Comparison of Different Cardiac Output Measurement Methods in Patients Undergoing Right Heart Catheterization
Study Details
Study Description
Brief Summary
The objective of this observational study is to compare cardiac output evaluation by the Direct Fick method, Indirect Fick method and Thermodiluition in pulmonary hypertension (PH) patients undergoing right heart catheterization (RHC).
The main questions it aims to answer are:
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Are these methods interchangeable?
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Can possible discrepancies influence risk stratification and therapeutic management of PH patients? All consecutive patients aged ≥18 years, referred for RHC for suspected PH, will be included. Exclusion criteria will be contraindications to RHC, cardiac shunts and failure to obtain informed consent. Patients will undergo RHC by a Swan-Ganz catheter through the right internal jugular vein ultrasound-guided cannulation and cardiac output will be calculated using the three above-mentioned methods.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| patients undergoing right heart catheterization
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Diagnostic Test: right heart catheterization
Right heart catheterization (RHC) is an invasive hemodynamic procedure that allows direct measurement of right-sided cardiac pressures, calculation of cardiac output and pulmonary vascular resistance. It is the gold standard for the diagnosis of pulmonary arterial hypertension. Right heart catheterization is commonly performed by accessing the internal jugular vein (echo-guided access). Swan Ganz catheter with a dedicated thermistor is used to perform RHC; it is advanced through the right heart chambers to measure right atrial, right ventricle, pulmonary artery and pulmonary arterial wedge pressures. Cardiac output is measured using Fick direct, Fick indirect and thermodilution methods.
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Outcome Measures
Primary Outcome Measures
- differences in cardiac output values measured using three different methods (Direct Fick, Indirect Fick and Thermodiluition) [through study completion, an average of 1 year]
In all patients cardiac output will be measured using the three methods to evaluate if the values obtained significantly differ
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age ≥18 years
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Suspected pulmonary hypertension at clinical and echocardiographic evaluation
Exclusion Criteria:
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contraindication to Right Heart Catheterization (RHC)
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cardiac shunt
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inability to provide informed consent
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | UOSD Emodinamica Diagnostica e Interventistica Ospedale SS Annunziata | Chieti | Italy | 66100 |
Sponsors and Collaborators
- UOSD Emodinamica Diagnostica e Interventistica
Investigators
- Principal Investigator: Livio Giuliani, MD PhD, Interventional Cardiology Unit, SS Annunziata Hospital, Chieti
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- CH2022-01