Early Childhood Obesity Programming by Intrauterine Growth Restriction
Study Details
Study Description
Brief Summary
The molecular mechanisms underlying developmental programming of childhood obesity remain poorly understood. Here, the investigators address major questions about early childhood obesity programming by studying CD3+ T-cells from intrauterine growth restricted (IUGR) newborns who have an increased risk for obesity and other metabolic disorders in adult life.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Detailed Description
Epidemiological studies of multiple cohorts suggest an increased risk for obesity, cardiovascular disease-related death and type 2 diabetes in low birth weight infants. However, the molecular mechanisms underlying developmental programming of childhood obesity remain poorly understood. Alterations in DNA methylation during fetal life have been proposed to be one of the mechanisms that regulate this phenotype. Here, the investigators address major questions about early childhood obesity programming by studying purified subpopulations of CD3+ T-cells from intrauterine growth restricted (IUGR) newborns who have an increased risk for obesity and other metabolic disorders in adult life. The investigators will correlate altered CD3+ T-cell DNA methylation profiles in cord and peripheral blood samples and functional changes in CD3+ T-cells with adiposity in childhood.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
IUGR infants Intrauterine growth restricted infants will be enrolled. There are no interventions. |
|
AGA infants Appropriate for gestational age infants will be enrolled. There are no interventions. |
Outcome Measures
Primary Outcome Measures
- Growth velocity [Until 24 months of age]
Change in growth velocity based on DNA methylation marks and functional profiles of CD3+ T-cells
- DNA methylation of CD3+ T-cells [At birth and 24 months of age]
Change in DNA methylation of CD3+ T-cells in the first 24 months of life in IUGR infants
- T-cell function [At birth, 12 and 24 months of age]
Change in T-cell function in the first 24 months of life in IUGR infants
Eligibility Criteria
Criteria
Inclusion Criteria:
- Healthy singleton term IUGR and AGA infants whose mothers are followed by the Obstetric Department of Montefiore Medical Center and who deliver at the Weiler Division of Montefiore Medical Center.
Exclusion Criteria:
- Multiple gestation, maternal depression, maternal renal disease, infants in extremis, Apgar score <7 at 5 min and umbilical artery pH ≤7.25, chromosomal/ congenital abnormalities, congenital infections and inborn errors of metabolism. We will also exclude infants born to mothers with a history of maternal smoking in the 2nd and 3rd trimester of pregnancy and maternal gestational diabetes/T2D.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Jack D. Weiler Hospital | Bronx | New York | United States | 10461 |
Sponsors and Collaborators
- Montefiore Medical Center
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Investigators
- Principal Investigator: Mamta Fuloria, MD, Montefiore Medical Center/Albert Einstein College of Medicine
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2018-8749
- R01HD092533