Diagnostic Value of D-dimer/Fibrinogen Ratio in Patients With Acute Aortic Dissection
Study Details
Study Description
Brief Summary
Acute aortic dissection is rare but potentially life-threatening disease with an incidence of 5-30 cases per million, annually. Therefore prompt diagnosis is crucial. D-dimer values have been shown to be useful in the diagnosis of acute aortic dissection. Fibrinogen levels have been shown to be low, normal or high in individuals with acute aortic dissection. This study aims to investigate whether D-dimer/fibrinogen ratio can be valuable for diagnosis of acute aortic dissection.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Acute aortic dissection Patients with a diagnosis of acute aortic dissection. |
Diagnostic Test: D-dimer/fibrinogen ratio
The ratio of D-dimer (ng/ml) to fibrinogen (mg/dl)
|
Acute pulmonary embolism Patients with a diagnosis of acute pulmonary embolism |
Diagnostic Test: D-dimer/fibrinogen ratio
The ratio of D-dimer (ng/ml) to fibrinogen (mg/dl)
|
Non-cardiac chest pain Patients with non-cardiac chest pain |
Diagnostic Test: D-dimer/fibrinogen ratio
The ratio of D-dimer (ng/ml) to fibrinogen (mg/dl)
|
Outcome Measures
Primary Outcome Measures
- Acute aortic dissection [24 hours]
Diagnosis of acute aortic dissection confirmed by contrast enhanced computed tomography, magnetic resonance imaging, echocardiography or aortography
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Diagnosis of acute aortic dissection
-
Diagnosis of acute pulmonary embolism
-
Diagnosis of non-cardiac chest pain
Exclusion Criteria:
-
Any etiology of chest pain other than acute aortic dissection, acute pulmonary embolism, or non-cardiac chest pain
-
Participants who do not give consent for enrollment
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital | Istanbul | Turkey | 34668 | |
2 | Kartal Dr. Lutfi Kirdar Training and Research Hospital | Istanbul | Turkey | 34890 |
Sponsors and Collaborators
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Eggebrecht H, Naber CK, Bruch C, Kröger K, von Birgelen C, Schmermund A, Wichert M, Bartel T, Mann K, Erbel R. Value of plasma fibrin D-dimers for detection of acute aortic dissection. J Am Coll Cardiol. 2004 Aug 18;44(4):804-9.
- Guan XL, Wang XL, Liu YY, Lan F, Gong M, Li HY, Liu O, Jiang WJ, Liu YM, Zhu JM, Sun LZ, Zhang HJ. Changes in the Hemostatic System of Patients With Acute Aortic Dissection Undergoing Aortic Arch Surgery. Ann Thorac Surg. 2016 Mar;101(3):945-51. doi: 10.1016/j.athoracsur.2015.08.047. Epub 2015 Oct 23.
- Hajsadeghi S, Kerman SR, Khojandi M, Vaferi H, Ramezani R, Jourshari NM, Mousavi SA, Pouraliakbar H. Accuracy of D-dimer:fibrinogen ratio to diagnose pulmonary thromboembolism in patients admitted to intensive care units. Cardiovasc J Afr. 2012 Sep;23(8):446-56. doi: 10.5830/CVJA-2012-041.
- Kara H, Bayir A, Degirmenci S, Kayis SA, Akinci M, Ak A, Celik B, Dogru A, Ozturk B. D-dimer and D-dimer/fibrinogen ratio in predicting pulmonary embolism in patients evaluated in a hospital emergency department. Acta Clin Belg. 2014 Aug;69(4):240-5. doi: 10.1179/2295333714Y.0000000029.
- 2020/514/169/B