyoming	United States	82414
786	Welch Cancer Center	Sheridan	Wyoming	United States	82801
787	Advance Oncology Center	Aguadilla		Puerto Rico	00603
788	Doctor's Cancer Center-Arecibo	Arecibo		Puerto Rico	00614
789	Cancer Center-Metro Medical Center Bayamon	Bayamon		Puerto Rico	00959-5060
790	Hematologia Oncologia San Pablo	Bayamon		Puerto Rico	00961
791	HIMA San Pablo Oncologic Hospital	Caguas		Puerto Rico	00726
792	Doctors Cancer Center	Manati		Puerto Rico	00674
793	Instituto Oncologia Moderna Ponce	Ponce		Puerto Rico	00716
794	San Juan Community Oncology Group	San Juan		Puerto Rico	00917
795	Primary Care Physician Group	San Juan		Puerto Rico	00920
796	Centro Comprensivo de Cancer de UPR	San Juan		Puerto Rico	00927
797	San Juan City Hospital	San Juan		Puerto Rico	00936
798	Centro de Hematologia y Oncologia del Sur	Santa Isabel		Puerto Rico	00757

Sponsors and Collaborators

• Southwest Oncology Group
• National Cancer Institute (NCI)

Investigators

• Principal Investigator: Kanwal Raghav, Southwest Oncology Group

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Southwest Oncology Group
• ClinicalTrials.gov Identifier: NCT03365882
• Other Study ID Numbers: S1613; NCI-2016-01422; S1613; S1613; S1613; U10CA180888
• First Posted: Dec 7, 2017
• Last Update Posted: May 10, 2022
• Last Verified: May 1, 2022

• Studies a U.S. FDA-regulated Drug Product: Yes
• Studies a U.S. FDA-regulated Device Product: Yes
• Additional relevant MeSH terms: Carcinoma; Adenocarcinoma; Rectal Neoplasms; Colonic Neoplasms; Recurrence; Antineoplastic Agents, Immunological; Trastuzumab; Cetuximab; Pertuzumab; Irinotecan; Camptothecin; Antibodies; Immunoglobulins; Antibodies, Monoclonal

Study Results

No Results Posted as of May 10, 2022