Induction Study #1 of Oral Ozanimod as Induction Therapy for Moderately to Severely Active Crohn's Disease
Sponsor
Celgene (Industry)
Overall Status
Recruiting
CT.gov ID
NCT03440372
Collaborator
(none)
600
565
2
76
1.1
0
Study Details
Study Description
Brief Summary
This is a study to explore the effect of oral ozanimod as an induction treatment for participants with moderately to severely active Crohn's Disease.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Study Design
Study Type:
Interventional
Anticipated Enrollment
:
600 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose:
Treatment
Official Title:
Induction Study #1 - A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Oral Ozanimod as Induction Therapy for Moderately to Severely Active Crohn's Disease
Actual Study Start Date
:
Feb 27, 2018
Anticipated Primary Completion Date
:
Mar 22, 2024
Anticipated Study Completion Date
:
Jun 28, 2024
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Administration of oral Ozanimod
|
Drug: Ozanimod
Specified dose on specified days
|
| Placebo Comparator: Administration of Placebo
|
Other: Placebo
Specified dose on specified days
|
Outcome Measures
Primary Outcome Measures
- Proportion of participants with a Crohn's Disease Activity Index (CDAI) score < 150 [Week 12]
Secondary Outcome Measures
- Proportion of participants with average daily abdominal pain score ≤ 1 point, and average daily stool frequency score ≤ 3 points with abdominal pain and stool frequency no worse than baseline [Week 12]
- Proportion of participants with a Simple Endoscopic Score for Crohn's Disease (SES-CD) score decrease from baseline of ≥ 50% [Week 12]
- Proportion of participants with CDAI reduction from baseline of ≥ 100 points or CDAI score < 150 [Week 12]
- Proportion of participants with CDAI reduction from baseline of ≥ 100 points or CDAI score < 150 and SES-CD decrease from baseline of ≥ 50% [Week 12]
- Proportion of participants with CDAI score < 150 and SES-CD decrease from baseline of ≥ 50% [Week 12]
- Proportion of participants with an average daily abdominal pain score ≤ 1 point, and average daily stool frequency score ≤ 3 points and both no worse than baseline AND an SES-CD ≤ 4 points and decrease ≥2 points [Week 12]
- Proportion of participants with an average daily abdominal pain score ≤ 1 point, and average daily stool frequency score ≤ 3 points and both no worse than baseline AND an SES-CD decrease from baseline of ≥ 50% [Week 12]
- Histologic Improvement based on differences between ozanimod and placebo in histologic disease activity scores (ie, Global Histologic Disease Activity Score changes) [Week 12]
- Proportion of participants with CDAI reduction from baseline of ≥ 70 points [Week 12]
- Proportion of participants with absence of ulcers ≥ 0.5 cm with no segment with any ulcerated surface ≥ 10% [Week 12]
- Proportion of participants with a Crohn's Disease Endoscopic Index of Severity (CDEIS) decrease from baseline of ≥ 50% [Week 12]
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
to 75 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
Crohn's disease for ≥ 3 months on endoscopy and on histological exam
-
Inadequate response or loss of response to corticosteroids, immunomodulators, and/or biologic therapies
-
Crohn's Disease Activity Index (CDAI) score ≥ 220 and ≤ 450
-
An average daily stool frequency ≥ 4 points and/or an abdominal pain of ≥ 2 points
-
Has Simple Endoscopic Score for Crohn's Disease (SES-CD) score of ≥ 6 (or SES-CD ≥ 4 in participants with isolated ileal disease)
Exclusion Criteria:
-
Has a diagnosis of ulcerative colitis, indeterminate colitis, radiation colitis, or ischemic colitis, or has strictures with prestenotic dilatation requiring procedural intervention
-
Has extensive small bowel resection (>100cm) or known diagnosis of short bowel syndrome, or requires total parenteral nutrition
-
Current stoma, ileal-anal pouch anastomosis, or fistula
Other protocol-defined inclusion/exclusion criteria apply
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Holland Center for Family Health | Peoria | Arizona | United States | 85381 |
| 2 | Elite Clinical Studies, LLC | Phoenix | Arizona | United States | 85018 |
| 3 | Arkansas Gastroenterology, P.A. | North Little Rock | Arkansas | United States | 72117 |
| 4 | Arkansas Gastroenterology, P.A. | North Little Rock | Arkansas | United States | 72117 |
| 5 | Sharp Chula Vista Medical Center | Chula Vista | California | United States | 91911 |
| 6 | Sharp Chula Vista Medical Center | Chula Vista | California | United States | 91911 |
| 7 | Valley View Internal Medicine | Garden Grove | California | United States | 92843 |
| 8 | Valley View Internal Medicine | Garden Grove | California | United States | 92843 |
| 9 | San Diego Clinical Trials | La Mesa | California | United States | 91942 |
| 10 | Children's Hospital of Los Angeles | Los Angeles | California | United States | 90027 |
| 11 | Children's Hospital Of Los Angeles | Los Angeles | California | United States | 90027 |
| 12 | Gastrointestinal Biosciences | Los Angeles | California | United States | 90067 |
| 13 | VA Northern California Health Care System | Mather | California | United States | 95655 |
| 14 | ABS Health, LLC | Mission Viejo | California | United States | 92691 |
| 15 | Alliance Clinical Research | Oceanside | California | United States | 92056 |
| 16 | Palo Alto Center-Palo Alto Medical Foundation Research Institute | Palo Alto | California | United States | 94304 |
| 17 | Inland Empire Liver Foundation | Rialto | California | United States | 92377 |
| 18 | Inland Empire Liver Foundation | Rialto | California | United States | 92377 |
| 19 | Medical Associates Research Group | San Diego | California | United States | 92123 |
| 20 | Medical Associates Research Group | San Diego | California | United States | 92123 |
| 21 | Childrens Hospital Colorado | Aurora | Colorado | United States | 80045 |
| 22 | Yale University | New Haven | Connecticut | United States | 06510 |
| 23 | Yale University | New Haven | Connecticut | United States | 06510 |
| 24 | Gastro Florida | Clearwater | Florida | United States | 33756-3839 |
| 25 | Gastro Florida | Clearwater | Florida | United States | 33756-3839 |
