A Study to Evaluate Change in Disease Activity of Subcutaneous (SC) Epcoritamab Combined With Intravenous and Oral Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine, and Prednisone (R-CHOP) or R-CHOP in Adult Participants With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)

Sponsor

AbbVie (Industry)

Overall Status

Recruiting

CT.gov ID

NCT05578976

Collaborator

Genmab (Industry)

900

Enrollment

377

Locations

Arms

Anticipated Duration (Months)

2.4

Patients Per Site

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

B-cell Lymphoma is an aggressive and rare cancer of a type of immune cells (a white blood cell responsible for fighting infections). The purpose of this study is to assess the change in disease activity of epcoritamab when combined with intravenous and oral rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP) or R-CHOP in adult participants globally with diffuse large b-cell lymphoma (DLBCL). Change in disease activity will be assessed.

Epcoritamab is an investigational drug being developed for the treatment of DLBCL. Study doctors put the participants in groups called treatment arms. Participants will receive epcoritamab combined with R-CHOP, followed by epcoritamab or R-CHOP followed by rituximab will be explored. Approximately 900 adult participants with with newly diagnosed DLBCL will be enrolled in the study in approximately 315 sites in globally.

In the Arm 1, participants will receive subcutaneous epcoritamab combined with intravenous and oral R-CHOP followed by subcutaneous epcoritamab in 21-day cycles. In the Arm 2, participants will receive intravenous and oral R-CHOP followed by intravenous rituximab in 21-day cycles.

There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and side effects.

Condition or Disease	Intervention/Treatment	Phase
Diffuse Large B-Cell Lymphoma	Drug: Epcoritamab Drug: Cyclophosphamide Drug: Rituximab Drug: Vincristine Drug: Doxorubicin Drug: Prednisone	Phase 3

Study Design

Study Type:

Interventional

Anticipated Enrollment :

900 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

A Phase 3, Randomized, Open-Label Study to Evaluate Safety and Efficacy of Epcoritamab in Combination With R-CHOP Compared to R-CHOP in Subjects With Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)

Actual Study Start Date :

Jan 11, 2023

Anticipated Primary Completion Date :

Jan 31, 2027

Anticipated Study Completion Date :

Jun 11, 2030

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Epcoritamab and R-CHOP Participants will receive subcutaneous epcoritamab combined with intravenous and oral rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP) followed by epcoritamab in 21-day cycles.	Drug: Epcoritamab Subcutaneous Injection (SC) Other Names: ABBV-GMAB-3013 Drug: Cyclophosphamide Intravenous (IV) Injection Drug: Rituximab IV Infusion Drug: Vincristine IV Infusion Drug: Doxorubicin IV Infusion Drug: Prednisone Oral; Tablet
Experimental: R-CHOP and Rituximab Participants will receive intravenous and oral R-CHOP followed by rituximab in 21-day cycles.	Drug: Cyclophosphamide Intravenous (IV) Injection Drug: Rituximab IV Infusion Drug: Vincristine IV Infusion Drug: Doxorubicin IV Infusion Drug: Prednisone Oral; Tablet

Arm

Intervention/Treatment

Experimental: Epcoritamab and R-CHOP

Participants will receive subcutaneous epcoritamab combined with intravenous and oral rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP) followed by epcoritamab in 21-day cycles.

Drug: Epcoritamab

Subcutaneous Injection (SC)

Other Names:

ABBV-GMAB-3013

Drug: Cyclophosphamide

Intravenous (IV) Injection

Drug: Rituximab

IV Infusion

Drug: Vincristine

IV Infusion

Drug: Doxorubicin

IV Infusion

Drug: Prednisone

Oral; Tablet

Experimental: R-CHOP and Rituximab

Participants will receive intravenous and oral R-CHOP followed by rituximab in 21-day cycles.

Drug: Cyclophosphamide

Intravenous (IV) Injection

Drug: Rituximab

IV Infusion

Drug: Vincristine

IV Infusion

Drug: Doxorubicin

IV Infusion

Drug: Prednisone

Oral; Tablet

Outcome Measures

Primary Outcome Measures

Number of Participants with Progression-Free Survival (PFS) [Up to Approximately 43 Months]
PFS is defined as the duration from randomization to the date of disease progression as determined by Lugano 2014 criteria as assessed by IRC, or death from any cause.

Secondary Outcome Measures

Number of Participants with Event-free survival (EFS) [Up to Approximately 43 Months]
EFS is defined as the duration from randomization to the date of disease progression determined by Lugano 2014 criteria as assessed by IRC, Initiation of any non-protocol-specified new anti-lymphoma therapy for any reason, or death from any cause.
Percentage of Participants with Complete Remission (CR) [Up to Approximately 28 Weeks]
CR is defined as the absence of lymphoma determined by fluorodeoxyglucose positron emission tomography (FDG-PET),determined by Lugano 2014 criteria as assessed by IRC.
Overall survival (OS) [Up to Approximately 73 Months]
OS is defined as time from randomization until death due to any causes.
Percentage of Participants with Minimal Residual Disease (MRD) Negativity [Up to Approximately 73 Months]
The MRD negativity rate is defined as the percentage of participants who achieve MRD negativity prior to the initiation of any non-protocol-specified new anti-lymphoma therapy.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 79 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Planned to receive treatment with 6 cycles of standard rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP) per investigator determination.
Must have newly diagnosed, histologically confirmed CD20+ diffuse large b-cell lymphoma [DLBCL] (de novo or histologically transformed from a diagnosis of follicular lymphoma) at most recent representative tumor biopsy based on the pathology report, with a World Health Organization (WHO) 2016 classification and including:
DLBCL, Not Otherwise Specified (NOS).
High grade B-cell lymphoma with MYC and BCL-2 and/or BCL-6 rearrangement with DLBCL morphology.
T-cell/histiocyte-rich large B-cell lymphoma.
Epstein Barr virus-positive DLBCL, NOS.
Follicular lymphoma Grade 3b.

Note: The local pathology report must be available at Screening to support CD20+ DLBCL histology.

