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CT-Based Versus Conventional Simulation for Palliative Radiotherapy of Non-Small Cell Lung Cancer

Sponsor
Alberta Health services (Other)
Overall Status
Completed
CT.gov ID
NCT00862030
Collaborator
(none)
20
Enrollment
1
Location
21
Duration (Months)
1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Radiotherapy (RT) treatment to the chest is a standard way of trying to decrease symptoms like cough or shortness of breath. Before any RT can be delivered, it must be planned, either using conventional x-rays ("fluoroscopy") or using computer tomography ("CT") scanning. This study is being done because the investigators do not know which of these two common ways of RT planning is better for balancing both treating the cancer and decreasing side effects.

Condition or Disease Intervention/Treatment Phase
  • Procedure: CT- simulation scan

Detailed Description

Standard RT planning will be performed under conventional simulation, followed by CT-simulation (for study purposes only). Retrospectively, 3D treatment fields will be designed using the CT-simulation data, and compared to the actual treatment fields planned using x-rays. Coverage of the tumour volume will be assessed, together with doses, field sizes and beam positions, to determine relative undercoverage of tumour and overcoverage of normal tissue between the two planning methods, if any.

Study Design

Study Type:
Observational
Anticipated Enrollment :
20 participants
Observational Model:
Cohort
Time Perspective:
Cross-Sectional
Official Title:
Comparison of Two-versus Three-Dimensional Treatment Planning for Patients Receiving Chest Radiotherapy for Symptom Control
Study Start Date :
Apr 1, 2009
Actual Primary Completion Date :
Jan 1, 2011
Actual Study Completion Date :
Jan 1, 2011

Arms and Interventions

Arm Intervention/Treatment
1

Study Cohort

Procedure: CT- simulation scan
Patients who are receiving standard palliative radiotherapy planned under x-rays will also undergo 1 CT-simulation scan which they would otherwise not require. The planning x-rays and CT scan will then be compared dosimetrically

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • Patients with local symptoms secondary to histologically-confirmed non-small cell lung cancer

    • Patients who will be receiving palliative-intent external beam radiotherapy

    • Patients who are clinically appropriate for conventional radiotherapy planning

    • Patients who can provide written informed consent

    Exclusion Criteria:
    • Patients who cannot provide written informed consent

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Cross Cancer Institute Edmonton Alberta Canada T6G 1Z2

    Sponsors and Collaborators

    • Alberta Health services

    Investigators

    • Principal Investigator: Dr. Alysa Fairchild, MD FRCPC, AHS Cancer Control Alberta

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00862030
    Other Study ID Numbers:
    • 24639
    First Posted:
    Mar 16, 2009
    Last Update Posted:
    Aug 8, 2011
    Last Verified:
    Aug 1, 2011
    Keywords provided by , ,
    Palliative radiotherapy
    Treatment planning
    Non-small cell lung cancer
    Additional relevant MeSH terms:
    Lung Neoplasms
    Carcinoma, Non-Small-Cell Lung

    Study Results

    No Results Posted as of Aug 8, 2011