Correlation Between Elastic Modulus of Ultrasonic Shear Wave and Tumor Stromal Component in Pancreatic Cancer

Sponsor
Xijing Hospital (Other)
Overall Status
Recruiting
CT.gov ID
NCT05187416
Collaborator
(none)
50
1
8
6.3

Study Details

Study Description

Brief Summary

Pancreatic cancer is a gastrointestinal tumor with a high degree of malignancy. Currently, there are many first-line chemotherapy regimens in clinical practice, but the individual selection of chemotherapy regimens has not been unanimously recognized.This study is aimed at exploring the correlation between the two-dimensional shear wave elastography (2D - SWE) parameters and pancreatic cancer stromal elements proportion through an ultrasound scan for resectable pancreatic cancer cases and postoperative pathological specimen analysis. Then determine if the pancreatic cancer two-dimensional shear wave elastography can guide clinicians selecting chemotherapy scheme by predicting tumor stromal elements .These results are expected to provide an effective non-invasive diagnostic basis for individualized treatment of pancreatic cancer.

Condition or Disease Intervention/Treatment Phase
  • Diagnostic Test: two-dimensional shear wave elastography

Study Design

Study Type:
Observational
Anticipated Enrollment :
50 participants
Observational Model:
Other
Time Perspective:
Other
Official Title:
Correlation Between Elastic Modulus of Ultrasonic Shear Wave and Tumor Stromal Component in Pancreatic Cancer
Anticipated Study Start Date :
Feb 1, 2022
Anticipated Primary Completion Date :
Oct 1, 2022
Anticipated Study Completion Date :
Oct 1, 2022

Outcome Measures

Primary Outcome Measures

  1. Elastic modulus measured by Ultrasonic shear wave and tumor stromal component assessed by pathological analysis in pancreatic cancer [Baseline (Preoperative ultrasound elastography examination)]

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 100 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No

Inclusion Criteria

  1. Patients with resectable pancreatic cancer underwent ultrasound examination before surgery

  2. Conventional ultrasound can clearly show pancreatic space-occupying lesions and the elastic measurements show good images

  3. The patient agrees to receive ultrasound elasticity examination and signs informed consent

  4. All patients had no history of radiotherapy or chemotherapy before ultrasound examination

  5. All clinical case data and auxiliary examination data are complete and accessible.

Exclusion Criteria

  1. Ultrasound evaluation was not performed before ultrasound-guided needle biopsy

  2. Conventional ultrasound could not clearly show pancreatic space-occupying lesions or poor elastic measurement images

  3. Patients who refuse to accept examination or give up treatment

  4. Patients receiving neoadjuvant chemotherapy or radiotherapy before ultrasound examination

  5. Incomplete clinical data and auxiliary examination data.

Contacts and Locations

Locations

Site City State Country Postal Code
1 Xijing Hospital Xi'an Shaanxi China 710032

Sponsors and Collaborators

  • Xijing Hospital

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Xijing Hospital
ClinicalTrials.gov Identifier:
NCT05187416
Other Study ID Numbers:
  • KY20212175-C-1
First Posted:
Jan 11, 2022
Last Update Posted:
Jan 19, 2022
Last Verified:
Oct 1, 2021
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Xijing Hospital
Additional relevant MeSH terms:

Study Results

No Results Posted as of Jan 19, 2022