Composite/intermediate histology with any of the following components is not allowed: high grade B-cell lymphoma, NOS; Hodgkin's lymphoma; primary mediastinal (thymic) large B-cell lymphoma; Burkitt; plasmablastic lymphoma or any CD20- lymphoma, such as anaplastic lymphoma kinase-positive large B-cell lymphoma, human herpesvirus type 8-positive DLBCL, or primary effusion lymphoma.

Availability of archival or freshly collected tumor tissue at Screening. Archival paraffin-embedded tissue must be obtained within 8 weeks prior to Cycle 1 Day 1.
Must have an IPI score of 2-5. The number of participants with IPI 2 will be capped at 35% of the overall sample size.
Must have an Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2 prior to initiating R-CHOP treatment. Note that participant with an initial ECOG performance status >= 3 may be screened if pre-phase treatment is planned. Participant may be eligible if ECOG performance status were to improve to 0-2 during pre-phase treatment.
Has at least one target lesion defined as:
= 1 measurable nodal lesion (long axis > 1.5 cm ) or >= 1 measurable extra-nodal lesion (long axis > 1 cm) on computed tomography (CT) scan or MRI. AND
Positron emission tomography (PET)-positive on PET-CT scan.
Laboratory values meeting the criteria laid out in the protocol.
Left ventricular ejection fraction must be >= 50% by multi-gated acquisition or transthoracic echocardiography at Screening.

Exclusion Criteria:

