Comparison of Complement Factors and Genetic Polymorphisms of AMD Between Patients With Systemic Lupus Erythematosus (SLE) With and Without Retinal "Pseudo-drusen-like" Deposits: Case-control Study (PL-AMD)
Study Details
Study Description
Brief Summary
The rationale of this research is to determine if patients with lupus and presenting retinal "pseudo-drusen-like" deposits have genetic and complement-related similarities with AMD patients.
Based on the results obtained, this study could lead to future research that could better target the treatment of patients with lupus or patients with AMD (Age related Macular Degeneration).
The primary objective is to check if patients with lupus, treated or not with antimalarial drugs, with "pseudo-drusen-like" deposits have a different complement profile (functional exploration of complement, complement factors, genetic complement polymorphisms involved in AMD) compared to patients without "pseudo-drusen-like" deposits.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Case (with pseudo-drusen-like deposits) Patients with lupus, treated or not with antimalarial drugs, with "pseudo-drusen-like" deposits |
Procedure: Blood test
Blood test for complement factors and genetic polymorphisms of AMD analysis
|
Control (without pseudo-drusen-like deposits) Patients with lupus, treated or not with antimalarial drugs, without "pseudo-drusen-like" deposits |
Procedure: Blood test
Blood test for complement factors and genetic polymorphisms of AMD analysis
|
Outcome Measures
Primary Outcome Measures
- Comparison of AMD genetic polymorphisms between case and control patients [Baseline]
- Comparison of complement factors between case and control patients [Baseline]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Systemic lupus erythematosus
-
Case patients : with "pseudo-drusen-like" deposit
-
Control patients : without "pseudo-drusen-like" deposit
Exclusion Criteria:
- Patient under a measure of legal protection
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Fondation ophtalmologique Adolphe de Rothschild | Paris | France | 75019 |
Sponsors and Collaborators
- Fondation Ophtalmologique Adolphe de Rothschild
Investigators
- Principal Investigator: Martine MAUGET FAYSSE, Fondation Ophtalmologique A. de Rothschild
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- MMT_2018_1