Developing Criteria for Cortical Resections
Study Details
Study Description
Brief Summary
The purpose of this study is to study how disease processes like tumors or epilepsy spread in the brain.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
The purpose of this study is to study how disease processes like tumors or epilepsy spread in the brain. During surgery small pieces of abnormal (unusual) brain tissue may be removed. We analyze these specimens using more advanced microscopic and electrophysiologic techniques than are usually applied to such tissue specimens. In addition, some tissues can be maintained in laboratory conditions to allow analysis over the longer term. No extra brain tissue is taken to perform these studies. The tissue analysis is performed by the research team and are compared to the routine (normal) electrical recordings that are taken during this type of brain surgery. Currently there are no instructions telling a doctor how much brain tissue should be cut out to prevent the spread of tumors or epilepsy. We are hoping that the results of this study help us to better know how much brain tissue needs to be removed to prevent the spread of tumors or epilepsy.
Study Design
Outcome Measures
Primary Outcome Measures
- measure electrical activity in tissue sample [at tissue aremoval time]
Eligibility Criteria
Criteria
Inclusion Criteria:
- Surgical candidates with epilepsy or brain tumor(s)
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | The University of Chicago Hospitals, The University of Chicago Comer Children's Hospital | Chicago | Illinois | United States | 60637 |
Sponsors and Collaborators
- University of Chicago
Investigators
- Principal Investigator: Wim van Drongelen, Ph.D., University of Chicago
Study Documents (Full-Text)
None provided.More Information
Publications
- Drongelen W van, Doren EL, Koch H, Marcuccilli CJ, Ramirez J-M, Elsen FP (2005) - Characterization of the persistent sodium current in neocortical networks of mice and humans. Abstract Washington DC: Society for Neuroscience
- Drongelen W van, Koch H, Marcuccilli CJ, Viemari J, Tryba AKH, Loweth JA, Ramirez J-M, Elsen F (2004) - Persistent sodium current plays a critical role in the generation of slow oscillations in vitro neocortex brain slices of mice and humans. Abstract Soc Neuroscience
- Marcuccilli CJ, Koch H, Pena F, Drongelen W van, Tryba AK, Parkis MA, Hecox KE, Kohrman MH, Frim DM, OConnor SE, Chico MS, Ramirez J-M (2003) - Rational pharmacotherapy: relationship between in vitro electrophysiology and clinical measures. Epilepsia 44, Suppl 9: 244-245
- Ramirez J-M, Koch H, Pena F, Drongelen W van, Tryba AK, Parkis MA, Loweth JA, Hecox KE, Kohrman MH, Frim DM, Chico MS, Marcuccilli CJ (2003) - In vitro electrophysiological differences between least and most abnormal tissue obtained from pediatric patients with intractable epilepsy. Epilepsia 44, Suppl 9: 245-246
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