| 26 | University of Florida Health Endocrinology - Medical Specialties - Medical Plaza | Gainesville | Florida | United States | 32608 |
| 27 | University of Florida Health Endocrinology - Medical Specialties - Medical Plaza | Gainesville | Florida | United States | 32608 |
| 28 | Qway Research LLC | Hialeah | Florida | United States | 33010 |
| 29 | Qway Research LLC | Hialeah | Florida | United States | 33010 |
| 30 | Floridian Clinical Research LLC | Hialeah | Florida | United States | 33016 |
| 31 | Floridian Clinical Research LLC | Hialeah | Florida | United States | 33016 |
| 32 | Harmony Medical Research Institute | Hialeah | Florida | United States | 33016 |
| 33 | The Center for Gastrointestinal Disorders | Hollywood | Florida | United States | 33021 |
| 34 | The Center for Gastrointestinal Disorders | Hollywood | Florida | United States | 33021 |
| 35 | Vista Health Research | Homestead | Florida | United States | 33033 |
| 36 | Vista Health Research | Homestead | Florida | United States | 33033 |
| 37 | Florida Center for Gastroenterology | Largo | Florida | United States | 33777 |
| 38 | Florida Center for Gastroenterology | Largo | Florida | United States | 33777 |
| 39 | Nova Clinical Research Center LLC | Miami | Florida | United States | 33125 |
| 40 | Nova Clinical Research Center LLC | Miami | Florida | United States | 33125 |
| 41 | LCC Medical Research Institute, LLC | Miami | Florida | United States | 33126 |
| 42 | Research Associates of South Florida LLC | Miami | Florida | United States | 33156 |
| 43 | Research Associates of South Florida LLC | Miami | Florida | United States | 33156 |
| 44 | Advanced Research for Health Improvement | Naples | Florida | United States | 34109 |
| 45 | Advanced Research for Health Improvement | Naples | Florida | United States | 34109 |
| 46 | NSB Research | New Smyrna Beach | Florida | United States | 32168 |
| 47 | NSB Research | New Smyrna Beach | Florida | United States | 32168 |
| 48 | HMD Research LLC | Orlando | Florida | United States | 32819 |
| 49 | HMD Research LLC | Orlando | Florida | United States | 32819 |
| 50 | Advanced Medical Research Center | Port Orange | Florida | United States | 32127 |
| 51 | Advanced Medical Research Center | Port Orange | Florida | United States | 32127 |
| 52 | Asclepes Research Centers | Weeki Wachee | Florida | United States | 34607 |
| 53 | Asclepes Research Centers | Weeki Wachee | Florida | United States | 34607 |
| 54 | Consultative Gastroenterology | Atlanta | Georgia | United States | 30308 |
| 55 | Consultative Gastroenterology | Atlanta | Georgia | United States | 30308 |
| 56 | Atlanta Gastroenterology Associates, LLC | Atlanta | Georgia | United States | 30342 |
| 57 | Atlanta Gastroenterology Associates, Llc | Atlanta | Georgia | United States | 30342 |
| 58 | Children's Center for Digestive Healthcare | Atlanta | Georgia | United States | 30342 |
| 59 | Children's Center for Digestive Healthcare | Atlanta | Georgia | United States | 30342 |
| 60 | Gastrointestinal Disease Research | Columbus | Georgia | United States | 31904 |
| 61 | Gastrointestinal Disease Research | Columbus | Georgia | United States | 31904 |
| 62 | Gastroenterology Associates Of Central Georgia LLC | Macon | Georgia | United States | 31201 |
| 63 | Gastroenterology Associates Of Central Georgia LLC | Macon | Georgia | United States | 31201 |
| 64 | Rush University Medical Center - University Cardiovascular Surgeons | Chicago | Illinois | United States | 60612 |
| 65 | Northwestern University | Chicago | Illinois | United States | 60622 |
| 66 | Northwestern University | Chicago | Illinois | United States | 60622 |
| 67 | Carle Foundation Hospital | Urbana | Illinois | United States | 61801 |
| 68 | Carle Foundation Hospital | Urbana | Illinois | United States | 61801 |
| 69 | Iowa Digestive Disease Center | Clive | Iowa | United States | 50325 |
| 70 | University of Kentucky Health Care | Lexington | Kentucky | United States | 40536 |
| 71 | University of Kentucky Health Care | Lexington | Kentucky | United States | 40536 |
| 72 | CroNOLA LLC | Houma | Louisiana | United States | 70360 |
| 73 | Centex Studies, Inc. | Lake Charles | Louisiana | United States | 70601 |
| 74 | Centex Studies, Inc. | Lake Charles | Louisiana | United States | 70601 |
| 75 | Nola Research Works | New Orleans | Louisiana | United States | 70125 |
| 76 | Nola Research Works | New Orleans | Louisiana | United States | 70125 |
| 77 | LSU Health Sciences Center Shreveport | Shreveport | Louisiana | United States | 71103 |
| 78 | Johns Hopkins Bayview Medical Center | Baltimore | Maryland | United States | 21224 |
| 79 | Digestive Disease Associates, PA | Catonsville | Maryland | United States | 21228 |
| 80 | Woodholme Gastroenterology Associates | Glen Burnie | Maryland | United States | 21061 |
| 81 | Woodholme Gastroenterology Associates | Glen Burnie | Maryland | United States | 21061 |
| 82 | Brigham and Women's Hospital - Crohn's and Colitis Center | Chestnut Hill | Massachusetts | United States | 02467 |
| 83 | Brigham and Women's Hospital - Crohn's and Colitis Center | Chestnut Hill | Massachusetts | United States | 02467 |
| 84 | Baystate Medical Center | Springfield | Massachusetts | United States | 01199 |
| 85 | Local Institution - 286 | Springfield | Massachusetts | United States | 01199 |
| 86 | Medex Research Institute | Caro | Michigan | United States | 48723 |
| 87 | Medex Research Institute | Caro | Michigan | United States | 48723 |
| 88 | Revive Research Institute | Southfield | Michigan | United States | 48034 |
| 89 | Revive Research Institute | Southfield | Michigan | United States | 48034 |
| 90 | Southern Therapy and Advanced Research | Jackson | Mississippi | United States | 39216 |
| 91 | Southern Therapy and Advanced Research | Jackson | Mississippi | United States | 39216 |
| 92 | Washington University School of Medicine | Saint Louis | Missouri | United States | 63110 |
| 93 | Washington University School Of Medicine | Saint Louis | Missouri | United States | 63110 |
| 94 | Englewood Hospital and Medical Center | Englewood | New Jersey | United States | 07631 |
| 95 | Englewood Hospital and Medical Center | Englewood | New Jersey | United States | 07631 |
