MusInDep: Perception of Music and Facial and Vocal Emotions in a Population With and Without Depression

Sponsor
Hôpital le Vinatier (Other)
Overall Status
Recruiting
CT.gov ID
NCT05143983
Collaborator
(none)
60
1
4
6.8
8.9

Study Details

Study Description

Brief Summary

Depressed subjects display a cognitive bias of information processing and emotional self-regulation, which reinforces negative experiences more than positive ones, known as the negativity bias. The link between depressive disorder and negativity bias has been much studied in terms of genetic, neurobiology, structural and functional neuroanatomy and cognitive sciences. It has been admitted that depressed subjects show impairment of facial expressions and prosody recognition, and of implicit memory.

Induction of depressive or elated mood with musical excerpts listening in healthy subjects influences facial emotions perception, respectively by reducing or enhancing recognition skills. However, no study to date already explored the interest of music-induced positive mood for alleviating negativity bias in depressed elderly population.

Main objective : to assess the impact of exposure to positive valence musical excerpts, on evaluation of facial emotions intensity, in a population of elderly patients hospitalized for depression, compared to neutral valence music listening.

Secondary objectives : to assess the impact of exposure to positive valence musical excerpts, on facial and vocal emotions recognition, and on implicit memory of faces, compared to neutral valence music listening.

The same methodology is also applied in a sample of control participants over 65 years to study the mood induction effect by music in elderlies.

Condition or Disease Intervention/Treatment Phase
  • Behavioral: Positive valence music
  • Behavioral: Neutral valence music
N/A

Detailed Description

The duration of the study, from first to last included subject, is estimated at 6 months, from January to June 2022. Each subject will participate for a period of 5 to 10 days.

Depressed group subjects will be pre-selected from all consecutive patients hospitalized or seen in consultation in geronto-psychiatric ward at Centre Hospitalier Le Vinatier, who agreed to participate in research. Patients will pass a basic cognitive task (MMSE) during the inclusion visit.

Healthy controls will be selected from relatives of patients admitted in Centre Hospitalier Le Vinatier, who agreed to participate in research.

Once included, subjects will be randomized, and will remain blind to study hypotheses until the study end.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
60 participants
Allocation:
Randomized
Intervention Model:
Crossover Assignment
Intervention Model Description:
Two groups of participants will be recruited: depressed patients and healthy controls. Each of these groups will be divided in two arms: one group listening to positive music at the first testing visit and neutral music at the second one, and the other group being exposed to positive and neutral conditions in the reverse order.Two groups of participants will be recruited: depressed patients and healthy controls. Each of these groups will be divided in two arms: one group listening to positive music at the first testing visit and neutral music at the second one, and the other group being exposed to positive and neutral conditions in the reverse order.
Masking:
Single (Participant)
Masking Description:
Subjects masked from the study hypothesis.
Primary Purpose:
Basic Science
Official Title:
Perception of Music and Facial and Vocal Emotions in a Population With and Without Depression
Actual Study Start Date :
Feb 7, 2022
Anticipated Primary Completion Date :
Jun 1, 2022
Anticipated Study Completion Date :
Sep 1, 2022

Arms and Interventions

Arm Intervention/Treatment
Active Comparator: depressed subjects, positive valence music listening at first

patients with major depressive disorder will be recruited and will complete 3 cognitive tasks after listening to positive musical excepts (3 minutes)

Behavioral: Positive valence music
Subjects will have to listen to 3 minutes of unfamiliar musical excerpts, with positive valence characteristics (fast tempo, major key). They will be told to listen carefully in order to then answer a short questionnaire. The listening will be followed by an liking scale (from 1 : not liked at all, to 5 : liked a lot) and a familiarity scale (from 1 : not familiar at all, to 5 : very familiar).

Other: depressed subjects, neutral valence music listening

patients with major depressive disorder will be recruited and will complete 3 cognitive tasks after listening to neutral valence musical excepts (3 minutes)

Behavioral: Neutral valence music
Subjects will have to listen to 3 minutes of unfamiliar musical excepts with neutral valence. They will be told to listen carefully in order to then answer to a short questionnaire. The listening will be followed by a liking scale (from 1 : not liked at all, to 5 : liked a lot) and a familiarity scale (from 1 : not familiar at all, to 5 : very familiar).

Other: healthy controls, positive valence music listening

healthy individuals will be recruited and will complete 3 cognitive task after listening to positive valence musical excepts (3 minutes)

Behavioral: Positive valence music
Subjects will have to listen to 3 minutes of unfamiliar musical excerpts, with positive valence characteristics (fast tempo, major key). They will be told to listen carefully in order to then answer a short questionnaire. The listening will be followed by an liking scale (from 1 : not liked at all, to 5 : liked a lot) and a familiarity scale (from 1 : not familiar at all, to 5 : very familiar).

Other: healthy controls, neutral valence music listening

healthy individuals will be recruited and will complete 3 cognitive task after listening to neutral valence musical excepts (3 minutes)

Behavioral: Neutral valence music
Subjects will have to listen to 3 minutes of unfamiliar musical excepts with neutral valence. They will be told to listen carefully in order to then answer to a short questionnaire. The listening will be followed by a liking scale (from 1 : not liked at all, to 5 : liked a lot) and a familiarity scale (from 1 : not familiar at all, to 5 : very familiar).

Outcome Measures

Primary Outcome Measures

  1. Emotional intensity score of facial expressions, rated by participants [up to 9 days]

    This intensity score will be calculated for a subject as the mean of intensity scores (from 1 to 5) attributed to negative faces and reverse intensity scores attributed to positive faces. This will give a "negativity score". The higher this score, the more negative emotions are judged as intense and the less positive emotions are judged as intense. This measurement will be collected by a computerized interface in two different sessions, one for each experimental condition.

Secondary Outcome Measures

  1. Emotions recognition [up to 7 days]

    Percentage of correct answers to facial and vocal emotion recognition

  2. Implicit memory [1 day]

    Percentage of identification of previously presented faces with positive expression

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 60 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • Men and Women between the ages of 18 and 60 years old

  • Major depressive episode of moderate to strong intensity, according to DSM-5 criteria, diagnosed by a Psychiatrist for subjects with depression ; GDS < 5 for healthy subjects

  • Being fluent in French

Exclusion Criteria:
    • Neurodegenerative disorder
  • Cognitive impairments (MMSE<26)

  • Sensory loss not sufficiently corrected, compromising the perception of oral instructions or visual or auditory stimuli

  • Impairment of awareness or attentional abilities restricting completion of cognitive tasks lasting 40 minutes.

And for Patients with depressive episode:
  • Psychotic or catatonic features of current depressive episode

  • Comorbid psychiatric disorder other than major unipolar depressive or anxiety disorders

  • Current treatment by electroconvulsive therapy

Contacts and Locations

Locations

Site City State Country Postal Code
1 Centre Hospitalier Le Vinatier Bron Cedex France 69678

Sponsors and Collaborators

  • Hôpital le Vinatier

Investigators

  • Principal Investigator: Jean-Michel DOREY, MD, PHD, CH le Vinatier

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Hôpital le Vinatier
ClinicalTrials.gov Identifier:
NCT05143983
Other Study ID Numbers:
  • 2021-A01916-35
First Posted:
Dec 3, 2021
Last Update Posted:
Mar 24, 2022
Last Verified:
Nov 1, 2021
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Hôpital le Vinatier
Additional relevant MeSH terms:

Study Results

No Results Posted as of Mar 24, 2022