History of prior systemic anti-lymphoma therapy for diagnosed diffuse large b-cell lymphoma (DLBCL) including any definitive radiotherapy with curative intent] other than corticosteroids with or without vincristine during prephase treatment, or non-curative intent palliative radiotherapy with the stipulation that radiated lesions cannot be selected as target lesion for response assessment.
Clinically significant cardiovascular disease as per the protocol.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Alabama at Birmingham - Main /ID# 225373	Birmingham	Alabama	United States	35233
2	University of Arizona Cancer Center - North Campus /ID# 227463	Tucson	Arizona	United States	85719-1478
3	University of Arkansas for Medical Sciences /ID# 225703	Little Rock	Arkansas	United States	72205
4	Sutter Health Alta Bates Summit Medical Center /ID# 229427	Berkeley	California	United States	94705-2067
5	Orange Coast Medical Center /ID# 229632	Fountain Valley	California	United States	92708-6728
6	Marin Cancer Care /ID# 226647	Greenbrae	California	United States	94904
7	Saddleback Memorial Medical Center /ID# 229631	Laguna Hills	California	United States	92653-3689
8	Long Beach Memorial Medical Ct /ID# 228996	Long Beach	California	United States	90806-1701
9	University of Southern California /ID# 225443	Los Angeles	California	United States	90033
10	Kaiser Permanente, Waterpark III Institute for Health Research /ID# 228618	Aurora	Colorado	United States	80014
11	UCHSC Anschultz Cancer Pavilion /ID# 226040	Aurora	Colorado	United States	80045-2517
12	Yale University /ID# 226022	New Haven	Connecticut	United States	06510
13	Christiana Care Health Service /ID# 228266	Newark	Delaware	United States	19713
14	Holy Cross Hospital /ID# 228539	Fort Lauderdale	Florida	United States	33308
15	Baptist MD Anderson Cancer Center - Jacksonville /ID# 227040	Jacksonville	Florida	United States	32207-8432
16	Orlando Health /ID# 232626	Orlando	Florida	United States	32806-2134
17	Cleveland Clinic Florida /ID# 229377	Weston	Florida	United States	33331-3609
18	Emory University /ID# 226052	Atlanta	Georgia	United States	30322-1013
19	Augusta University Georgia Cancer Center /ID# 227131	Augusta	Georgia	United States	30912-0003
20	Straub Medical Center /ID# 229464	Honolulu	Hawaii	United States	96813-3097
21	Rush University Medical Center /ID# 225453	Chicago	Illinois	United States	60612
22	Loyola University Medical Ctr /ID# 227029	Maywood	Illinois	United States	60153
23	Southern IL Univ School of Med /ID# 228999	Springfield	Illinois	United States	62702
24	Midwestern Regional CTC /ID# 229840	Zion	Illinois	United States	60099
25	Parkview Cancer Institute /ID# 227026	Fort Wayne	Indiana	United States	46845-1739
26	Goshen Center for Cancer Care /ID# 225534	Goshen	Indiana	United States	46526
27	Norton Cancer Institute - St Matthews /ID# 225420	Louisville	Kentucky	United States	40207
28	Ochsner Clinic Foundation-New Orleans /ID# 226148	New Orleans	Louisiana	United States	70121
29	University of Maryland School of Medicine /ID# 225421	Baltimore	Maryland	United States	21201-1544
30	Johns Hopkins University /ID# 225369	Baltimore	Maryland	United States	21287
31	Walter Reed National Military Medical Center /ID# 231016	Bethesda	Maryland	United States	20889-0004
32	Dana-Farber Cancer Institute /ID# 225506	Boston	Massachusetts	United States	02215
33	UMass Chan Medical School /ID# 226939	Worcester	Massachusetts	United States	01655
34	University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 225462	Ann Arbor	Michigan	United States	48109
35	St. Joseph Mercy Hospital /ID# 228206	Ypsilanti	Michigan	United States	48197-1051
36	Mmcorc /Id# 226680	Saint Louis Park	Minnesota	United States	55416
37	University of Mississippi Medical Center /ID# 228045	Jackson	Mississippi	United States	39216-4500
38	Bozeman Health Cancer Center /ID# 229368	Bozeman	Montana	United States	59715
39	NJ Hematology Oncology Association /ID# 228058	Brick	New Jersey	United States	08724
40	Titan Health Partners LLC, d/b/a Astera Cancer Care /ID# 226654	East Brunswick	New Jersey	United States	08816
41	Morristown Medical Center /ID# 239457	Morristown	New Jersey	United States	07960-6136
42	Saint Peter's University Hospital /ID# 229471	New Brunswick	New Jersey	United States	08901-1766
43	The Valley Hospital /ID# 229331	Paramus	New Jersey	United States	07652
44	Roswell Park Comprehensive Cancer Center /ID# 239127	Buffalo	New York	United States	14263
45	NYU Langone - Laura and Isaac Perlmutter Cancer Center /ID# 226141	New York	New York	United States	10016-4744
46	Icahn School of Medicine at Mount Sinai /ID# 225370	New York	New York	United States	10029-6504
47	Memorial Sloan Kettering Cancer Center-Koch Center /ID# 225379	New York	New York	United States	10065-6007
48	Novant Health Presbyterian Medical Center /ID# 227753	Charlotte	North Carolina	United States	28204
49	East Carolina University Brody School of Medicine /ID# 225992	Greenville	North Carolina	United States	27834
50	Novant Health Forsyth Medical Center /ID# 228339	Winston-Salem	North Carolina	United States	27103
51	The Christ Hospital /ID# 229334	Cincinnati	Ohio	United States	45219
52	University of Cincinnati /ID# 225374	Cincinnati	Ohio	United States	45267
53	University of Oklahoma, Stephenson Cancer Center /ID# 225556	Oklahoma City	Oklahoma	United States	73104-5418