| 96 | University of New Mexico Hospital | Albuquerque | New Mexico | United States | 87106 |
| 97 | Advantage Clinical Trials | Bronx | New York | United States | 10468 |
| 98 | NY Scientific | Brooklyn | New York | United States | 11235 |
| 99 | NY Scientific | Brooklyn | New York | United States | 11235 |
| 100 | Adirondack Medical Research Center | Glens Falls | New York | United States | 12801 |
| 101 | Northwell Health | Great Neck | New York | United States | 11021 |
| 102 | Cornell University | New York | New York | United States | 10021 |
| 103 | Cornell University | New York | New York | United States | 10021 |
| 104 | Lenox Hill Hospital | New York | New York | United States | 10075 |
| 105 | Lenox Hill Hospital | New York | New York | United States | 10075 |
| 106 | Circuit Clinical | Orchard Park | New York | United States | 14127 |
| 107 | Asheville Gastroenterology Associates, P.A. | Asheville | North Carolina | United States | 28801 |
| 108 | Local Institution - 017 | Asheville | North Carolina | United States | 28801 |
| 109 | Carolinas HealthCare System Digestive Health | Charlotte | North Carolina | United States | 28204 |
| 110 | Carolinas HealthCare System Digestive Health | Charlotte | North Carolina | United States | 28204 |
| 111 | Internal Medicine Research | Charlotte | North Carolina | United States | 28207 |
| 112 | Internal Medicine Research | Charlotte | North Carolina | United States | 28207 |
| 113 | Carolina Research Center | Greenville | North Carolina | United States | 27834 |
| 114 | Carolina Research Center | Greenville | North Carolina | United States | 27834 |
| 115 | Great Lakes Medical Research, LLC | Beachwood | Ohio | United States | 44122 |
| 116 | Great Lakes Medical Research, LLC | Beachwood | Ohio | United States | 44122 |
| 117 | Cleveland Clinic - Taussig Cancer Institute | Cleveland | Ohio | United States | 44195 |
| 118 | Local Institution - 018 | Cleveland | Ohio | United States | 44195 |
| 119 | Great Lakes Gastroenterology | Mentor | Ohio | United States | 44060 |
| 120 | Great Lakes Gastroenterology | Mentor | Ohio | United States | 44060 |
| 121 | Great Lakes Medical Research, LLC | Warren | Ohio | United States | 44483 |
| 122 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 123 | University Of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 124 | Digestive Disease Specialists | Oklahoma City | Oklahoma | United States | 73112 |
| 125 | Digestive Disease Specialists | Oklahoma City | Oklahoma | United States | 73112 |
| 126 | Oregon Health & Science University | Portland | Oregon | United States | 97239 |
| 127 | Oregon Health & Science University | Portland | Oregon | United States | 97239 |
| 128 | Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | United States | 17033 |
| 129 | Penn State University Milton S Hershey Medical Center | State College | Pennsylvania | United States | 16803 |
| 130 | Medical University Of South Carolina | Charleston | South Carolina | United States | 29425 |
| 131 | Local Institution - 121 | Nashville | Tennessee | United States | 37211 |
| 132 | Quality Medical Research | Nashville | Tennessee | United States | 37211 |
| 133 | Vanderbilt University Medical Center | Nashville | Tennessee | United States | 37212 |
| 134 | Advanced Gastroenterology | Union City | Tennessee | United States | 38261 |
| 135 | Avant Research Associates, LLC - Austin | Austin | Texas | United States | 78742 |
| 136 | Avant Research Associates, LLC - Austin | Austin | Texas | United States | 78742 |
| 137 | Baylor College of Medicine | Houston | Texas | United States | 77030 |
| 138 | Houston Methodist Hospital | Houston | Texas | United States | 77030 |
| 139 | Houston Methodist Hospital | Houston | Texas | United States | 77030 |
| 140 | Texas Children's Hospital | Houston | Texas | United States | 77030 |
| 141 | Biopharma Informatic Inc. Research Center | Houston | Texas | United States | 77043 |
| 142 | GI Specialists of Houston | Houston | Texas | United States | 77070 |
| 143 | Local Institution - 082 | Houston | Texas | United States | 77070 |
| 144 | Local Institution - 088 | Houston | Texas | United States | 77084 |
| 145 | Premier Vein and Vascular Center | Houston | Texas | United States | 77084 |
| 146 | Sun Research Institute | San Antonio | Texas | United States | 78215 |
| 147 | Sun Research Institute | San Antonio | Texas | United States | 78215 |
| 148 | Texas Digestive Disease Consultants - Southlake | Southlake | Texas | United States | 76092 |
| 149 | Texas Digestive Disease Consultants - Southlake | Southlake | Texas | United States | 76092 |
| 150 | Digestive Health Specialists of Tyler | Tyler | Texas | United States | 75701 |
| 151 | Digestive Health Specialists of Tyler | Tyler | Texas | United States | 75701 |
| 152 | University of Utah School of Medicine | Salt Lake City | Utah | United States | 84132 |
| 153 | University Of Utah School Of Medicine | Salt Lake City | Utah | United States | 84132 |
| 154 | Gastroenterology Associates, PC | Gainesville | Virginia | United States | 20155 |
| 155 | Local Institution - 189 | Gainesville | Virginia | United States | 20155 |
| 156 | Local Institution - 139 | Petersburg | Virginia | United States | 23805 |
| 157 | Summit Clinical Research, LLC | Petersburg | Virginia | United States | 23805 |
| 158 | Virginia Gastroenterology Institute PC | Suffolk | Virginia | United States | 23434 |
| 159 | University of Washington Medical Center | Seattle | Washington | United States | 98195 |
| 160 | Dermatologist Specialists of Spokane | Spokane | Washington | United States | 99204 |
| 161 | Dermatologist Specialists of Spokane | Spokane | Washington | United States | 99204 |
| 162 | Aurora Health Care Aurora Research | Grafton | Wisconsin | United States | 53024 |
| 163 | Sanatorio Guemes | Ciudad Autonoma de Buenos Aires | Argentina | 1180 | |
| 164 | Hospital Privado Centro Medico de Cordoba | Cordoba | Argentina | X5016 | |
| 165 | Local Institution - 495 | Cordoba | Argentina | X5016 | |
| 166 | Instituto Medico de la Fundacion Estudios Clinicos | Rosario | Argentina | 2000 | |
| 167 | Local Institution - 497 | Rosario | Argentina | 2000 | |
| 168 | Universidad Nacional De Rosario - Hospital Provincial Del Centenario | Rosario | Argentina | 2000 | |
