Correlation Between Thermal Patterns of Infrared Thermal Imaging and Clinical Phenotype in Patients With Postherpetic Neuralgia

Sponsor
Xianwei Zhang,MD (Other)
Overall Status
Recruiting
CT.gov ID
NCT05568186
Collaborator
(none)
166
1
12
13.8

Study Details

Study Description

Brief Summary

Postherpetic neuralgia (PHN) is the most frequent complication of herpes zoster(HZ) and is defined as pain persisting for >1month after the healing of herpetic skin lesion or pain persisting for > 3 months following the onset of HZ. PHN manifests as spontaneous throbbing, stabbing, or burning, usually accompanied by various abnormal sensory symptoms , which affect 5-20% of patients with HZ. Due to the lack of accurate and objective auxiliary examination tools, it is difficult for diagnosis and treatment of PHN. As a non-invasive examination method, infrared thermal imaging (IRT) can play a role in the diagnosis and treatment of neuropathic pain by objectively reflecting the changes and distribution characteristics of human body surface temperature. However, there are few studies on the relationship between clinical phenotype and thermal infrared image temperature changes in PHN patients, and the relationship between the thermal pattern of skin temperature and the duration of disease and treatment progress in PHN patients has not been fully elucidated. This study was conducted to investigate the relationship of thermal imaging data with the duration of the disease, clinical phenotype, treatment effect, in order to explore the role of infrared thermal imaging in the diagnosis and treatment of PHN. Methods:all PHN patients will included. At each visit, a pain NRS score was performed, and clinical phenotypes were tested and labeled, including: allodynia, numbness, itching, heat sensation, cold sensation, and the most painful area(MPA). Infrared thermal imaging was performed, the Average Relative Temperature (ART) within the affected area and the contralateral area was compared. The relationship between the temperature change and duration of the disease, clinical phenotype, treatment effect was assessed.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    patients with the follow conditions were excluded: 1)The skin area was lesions because of other disease(trauma, inflammation, skin scar, skin disease, tumor, etc.); 2) history of psychiatric diseases, chronic pain. 3) inabilities to complete IRT examination.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    166 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    Correlation Between Different Thermal Patterns of Infrared Thermal Imaging and Clinical Phenotype and Prognosis in Patients With Postherpetic Neuralgia
    Actual Study Start Date :
    Oct 1, 2022
    Anticipated Primary Completion Date :
    Oct 1, 2023
    Anticipated Study Completion Date :
    Oct 1, 2023

    Outcome Measures

    Primary Outcome Measures

    1. Thermal pattern difference between affected side and contralateral side [1 year]

      Thermal pattern difference between affected side and contralateral side

    2. temperature difference between affected side and contralateral side [1 year]

      temperature difference between affected side and contralateral side

    Secondary Outcome Measures

    1. the relationship between the temperature change and disease duration [1 year]

      the relationship between the temperature change and disease duration

    2. the relationship between the temperature change and Pain Scores on Visual Analog Scale at each visit [1 year]

      the relationship between the temperature change and Pain Scores on Visual Analog Scale at each visit

    3. the relationship between the temperature change and clinical phenotype [1 year]

      the relationship between the temperature change and clinical phenotype

    4. the relationship between the temperature change and treatment effect [1 year]

      the relationship between the temperature change and treatment effect

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
      1. patients>18 years-old 2) pain lasts at least 1 month after lesion crusting 3) Agreed to participate the research
    Exclusion Criteria:
    • 1))the skin area was lesions because of other disease(trauma, inflammation, skin scar, skin disease, tumor, etc.); 2) history of psychiatric diseases, chronic pain. 3)inabilities to complete IRT examination. 4) Disagree to participate to the research

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China 430030

    Sponsors and Collaborators

    • Xianwei Zhang,MD

    Investigators

    • Principal Investigator: Xianwei Zhang, Doctor, Huazhong University of Science and Technology

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Xianwei Zhang,MD, professor, Huazhong University of Science and Technology
    ClinicalTrials.gov Identifier:
    NCT05568186
    Other Study ID Numbers:
    • postherpetic neuralgia
    First Posted:
    Oct 5, 2022
    Last Update Posted:
    Oct 5, 2022
    Last Verified:
    Oct 1, 2022
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Xianwei Zhang,MD, professor, Huazhong University of Science and Technology
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Oct 5, 2022