CORNEAL EPITHELIAL MAPPING IN DIABETICS
Study Details
Study Description
Brief Summary
The corneal epithelium is the outermost layer that covers the front of the eye; it not only functions as a barrier that blocks the passage of foreign material, but also plays an important role in maintaining high optical quality. The stem cells in the basal layer of the limbal epithelium hold a physiological significance in the renewal and metabolism of corneal epithelium, particularly under stressful situations.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
The cornea in diabetic patients suffers from cellular dysfunction and dysfunctional repairal mechanisms, which include recurrent erosions, delayed wound healing, ulcers, and edema. In addition and undoubtedly related to epithelial dysfunction, alterations in epithelial basement membrane occur.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Healthy control
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Other: corneal imaging
corneal imaging using AS-OCT
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Diabetics with macular edema
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Other: corneal imaging
corneal imaging using AS-OCT
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Diabetics without macular edema
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Other: corneal imaging
corneal imaging using AS-OCT
|
Outcome Measures
Primary Outcome Measures
- corneal epithelial thickness [2 years]
corneal thickness in diabetics using OCT
Eligibility Criteria
Criteria
Inclusion Criteria:
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The patients aged between 40- 60 years old of both genders.
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The patients in (Group A) should be diabetics for more than 10 years and free from any other systemic diseases with diabetic macular edema (by OCT).
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The patients in (Group B) should be diabetics for more than 10 years and free from any other systemic diseases without diabetic macular edema (by OCT).
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The patients in (Group C) should be free of any systemic diseases and normal macular thickness (by OCT)
Exclusion Criteria:
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Previous history of any intraocular surgery, intravitreal injection, laser or refractive surgery.
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Ocular surface disorders (e.g. dry eye) or any corneal pathology.
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Corneal scars or epithelial dystrophies.
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Use of any topical medications.
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Elevated IOP, pregnancy or lactation.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Minia University | Minya | Egypt | 61111 |
Sponsors and Collaborators
- Minia University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- MiniaUN