| 169 | Local Institution - 492 | San Miguel de Tucuman | Argentina | 4000 | |
| 170 | Sanatorio 9 de Julio - CICE 9 de Julio | San Miguel de Tucuman | Argentina | 4000 | |
| 171 | Concord Repatriation General Hospital | Concord | New South Wales | Australia | 2139 |
| 172 | Local Institution - 310 | Concord | New South Wales | Australia | 2139 |
| 173 | Local Institution - 319 | Kingswood | New South Wales | Australia | 2747 |
| 174 | Nepean Hospital | Kingswood | New South Wales | Australia | 2747 |
| 175 | Local Institution - 323 | Wollongong | New South Wales | Australia | 2500 |
| 176 | Wollongong Hospital | Wollongong | New South Wales | Australia | 2500 |
| 177 | Local Institution - 311 | Woolloongabba | Queensland | Australia | 4102 |
| 178 | Princess Alexandra Hospital | Woolloongabba | Queensland | Australia | 4102 |
| 179 | Local Institution - 308 | Adelaide | South Australia | Australia | 5000 |
| 180 | Royal Adelaide Hospital | Adelaide | South Australia | Australia | 5000 |
| 181 | Local Institution - 320 | Woodville South | South Australia | Australia | 5011 |
| 182 | The Queen Elizabeth Hospital | Woodville South | South Australia | Australia | 5011 |
| 183 | Harry Perkins Medical Research Institute, Fiona Stanley Hospital | Murdoch | Western Australia | Australia | 6150 |
| 184 | Local Institution - 316 | Murdoch | Western Australia | Australia | 6150 |
| 185 | Ballarat Base Hospital | Ballarat | Australia | 3350 | |
| 186 | Grodno City Clinical Hospital #4 | Grodno | Belarus | 230026 | |
| 187 | Local Institution - 745 | Grodno | Belarus | 230026 | |
| 188 | Local Institution - 737 | Vitebsk | Belarus | 210604 | |
| 189 | Vitebsk Regional Clinical Specialized Center | Vitebsk | Belarus | 210604 | |
| 190 | Algemeen Ziekenhuis Klina | Brasschaat | Belgium | 2930 | |
| 191 | Local Institution - 940 | Brussels | Belgium | 1090 | |
| 192 | Universitair Ziekenhuis Brussel | Brussels | Belgium | 1090 | |
| 193 | University Hospital Brussels | Brussels | Belgium | 1090 | |
| 194 | CHU Saint-Luc | Brussels | Belgium | 1200 | |
| 195 | Queen Fabiola Children's University Hospital | Brussels | Belgium | 1200 | |
| 196 | Universitair Ziehenhuis Antwerpen | Edegem | Belgium | 2650 | |
| 197 | Universitair Ziekenhuis Gent | Ghent | Belgium | 9000 | |
| 198 | Local Institution - 942 | Leuven | Belgium | 3000 | |
| 199 | Universitair Ziekenhuis Leuven, Campus Gasthuisberg | Leuven | Belgium | 3000 | |
| 200 | Clinique du Montlegia | Liege | Belgium | 4000 | |
| 201 | Local Institution - 936 | Liege | Belgium | 4000 | |
| 202 | Local Institution - 938 | Seraing | Belgium | 4100 | |
| 203 | Sart Tilman Hospital Department of Gastroenterology and Hepatology | Seraing | Belgium | 4100 | |
| 204 | Hospital Centre of Walloon Picarde | Tournai | Belgium | 7500 | |
| 205 | Local Institution - 743 | Banja Luka | Bosnia and Herzegovina | 78000 | |
| 206 | University Clinical Centre of the Republic of Srpska | Banja Luka | Bosnia and Herzegovina | 78000 | |
| 207 | University Clinical Hospital Mostar | Mostar | Bosnia and Herzegovina | 88000 | |
| 208 | Clinical Center University of Sarajevo | Sarajevo | Bosnia and Herzegovina | 71000 | |
| 209 | General Hospital "Prim.dr. Abdulah Nakas" | Sarajevo | Bosnia and Herzegovina | 71000 | |
| 210 | Local Institution - 738 | Sarajevo | Bosnia and Herzegovina | 71000 | |
| 211 | Local Institution - 746 | Plovdiv | Bulgaria | 4002 | |
| 212 | Multiprofile Hospital for Active Treatment Medline | Plovdiv | Bulgaria | 4002 | |
| 213 | Local Institution - 747 | Sofia | Bulgaria | 1202 | |
| 214 | Second MHAT Sofia AD | Sofia | Bulgaria | 1202 | |
| 215 | Local Institution - 749 | Sofia | Bulgaria | 1606 | |
| 216 | University Multiprofile Hospital for Active Treatment Sveti Ivan Rilski EAD | Sofia | Bulgaria | 1606 | |
| 217 | Local Institution - 748 | Sofia | Bulgaria | 1784 | |
| 218 | University Multiprofile Hospital for Active Treatment ACIBADEM City Clinic Sofia | Sofia | Bulgaria | 1784 | |
| 219 | ACIBADEM City Clinic Medical Center Bregalnitsa | Varna | Bulgaria | 9002 | |
| 220 | Local Institution - 273 | Calgary | Alberta | Canada | T2N 4Z6 |
| 221 | University of Calgary Health - The Gastrointestinal Research Group (GIRG) | Calgary | Alberta | Canada | T2N 4Z6 |
| 222 | Local Institution - 263 | Kelowna | British Columbia | Canada | V1Y 1Z9 |
| 223 | Okanagan Clinical Trials Ltd | Kelowna | British Columbia | Canada | V1Y 1Z9 |
| 224 | Vancouver Hospital Gastrointestinal Research Unit The Gordon and Leslie Diamond Centre | Vancouver | British Columbia | Canada | V5Z1M9 |
| 225 | Local Institution - 261 | Winnipeg | Manitoba | Canada | R3CON2 |
| 226 | Winnipeg Clinic Dermatology Research | Winnipeg | Manitoba | Canada | R3CON2 |
| 227 | Local Institution - 268 | Bridgewater | Nova Scotia | Canada | B4V 3N2 |
| 228 | Viable Clinical Research | Bridgewater | Nova Scotia | Canada | B4V 3N2 |
| 229 | Local Institution - 252 | London | Ontario | Canada | N6A 5A5 |
| 230 | London Health Sciences Centre, University Hospital | London | Ontario | Canada | N6A 5A5 |
| 231 | LHSC Victoria Hospital | London | Ontario | Canada | N6A 5W9 |
| 232 | Local Institution - 251 | London | Ontario | Canada | N6A 5W9 |
| 233 | Local Institution - 271 | Vaughan | Ontario | Canada | L4L 4Y7 |
| 234 | Toronto Digestive Disease Associates Inc | Vaughan | Ontario | Canada | L4L 4Y7 |
| 235 | Local Institution - 390 | Santiago | Chile | 8320000 | |
| 236 | Clinical Hospital Center Osijek | Osijek | Croatia | 31000 | |
| 237 | Clinical Hospital Centre Rijeka | Rijeka | Croatia | 51000 | |
| 238 | Clinical Hospital Center Split | Split | Croatia | HR-21000 | |
| 239 | Clinical Hospital Center Sestre milosrdnice Clinic of Internal Diseases | Zagreb | Croatia | 10000 | |
| 240 | Clinical Hospital Dubrava | Zagreb | Croatia | 10000 | |
| 241 | Local Institution - 766 | Zagreb | Croatia | 10000 | |
| 242 | University Hospital Centre Zagreb, Clinic of Internal Diseases | Zagreb | Croatia | 10000 | |
| 243 | Local Institution - 767 | Brno | Czechia | 615 00 | |
| 244 | Military Hospital Brno | Brno | Czechia | 615 00 | |
| 245 | Local Institution - 772 | Brno | Czechia | 656 91 | |
| 246 | St. Anne's University Hospital Brno | Brno | Czechia | 656 91 | |