54	Kaiser Permanente - Northwest /ID# 225488	Portland	Oregon	United States	97227
55	Thomas Jefferson University /ID# 225623	Philadelphia	Pennsylvania	United States	19107-4414
56	UPMC Hillman Cancer Ctr /ID# 225423	Pittsburgh	Pennsylvania	United States	15232
57	Lankenau Medical Center /ID# 228918	Wynnewood	Pennsylvania	United States	19096
58	Medical University of South Carolina /ID# 225427	Charleston	South Carolina	United States	29425
59	Gibbs Cancer Center & Research /ID# 229372	Spartanburg	South Carolina	United States	29303-3040
60	Thompson Cancer Survival Ctr /ID# 227123	Knoxville	Tennessee	United States	37916
61	University of Texas Southwestern Medical Center /ID# 225492	Dallas	Texas	United States	75390-7208
62	Millennium Research & Clinical Development /ID# 228284	Kingwood	Texas	United States	77339-6008
63	Joe Arrington Cancer Research /ID# 227217	Lubbock	Texas	United States	79410
64	Intermountain Medical Center /ID# 231184	Murray	Utah	United States	84107-5701
65	University of Virginia Cancer Center - West Complex /ID# 225433	Charlottesville	Virginia	United States	22903-3363
66	Virginia Commonwealth University Medical Center Main Hospital /ID# 225796	Richmond	Virginia	United States	23219
67	Swedish Cancer Institute - Edmonds /ID# 226845	Seattle	Washington	United States	98104
68	University of Washington /ID# 225581	Seattle	Washington	United States	98109
69	Multicare Institute for Research and Innovation /ID# 225432	Tacoma	Washington	United States	98405
70	UW, Cancer Ctr ProHealth Care /ID# 228741	Waukesha	Wisconsin	United States	53188
71	Hospital Italiano de Buenos Aires /ID# 228270	Ciudad Autonoma Buenos Aires	Ciuadad Autonoma De Buenos Aires	Argentina	1199
72	Instituto Alexander Fleming /ID# 239473	Ciudad Autonoma de Buenos Aire	Ciuadad Autonoma De Buenos Aires	Argentina	1426
73	Cemic /Id# 228264	Ciudad Autonoma de Buenos Aire	Ciuadad Autonoma De Buenos Aires	Argentina	1431
74	Hospital Privado Univesitario /ID# 228778	Cordoba		Argentina	5016
75	Clinica de Nefrologia, Urologia y Enfermedades Cardiovasculares /ID# 238730	Santa Fe		Argentina	3000
76	Liverpool Hospital /ID# 230072	Liverpool	New South Wales	Australia	2170
77	Royal Adelaide Hospital /ID# 225683	Adelaide	South Australia	Australia	5000
78	Alfred Health /ID# 225999	Melbourne	Victoria	Australia	3004
79	Monash Medical Centre /ID# 225680	Melbourne	Victoria	Australia	3168
80	Hollywood Private Hospital /ID# 251837	Nedlands	Western Australia	Australia	6009
81	Perth Blood Institute Ltd /ID# 225679	Nedlands	Western Australia	Australia	6009
82	Royal Perth Hospital /ID# 226583	Perth	Western Australia	Australia	6000
83	Medizinische Universitaet Innsbruck /ID# 228364	Innsbruck	Tirol	Austria	6020
84	Medizinische Universitaet Wien /ID# 252095	Vienna	Wien	Austria	1090
85	Klinik Ottakring /ID# 243941	Vienna	Wien	Austria	1160
86	Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 228360	Salzburg		Austria	5020
87	Uza /Id# 227095	Edegem	Antwerpen	Belgium	2650
88	CHU UCL Namur - site Godinne /ID# 225742	Godinne	Namur	Belgium	5530
89	UZ Gent /ID# 250031	Gent	Oost-Vlaanderen	Belgium	9000
90	Universitair Ziekenhuis Leuven /ID# 225951	Leuven	Vlaams-Brabant	Belgium	3000
91	AZ-Delta /ID# 225736	Roeselare	West-Vlaanderen	Belgium	8800
92	Institut Jules Bordet /ID# 225954	Anderlecht		Belgium	1070
93	ZNA Middelheim /ID# 225741	Antwerp		Belgium	2020
94	AZ Sint-Jan Brugge /ID# 225735	Brugge		Belgium	8000
95	Pôle Hospitalier Jolimont /ID# 225738	La Louvière		Belgium	7100
96	Centre Hospitalier Universitaire du Sart Tilman CHU de Liege /ID# 225952	Liege		Belgium	4000
97	Vitaz /Id# 226153	Sint-Niklaas		Belgium	9100
98	Hospital de Clinicas da Universidade Federal do Parana /ID# 226027	Curitiba	Parana	Brazil	80060-900
99	Hospital Amaral Carvalho - Fundacao Doutor Amaral Carvalho /ID# 226065	Jaú	Sao Paulo	Brazil	17210-070
100	Fundacao Antonio Prudente - AC Camargo Cancer Center /ID# 226809	São Paulo	Sao Paulo	Brazil	01509-900
101	Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) /ID# 226026	Rio de Janeiro		Brazil	20231-050
102	Real e Benemérita Associação Portuguesa de Beneficência /ID# 226023	Sao Paulo		Brazil	01323-001
103	Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo /ID# 226048	Sao Paulo		Brazil	05403-000
104	UMHAT Sveti Georgi /ID# 245780	Plovdiv		Bulgaria	4002
105	Acibadem City Clinic Tokuda University Hospital EAD /ID# 244616	Sofia		Bulgaria	1407
106	UMHAT Sveti Ivan Rilski /ID# 244615	Sofia		Bulgaria	1431
107	SHAT Hematologic Diseases /ID# 250102	Sofia		Bulgaria	1756
108	Tom Baker Cancer Centre /ID# 226077	Calgary	Alberta	Canada	T2N 4N2
109	BC Cancer - Vancouver /ID# 230573	Vancouver	British Columbia	Canada	V5Z 1L3
110	BC Cancer - Victoria /ID# 250741	Victoria	British Columbia	Canada	V8R 6V5
111	Saint John Regional Hospital /ID# 233547	Saint John	New Brunswick	Canada	E2L 4L2
112	William Osler Health System /ID# 250973	Brampton	Ontario	Canada	L6R 3J7
113	Juravinski Cancer Centre /ID# 226084	Hamilton	Ontario	Canada	L8V 1C3
114	Victoria Hospital /ID# 226885	London	Ontario	Canada	N6A 4L6
115	CSSS Alphonse-Desjardins, CHAU de Levis /ID# 229897	Levis	Quebec	Canada	G6V 3Z1
116	CIUSSS du Nord-de-l'ile-de-Montréal_Hopital du Sacré-Coeur de Montréal /ID# 233509	Montreal	Quebec	Canada	H4J 1C5
117	CHUQ- Hôpital de l'Enfant-Jesus /ID# 226074	Quebec City	Quebec	Canada	G1J 1Z4
