GnRH Agonist and Antagonists in an Oocyte Donation Program
Study Details
Study Description
Brief Summary
The primary purpose of this study is to evaluate the effect of the two different protocols (long protocol vs antagonist protocol) on oocyte / embryo quality.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 4 |
Detailed Description
The cycles with antagonists of the GnRHa present a series of advantages with respect the GnRHa in an oocyte donation program: treatment cycles are simpler and shorter, a lower amount of dose of gonadotrophins is needed for stimulation, and most important, a decreased rate of ovarian hyperstimulation syndrome is observed. Nevertheless, several clinical trials relate their use to a greater rate of abortion and worse oocyte/ embryo quality. In order to discriminate the endometrial factor from the quality of oocyte cohort, the best strategy is the oocyte donation model. In the present study, for the first time, the effect of different protocols (long versus antagonist protocol) will be studied in the same donor, acting as its own control, undergoing COH. We will compare the COH´s parameters and IVF outcome obtained in the same donor submitted to, firstly, GnRH antagonist protocol (Cetrorelix- n= 45) versus another consecutive cycle with long protocol (Ac. Leuprolide- n= 45).
Study Design
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
Inclusion Criteria:
- oocyte donors with age range: 18 - 34; BMI: 18 - 29 kg/m2;
Exclusion Criteria:
- PCO
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Instituto Valenciano de Infertilidad Spain | Valencia | Spain | 46015 |
Sponsors and Collaborators
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Investigators
- Principal Investigator: Marco Melo, MDPhD, Instituto Valenciano de Infertilidad
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- VLC-MM-0706-307-19