Effect of Cranberry Extract on the Urinary System

Sponsor

Kırklareli University (Other)

Overall Status

Completed

CT.gov ID

NCT05260554

Collaborator

(none)

Enrollment

Location

Actual Duration (Days)

2.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

In this study, we will try to emphasize the effects of using cranberry tablets, which is an alternative to antibiotic therapy, during uncomplicated urinary tract infections (only urinary tract, bladder and kidney infections did not).

Condition or Disease	Intervention/Treatment	Phase
Urinary Tract Disease Cystitis Antibiotic Reaction	Drug: Fosfomycin Dietary Supplement: Cranberry

Detailed Description

This study was Istanbul Kartal Dr. Lütfi Kırdar Training and Research Hospital Emergency Medicine Clinic and Kırklareli Training and Research Hospital Emergency Service and Internal Medicine Polyclinic. Our study; includes patients who applied to the Emergency Department and Internal Medicine outpatient clinic with the complaint of dysuria and had normal WBC, CRP, urea, and creatinine values in their analysis, and leukocyturia was found in the urine test. Two options were offered in the treatment to these patients. Vaccinium Macrocarpon Aiton preparation or fosfomycin was given for seven days. The patients were asked whether their complaints had decreased according to the Lykert-Type verbal scale at the time of admission and on the first, third, and seventh days. When the treatment was finished, leukocytes were checked in the urinalysis. This outcome was compared between the 2 treatment options. We also noted whether nausea.

Study Design

Study Type:

Observational

Actual Enrollment :

2 participants

Observational Model:

Case-Control

Time Perspective:

Prospective

Official Title:

Effects of Use of Cranberry Extract Instead of Antibiotics During Uncomplicated Urinary Tract Infection

Actual Study Start Date :

Jan 26, 2022

Actual Primary Completion Date :

Feb 18, 2022

Actual Study Completion Date :

Feb 18, 2022

Arms and Interventions

Arm	Intervention/Treatment
using fosfomycin The patients in this group; have been prescribed fosfomycin for 7 days (3 doses, two days apart).	Drug: Fosfomycin In this group with urinary tract inflammation; Fosfomycin was prescribed for 7 days (3 doses, 2 days apart). There are 80 patients in total. Other Names: monurol
using cranberry extract The patients in this group; took 7 days (1 tablet each day) of cranberry tablets.	Dietary Supplement: Cranberry In this group with urinary tract inflammation; 7 days (used every day) cranberry tablet was given. There are 80 patients in total.

Arm

Intervention/Treatment

using fosfomycin

The patients in this group; have been prescribed fosfomycin for 7 days (3 doses, two days apart).

Drug: Fosfomycin

In this group with urinary tract inflammation; Fosfomycin was prescribed for 7 days (3 doses, 2 days apart). There are 80 patients in total.

Other Names:

monurol

using cranberry extract

The patients in this group; took 7 days (1 tablet each day) of cranberry tablets.

Dietary Supplement: Cranberry

In this group with urinary tract inflammation; 7 days (used every day) cranberry tablet was given. There are 80 patients in total.

Outcome Measures

Primary Outcome Measures

Treatment time [7 days]
After 7 days of treatment, the 2 treatment options were compared with each other.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Older than 18
who have urinary tract inflammation
who haven't kidney dissease previous

Exclusion Criteria:

Younger than 18
Who have kidney inflammation
Pregnant patients
Who have blood test abnormal (WBC, Ure, Creatin, CRP high level)

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Oya Guven, MD	Kirklareli	Center	Turkey	39000

Sponsors and Collaborators

Kırklareli University

Investigators

Study Director: Oya Guven, Kırklareli University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Oya Guven, MD, Assistant Professor, Kırklareli University

ClinicalTrials.gov Identifier:

NCT05260554

Other Study ID Numbers:

Kırklareli University

First Posted:

Mar 2, 2022

Last Update Posted:

Mar 2, 2022

Last Verified:

Feb 1, 2022

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Yes

Studies a U.S. FDA-regulated Device Product:

Product Manufactured in and Exported from the U.S.:

Keywords provided by Oya Guven, MD, Assistant Professor, Kırklareli University

Urinary Tract Disease

Cranberry extract

Antibiotic

Cystitis

Additional relevant MeSH terms:

Cystitis

Urologic Diseases

Fosfomycin

Study Results

No Results Posted as of Mar 2, 2022