118	Saskatoon Cancer Centre /ID# 226082	Saskatoon	Saskatchewan	Canada	S7N 4H4
119	Beijing Cancer Hospital /ID# 229819	Beijing	Beijing	China	100142
120	Peking University Third Hospital /ID# 230975	Beijing	Beijing	China	100191
121	Fujian Provincial Cancer Hospital /ID# 238430	Fuzhou	Fujian	China	350014
122	The First Affiliated Hospital of Xiamen University /ID# 238426	Xiamen	Fujian	China	361003
123	Sun Yat-Sen University Cancer Center /ID# 238371	Guangzhou	Guangdong	China	510060
124	Guangdong Provincial People's Hospital /ID# 230945	Guangzhou	Guangdong	China	510080
125	Nanfang Hospital of Southern Medical University /ID# 238436	Guangzhou	Guangdong	China	510515
126	The Fourth Hospital of Hebei Medical University /ID# 238656	Shijiazhuang	Hebei	China	050011
127	Harbin Medical University Cancer Hospital /ID# 241755	Harbin	Heilongjiang	China	150081
128	Henan Cancer Hospital /ID# 230398	Zhengzhou	Henan	China	450008
129	Hunan Cancer Hospital /ID# 232496	Changsha	Hunan	China	410006
130	Jiangsu Cancer Hospital /ID# 232469	Nanjing	Jiangsu	China	210009
131	The First Affiliated Hospital of Soochow University /ID# 232569	Suzhou	Jiangsu	China	215006
132	Duplicate_The Affiliated Hospital of XuZhou Medical University /ID# 233174	Xuzhou	Jiangsu	China	221000
133	The First Affiliated Hospital of Nanchang University /ID# 230399	Nanchang	Jiangxi	China	330006
134	The First Hospital of Jilin University /ID# 239618	Changchun	Jilin	China	130021
135	The First Hospital of China Medical University /ID# 233201	Shenyang	Liaoning	China	110001
136	Shandong Cancer Hospital /ID# 233200	Jinan	Shandong	China	251601
137	Shanghai East Hospital /ID# 233516	Pudong New District	Shanghai	China	200136
138	Fudan University Shanghai Cancer Center /Id# 251516	Shanghai	Shanghai	China	200032
139	West China Hospital, Sichuan University /ID# 233173	Chengdu	Sichuan	China	610041
140	Tianjin Medical University Cancer Institute and Hospital /ID# 230974	Tianjin	Tianjin	China	300222
141	The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 230387	Hangzhou	Zhejiang	China	310006
142	The second Affiliated hospital of Zhejiang University school of Medicine /ID# 231249	Hangzhou	Zhejiang	China	310009
143	Zhejiang Cancer hospital /ID# 231388	Hangzhou	Zhejiang	China	310022
144	The Fifth Medical Center of PLA General Hospital /ID# 230941	Beijing		China	100071
145	Jiangxi Cancer Hospital /ID# 233379	Nanchang		China	330029
146	Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 234152	Wuhan		China	420022
147	Clinical Hospital Dubrava /ID# 251809	Zagreb	Grad Zagreb	Croatia	10000
148	Klinicka bolnica Merkur /ID# 252481	Zagreb	Grad Zagreb	Croatia	10000
149	Klinicki bolnicki centar Zagreb /ID# 250709	Zagreb	Grad Zagreb	Croatia	10000
150	Klinicki bolnicki centar Rijeka /ID# 251811	Rijeka	Primorsko-goranska Zupanija	Croatia	51000
151	Klinicki bolnicki centar Split /ID# 250729	Split	Splitsko-dalmatinska Zupanija	Croatia	21000
152	Opca bolnica Dr. Josip Bencevic /ID# 251812	Slavonski Brod		Croatia	35000
153	Fakultni Nemocnice Brno /ID# 225953	Brno		Czechia	625 00
154	Fakultni nemocnice Hradec Kralove /ID# 225955	Hradec Kralove		Czechia	500 05
155	Fakultni nemocnice Ostrava /ID# 225957	Ostrava		Czechia	708 52
156	Fakultni nemocnice Kralovske Vinohrady /ID# 225956	Praha		Czechia	100 34
157	Vseobecna fakultni nemocnice v Praze /ID# 225396	Praha		Czechia	128 08
158	Fakultni Nemocnice v Motole /ID# 225958	Praha		Czechia	150 06
159	Rigshospitalet /ID# 226576	Copenhagen Ø	Hovedstaden	Denmark	2100
160	Aarhus University Hospital /ID# 226594	Aarhus N	Midtjylland	Denmark	8200
161	Odense University Hospital /ID# 226593	Odense C	Syddanmark	Denmark	5000
162	Sygehus Lillebælt, Vejle /ID# 226592	Vejle	Syddanmark	Denmark	7100
163	Roskilde Hospital /ID# 226597	Roskilde		Denmark	4000
164	Centre Antoine Lacassagne - Nice /ID# 238339	Nice	Alpes-Maritimes	France	06189
165	Chu de Nice-Hopital L'Archet Ii /Id# 226127	Nice	Alpes-Maritimes	France	06200
166	CHU Clermont-Ferrand /ID# 229283	Clermont	Auvergne-Rhone-Alpes	France	63100
167	HCL - Hopital Lyon Sud /ID# 227086	Pierre Benite CEDEX	Auvergne-Rhone-Alpes	France	69495
168	Institut Paoli-Calmettes /ID# 226557	Marseille	Bouches-du-Rhone	France	13009
169	CHU de Rennes - PONTCHAILLOU /ID# 228207	Rennes	Bretagne	France	35000
170	CHU Dijon /ID# 238345	Dijon	Cote-d Or	France	21000
171	CHU Limoges - Dupuytren 1 /ID# 234235	Limoges CEDEX 1	Franche-Comte	France	87042
172	CHU Bordeaux - Hopital Haut Leveque /ID# 226130	Pessac	Gironde	France	33604
173	CHRU Lille - Hopital Claude Huriez /ID# 226101	Lille	Hauts-de-France	France	59037
174	CHU Montpellier - Hôpital Saint Eloi /ID# 228191	Montpellier Cedex 5	Herault	France	34295
175	CHRU Nancy - Hopitaux de Brabois /ID# 226102	Vandoeuvre-les-Nancy	Meurthe-et-Moselle	France	54500
176	CHU de Nantes, Hotel Dieu -HME /ID# 226125	Nantes	Pays-de-la-Loire	France	44000
177	CHU Poitiers - La milétrie /ID# 226578	Poitiers	Poitou-Charentes	France	86000
178	Centre Hospitalier de la Cote Basque /ID# 249143	Bayonne	Pyrenees-Atlantiques	France	64100
179	CHU Amiens-Picardie Site Sud /ID# 238347	Amiens CEDEX 1	Somme	France	80054
180	Chu Angers /Id# 245931	Angers		France	49933
181	CHU de CAEN - Hopital de la Cote de Nacre /ID# 226582	Caen		France	14033
182	Hopital Henri Mondor /ID# 226560	Creteil		France	94000
