Early Vitrectomy for Endophthalmitis After Cataract Surgery

Sponsor

Benha University (Other)

Overall Status

Completed

CT.gov ID

NCT05249413

Collaborator

(none)

Enrollment

Location

84.4

Actual Duration (Months)

0.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Post-operative infectious endophthalmitis is devastating condition that causes a diffuse intraocular inflammation and may lead to blindness. Acute post-operative endophthalmitis usually presented within 6 weeks of intraocular procedure and diagnosis is confirmed by clinical examination and by the aid of B-scan ultrasonography.

Condition or Disease	Intervention/Treatment	Phase
Endophthalmitis Cataract Vitreous Detachment Retinal Detachment	Procedure: Early 23-gauge pars-plana vitrectomy

Detailed Description

There is no consensus regarding the timing of vitrectomy in cases with endophthalmitis after cataract surgery. The Endophthalmitis Vitrectomy Study concluded that vitrectomy should be preserved for cases with only light perception. The advances in posterior segment machines and small gauge cannulas decrease the incidence of intra-operative complications and encourage for early intervention in cases with endophthalmitis after primary cataract surgery.

Study Design

Study Type:

Observational

Actual Enrollment :

11 participants

Observational Model:

Case-Only

Time Perspective:

Retrospective

Official Title:

Outcomes of Early Vitrectomy for Endophthalmitis After Cataract Surgery in Delta Population, Egypt, 2015-2020.

Actual Study Start Date :

Jan 2, 2015

Actual Primary Completion Date :

Dec 30, 2020

Actual Study Completion Date :

Jan 15, 2022

Arms and Interventions

Arm	Intervention/Treatment
Endophthalmitis after primary cataract surgery. Cases diagnosed as acute post-operative endophthalmitis after primary cataract surgery.	Procedure: Early 23-gauge pars-plana vitrectomy pars-plana vitrectomy for management of acute post-operative endophthalmitis.

Arm

Intervention/Treatment

Endophthalmitis after primary cataract surgery.

Cases diagnosed as acute post-operative endophthalmitis after primary cataract surgery.

Procedure: Early 23-gauge pars-plana vitrectomy

pars-plana vitrectomy for management of acute post-operative endophthalmitis.

Outcome Measures

Primary Outcome Measures

Best-corrected visual acuity [Baseline and 3 months after intervention.]
Changes in visual acuity from baseline and after early vitrectomy operation.

Secondary Outcome Measures

Other prognostic factors [Baseline and 3 months after intervention.]
Other factors that may influence the final visual outcome in cases with endophthalmitis as (intraocular tamponade, posterior vitreous detachment, systemic condition and virulence of causative organism)

Eligibility Criteria

Criteria

Ages Eligible for Study:

3 Years to 80 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Acute onset endophthalmitis within 6 weeks after primary cataract surgeries.
Patients had undergone early pars-plana vitrectomy within 48 hours of their confirmed diagnosis.