Evaluation of Different Colorectal Cancer Screening Strategies
A large-scale randomized controlled trial was conducted to compare different colorectal neoplasms screening strategies.
|Condition or Disease||Intervention/Treatment||Phase|
Arms and Interventions
|Placebo Comparator: Risk score
Diagnostic Test: APCS score
APCS score can concentrate the high-risk population.
|Active Comparator: Fecal immunochemical test
Diagnostic Test: Fecal immunochemical test
Fecal immunochemical test can concentrate the high-risk population.
Primary Outcome Measures
- Detection rate [up to 30 months]
Detection of intestinal lesions in population
50-74 years old
Informed consent is available
Previous colorectal cancer
Previous colorectal resection
Previous received cancer-related treatment (except non-melanoma skin cancer)
Colonoscopy, sigmoidoscopy, CT colonoscopy, and barium enema were performed within 5 years
Fecal occult blood or fecal DNA was performed within one year
Symptoms of lower digestive tract diseases requiring colonoscopy include: (1) rectal bleeding occurred more than once in the past 6 months, (2) recorded iron deficiency anemia, and (3) recorded significant weight loss within 6 months (> 10% of baseline weight)
Suffering from other diseases that affect the benefit of screening or intolerance to colonoscopy (for example, severe pulmonary disease, end-stage renal disease, end-stage liver disease, severe heart failure or recently diagnosed cancer, except non-melanoma skin cancer)
Contacts and Locations
LocationsNo locations specified.
Sponsors and Collaborators
- Shandong University
Study Documents (Full-Text)None provided.