Association Between Post-covid Infection Status and Perioperative Morbidity:A Ambispective Cohort Study.
Study Details
Study Description
Brief Summary
With the knowledge of currently transmitted omicron variant being less virulent, over 90 percent of the Chinese population is fully vaccinated, and the Chinese health workers have sufficient experience treating the illness. China 's epidemic prevention and control has entered a new stage to restore the normal functioning of society and basic medical services, On Dec, 7, China released a circular on further optimizing its COVID-19 response, announcing 10 new prevention and control measures.This has marked the watershed for sharply increased number of elective surgical patients diagnosed with COVID-19 during preoperativley, fully recovered or during recovery.
Beijing faced a wave of omicron infection starting that would result in of a wide range of population infections. At which time there is limited evidence regarding the optimal timing of surgery following SARS-CoV-2 infection especially for omiron among Chinsese patients .This study intends to explore the relationship between the incidence of postoperative complications after elective surgery and COVID-19 infection in Peking Union Medical College Hospital, and provide data support for the policy formulation of elective surgical timing for patients after COVID-19 infection.
Condition or Disease | Intervention/Treatment | Phase |
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Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Covid-19 infection group Patients who have been infected with Covid-19 before elective surgery. |
Procedure: Receiving elective surgery
Receiving elective surgery in Peking Union Medical College Hospital
|
Control group Patients who were not infected with COVID-19 before elective surgery. |
Procedure: Receiving elective surgery
Receiving elective surgery in Peking Union Medical College Hospital
|
Outcome Measures
Primary Outcome Measures
- Perioperative complications [The day of discharge]
Perioperative complications include: Respiratory system complications: pneumonia, acute respiratory distress syndrome, pulmonary edema, postoperative hypoxia, atelectasis, pleural effusion, ventilator support ≥ 48 hours, etc; Cardiovascular complications: cardiac arrest, arrhythmia, new hypertension, new hypotension, heart failure, myocardial infarction, etc Digestive system complications: nausea and vomiting, intestinal obstruction, peritonitis, etc Neurological complications: cerebrovascular events (cerebral infarction, cerebral hemorrhage), delirium, etc Blood system complications: deep vein thrombosis, pulmonary embolism, massive hemorrhage, transfusion related adverse reactions, etc Urinary system complications: acute renal injury, urinary retention, urinary system infection, etc Others: surgical incision infection, blood flow infection, poor wound healing, etc
Secondary Outcome Measures
- Length of intensive care unit stay [The day of discharge]
Calculate the number of days the patient stays in the intensive care unit after surgery.
Other Outcome Measures
- Length of hospital stay [The day of discharge]
Calculate the number of days the patient stays in the hospital.
- Readmission rate during 30 days after surgery [30 days after operation]
Readmission due to surgery complications during 30 days after operation
- Postoperative mechanical ventilation time [The day of discharge]
Length of mechanical ventilation time after surgery
- Mortality within 30 days after operation [30 days after operation]
Mortality within 30 days after operation
Eligibility Criteria
Criteria
Inclusion Criteria:
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Accept elective surgery in Peking Union Medical College Hospital.
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Patients can understand the research protocol and are willing to participate in the research, and sign the informed consent form.
Exclusion Criteria:
- Patients participating in other clinical studies.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Peking Union Medical College Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Bryant JM, Boncyk CS, Rengel KF, Doan V, Snarskis C, McEvoy MD, McCarthy KY, Li G, Sandberg WS, Freundlich RE. Association of Time to Surgery After COVID-19 Infection With Risk of Postoperative Cardiovascular Morbidity. JAMA Netw Open. 2022 Dec 1;5(12):e2246922. doi: 10.1001/jamanetworkopen.2022.46922.
- COVIDSurg Collaborative. Outcomes and Their State-level Variation in Patients Undergoing Surgery With Perioperative SARS-CoV-2 Infection in the USA: A Prospective Multicenter Study. Ann Surg. 2022 Feb 1;275(2):247-251. doi: 10.1097/SLA.0000000000005310.
- El-Boghdadly K, Cook TM, Goodacre T, Kua J, Denmark S, McNally S, Mercer N, Moonesinghe SR, Summerton DJ. Timing of elective surgery and risk assessment after SARS-CoV-2 infection: an update: A multidisciplinary consensus statement on behalf of the Association of Anaesthetists, Centre for Perioperative Care, Federation of Surgical Specialty Associations, Royal College of Anaesthetists, Royal College of Surgeons of England. Anaesthesia. 2022 May;77(5):580-587. doi: 10.1111/anae.15699. Epub 2022 Feb 22.
- Quinn KL, Huang A, Bell CM, Detsky AS, Lapointe-Shaw L, Rosella LC, Urbach DR, Razak F, Verma AA. Complications Following Elective Major Noncardiac Surgery Among Patients With Prior SARS-CoV-2 Infection. JAMA Netw Open. 2022 Dec 1;5(12):e2247341. doi: 10.1001/jamanetworkopen.2022.47341.
- K23C0257