Evaluation of Different Colorectal Cancer Screening Strategies
Study Details
Study Description
Brief Summary
A large-scale randomized controlled trial was conducted to compare different colorectal neoplasms screening strategies.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Placebo Comparator: Risk score
|
Diagnostic Test: APCS score
APCS score can concentrate the high-risk population.
|
Active Comparator: Fecal immunochemical test
|
Diagnostic Test: Fecal immunochemical test
Fecal immunochemical test can concentrate the high-risk population.
|
Outcome Measures
Primary Outcome Measures
- Detection rate [up to 30 months]
Detection of intestinal lesions in population
Eligibility Criteria
Criteria
Inclusion Criteria:
-
50-74 years old
-
Informed consent is available
Exclusion Criteria:
-
Previous colorectal cancer
-
Previous colorectal resection
-
Previous received cancer-related treatment (except non-melanoma skin cancer)
-
Colonoscopy, sigmoidoscopy, CT colonoscopy, and barium enema were performed within 5 years
-
Fecal occult blood or fecal DNA was performed within one year
-
Symptoms of lower digestive tract diseases requiring colonoscopy include: (1) rectal bleeding occurred more than once in the past 6 months, (2) recorded iron deficiency anemia, and (3) recorded significant weight loss within 6 months (> 10% of baseline weight)
-
Suffering from other diseases that affect the benefit of screening or intolerance to colonoscopy (for example, severe pulmonary disease, end-stage renal disease, end-stage liver disease, severe heart failure or recently diagnosed cancer, except non-melanoma skin cancer)
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Shandong University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2022SDU-QILU-106