Computed Tomography Angiography Accuracy in Brain Death Diagnosis
Study Details
Study Description
Brief Summary
The purpose of this study is to assess the reliability of computed tomography angiography (CTA) to diagnose brain death, face of several conditions that make impossible to define such diagnosis using clinical criteria exclusively.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Critically ill patients, presenting Glasgow Coma Score 5 or lower, will be submitted to the Computed Tomography Angiography (CTA) of the skull assessment, and follow a clinical evaluation for brain death, additionally, transcranial Doppler would be applied as the gold standard for brain death.
We will exclude patients whose do not can be submitted to contrast injection, or if a brain death clinical evaluation has been performed prior the CTA.
Study Design
Outcome Measures
Primary Outcome Measures
- Assess the presence or absence of contrast medium filling of the intracranial vessels in comatose patients. [1 year]
After excluding confounding factors, we will submit comatose patients to CTA. Immediately after the exam, we will perform clinical evaluation for brain death and calculate CTA sensibility and specificity for this diagnosis. Time between these two interventions will be measured.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Individuals of any age or sex with brain death suspicion raised, before clinical test.
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Comatose patients presenting Glasgow Coma Score as or under 5 points, under sedative agents or not.
Exclusion Criteria:
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Brain dead patients clinically confirmed.
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Contraindications to the use of contrast medium (renal failure or allergy).
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Hospital das Clínicas da Faculdade de Medicina da USP. | São Paulo | Brazil | 05403000 |
Sponsors and Collaborators
- Sergio Brasil, MD MSc
- University of Sao Paulo
Investigators
- Principal Investigator: Sergio Brasil, MD, University of Sao Paulo
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 12500913400000068