| 247 | Hepato-Gastroenterologie HK, s. r. o. | Hradec Králové | Czechia | 500 12 | |
| 248 | Local Institution - 773 | Hradec Králové | Czechia | 500 12 | |
| 249 | Local Institution - 775 | Most | Czechia | 43401 | |
| 250 | Soukroma Gastroenterologicka ambulance a endoskopie | Most | Czechia | 43401 | |
| 251 | Local Institution - 771 | Olomouc | Czechia | 77900 | |
| 252 | PreventaMed | Olomouc | Czechia | 77900 | |
| 253 | Krajská nemocnice Pardubice, Kožní oddelení | Pardubice | Czechia | 532 03 | |
| 254 | Local Institution - 774 | Pardubice | Czechia | 532 03 | |
| 255 | Local Institution - 769 | Plzen | Czechia | 30460 | |
| 256 | University Hospital Pilsen | Plzen | Czechia | 30460 | |
| 257 | University Hospital Motol | Prague 5 | Czechia | 150 06 | |
| 258 | ISCARE, a.s. | Prague 9 | Czechia | 190 00 | |
| 259 | Local Institution - 770 | Prague 9 | Czechia | 190 00 | |
| 260 | Institut klinicke a experimentalni mediciny | Praha 4 | Czechia | 14021 | |
| 261 | Local Institution - 776 | Praha 4 | Czechia | 14021 | |
| 262 | Bispebjerg Hospital | Copenhagen | Denmark | 2400 | |
| 263 | Holbaek Hospital | Holbaek | Denmark | 4300 | |
| 264 | Nykobing F Hospital | Nykobing F | Denmark | 4800 | |
| 265 | Turku University Hospital | Turku | Finland | FI-20520 | |
| 266 | CHU Amiens Picardie - Site Sud | Amiens cedex 1 | France | 80054 | |
| 267 | Local Institution - 638 | Amiens cedex 1 | France | 80054 | |
| 268 | Centre Hospitalier Intercommunal de Creteil | Creteil Cedex | France | 94010 | |
| 269 | CHU de Dijon Bourgogne - Hopital Francois Mitterand | Dijon Cedex | France | 21079 | |
| 270 | CHU de Grenoble Alpes | Grenoble Cedex 9 | France | 38700 | |
| 271 | Local Institution - 615 | Grenoble Cedex 9 | France | 38700 | |
| 272 | CHRU de Lille - Hopital Claude Huriez | Lillie Cedex | France | 59037 | |
| 273 | Local Institution - 633 | Lillie Cedex | France | 59037 | |
| 274 | Hopital Nord | Marseille cedex 20 | France | 13915 | |
| 275 | Hospital Pontchaillou | Rennes | France | 35033 | |
| 276 | Local Institution - 641 | Rennes | France | 35033 | |
| 277 | CHU de Rouen Hopital Charles Nicolle | Rouen Cedex | France | 76031 | |
| 278 | CHU de Toulouse Hopital Rangueil | Toulouse Cedex 09 | France | 31059 | |
| 279 | Local Institution - 643 | Toulouse Cedex 09 | France | 31059 | |
| 280 | Charite - Universitaetsmedizin Berlin | Berlin | Germany | 10117 | |
| 281 | Local Institution - 626 | Berlin | Germany | 10117 | |
| 282 | Gastroenterology Am Bayerischen Platz | Berlin | Germany | 10825 | |
| 283 | DRK Clinics Berlin | Berlin | Germany | 14050 | |
| 284 | Local Institution - 650 | Berlin | Germany | 14050 | |
| 285 | Agaplesion Markus Krankenhaus | Frankfurt | Germany | 60431 | |
| 286 | Local Institution - 662 | Frankfurt | Germany | 60431 | |
| 287 | Interdisciplinary Crohn Colitis Center Rhein Main | Frankfurt | Germany | 60594 | |
| 288 | Local Institution - 654 | Frankfurt | Germany | 60594 | |
| 289 | Local Institution - 659 | Hamburg | Germany | 20246 | |
| 290 | University Hospital Hamburg-Eppendorf | Hamburg | Germany | 20246 | |
| 291 | Local Institution - 651 | Leipzig | Germany | 04103 | |
| 292 | Universitaetsklinikum Leipzig AoeR | Leipzig | Germany | 04103 | |
| 293 | Local Institution - 655 | Ludwigshafen am Rhein | Germany | 67067 | |
| 294 | Practice for Gastroenterology and Internal Medicine | Ludwigshafen am Rhein | Germany | 67067 | |
| 295 | St Marien und St Annastiftskrankenhaus | Ludwigshafen am Rhein | Germany | 67067 | |
| 296 | Synesis Research Center | Munich | Germany | 80331 | |
| 297 | Local Institution - 666 | Tuebingen | Germany | 72076 | |
| 298 | Universitaetsklinikum Tuebingen | Tuebingen | Germany | 72076 | |
| 299 | Local Institution - 663 | Ulm | Germany | 89081 | |
| 300 | Universitaetsklinikum Ulm | Ulm | Germany | 89081 | |
| 301 | Local Institution - 975 | Dublin 4 | Dublin | Ireland | DO4 T6F4 |
| 302 | St Vincent's University Hospital | Dublin 4 | Dublin | Ireland | DO4 T6F4 |
| 303 | Beaumont Hospital | Dublin 9 | Ireland | D09 V2N0 | |
| 304 | Local Institution - 973 | Dublin 9 | Ireland | D09 V2N0 | |
| 305 | Bat Yamon Medical Center, Clalit Medical Services | Bat Yam | Israel | 5962025 | |
| 306 | Local Institution - 339 | Jerusalem | Israel | 91031 | |
| 307 | Shaare Zedek Medical Center | Jerusalem | Israel | 91031 | |
| 308 | Galilee Medical Center | Nahariya | Israel | 22100 | |
| 309 | Local Institution - 344 | Nahariya | Israel | 22100 | |
| 310 | Chaim Sheba Medical Center | Ramat Gan | Israel | 52621 | |
| 311 | Local Institution - 342 | Ramat Gan | Israel | 52621 | |
| 312 | Kaplan Medical Center | Rechovot | Israel | 76100 | |
| 313 | Local Institution - 338 | Rechovot | Israel | 76100 | |
| 314 | University Polyclinic Hospital of Bari | Bari | Italy | 70124 | |
| 315 | Local Institution - 677 | Bologna | Italy | 40138 | |
| 316 | Polyclinic S. Orsola-Malpighi | Bologna | Italy | 40138 | |
| 317 | Civil Hospital of Brescia | Brescia | Italy | 25123 | |
| 318 | Local Institution - 684 | Brescia | Italy | 25123 | |
| 319 | Poliambulanza Hospital | Brescia | Italy | 25124 | |
| 320 | IRCCS "Savario De Bellis" | Castellana Grotte | Italy | 70013 | |
| 321 | Local Institution - 689 | Castellana Grotte | Italy | 70013 | |
| 322 | Local Institution - 679 | Catanzaro | Italy | 88100 | |
| 323 | University Hospital Mater Domini | Catanzaro | Italy | 88100 | |
| 324 | "Ss. Annunziata" Policlinic of Chieti | Chieti | Italy | 66100 | |
| 325 | Local Institution - 674 | Messina | Italy | 98125 | |
| 326 | University Polyclinic Hospital G. Martino | Messina | Italy | 98125 | |
| 327 | Maggiore Polyclinic Hospital, IRCCS Ca' Granda | Milano | Italy | 20122 | |
| 328 | Humanitas Research Hospital - Humanitas Mirasole S.p.A | Milan | Italy | 20089 | |
| 329 | Local Institution - 672 | Milan | Italy | 20089 | |
| 330 | Azienda Socio Sanitaria Territoriale (ASST) di Monza | Monza | Italy | 20900 | |
| 331 | Local Institution - 678 | Monza | Italy | 20900 | |
| 332 | Hospital of Di Padova | Padova | Italy | 35128 | |
| 333 | Local Institution - 685 | Padova | Italy | 35128 | |
| 334 | United Hospitals Villa Sofia Cervello | Palermo | Italy | 90146 | |
| 335 | Polyclinic San Matteo IRCCS | Pavia | Italy | 27100 | |