183	CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 243899	La Roche Sur Yon		France	85000
184	CHU Grenoble - Hopital Michallon /ID# 226128	La Tronche		France	38700
185	AP-HP - Hopital Saint-Louis /ID# 226126	Paris		France	75010
186	Hopital Pitie Salpetriere /ID# 238343	Paris		France	75013
187	Centre Henri Becquerel /ID# 226103	Rouen		France	76038
188	IUCT Oncopole /ID# 226129	Toulouse Cedex 9		France	31059
189	Universitaetsklinikum Tuebingen /ID# 229662	Tubingen	Baden-Wuerttemberg	Germany	72076
190	Schwarzwald-Baar-Klinikum /ID# 227143	Villingen-Schwenningen	Baden-Wuerttemberg	Germany	78052
191	Universitaetsklinikum Giessen /ID# 239181	Gießen	Hessen	Germany	35392
192	Universitaetsklinikum des Saarlandes /ID# 227051	Homburg	Saarland	Germany	66424
193	Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 227117	Kiel	Schleswig-Holstein	Germany	24105
194	Vivantes Klinikum Am Urban /ID# 227118	Berlin		Germany	10967
195	Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 227048	Berlin		Germany	12203
196	Helios Klinikum Berlin-Buch /ID# 227114	Berlin		Germany	13125
197	St. Antonius Hospital /ID# 232429	Eschweiler		Germany	52249
198	Universitaetsmedizin Goettingen /ID# 227120	Goettingen		Germany	37075
199	Klinikum Kassel /ID# 228303	Kassel		Germany	34125
200	Rotkreuzkliniken Munchen /ID# 232430	Munich		Germany	80634
201	Universitaetsklinikum Regensburg /ID# 231231	Regensburg		Germany	93042
202	Klinikum Mutterhaus der Borromäerinnen /ID# 233434	Trier		Germany	54290
203	Universitaetsklinikum Wuerzburg /ID# 227113	Wuerzburg		Germany	97080
204	General Hospital of Athens Laiko /ID# 225399	Athens	Attiki	Greece	11527
205	Alexandra General Hospital /ID# 225402	Athens	Attiki	Greece	11528
206	University General Hospital Attikon /ID# 225401	Athens	Attiki	Greece	12462
207	General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 225416	Athens		Greece	10676
208	University General Hospital of Ioannina /ID# 225400	Ioannina		Greece	45500
209	General University Hospital of Thessaloniki AXEPA /ID# 225398	Thessaloniki		Greece	54636
210	Theageneio Anticancer Hospital /ID# 225516	Thessaloniki		Greece	54639
211	Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont /ID# 226838	Szeged	Csongrad	Hungary	6725
212	Debreceni Egyetem Klinikai Kozpont /ID# 226821	Debrecen	Hajdu-Bihar	Hungary	4032
213	Somogy Megyei Kaposi Mor Oktato Korhaz /ID# 245938	Kaposvár	Somogy	Hungary	7400
214	Markusovszky Egyetemi Oktatokorhaz /ID# 226846	Szombathely	Vas	Hungary	9700
215	Semmelweis Egyetem /ID# 227239	Budapest		Hungary	1085
216	Orszagos Onkologiai Intezet /ID# 227294	Budapest		Hungary	1122
217	Tolna Megyei Balassa Janos Korhaz /ID# 250063	Szekszard		Hungary	7100
218	Assuta Tel Aviv Medical Center /ID# 226066	Tel Aviv	HaMerkaz	Israel	6971028
219	The Chaim Sheba Medical Center /ID# 225600	Ramat Gan	Tel-Aviv	Israel	5265601
220	Tel Aviv Sourasky Medical Center /ID# 225891	Tel Aviv-Yafo	Tel-Aviv	Israel	6423906
221	Rambam Health Care Campus /ID# 225981	Haifa		Israel	3109601
222	Hadassah /ID# 225614	Jerusalem		Israel	91120
223	Meir Medical Center /ID# 225612	Kfar Saba		Israel	4428164
224	Rabin Medical Center /ID# 225862	Petakh Tikva		Israel	4941492
225	Fondazione di Religione e di Culto Casa Sollievo della Sofferenza /ID# 225554	San Giovanni Rotondo	Foggia	Italy	71013
226	Ospedale San Raffaele IRCCS /ID# 225555	Milan	Milano	Italy	20132
227	IEO -Istituto Europeo di Oncologia /ID# 225545	Milan	Milano	Italy	20141
228	Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino /ID# 225775	Torino	Piemonte	Italy	10126
229	Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo /ID# 225542	Alessandria		Italy	15121
230	Centro di Riferimento Oncologico /ID# 225553	Aviano		Italy	33081
231	I.R.C.C.S Istituto Tumori Giovanni Paolo II /ID# 225548	Bari		Italy	70124
232	IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 225551	Bologna		Italy	40138
233	ASST Spedali civili di Brescia /ID# 225549	Brescia		Italy	25123
234	Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRCCS /ID# 252192	Meldola		Italy	47014
235	Azienda Ospedaliera Universitaria Federico II /ID# 225543	Napoli		Italy	80131
236	Azienda Ospedaliero Universitaria Maggiore della Carita di Novara /ID# 225773	Novara		Italy	28100
237	A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 225541	Palermo		Italy	90146
238	Azienda Ospedaliero Universitaria Pisana-Stabilimento di Santa Chiara /ID# 225575	Pisa		Italy	56126
239	Ospedale Santa Maria Croci /ID# 225571	Ravenna		Italy	48121
240	NHO Nagoya Medical Center /ID# 230677	Nagoya-shi	Aichi	Japan	460-0001
241	Aichi Cancer Center Hospital /ID# 226090	Nagoya-shi	Aichi	Japan	464-8681
242	National Cancer Center Hospital East /ID# 250151	Kashiwa-shi	Chiba	Japan	277-8577
243	Matsuyama Red Cross Hospital /ID# 251068	Matsuyama-shi	Ehime	Japan	790-8524
244	National Hospital Organization Kyushu Cancer Center /ID# 251622	Fukuoka-shi	Fukuoka	Japan	811-1395
245	Kyushu University Hospital /ID# 226091	Fukuoka-shi	Fukuoka	Japan	812-8582
246	Fukushima Medical University Hospital /ID# 250869	Fukushima-shi	Fukushima	Japan	960-1295
247	Hokkaido University Hospital /ID# 250149	Sapporo-shi	Hokkaido	Japan	060-8648
248	Kobe City Medical Center General Hospital /ID# 250597	Kobe-shi	Hyogo	Japan	650-0047
249	University of Tsukuba Hospital /ID# 251282	Tsukuba-shi	Ibaraki	Japan	305-8576
