Discriminant Ability of the Shock Index, Modified Shock Index, and Reverse Shock Index Multiplied by the Glasgow Coma Scale on Mortality in Adult Trauma Patients: A PATOS Study

Sponsor

Mackay Memorial Hospital (Other)

Overall Status

Completed

CT.gov ID

NCT05549986

Collaborator

(none)

105,641

Enrollment

Actual Duration (Months)

Study Details

Study Description

Brief Summary

We evaluated a cohort of adult trauma patients transported to emergency departments. The first vital signs were used to calculate the SI, MSI, and rSIG. The areas under the receiver operating characteristic curves (AUROCs) and test results were used to compare the discriminant performance of the indices on short-term mortality and poor functional outcome. A subgroup analysis of geriatric patients, traumatic brain injury, penetrating injury, and non-penetrating injury was performed.

Condition or Disease	Intervention/Treatment	Phase
Trauma Shock, Traumatic Morality	Other: Observational

Study Design

Study Type:

Observational

Actual Enrollment :

105641 participants

Observational Model:

Cohort

Time Perspective:

Retrospective

Official Title:

Discriminant Ability of the Shock Index, Modified Shock Index, and Reverse Shock Index Multiplied by the Glasgow Coma Scale on Mortality in Adult Trauma Patients: A PATOS Study

Actual Study Start Date :

Jan 1, 2016

Actual Primary Completion Date :

Dec 31, 2020

Actual Study Completion Date :

Dec 31, 2020

Arms and Interventions

Arm	Intervention/Treatment
Mortality group Patients encountered in-hospital mortality or 30-day mortality	Other: Observational Observational
Survival group Patients did not encounter in-hospital mortality or 30-day mortality	Other: Observational Observational

Arm

Intervention/Treatment

Mortality group

Patients encountered in-hospital mortality or 30-day mortality

Other: Observational

Observational

Survival group

Patients did not encounter in-hospital mortality or 30-day mortality

Other: Observational

Observational

Outcome Measures

Primary Outcome Measures

Discriminant power of SI, MSI, and rSIG on short-term mortality for adult traumatic patients [30 days]
AUROC in associated with short-term mortality with SI, MSI, rSIG

Secondary Outcome Measures

Discriminant power of SI, MSI, and rSIG on functional outcome for adult traumatic patients [We defined no symptoms, no significant disability, slight disability, and moderate disability (MRS 0-3) as favorable functional outcomes and moderately severe disability, severe disability, and death (MRS 4-6) as poor functional outcomes]
AUROC in associated with functional outcome with SI, MSI, rSIG

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Adult patients (≥18 years) EMS-transported from January 2016 to December 2020

Exclusion Criteria:

Patients with missing entries of age, sex, triage, SBP, DBP, HR, or GCS were excluded.
Entries with missing records of in-hospital mortality or 30-day mortality were excluded from the short-term mortality cohort analyses.
Patients without a Modified Rankin Scale (MRS) record at discharge were excluded from the functional outcome cohort analyses.