| 336 | Polyclinic Tor Vergata | Roma | Italy | 00133 | |
| 337 | Local Institution - 675 | Roma | Italy | 00168 | |
| 338 | Univerisity Polyclinic Foundation Agostino Gemelli | Roma | Italy | 00168 | |
| 339 | Azienda Ospedaliera San Camillo Forlanini | Rome | Italy | 00152 | |
| 340 | Local Institution - 671 | Rome | Italy | 00152 | |
| 341 | Integrated University Hospital Santa Maria della Misericordia of Udine | Udine | Italy | 33100 | |
| 342 | Local Institution - 680 | Udine | Italy | 33100 | |
| 343 | A.O. Universitaria Fondazione Macchi | Varese | Italy | 21100 | |
| 344 | Local Institution - 676 | Verona | Italy | 37024 | |
| 345 | Sacred Heart Don Calabria | Verona | Italy | 37024 | |
| 346 | Korea University Medical Center - Korea University Ansan Hospital | Ansan | Korea, Republic of | 152-703 | |
| 347 | Local Institution - 441 | Busan | Korea, Republic of | 49201 | |
| 348 | Hanyang University Guri Hospital | Guri-si | Korea, Republic of | 11923 | |
| 349 | Local Institution - 436 | Seongnam-si | Korea, Republic of | 13620 | |
| 350 | Seoul National University Bundang Hospital | Seongnam-si | Korea, Republic of | 13620 | |
| 351 | Local Institution - 440 | Seoul | Korea, Republic of | 06591 | |
| 352 | Local Institution - 430 | Seoul | Korea, Republic of | 120-752 | |
| 353 | Severance Hospital | Seoul | Korea, Republic of | 120-752 | |
| 354 | Local Institution - 433 | Seoul | Korea, Republic of | 135-710 | |
| 355 | Samsung Medical Center | Seoul | Korea, Republic of | 135-710 | |
| 356 | Local Institution - 442 | Seoul | Korea, Republic of | 138-736 | |
| 357 | Kangbuk Samsung Hospital | Seoul | Korea, Republic of | 3181 | |
| 358 | Ewha Womans University Mokdong Hospital | Seoul | Korea, Republic of | 7985 | |
| 359 | Local Institution - 439 | Seoul | Korea, Republic of | 7985 | |
| 360 | Local Institution - 602 | Riga | Latvia | LV-1002 | |
| 361 | P. Stradins Clinical University Hospital | Riga | Latvia | LV-1002 | |
| 362 | Digestive Diseases Center Gastro | Riga | Latvia | LV-1006 | |
| 363 | Local Institution - 601 | Riga | Latvia | LV-1006 | |
| 364 | Riga East Clinical University Hospital clinic Gailezers | Riga | Latvia | LV-1038 | |
| 365 | Investigacion Biomedica para el desarrollo de Farmacos, S.A. de C.V. | Zapapan | Jalisco | Mexico | 45030 |
| 366 | Local Institution - 526 | Zapapan | Jalisco | Mexico | 45030 |
| 367 | Centro Regiomontano de Estudios Clinicos Roma SC. | Monterrey | Nuevo León | Mexico | 64610 |
| 368 | Local Institution - 532 | Monterrey | Nuevo León | Mexico | 64610 |
| 369 | Instituto Tecnológico y de Estudios Superiores de Monterrey | Monterrey | Nuevo León | Mexico | 64718 |
| 370 | Local Institution - 525 | Monterrey | Nuevo León | Mexico | 64718 |
| 371 | Local Institution - 529 | Santiago de Queretaro | Querétaro | Mexico | 76070 |
| 372 | SMIQ | Santiago de Queretaro | Querétaro | Mexico | 76070 |
| 373 | Hospital Christus Muquerza del Parque S.A. de C.V. | Chihuahua | Mexico | 31020 | |
| 374 | Local Institution - 528 | Chihuahua | Mexico | 31020 | |
| 375 | Centro de Investigacion Clinica Acelerada (CICA) S.C. | Mexico | Mexico | 07020 | |
| 376 | Local Institution - 527 | Mexico | Mexico | 07020 | |
| 377 | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | Tlalpan | Mexico | 14080 | |
| 378 | Local Institution - 530 | Tlalpan | Mexico | 14080 | |
| 379 | "Sfanta Treime" Clinical Municipal Hospital | Chisinau | Moldova, Republic of | MD-2068 | |
| 380 | Local Institution - 811 | Chisinau | Moldova, Republic of | MD-2068 | |
| 381 | Clinical Hospital of the Ministry of Health, Department of Endoscopic Surgery | Chisinau | Moldova, Republic of | MD2005 | |
| 382 | "Sf. Arhanghel Mihail" Municipal Clinical Hospital | Chisinau | Moldova, Republic of | MD2025 | |
| 383 | Local Institution - 809 | Chisinau | Moldova, Republic of | MD2025 | |
| 384 | Local Institution - 812 | Chisinau | Moldova, Republic of | MD2025 | |
| 385 | Local Institution - 813 | Chisinau | Moldova, Republic of | MD2025 | |
| 386 | Republican Clinical Hospital, Department of Colorectal Surgery | Chisinau | Moldova, Republic of | MD2025 | |
| 387 | Republican Clinical Hospital | Chisinau | Moldova, Republic of | MD2025 | |
| 388 | Akershus University Hospital | Lørenskog | Norway | 1478 | |
| 389 | Lovisenberg Diakonale Sykehus | Oslo | Norway | 0440 | |
| 390 | Local Institution - 820 | Bialystok | Poland | 15-276 | |
| 391 | SP ZOZ Wojewodzki Szpital Zespolony im. J. Sniadeckiego | Bialystok | Poland | 15-276 | |
| 392 | Local Institution - 818 | Bochnia | Poland | 32-700 | |
| 393 | Medical Services Center MaxMed | Bochnia | Poland | 32-700 | |
| 394 | Nzoz All-Medicus | Katowice | Poland | 40-660 | |
| 395 | Kornel Gibinski Independent Public Central Clinical Hospital in Katowice | Katowice | Poland | 40-752 | |
| 396 | Local Institution - 819 | Katowice | Poland | 40-752 | |
| 397 | GLOBE Clinical Research Sp. z o.o. LLC | Klodzko | Poland | 57-300 | |
| 398 | Local Institution - 817 | Klodzko | Poland | 57-300 | |
| 399 | Local Institution - 815 | Krakow | Poland | 30-363 | |
| 400 | PLEJADY Sp. z o.o. (LLC) Medical Centre | Krakow | Poland | 30-363 | |
| 401 | Landa Specialist Doctor's Offices | Krakow | Poland | 31-156 | |
| 402 | Local Institution - 823 | Krakow | Poland | 31-156 | |
| 403 | Krakow Medical Center LLC | Krakow | Poland | 31-501 | |
| 404 | Local Institution - 826 | Krakow | Poland | 31-501 | |
| 405 | Local Institution - 829 | Lodz | Poland | 90-302 | |
| 406 | Santa Familia Centrum Badan, Profilaktyki i Leczenia | Lodz | Poland | 90-302 | |
| 407 | Local Institution - 888 | Lodz | Poland | 91-839 | |
| 408 | Salve Limited Liability Company Limited Partnership, Outpatient Clinic | Lodz | Poland | 91-839 | |
| 409 | 1 Military Clinical Hospital in Lublin | Lublin | Poland | 20-049 | |
| 410 | Local Institution - 760 | Lublin | Poland | 20-049 | |
| 411 | Local Institution - 830 | Olsztyn | Poland | 10-561 | |
| 412 | Provincial Specialist Hospital in Olsztyn | Olsztyn | Poland | 10-561 | |
| 413 | SOLUMED Medical Center | Poznan | Poland | 60-529 | |
| 414 | Local Institution - 575 | Poznan | Poland | 60-702 | |
| 415 | GASTROMED Kopon, Zmudzinski and Partners Specialist Centre for Gastroenterology and Endoscopy, Spe | Torun | Poland | 87-100 | |
