Dark Halo and MNV: a Study Between ICGA and OCTA
Study Details
Study Description
Brief Summary
The aim of study is to compare the evaluation of dark halo area of macular neovascularization (MNV) between indocyanine green angiography (ICGA) and optical coherence tomography angiography (OCTA) in order to identify OCTA as effective and useful biomarker in MNV
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Dark halo is defined as a dark perilesional of flow decrease due to an area of reduced choroidal flow adjacent to the macular neovascularization (MNV).
The detection of MNV vascular details was only possible through invasive dye injection, such as fluorescein angiography (FA) or indocyanine green angiography (ICGA).
Optical coherence tomography angiography (OCTA) is a recent imaging technique that is able to detect the perfusion and non-perfusion areas carefully.
The aim of study is to compare the evaluation of dark halo area of MNV between ICGA and OCTA
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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MNV group Eyes affected by MNV. The dark halo of MNV was evaluated by OCTA and ICGA |
Diagnostic Test: Optical Coherence Tomography Angiography (OCTA) and indocyanine green angiography (ICGA)
OCTA and ICGA is able to detect the dark halo as a area of reduced perfusion around MVN
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Outcome Measures
Primary Outcome Measures
- Dark halo measurement [three years]
The OCTA and ICGA parameters analyzed are: the area of dark halo (mm2) that surrounds the coroidal neovascularization.
Eligibility Criteria
Criteria
Inclusion Criteria:
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age older than 55 years
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diagnosis of macular neovascularization
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absence of previous treatment with anti-Vegf injections
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absence of other retinal vascular diseases
Exclusion Criteria:
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age younger than 55 years
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absence diagnosis of macular neovascularization
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presence of previous treatment with anti-Vegf injections
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presence of other retinal vascular diseases
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | University of Naples "Federico II" | Naples | Italy | 80100 |
Sponsors and Collaborators
- Federico II University
Investigators
- Principal Investigator: Gilda Cennamo, Università Federico II
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 9009/21