250	Kanazawa University Hospital /ID# 251770	Kanazawa-shi	Ishikawa	Japan	920-8641
251	Kagoshima University Hospital /ID# 250163	Kagoshima-shi	Kagoshima	Japan	890-8520
252	Tokai University Hospital /ID# 251281	Isehara-shi	Kanagawa	Japan	259-1193
253	Tohoku University Hospital /ID# 250150	Sendai-shi	Miyagi	Japan	9808574
254	Okayama University Hospital /ID# 250161	Okayama-shi	Okayama	Japan	700-8558
255	Kindai University Hospital /ID# 250160	Osakasayama-shi	Osaka	Japan	589-8511
256	Osaka University Hospital /ID# 251283	Suita-shi	Osaka	Japan	565-0871
257	National Cancer Center Hospital /ID# 226089	Chuo-ku	Tokyo	Japan	104-0045
258	The Cancer Institute Hospital Of JFCR /ID# 230269	Koto-ku	Tokyo	Japan	135-8550
259	Yamagata University Hospital /ID# 230003	Yamagata-shi	Yamagata	Japan	990-9585
260	Seoul National University Bundang Hospital /ID# 225763	Seongnam	Gyeonggido	Korea, Republic of	13620
261	Inje University Busan Paik Hospital /ID# 232262	Busan		Korea, Republic of	47392
262	Dong-A University Hospital /ID# 228451	Busan		Korea, Republic of	49201
263	Keimyung University Dongsan Medical Center /ID# 232264	Daegu		Korea, Republic of	41931
264	Jeonbuk National University Hospital /ID# 232263	Jeonju		Korea, Republic of	54907
265	Seoul National University Hospital /ID# 225760	Seoul		Korea, Republic of	03080
266	Asan Medical Center /ID# 225758	Seoul		Korea, Republic of	05505
267	Samsung Medical Center /ID# 225759	Seoul		Korea, Republic of	06351
268	The Catholic University of Korea, Seoul St. Mary's Hospital /ID# 225761	Seoul		Korea, Republic of	06591
269	Ulsan University Hospital /ID# 226971	Ulsan		Korea, Republic of	44033
270	Centro de Investigacion Clínica Chapultepec SA de CV /ID# 228292	Morelia	Michoacan	Mexico	58260
271	Hospital Universitario Dr. Jose Eleuterio Gonzalez /ID# 228752	Monterrey	Nuevo Leon	Mexico	64460
272	Centro de Investigacion Clínica Chapultepec S.A. de C.V. /ID# 228613	Ciudad de Mexico		Mexico	04100
273	Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran /ID# 228756	Ciudad de Mexico		Mexico	14080
274	Flevoziekenhuis /ID# 229606	Almere	Flevoland	Netherlands	1315 RA
275	Gelre Ziekenhuizen /ID# 229762	Apeldoorn	Gelderland	Netherlands	7334 DZ
276	Tergooi /ID# 229772	Hilversum	Noord-Holland	Netherlands	1213 XZ
277	Dijklander Ziekenhuis /ID# 229900	Hoorn Nh	Noord-Holland	Netherlands	1624 NP
278	Zaans Medisch Centrum /ID# 230614	Zaandam	Noord-Holland	Netherlands	1502 DV
279	Albert Schweitzer Ziekenhuis /ID# 229560	Dordrecht	Zuid-Holland	Netherlands	3318 AT
280	Noordwest Ziekenhuisgroep /ID# 230613	Alkmaar		Netherlands	1815 JD
281	Meander Medisch Centrum /ID# 229608	Amersfoort		Netherlands	3813 TZ
282	Vrije Universiteit Medisch Centrum /ID# 225608	Amsterdam		Netherlands	1081 HV
283	Onze Lieve Vrouwe Gasthuis /ID# 229761	Amsterdam		Netherlands	1091 AC
284	Amphia Ziekenhuis /ID# 229550	Breda		Netherlands	4818 CK
285	Haaglanden Medisch Centrum /ID# 229686	Den Haag		Netherlands	2512 VA
286	Deventer Ziekenhuis /ID# 229937	Deventer		Netherlands	7416 SE
287	Catharina Ziekenhuis /ID# 230465	Eindhoven		Netherlands	5623 EJ
288	Maxima Medisch Centrum /ID# 225603	Eindhoven		Netherlands	5631 BM
289	Medisch Spectrum Twente /ID# 225610	Enschede		Netherlands	7512 KZ
290	Universitair Medisch Centrum Groningen /ID# 225602	Groningen		Netherlands	9713 GZ
291	Spaarne Gasthuis /ID# 229621	Haarlem		Netherlands	2035 RC
292	Medisch Centrum Leeuwarden /ID# 225605	Leeuwarden		Netherlands	8934 AD
293	Leids Universitair Medisch Centrum /ID# 225606	Leiden		Netherlands	2333 ZA
294	Maastricht Universitair Medisch Centrum /ID# 225607	Maastricht		Netherlands	6229 HX
295	St. Antonius Ziekenhuis /ID# 229901	Nieuwegein		Netherlands	3435 CM
296	Canisius-Wilhelmina Ziekenhuis /ID# 231291	Nijmegen		Netherlands	6532 SZ
297	Jeroen Bosch Ziekenhuis /ID# 229765	S Hertogenbosch		Netherlands	5223 GZ
298	Elisabeth Tweesteden Ziekenhuis /ID# 229773	Tilburg		Netherlands	5022 GC
299	Diakonessenhuis /ID# 251793	Utrecht		Netherlands	3582 KE
300	North Shore Hospital /ID# 250992	Takapuna	Auckland	New Zealand	0622
301	Christchurch Hospital /ID# 250993	Christchurch	Canterbury	New Zealand	8011
302	Szpital Wojewodzki w Opolu sp. z o.o. /ID# 229669	Opole	Dolnoslaskie	Poland	45-372
303	Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka /ID# 228723	Slupsk	Pomorskie	Poland	76-200
304	Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej /ID# 225986	Kielce	Swietokrzyskie	Poland	25-734
305	SP ZOZ MSWiA z Warminsko-Mazurskim Centrum Onkologii /ID# 225985	Olsztyn	Warminsko-mazurskie	Poland	10-228
306	ARS-MEDICAL Sp. z o.o. /ID# 225848	Pila	Wielkopolskie	Poland	64-920
307	Centrum Medyczne Pratia Poznan /ID# 227236	Skorzewo	Wielkopolskie	Poland	60-185
308	CCA Braga - Hospital de Braga /ID# 249112	Braga		Portugal	4710-243
309	IPO Lisboa FG, EPE /ID# 249109	Lisboa		Portugal	1099-023
310	Centro Hospitalar Universitario de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 249111	Lisboa		Portugal	1649-035
311	Unidade Local de Saúde de Matosinhos, EPE /ID# 249113	Matosinhos		Portugal	4464-513
312	Hematology and Oncology Institute /ID# 230054	Manati		Puerto Rico	00674
313	Pan American Center for Oncology Trials, LLC /ID# 230052	Rio Piedras		Puerto Rico	00935
314	VA Caribbean Healthcare System /ID# 230053	San Juan		Puerto Rico	00921-3201
