Comparing Different Ways of Delivering Humidity to Children With Croup
Study Details
Study Description
Brief Summary
Croup affects 5% of children under 6 years of age, resulting in visits to hospital Emergency Departments, and in 1% of children, hospitalization. Traditionally, the first therapy offered is humidification which can liquify airway secretions and decrease airway swelling. This study will compare the effectivenesss of 40% and 100% humidity through a specially designed machine called a nebulizer, with the usual humidity set-up (blown into the patient's face from a hose).
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Phase 2 |
Study Design
Outcome Measures
Primary Outcome Measures
- changes in the croup score from baseline to 30 and 60 minutes []
Secondary Outcome Measures
- steroid or epinephrine treatment at 60 minutes []
- discharge rate at 60 minutes []
- change in pulse, respiratory rate, and oxygen saturation at 60 minutes []
Eligibility Criteria
Criteria
Inclusion Criteria:
-
children aged 3 months - 10 years
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croup score greater than or equal to 2 after a 30 minute waiting period
Exclusion Criteria:
-
Symptoms of croup requiring immediate intervention with nebulized epinephrine or intubation
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symptoms or signs of alternative causes of stridor
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inability of caregivers to understand or speak English and/or sign for informed consent
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history of chronic pulmonary disease except for asthma, or co-existent systemic disease
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previous history of intubation
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duration of present illness >1 week
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systemic or inhaled glucocorticoids in previous 48 hours
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epinephrine in previous 4 hours
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | The Hospital for Sick Children | Toronto | Ontario | Canada | M5G 1X8 |
Sponsors and Collaborators
- The Hospital for Sick Children
- The Physicians' Services Incorporated Foundation
Investigators
- Principal Investigator: Dennis Scolnik, MD, The Hospital for Sick Children, Toronto Canada
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 0020010158