Epinephrine and Cortisol in Depression
Study Details
Study Description
Brief Summary
This study investigates the effects of two hormones called epinephrine and cortisol on how the brain processes emotional material using functional MRI to measure brain activity. The study hopes to learn how epinephrine and cortisol affect the brain differently in depressed and non-depressed individuals.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Early Phase 1 |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Active Comparator: Healthy Arm, CORT + EPI, then PLB + EPI Healthy participant will receive cortisol pill and epinephrine infusion |
Drug: Hydrocortisone Acetate (CORT)
Participants will receive a single dose of hydrocortisone at a dosage of 0.65 mg/kg
Other Names:
Drug: Epinephrine Sulfate (EPI)
Participants will receive a continuous infusion of epinephrine at a dosage of 80 ng/kg/min
Other Names:
|
Active Comparator: Healthy Arm, PLB + EPI, then CORT + EPI Healthy participant will receive placebo pill and epinephrine infusion |
Drug: Epinephrine Sulfate (EPI)
Participants will receive a continuous infusion of epinephrine at a dosage of 80 ng/kg/min
Other Names:
Drug: Placebo (PLB)
Participants will receive a placebo
|
Experimental: Depression Arm, CORT + EPI, then PLB + EPI Depressed participant will receive cortisol pill and epinephrine infusion |
Drug: Hydrocortisone Acetate (CORT)
Participants will receive a single dose of hydrocortisone at a dosage of 0.65 mg/kg
Other Names:
Drug: Epinephrine Sulfate (EPI)
Participants will receive a continuous infusion of epinephrine at a dosage of 80 ng/kg/min
Other Names:
|
Experimental: Depression Arm, PLB + EPI, then CORT + EPI Depressed participant will receive placebo pill and epinephrine infusion |
Drug: Epinephrine Sulfate (EPI)
Participants will receive a continuous infusion of epinephrine at a dosage of 80 ng/kg/min
Other Names:
Drug: Placebo (PLB)
Participants will receive a placebo
|
Outcome Measures
Primary Outcome Measures
- Sadness-induced subgenual cingulate activity as measured by functional magnetic resonance imaging [2 hours]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Weight of less than 280 pounds
-
HAM-D Score of greater than 7 for depression participants
Exclusion Criteria:
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Psychotropic medications
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Recent surgery
-
Endocrine disorders
-
Liver disease
-
Kidney disease
-
Thyroid disorder
-
History of malaria
-
Tuberculosis
-
Osteoporosis
-
Glaucoma or cataracts
-
Chronic expressed infections (herpes, HIV, etc)
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History of congestive heart failure
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History of recurring seizures
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Stomach ulcers
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Comorbid psychosis
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Current use of illicit drugs
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Diabetes
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Any cardiovascular disease (angina, hypovolemia, coronary artery disease, low/high blood pressure, etc)
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Any pulmonary disease
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Any cerebrovascular disease
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Sulfate hypersensitivity
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Glaucoma
-
Infection
-
Pregnancy
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Parkinson's Disease
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Panic Disorder
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Over 280 pounds in weight
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In-dwelling ferrous metals
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Left handed
-
Abnormal hearing
-
Claustrophobic
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Head injury with loss of consciousness
-
Active suicidal ideation
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Stanford University
Investigators
- Principal Investigator: Keith Sudheimer, Ph.D., Stanford University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 53325