| 416 | Local Institution - 822 | Torun | Poland | 87-100 | |
| 417 | H-T. Medical Center Sp. z o.o. LLC Limited Partnership | Tychy | Poland | 43-100 | |
| 418 | Local Institution - 824 | Tychy | Poland | 43-100 | |
| 419 | Local Institution - 827 | Ul. Piotrkowska 177 | Poland | 90-447 | |
| 420 | Polimedica | Ul. Piotrkowska 177 | Poland | 90-447 | |
| 421 | Local Institution - 410 | Warsaw | Poland | 00-632 | |
| 422 | Maternal Pediatric and Adolescent Healthcare Centre | Warsaw | Poland | 00-632 | |
| 423 | Niepubliczny Zaklad Opieki Zdrowotnej VIVAMED | Warszawa | Poland | 03-580 | |
| 424 | Hyperclinica MedLife Grivita | Bucharest | Romania | 010719 | |
| 425 | Local Institution - 808 | Bucharest | Romania | 010719 | |
| 426 | Local Institution - 836 | Bucharest | Romania | 010719 | |
| 427 | Center of Diagnosis and Treatment Provita | Bucharest | Romania | 021494 | |
| 428 | Local Institution - 795 | Bucharest | Romania | 021494 | |
| 429 | Fundeni Clinical Institute | Bucharest | Romania | 022328 | |
| 430 | Local Institution - 837 | Bucharest | Romania | 022328 | |
| 431 | Bucharest University Emergency Hospital, Department of Internal Medicine II | Bucharest | Romania | 050098 | |
| 432 | Local Institution - 839 | Bucharest | Romania | 050098 | |
| 433 | Dr. Carol Davila Central Military Emergency Clinical Hospital | Bucharest | Romania | 10825 | |
| 434 | Local Institution - 842 | Bucharest | Romania | 10825 | |
| 435 | Craiova County Emergency Clinical Hospital | Craiova | Romania | 200642 | |
| 436 | Local Institution - 843 | Craiova | Romania | 200642 | |
| 437 | Colentina Clinical Hospital | Napoca | Romania | 400001 | |
| 438 | Local Institution - 838 | Napoca | Romania | 400001 | |
| 439 | Local Institution - 840 | Targu Mures | Romania | 540136 | |
| 440 | Targu Mures County Emergency Clinical Hospital | Targu Mures | Romania | 540136 | |
| 441 | Chita State Medical Academy | Chita | Russian Federation | 672090 | |
| 442 | Local Institution - 598 | Chita | Russian Federation | 672090 | |
| 443 | Irkutsk State Medical Academy of Postgraduate Education | Irkutsk | Russian Federation | 664049 | |
| 444 | Local Institution - 848 | Irkutsk | Russian Federation | 664049 | |
| 445 | City Clinical Hospital No 7 - Kazan | Kazan | Russian Federation | 420103 | |
| 446 | Local Institution - 892 | Kazan | Russian Federation | 420103 | |
| 447 | Regional Clinical Hospital | Khanty-mansiysk | Russian Federation | 628012 | |
| 448 | Federal Siberian Research and Clinical Center | Krasnoyarsk | Russian Federation | 660037 | |
| 449 | Local Institution - 927 | Krasnoyarsk | Russian Federation | 660037 | |
| 450 | Moscow Clinical Scientific and Practical Center | Moscow | Russian Federation | 111123 | |
| 451 | Local Institution - 594 | Novosibirsk | Russian Federation | 630007 | |
| 452 | Novosibirskiy Gastrocenter | Novosibirsk | Russian Federation | 630007 | |
| 453 | Local Institution - 858 | Petrozavodsk | Russian Federation | 185019 | |
| 454 | Republican Hospital na VA Baranov | Petrozavodsk | Russian Federation | 185019 | |
| 455 | Evromedservis | Pushkin | Russian Federation | 196603 | |
| 456 | Local Institution - 859 | Pushkin | Russian Federation | 196603 | |
| 457 | Clinic UZI 4D, LLC | Pyatigorsk | Russian Federation | 357502 | |
| 458 | Local Institution - 960 | Pyatigorsk | Russian Federation | 357502 | |
| 459 | Local Institution - 846 | Pyatigorsk | Russian Federation | 357538 | |
| 460 | Pyatigorsk City Hospital 2 | Pyatigorsk | Russian Federation | 357538 | |
| 461 | Local Institution - 883 | Rostov-on-Don | Russian Federation | 344022 | |
| 462 | Rostov State Medical University | Rostov-on-Don | Russian Federation | 344022 | |
| 463 | Medical Center Reavita Med Spb LLC | Saint Petersburg | Russian Federation | 194354 | |
| 464 | Local Institution - 844 | Samara | Russian Federation | 443041 | |
| 465 | Samara Station Railway Clinical Hospital under OAO Russian Railways | Samara | Russian Federation | 443041 | |
| 466 | Local Institution - 862 | St Petersburg | Russian Federation | 194044 | |
| 467 | S.M. Kirov Military Medical Academy | St Petersburg | Russian Federation | 194044 | |
| 468 | Clinical and Diagnostic Center with an outpatient department under the Presidential Executive Office | St. Petersburg | Russian Federation | 195067 | |
| 469 | Local Institution - 845 | St. Petersburg | Russian Federation | 195067 | |
| 470 | Local Institution - 856 | St. Petersburg | Russian Federation | 195257 | |
| 471 | SPb SBIH City Hospital of Saint Martyr Elizaveta | St. Petersburg | Russian Federation | 195257 | |
| 472 | Budget Institution of the Khanty-Mansiysk Autonomous Okrug - Ugra Surgut Regional Clinical Hospital | Surgut | Russian Federation | 628408 | |
| 473 | Local Institution - 806 | Tula | Russian Federation | 300053 | |
| 474 | Tula Regional Clinical Hospital | Tula | Russian Federation | 300053 | |
| 475 | City Clinical Hospital #21 | Ufa | Russian Federation | 450071 | |
| 476 | Local Institution - 861 | Ufa | Russian Federation | 450071 | |
| 477 | Ulyanovsk Regional Clinical Hospital | Ulyanovsk | Russian Federation | 432017 | |
| 478 | Local Institution - 855 | Veliky Novgorod | Russian Federation | 173008 | |
| 479 | Novgorod Regional Clinical Hospital | Veliky Novgorod | Russian Federation | 173008 | |
| 480 | Local Institution - 935 | Vladimir | Russian Federation | 600023 | |
| 481 | Regional Clinical Hospital | Vladimir | Russian Federation | 600023 | |
| 482 | Local Institution - 999 | Vladivostok | Russian Federation | 690091 | |
| 483 | Primorsky Regional Clinical Hospital No.1 | Vladivostok | Russian Federation | 690091 | |
| 484 | Local Institution - 986 | Vladivostok | Russian Federation | 690922 | |
| 485 | Medical Center of Far-Eastern Federal University | Vladivostok | Russian Federation | 690922 | |
| 486 | King Fahad Specialist Hospital | Dammam | Saudi Arabia | 32253 | |
| 487 | King Abdul Aziz University Hospital | Jeddah | Saudi Arabia | 22252 | |
| 488 | Local Institution - 537 | Jeddah | Saudi Arabia | 22252 | |
| 489 | King Saud Medical Complex | Riyadh | Saudi Arabia | 12746 | |
| 490 | Local Institution - 536 | Riyadh | Saudi Arabia | 12746 | |