315	Narodny Onkologicky ustav /ID# 238847	Bratislava		Slovakia	831 01
316	Univerzitna nemocnica L. Pasteura Kosice /ID# 240174	Kosice		Slovakia	040 01
317	Univerzitna nemocnica Martin /ID# 240828	Martin		Slovakia	036 01
318	Wits Clinical Research Site /ID# 227799	Johannesburg	Gauteng	South Africa	2193
319	Wits Clinical Research Site /ID# 227803	Johannesburg	Gauteng	South Africa	2193
320	Albert Alberts Stem Cell Transplant Centre /ID# 227798	Pretoria	Gauteng	South Africa	0044
321	University of Cape Town /ID# 227802	Cape Town	Western Cape	South Africa	7925
322	Haemalife Inc. Netcare Kuilsrivier Hospital /ID# 243391	Kuilsrivier	Western Cape	South Africa	7580
323	Instituto Catalan de Oncologia (ICO) Badalona /ID# 228063	Badalona	Barcelona	Spain	08916
324	Instituto Catalan de Oncologia (ICO) L'Hospitalet /ID# 227393	Hospitalet de Llobregat	Barcelona	Spain	08908
325	CLINICA UNIVERSIDAD DE NAVARRA-Pamplona /ID# 225809	Pamplona	Navarra	Spain	31008
326	Hospital Parc de Salut del Mar /ID# 225810	Barcelona		Spain	08003
327	Hospital Universitario Vall d'Hebron /ID# 225811	Barcelona		Spain	08035
328	Hospital Clinic de Barcelona /ID# 226651	Barcelona		Spain	08036
329	Hospital Santa Creu i Sant Pau /ID# 225813	Barcelona		Spain	08041
330	Hospital Universitario Reina Sofia /ID# 225806	Cordoba		Spain	14004
331	Hospital General Universitario Gregorio Maranon /ID# 239768	Madrid		Spain	28007
332	CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 228228	Madrid		Spain	28027
333	Hospital Universitario Infanta Leonor /ID# 225816	Madrid		Spain	28031
334	MD Anderson Madrid /ID# 225817	Madrid		Spain	28033
335	Hospital Universitario Ramon y Cajal /ID# 241750	Madrid		Spain	28034
336	Hospital Universitario Fundacion Jimenez Diaz /ID# 225804	Madrid		Spain	28040
337	Hospital Universitario 12 de Octubre /ID# 225815	Madrid		Spain	28041
338	Hospital Clinico Universitario de Valencia /ID# 225818	Valencia		Spain	46010
339	Skane University Hospital Lund /ID# 227285	Lund	Skane Lan	Sweden	SE 221 41
340	Sodra Alvsborgs sjukhus /ID# 228885	Boras	Vastra Gotalands Lan	Sweden	501 82
341	Linkoping University Hospital /ID# 233521	Linkoping		Sweden	581 85
342	Kantonsspital Aarau AG /ID# 229112	Aarau	Aargau	Switzerland	5001
343	Spital Thun /ID# 229499	Thun	Bern	Switzerland	3600
344	KSW Kantonsspital Winterthur /ID# 241631	Winterthur	Zuerich	Switzerland	8400
345	Universitatsspital Zurich /ID# 228916	Zurich	Zuerich	Switzerland	8091
346	Kaohsiung Chang Gung Memorial Hospital /ID# 226670	Kaohsiung City	Kaohsiung	Taiwan	833
347	China Medical University Hospital /ID# 226188	Taichung City		Taiwan	40447
348	Taichung Veterans General Hospital /ID# 226674	Taichung		Taiwan	40705
349	National Cheng Kung University Hospital /ID# 226671	Tainan		Taiwan	704
350	Gazi University Medical Faculty /ID# 226571	Ankara		Turkey	06560
351	Ankara Universitesi Fakultesi /ID# 227331	Ankara		Turkey	06620
352	Anadolu Saglik Merkezi /ID# 225777	Dilovası		Turkey	41455
353	Koc Universitesi Hastanesi Translasyonel Tip Arastirma Merkezi /ID# 228950	Istanbul		Turkey	34010
354	Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 225920	Istanbul		Turkey	34098
355	Bagcilar Medipol Mega Universite Hastanesi /ID# 226726	Istanbul		Turkey	34214
356	Dokuz Eylul University Medical Faculty /ID# 225782	Izmir		Turkey	35340
357	Inonu University Medical Faculty /ID# 226572	Malatya		Turkey	44280
358	Ondokuz Mayis Universitesi Tip /ID# 251247	Samsun		Turkey	55139
359	Karadeniz University /ID# 226573	Trabzon		Turkey	61000
360	Baskent Universitesi Adana Uyg. ve Arast. Merkezi Yuregir Baskent Hastanesi /ID# 225921	Yuregir		Turkey	01240
361	University Hospital of Derby and Burton NHS Foundation Trust /ID# 229066	Derby	Derbyshire	United Kingdom	DE22 3NE
362	Gloucestershire Hospitals NHS Foundation Trust /ID# 229067	Cheltenham	Gloucestershire	United Kingdom	GL53 7AN
363	University Hospital Southampton NHS Foundation Trust /ID# 226598	Southampton	Hampshire	United Kingdom	SO16 6YD
364	Norfolk and Norwich University Hospitals NHS Foundation Trust /ID# 226692	Norwich	Norfolk	United Kingdom	NR4 7UY
365	Oxford University Hospitals NHS Foundation Trust /ID# 226687	Oxford	Oxfordshire	United Kingdom	OX3 9DU
366	NHS Greater Glasgow and Clyde /ID# 229463	Glasgow	Scotland	United Kingdom	G12 0XH
367	University Hospitals of North Midlands NHS Trust /ID# 229202	Stoke-on-Trent	Staffordshire	United Kingdom	ST4 6QG
368	University Hospitals Birmingham NHS Foundation Trust /ID# 229197	Birmingham		United Kingdom	B15 2TH
369	East Suffolk and North Essex NHS Foundation Trust /ID# 229056	Colchester		United Kingdom	CO4 5JL
370	NHS Lothian /ID# 229055	Edinburgh		United Kingdom	EH3 9HE
371	Leeds Teaching Hospitals NHS Trust /ID# 229360	Leeds		United Kingdom	LS9 7TF
372	Imperial College Healthcare NHS Trust /ID# 242215	London		United Kingdom	W2 1NY
373	The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 226690	Newcastle upon Tyne		United Kingdom	NE7 7DN
374	University Hospital Plymouth NHS Trust /ID# 226689	Plymouth		United Kingdom	PL6 5FP
375	Portsmouth Hospitals University NHS Trust /ID# 233400	Portsmouth		United Kingdom	PO6 3LY
376	South Tyneside and Sunderland NHS Foundation Trust /ID# 229458	South Shields		United Kingdom	NE34 0PL
377	Royal Cornwall Hospitals NHS Trust /ID# 229827	Truro		United Kingdom	TR1 3LJ