Effect of Different Antihypertensive Treatment on Serum Uric Acid in Newly Diagnosed Hypertensive Patients
Study Details
Study Description
Brief Summary
Assessment of the influence of different antihypertensive drugs on serum uric acid in newly diagnosed hypertension patients.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated appropriately.
Thiazide-type diuretics, angiotensin-converting enzyme (ACE) inhibitors and some of angiotensin-II receptor blockers (ARB) were reported to reduce renal excretion of urate and increased serum uric acid levels, Beta-blockers also elevate serum uric acid levels.
Hyperuricemia is a risk factor for cardiovascular diseases. Hyperuricemia was found to correlate with hypertension excluding the influence of other factors such as age and renal function. Furthermore, many studies found that hyperuricemia was independently associated with cardiovascular events in patients treated with antihypertensive drugs.
It is important to control serum uric acid levels in hypertensive patients treated with antihypertensive drugs in order to reduce the risk of gout and cardiovascular events. There is a gap in knowledge in studies showing the effect of antihypertensive drugs on serum uric acid in newly diagnosed hypertensive patients.
Study Design
Outcome Measures
Primary Outcome Measures
- The effect of different antihypertensive drugs on serum uric acid in newly diagnosed hypertension. [6 months from baseline]
we will measure the change of the level of serum uric acid after 6 months from the treatment of antihypertensive durgs
Secondary Outcome Measures
- obesity [6 months from baseline]
it will be measured by BMI (kg/m2)
Eligibility Criteria
Criteria
Inclusion Criteria:
- All newly diagnosed hypertensive patients aged 30 years old and above will be invited to participate in this study
Exclusion Criteria:
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Patients below 30 years old.
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Patients with kidney disease.
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Patients who are taking medications known to increase SUA as (Thiazide and Loop diuretics, Salicylates, Cyclosporin use) or decrease the level of uric acid in the urine as (Allopurinol, Febuoxstate).
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Assiut University
Investigators
- Principal Investigator: Dalia Mahran, Professor, faculty of medicine
Study Documents (Full-Text)
None provided.More Information
Publications
- Shankar A, Klein R, Klein BE, Nieto FJ. The association between serum uric acid level and long-term incidence of hypertension: Population-based cohort study. J Hum Hypertens. 2006 Dec;20(12):937-45. Epub 2006 Oct 5.
- Verdecchia P, Schillaci G, Reboldi G, Santeusanio F, Porcellati C, Brunetti P. Relation between serum uric acid and risk of cardiovascular disease in essential hypertension. The PIUMA study. Hypertension. 2000 Dec;36(6):1072-8.
- Uric acid in Hypertension