Analysis of FAZ in Diabetic Retinopathy Using OCT Angiography
Study and assessment of characteristic changes in foveal avascular zone during different stages of diabetic retinopathy using OCTA.
|Condition or Disease||Intervention/Treatment||Phase|
OCTA is superior to other retinal imaging techniques like fluorescein angiography(FA) as it does not require dye injection, Intravenous dye injection is time consuming and can have adverse side effects. Furthermore, the edges of the capillaries can become blurred due to dye leakage and imaging of the retina can only be 2D when using FA.
OCTA provides both structural and functional (i.e. blood flow) information in tandem. The "corresponding" OCT b-scans can be co-registered with the simultaneous OCT angiograms so the operator is able to scroll through the OCT angiogram like a cube scan. As a result, the precise location of pathology can be viewed on the corresponding OCT b-scans. This makes OCTA a better tool when detecting the exact location of a retinal pathology.
In diabetic retinopathy OCTA can show choriocapillaris abnormalities and/or retinal microvascular abnormalities such as microaneurysms, vascular remodeling adjacent to the foveal avascular zone (FAZ), enlarged FAZ, and capillary tortuosity and dilation through different stages. OCTA can show smaller vascular changes not detectable by FA.
Arms and Interventions
Device: OCT angiography
OCT angiography of foveal avascular zone in diabetic retinopathy
Primary Outcome Measures
- Mean area of FAZ in various stages of diabetic retinopathy and difference between these groups in superficial and deep capillary plexuses [baseline]
analysis of foveal avascular zone in different stages of diabetic retinopathy using OCT angiography
- Diabetic patients suffering from different stages of diabetic retinopathy.
- Other ocular problems affecting vision including glaucoma, cataract, amblyopia, hypertensive retinopathy, vein occlusion and uveitis.
Contacts and Locations
LocationsNo locations specified.
Sponsors and Collaborators
- Kareem Mohammad Ali
- Study Chair: Ziad Hn El Daly, MD, Assuit Universoty
Study Documents (Full-Text)None provided.
- OCT angiography