Early Identification and Predictive Parsing for High Risk Group of Schizophrenia
Study Details
Study Description
Brief Summary
An accurate identification of individuals at ultra-high risk (UHR) based on psychometric tools to prospectively identify psychosis as early as possible is required for indicated preventive intervention. The diagnostic comparability of several psychometric tools is unknown. To address the psychometric comparability of the CAARMS, SIPS and BSABS for subjects who are the immediate family and three-generation blood kinship of patients with schizophrenia. To verify the viability and reliability of the three instruments for these subjects. subjects who all are immediate family and three-generation blood kinship of patients with schizophreniawere interviewed. All the subjects were assessed for a UHR state by three psychometric tools including CAARMS, SIPS and BSABS. The psychometric diagnosis results including at risk of psychosis (UHR+), not at risk of psychosis (UHR-), and Psychosis. Demographic and clinical characteristics interviewed by these three instruments were also measured. The inter-rater agreement was assessed for evaluation of the coherence of the three scales. Transition rates of CAARMS, SIPS and BSABS for UCH+ subjects within 2 years were also recorded.There is good diagnostic agreement between the CAARMS, SIPS and BSABS towards identification of UHR subjects who are immediate family and three-generation blood kinship of patients with schizophrenia. Also, these three instruments are reliable and valid for assessing and detecting at risk mental states in these subjects.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Outcome Measures
Primary Outcome Measures
- The overall agreement percent [2 years]
diagnostic comparison of CAARMS and SIPS, SIPS and BSABS, CAARMS and BSABS.
- the inter-rater reliability [2 years]
Inter-rater correlation (ICC) coefficients of CAARMS, SIPS and BSABS subscales.
- the transition rates of UHR+ to psychosis within 2 years [2 years]
Transition rates of CAARMS, SIPS and BSABS for UCH+ subjects within 2 years follow-up.
Eligibility Criteria
Criteria
Inclusion Criteria:
- all are immediate family and three-generation blood kinship of patients with schizophrenia
Exclusion Criteria:
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Dept. of Psychological Rehabilitation, Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology | Wuhan | Hubei | China | 430022 |
Sponsors and Collaborators
- Wuhan Mental Health Centre
- Health Commission of Hubei Province
Investigators
- Principal Investigator: Peng Wang, Master, Dept. of Psychological Rehabilitation, Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- ky2018.45