Randomized Controlled Trial Assessing the Effect of Dexamethasone on Postoperative Function After Distal Radius Fixation
The study is designed to assess the use of intraoperative dexamethasone on postoperative analgesia and stiffness after open reduction and internal fixation of distal radius fractures. The idea is that the dexamethasone will aid in reducing postoperative swelling which will then improve pain control as well as overall function.
Arms and Interventions
Patient will receive intraoperative dexamethasone during distal radius open reduction and internal fixation
Intraoperative intravenous dexamethasone
|Placebo Comparator: No dexamethasone|
Patient will not receive intraoperative dexamethasone during distal radius open reduction and internal fixation
Other: No dexamethasone
No intraoperative intravenous dexamethasone
Primary Outcome Measures
- Patient rated wrist evaluation [48 hours, 1 week, 2 weeks]
15-item questionnaire designed to measure wrist pain and disability in activities of daily living. PWRE will be assessed at multiple time point to assess for change in the score. The higher the score, the more function exhibited.
Secondary Outcome Measures
- Finger-to-palm distance [48 hours, 1 week, 2 weeks]
Objective measure to quantify stiffness. This is measured by measuring the distance from the tip of the third finger to the palm during attempted creation of a fist. FTP will be measured at multiple time points to assess for change.
- Visual analog scale [48 hours, 1 week, 2 weeks]
Validated, subjective measure for pain. Measured on a 10 point scale, 0 being no pain and 10 being maximum pain. VAS will be evaluated at multiple time points to assess for change.
- Total opioid consumption [48 hours, 1 week, 2 weeks]
Measuring total opioid consumption postoperatively. This will be measured by self reported mechanism. Assessed at multiple time points to assess for change.
Provision of signed and dated informed consent form
Willingness to comply with study procedures and
Male or female greater than 18 years old
American Society of Anesthesia class I/II/III
Ability to take oral medicine in order to assess opioid regimen postop
Distal radius open reduction and internal fixation surgery with single incision and volar plate
Ability to consent for and receive a preoperative upper extremity nerve block by anesthesia
Chronic opioid users
Prescriptions for selective-serotonin reuptake inhibitors, gabapentin, duloxetine within 3 days of surgery
History of diabetes and A1C > 8
Systemic glucocorticoids within 1 month of study enrollment
Inability to take ibuprofen or acetaminophen due to allergy or condition
History of hepatitis
Pregnancy or lactation
Allergic to opioids
Known allergic reactions to components of IV dexamethasone
Contacts and Locations
LocationsNo locations specified.
Sponsors and Collaborators
- Northwell Health
Study Documents (Full-Text)None provided.
- Northwell Health