| 491 | King Fahad National Guard Hospital | Riyadh | Saudi Arabia | 14611 | |
| 492 | Local Institution - 535 | Riyadh | Saudi Arabia | 14611 | |
| 493 | General University Hospital of Alicante | Alicante | Spain | 03010 | |
| 494 | Local Institution - 703 | Alicante | Spain | 03010 | |
| 495 | Local Institution - 690 | Badalona | Spain | 08916 | |
| 496 | University Hospital Germans Trias i Pujol | Badalona | Spain | 08916 | |
| 497 | University Hospital of the Canary Islands (HUC) La Laguna | La Laguna | Spain | 38320 | |
| 498 | Local Institution - 691 | Madrid | Spain | 28006 | |
| 499 | University Hospital de La Princesa | Madrid | Spain | 28006 | |
| 500 | Local Institution - 692 | Madrid | Spain | 28046 | |
| 501 | University Hospital La Paz | Madrid | Spain | 28046 | |
| 502 | University Hospital Virgen Macarena | Sevilla | Spain | 41009 | |
| 503 | University Hospital Virgen del Rocio | Sevilla | Spain | 41013 | |
| 504 | Local Institution - 700 | Viladecans | Spain | 08840 | |
| 505 | Viladecans Hospital | Viladecans | Spain | 08840 | |
| 506 | Lindenhofspital | Bern | Switzerland | 3001 | |
| 507 | Local Institution - 967 | Bern | Switzerland | 3001 | |
| 508 | Cantonal Hospital Saint Gallen | St.Gallen | Switzerland | 9007 | |
| 509 | University Hospital Zurich | Zurich | Switzerland | 8091 | |
| 510 | Bulent Ecevit Universitesi Uygulama ve Arastirma Hastanesi | Kozlu | Taiwan | 67000 | |
| 511 | Local Institution - 363 | Kozlu | Taiwan | 67000 | |
| 512 | Ankara University Medical Faculty Cebeci Hospital | Ankara | Turkey | 06590 | |
| 513 | Uludag Universitesi Tip Fakultesi | Bursa | Turkey | 16059 | |
| 514 | Bezmialem Foundation University Medical Faculty | Istanbul | Turkey | 34093 | |
| 515 | Local Institution - 362 | Istanbul | Turkey | 34093 | |
| 516 | Marmara University | Istanbul | Turkey | 34840 | |
| 517 | Local Institution - 354 | Izmit/Kocaeli | Turkey | 41380 | |
| 518 | Goztepe Prof. Dr. Suleyman Yalcin City Hospital | Kadiköy/Istanbul | Turkey | 41380 | |
| 519 | Karadeniz Teknik Universitesi Tip Fakultesi Farabi Hastanesi | Trabzon | Turkey | 61080 | |
| 520 | Local Institution - 359 | Trabzon | Turkey | 61080 | |
| 521 | Chernivtsi Regional Clinical Hospital | Chernivtsi | Ukraine | 58001 | |
| 522 | Local Institution - 914 | Chernivtsi | Ukraine | 58001 | |
| 523 | Local Institution - 950 | Dnipropetrovsk | Ukraine | 49074 | |
| 524 | Si Institute Of Gastroenterology Of Namsu Dept Of Stomach And Duodenum Diseases | Dnipropetrovsk | Ukraine | 49074 | |
| 525 | Ivano-Frankivsk Central City Clinical Hospital | Ivano-Frankivsk | Ukraine | 76018 | |
| 526 | Local Institution - 912 | Ivano-Frankivsk | Ukraine | 76018 | |
| 527 | V.T. Zaitsev Institute of General and Emergency Surgery | Kharkiv | Ukraine | 61018 | |
| 528 | Kyiv City Clinical Hospital #18 | Kyiv | Ukraine | 01030 | |
| 529 | Local Institution - 901 | Kyiv | Ukraine | 01030 | |
| 530 | Local Institution - 915 | Kyiv | Ukraine | 02000 | |
| 531 | Medical Center Consilium Medical | Kyiv | Ukraine | 02000 | |
| 532 | Local Institution - 911 | Kyiv | Ukraine | 02175 | |
| 533 | Ok Clinic Medical Center within International Institute of Clinical Trials, LLC | Kyiv | Ukraine | 02175 | |
| 534 | Kyiv Regional Hospital #2 | Kyiv | Ukraine | 04053 | |
| 535 | Local Institution - 918 | Kyiv | Ukraine | 04053 | |
| 536 | Kyiv Regional Clinical Hospital | Kyiv | Ukraine | 04107 | |
| 537 | Local Institution - 908 | Kyiv | Ukraine | 04107 | |
| 538 | Local Institution - 562 | Kyiv | Ukraine | 4210 | |
| 539 | Public City Clinical Hospital of Emergency Medical Care | Lviv | Ukraine | 79059 | |
| 540 | Local Institution - 905 | Poltava | Ukraine | 36011 | |
| 541 | Poltava M.V. Sklifosovskyi Regional Clinical Hospital under Poltava Regional Council | Poltava | Ukraine | 36011 | |
| 542 | Local Institution - 934 | Ternopil | Ukraine | 46008 | |
| 543 | Ternopil City Public Emergency Medical Care Hospital | Ternopil | Ukraine | 46008 | |
| 544 | Local Institution - 909 | Vinnytsia | Ukraine | 02029 | |
| 545 | Vinnytsia City Clinical Hospital #1 | Vinnytsia | Ukraine | 02029 | |
| 546 | Local Institution - 971 | Vinnytsia | Ukraine | 21018 | |
| 547 | Vinnytsia M.I. Pyrohov Regional Clinical Hospital | Vinnytsia | Ukraine | 21018 | |
| 548 | First Private Clinic | Zhytomyr | Ukraine | 10003 | |
| 549 | Local Institution - 557 | Birmingham | United Kingdom | B15 2SQ | |
| 550 | Bristol Royal Infirmary | Bristol | United Kingdom | BS2 8HW | |
| 551 | Local Institution - 712 | Dundonald | United Kingdom | BT16 1RH | |
| 552 | Ulster Hospital | Dundonald | United Kingdom | BT16 1RH | |
| 553 | Local Institution - 713 | Glasgow | United Kingdom | G51 4TF | |
| 554 | Queen Elizabeth University Hospital | Glasgow | United Kingdom | G51 4TF | |
| 555 | Victoria Hospital Blackpool | Lancashire Blackpool | United Kingdom | FY3 8NR | |
| 556 | Local Institution - 722 | London | United Kingdom | E1 1BB | |
| 557 | Royal London Hospital | London | United Kingdom | E1 1BB | |
| 558 | University College London Hospitals NHS Foundation Trust - University College Hospital | London | United Kingdom | NW1 2BU | |
| 559 | Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital | London | United Kingdom | SE1 9RT | |
| 560 | Local Institution - 715 | London | United Kingdom | SE1 9RT | |
| 561 | John Radcliffe Hospital | Oxford | United Kingdom | OX3 9DU | |
| 562 | Royal Shrewsbury Hospital | Shrewsbury | United Kingdom | SY38XQ | |
| 563 | Local Institution - 723 | Southampton | United Kingdom | SO16 6YD | |
| 564 | University Hospital Southampton NHS Foundation Trust - Southampton General Hospital | Southampton | United Kingdom | SO16 6YD | |
| 565 | Torbay Hospital | Torquay | United Kingdom | TQ2 7AA |
Sponsors and Collaborators
- Celgene
Investigators
- Study Director: Bristol-Myers Squibb, Bristol-Myers Squibb
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.Responsible Party:
Celgene
ClinicalTrials.gov Identifier:
NCT03440372
Other Study ID Numbers:
- RPC01-3201
- U1111-1203-7225
- 2017-004292-31
First Posted:
Feb 22, 2018
Last Update Posted:
Aug 24, 2022
Last Verified:
Aug 1, 2022
Studies a U.S. FDA-regulated Drug Product:
Yes
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Celgene
Additional relevant MeSH terms: