Contrast-associated Acute Kidney Injury in Patients With Different Types of Coronary Artery Disease
Study Details
Study Description
Brief Summary
The goal of the study is to assess the prevalence of contrast-associated acute kidney injury in patients with stable coronary artery disease, ST-elevation myocardial infarction and unstable angina/NSTEMI, assess the risk factors of contrast-induced acute kidney injury development and the influence of contrast-induced kidney injury on 1-year prognosis.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Stable coronary artery disease
|
Other: Iodinated contrast
Intra-arterial injection of iodinated contrast media during percutaneous coronary intervention
|
ST-elevation myocardial infarction
|
Other: Iodinated contrast
Intra-arterial injection of iodinated contrast media during percutaneous coronary intervention
|
Non-ST-elevation myocardial infarction
|
Other: Iodinated contrast
Intra-arterial injection of iodinated contrast media during percutaneous coronary intervention
|
Outcome Measures
Primary Outcome Measures
- Contrast associated acute kidney injury [48-72 hours]
Number of patients with contrast associated kidney injury after contrast exposure
Secondary Outcome Measures
- Overall mortality [1 year]
- Cardiovascular mortality [1 year]
- Myocardial infarction [1 year]
Number of patients with myocardial infarction
- Stroke [1 year]
- Repeat revascularization [1 year]
PCI or CABG
- Repeat hospitalisation [1 year]
- Acute decompensation of heart failure [1 year]
Number of patients with acute decompensation of heart failure
- Chronic kidney disease progression [1 year]
Progression of chronic kidney disease in patients with decreased glomerular filtration rate on inclusion
- New-onset dialysis [1 year]
Number of patients with new-onset dialysis
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Males and females aged 18-80
-
Stable CAD receiving optimal medical treatment requiring PCI or STEMI or NSTEMI
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Intra-arterial injection of iodinated contrast media
-
Informed consent
Exclusion Criteria:
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Age less than 18
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Pregnancy, lactation
-
Refuse to sign the informed consent
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Contraindications for PCI
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Other conditions affecting prognosis (oncology, liver failure etc)
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CKD stage 4-5
-
Patients receiving nephrotoxic drugs
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Sechenov University | Moscow | Russian Federation |
Sponsors and Collaborators
- I.M. Sechenov First Moscow State Medical University
Investigators
- Study Director: Olga Mironova, MD PhD, I. M. Sechenov First Moscow State Medical University (Sechenov University)
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 11/2019