Differential Sensory Block During Labor Epidural Analgesia: a Prospective Observational Study to Investigate the Relationship of Lower and Upper Sensory Block Levels to Cold With Sensory Block to Pinprick and Light Touch

Sponsor
Samuel Lunenfeld Research Institute, Mount Sinai Hospital (Other)
Overall Status
Recruiting
CT.gov ID
NCT05187962
Collaborator
(none)
50
1
5.3
9.4

Study Details

Study Description

Brief Summary

Epidural analgesia remains the gold standard for pain control during labor and delivery. Proper assessment of an epidural's level of blockade is important for providing safe and effective analgesia. Previous studies have established that the most commonly tested modality for adequacy of epidural blockade is a patient's sensory blockade to cold temperature. In a study performed at our institution, Soares et. al. (publication pending) documented two thresholds of sensory block to ice: one defined as the lower sensory block level, in which the patient is able to notice the cold sensation but perceives that it is not as cold as a control dermatome; the other defined as the upper sensory block level, in which the patient perceives that the cold sensation is at approximately the same temperature as if it were applied to a non-anesthetized area such as the neck or face. Although this a known finding to nurses and physicians assessing the sensory block to ice, this phenomenon and its magnitude has not been previously reported in epidural anesthesia. The goal of this study is to examine patients with labour epidurals and to determine the dermatomal relationship between the lower and upper sensory block levels to cold when compared with sensory blockade to both pinprick and light touch.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    50 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    Differential Sensory Block During Labor Epidural Analgesia: a Prospective Observational Study to Investigate the Relationship of Lower and Upper Sensory Block Levels to Cold With Sensory Block to Pinprick and Light Touch
    Actual Study Start Date :
    Dec 21, 2021
    Anticipated Primary Completion Date :
    Jun 1, 2022
    Anticipated Study Completion Date :
    Jun 1, 2022

    Arms and Interventions

    Arm Intervention/Treatment
    Women receiving epidural analgesia for labor

    Sensory block level check Patients will have their sensory block level checked using 3 modalities: ice, pin prick and soft touch (cotton ball).

    Outcome Measures

    Primary Outcome Measures

    1. Lower sensory block level: ice test [5 minutes]

      The lower sensory block level to ice, defined as the dermatome at which there is a complete loss of cold perception.

    2. Upper sensory block level: ice test [5 minutes]

      The upper sensory block level to ice is defined as the dermatome at which there is an altered cold perception without complete sensitivity loss.

    3. Lower sensory block level: pinprick test [5 minutes]

      The lower sensory block level to pinprick, defined as the dermatome at which there is a complete loss of sharp sensation.

    4. Upper sensory block level: pinprick test [5 minutes]

      The upper sensory block level to pinprick is defined as the dermatome at which there is an altered sharp sensation without complete sensitivity loss.

    5. Sensory block level: soft touch test [5 minutes]

      The sensory block level using soft touch is defined as the dermatome below which the patient can feel a light touch.

    Secondary Outcome Measures

    1. Motor block score using Bromage score [5 minutes]

      Motor block will be assessed with the Bromage score: 0 = able to raise the extended leg; 1 = unable to raise the extended leg but able to flex knees; 2 = unable to flex knees, but able to flex ankle; 3 = unable to flex ankle.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 60 Years
    Sexes Eligible for Study:
    Female
    Inclusion Criteria:
    • ASA Physical Status Classification II and III parturients

    • Requested and received a labour epidural

    • Capable of consenting to the study

    • Have no language barrier which may obfuscate the sensory block assessment

    • Are receiving programmed intermittent epidural boluses (PIEB) for maintenance analgesia, which is the Mount Sinai Hospital default maintenance regimen

    Exclusion Criteria:
    • Medical comorbidities that could compromise the body's sensitivity to cold, pinprick, or touch

    • Epidurals performed under a combined spinal-epidural (CSE) or dural puncture epidural (DPE) technique

    • Epidurals with a documented unintentional dural puncture

    • Inadequate epidural analgesia requiring either manually administered epidural boluses, an increase in the concentration of their maintenance local anesthetic, or a repeat of their epidural

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Mount Sinai Hospital Toronto Ontario Canada M5G1X5

    Sponsors and Collaborators

    • Samuel Lunenfeld Research Institute, Mount Sinai Hospital

    Investigators

    • Principal Investigator: Jose CA Carvalho, MD, MOUNT SINAI HOSPITAL

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital
    ClinicalTrials.gov Identifier:
    NCT05187962
    Other Study ID Numbers:
    • 21-08
    First Posted:
    Jan 12, 2022
    Last Update Posted:
    Jan 12, 2022
    Last Verified:
    Jan 1, 2022
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Samuel Lunenfeld Research Institute, Mount Sinai Hospital
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Jan 12, 2022