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Comparison of Magnetic Resonance Techniques for the Measurement of Cerebral Blood Perfusion

Sponsor
Barcelonabeta Brain Research Center, Pasqual Maragall Foundation (Other)
Overall Status
Active, not recruiting
CT.gov ID
NCT04486248
Collaborator
(none)
30
Enrollment
1
Location
38.7
Anticipated Duration (Months)
0.8
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

In this project, we aim at implementing a te-ASL sequence and to compare it to two reference ASL sequences with a fixed PLD on healthy individuals. On the one hand, the te-ASL sequence will be compared against a 3D pCASL with a PLD of 1800 ms, as the current reference according the Consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. On the other, as the implemented te-ASL sequence will have a 2D readout, it will also be compared to a 2D pCASL ASL sequence with the same PLD, in order to be able to disentangle differences due to the dynamic PLD scheme from those arising from the different read-out schemes.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    30 participants
    Observational Model:
    Other
    Time Perspective:
    Cross-Sectional
    Official Title:
    Comparison of Magnetic Resonance Techniques for the Measurement of Cerebral Blood Perfusion
    Actual Study Start Date :
    Oct 9, 2019
    Actual Primary Completion Date :
    Feb 24, 2020
    Anticipated Study Completion Date :
    Dec 31, 2022

    Outcome Measures

    Primary Outcome Measures

    1. ASL perfusion MRI data [Through study completion, an average of 1 year]

      Quantification of cerebral blood flow

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • To sign the study informed consent form approved by the corresponding authorities.

    • Healthy men and women (older than 18 years old).

    Exclusion Criteria:

    • Inability or unwillingness to give written informed consent or communicate with the study staff or illiteracy.

    • Any contraindication to perform brain MRI procedure (e.g. pacemaker, MRI-incompatible aneurysm clips).

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 BarcelonaBeta Brain Research Center Barcelona Spain 08005

    Sponsors and Collaborators

    • Barcelonabeta Brain Research Center, Pasqual Maragall Foundation

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
    ClinicalTrials.gov Identifier:
    NCT04486248
    Other Study ID Numbers:
    • ASL/BBRC2019
    First Posted:
    Jul 24, 2020
    Last Update Posted:
    Apr 21, 2022
    Last Verified:
    Sep 1, 2021
    Individual Participant Data (IPD) Sharing Statement:
    Undecided
    Plan to Share IPD:
    Undecided
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No

    Study Results

    No Results Posted as of Apr 21, 2022