CIDAI-BAS: Detection of Cerebral Ischemia With Artificial Intelligence.

Linda Block (Other)
Overall Status
Recruiting ID
Göteborg University (Other)

Study Details

Study Description

Brief Summary

In patients undergoing planned surgery for carotid tromendarterendectomy, a non-invasive device that registers heart rate variability is attached. Furthermore a non-invasive device that monitors cerebral oxygenation- near infrared spectroscopy as well as electroencephalography is also attached. At times when surgeons clamps the carotid artery, there will be a moment with controlled cerebral ischemia.

This will be registered by the devices. The information obtained will be used to teach artificial intelligence what patterns are related to cerebral ischemia. The same procedure will be performed in patients undergoing ocklusive cerebral trombectomy, so the artificial intelligence will learn to recognize cerebral reperfusion.Blood samples will be drawn before and after cerebral ischemia may occur and will be analyzed for neurobiomarkers and cardiac biomarkers.

Condition or Disease Intervention/Treatment Phase
  • Other: No intervention

Detailed Description

Please see the published study protocol for details.

The neurobiomarkers that will be analyzed for detection of cerebral ischemia is Glial Fibrillary Acidic Protein, Neurofilament light chains, S-100, Neuron specific endolas, Total-tau. Cardiac biomarkers are troponin-t and NT-pro brain natriuretic peptide.

Blood sampling will occur before anesthesia induction and 2 hours after plausible ischemia for patients undergoung surgery for carotid endarterectomy. for patients undergoing acute thrombectomy blood sampling will be performed as soon as possible after patient has arrived to the hospital.

Study Design

Study Type:
Anticipated Enrollment :
20 participants
Observational Model:
Time Perspective:
Official Title:
Detection of Cerebral Ischemia With Artificial Intelligence- Biomarkers as Indicators in Controlled Cerebral Ischemia and Reperfusion.
Actual Study Start Date :
Oct 1, 2020
Anticipated Primary Completion Date :
Dec 1, 2025
Anticipated Study Completion Date :
Dec 1, 2026

Arms and Interventions

Arm Intervention/Treatment
Cerebral ischemia

Patients undergoing planned surgery for carotid stenosis

Other: No intervention
there will be NO intervention


Patients undergoing cerebral trombectomy.

Other: No intervention
there will be NO intervention

Outcome Measures

Primary Outcome Measures

  1. Heart Rate variability [2020-2022]

    Changes in Heart Rate Variability from baseline.

  2. Near infrared spectroscopy [2020-2022]

    Changes in Near Infrared spectroscopy from baseline.

  3. Electroencephalography [2020-2022]

    Changes in electroencephalography from baseline, more precisely the Power in alpha bands, beta band, delta bands and quotas between these.

  4. Biomarkers indicating cerebral ischemia in blood [2020-2022]

    Changes in levels of biomarkers in blood from baseline. Total tau, neurofilament light chains, glial fibrillary acidic protein, S-100, neuron specific endolas.

  5. Biomarkers indicating cardiac ischemia in blood [2020-2022]

    Changes in levels of biomarkers in blood from baseline. Troponin T

Eligibility Criteria


Ages Eligible for Study:
18 Years to 100 Years
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Inclusion Criteria:
  • Patients planned for carotid surgery or trombectomy

  • Giving informed consent to participate

Exclusion Criteria:
  • Patients that do not consent Patients with arrythmia or pacemaker

Contacts and Locations


Site City State Country Postal Code
1 Sahlgrenska University hospital Gothenburg Sweden 41345

Sponsors and Collaborators

  • Linda Block
  • Göteborg University


  • Principal Investigator: Linda Block, PhD, Inst Clin Sciences

Study Documents (Full-Text)

None provided.

More Information


Responsible Party:
Linda Block, Doctor, MD, PhD, Göteborg University Identifier:
Other Study ID Numbers:
First Posted:
Apr 18, 2019
Last Update Posted:
Jan 25, 2022
Last Verified:
Jan 1, 2022
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD:
Studies a U.S. FDA-regulated Drug Product:
Studies a U.S. FDA-regulated Device Product:
Additional relevant MeSH terms:

Study Results

No Results Posted as of Jan 25, 2022