Correlation Between Optical Coherence Tomography Angiography and Photopic Negative Response in Patients With Glaucoma
Study Details
Study Description
Brief Summary
Open angle glaucoma (OAG) is considered a common cause of irreversible vision loss worldwide. It is an optic neuropathy associated with progressive loss and degeneration of the retinal ganglion cell layer (RGC) and its axons (retinal nerve fiber layer; RNFL), which lead to neuroretinal rim excavation and corresponding visual field defects.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Open angle glaucoma (OAG) is considered a common cause of irreversible vision loss worldwide. It is an optic neuropathy associated with progressive loss and degeneration of the retinal ganglion cell layer (RGC) and its axons (retinal nerve fiber layer; RNFL), which lead to neuroretinal rim excavation and corresponding visual field defects.
OCT Angiography (OCTA) is a promising tool for diagnosing and monitoring glaucomatous patients. It can evaluate glaucomatous damage and assess the ganglion cells' health by measuring blood flow within the optic nerve and the retina Correlation between vascular , structural and functional changes of the peripapillary retinal nerve fiber (RNFL) and macular/ganglion cell complex (GCC) can lead to early detection of glaucomatous changes.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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mild Primary Open Angle Glaucoma group (Group I) 28 eyes of 16 patients with mild primary open angle glaucoma as group I. |
Diagnostic Test: Optical Coherence Tomography- Angiography
Peripapillary retinal nerve fiber layer thickness, ganglion cell complex, superficial and deep capillary plexus vessel density were measured.
Other Names:
Diagnostic Test: Photopic negative response
Both the implicit time and amplitude of PhNR were recorded.
Other Names:
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moderate to severe Primary Open Angle Glaucoma group (Group II) 44 eyes of 24 patients with moderate to severe primary open angle glaucoma as group II. |
Diagnostic Test: Optical Coherence Tomography- Angiography
Peripapillary retinal nerve fiber layer thickness, ganglion cell complex, superficial and deep capillary plexus vessel density were measured.
Other Names:
Diagnostic Test: Photopic negative response
Both the implicit time and amplitude of PhNR were recorded.
Other Names:
|
Control Group 80 eyes of 40 healthy subjects as control group. |
Diagnostic Test: Optical Coherence Tomography- Angiography
Peripapillary retinal nerve fiber layer thickness, ganglion cell complex, superficial and deep capillary plexus vessel density were measured.
Other Names:
Diagnostic Test: Photopic negative response
Both the implicit time and amplitude of PhNR were recorded.
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Correlation between vascular, structural and functional changes of the peripapillary retinal nerve fiber and macular ganglion cell complex in patients with open angle glaucoma. [Immediately after OCTA and electroretinogram diagnostic tests for each eye.]
Correlation between RNFL thickness and GCC measured by OCT-A with implicit time and amplitude of Photopic Negative Response (PhNR) measured by electroretinogram.
Secondary Outcome Measures
- Assess the validity of OCTA parameters and PhNR in early detection of glaucoma changes. [Immediately after OCTA and electroretinogram diagnostic tests for each eye.]
Changes in the parameters were measured by OCT-A as Superficial and deep vessel Density.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age of 30 years or older for both control and glaucoma groups.
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Spherical equivalent (SE) between -2 and +2 D.
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No history of previous eye surgery, trauma, or systemic diseases.
Exclusion Criteria:
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Spherical equivalent greater than +/- 2.00 diopters (D).
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Media opacity as (cataract or corneal scar).
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Any history of ocular surgeries or trauma.
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Optic nerve anomaly or other retinal diseases.
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Unreliable visual field tests (33% fixation losses, false positive, and false- negative results).
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Benha University | Banhā | Benha | Egypt | 13511 |
Sponsors and Collaborators
- Benha University
Investigators
- Study Chair: Marwa A Tabl, MD, Benha University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- RC-9-11-01