The Effects of Nitrogen Protoxide and Oxygen on Corneal Endothelial in Pediatric Patients
Study Details
Study Description
Brief Summary
To evaluate the mean changes in Endothelial Cell and Corneal pachymetry in eyes that operated under N2O + sevoflurane and O2 + sevoflurane general anesthesia.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Detailed Description
40 eyes of 40 patients who had extraocular surgery under general anesthesia will be included in this prospective study. Cell density, Cell variatio, Hexagonality rate and pachymetry specular microscopy results at before surgery and 1 week and 1 month after surgery will be analyzed. O2 (1 l/min) with 50% air and N2O (1 l/min) with 50% air will be applied to each group with flow rate 2 l/min totally, respectively. The duration of surgery will be recorded.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Active Comparator: corneal endothal Evaluate the effects of nitrogen protoxide to corneal endothal and compare with oxygen. |
Other: Nitrogen protoxide
Other: Oxygen
|
Active Comparator: Cell density Evaluate the effects of nitrogen protoxide to Cell density and compare with oxygen. |
Other: Nitrogen protoxide
Other: Oxygen
|
Outcome Measures
Primary Outcome Measures
- Change of corneal endothal number [after surgery at first day, 1th week and 1th month]
Nitrogen protoxide and oxygen may be change this number
- Change of Cell density rate [after surgery at first day, 1th week and 1th month]
Nitrogen protoxide and oxygen may be change this rate
- Change of Cell variation rate [at before surgery and 1 week and 1 month after surgery]
Nitrogen protoxide and oxygen may be change this rate
- Change of Hexagonality rate [after surgery at first day, 1th week and 1th month]
Nitrogen protoxide and oxygen may be change this rate
- Change of pachymetry specular microscopy results [after surgery at first day, 1th week and 1th month]
Nitrogen protoxide and oxygen may be change these results
Eligibility Criteria
Criteria
Inclusion Criteria:
- 40 eyes of 40 pediatric patients who had extraocular surgery under general anesthesia
Exclusion Criteria:
- None
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Inonu University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Asozkan-4