Effect of a Third COVID-19 Booster Among Health Care Workers

Sponsor
Hong Kong Sanatorium & Hospital (Industry)
Overall Status
Not yet recruiting
CT.gov ID
NCT05373459
Collaborator
(none)
3,300
1
7.5
438.6

Study Details

Study Description

Brief Summary

A new wave of COVID-19 infections, mainly caused by the Omicron/ Delta variant, has been sweeping the globe since the start of 2022. In response, the administration of a third dose of COVID-19 vaccine was considered to address potential waning immunity over time and reduced effectiveness against the Omicron/ Delta variant. The pandemic also resulted in many infections among health care workers (HCWs) and their households. In this study, a retrospective analysis would perform on risk of COVID-19 infection and their outcome in relation to their COVID-19 vaccination history by using the data repository from one of the Hong Kong private hospitals.

HCWs were required to submit a standardized online self-declaration form for report of 1) demographic of the HCWs, 2) symptoms related history and 3) COVID-19 exposure history once they were COVID-19 confirmed by rapid antigen test against COVID-19 and/or polymerase chain reaction (PCR) test for COVID-19. Subsequent follow up such as contact tracing, COVID-19 PCR testing results of these HCWs and status of return to work were captured by the infection control team in a systematic manner.

Condition or Disease Intervention/Treatment Phase
  • Biological: Third COVID-19 booster

Study Design

Study Type:
Observational
Anticipated Enrollment :
3300 participants
Observational Model:
Cohort
Time Perspective:
Retrospective
Official Title:
Effect of a Third COVID-19 Booster on COVID-19 Infection Rate and Return to Works During Fifth Wave COVID-19 Among Health Care Workers
Anticipated Study Start Date :
May 16, 2022
Anticipated Primary Completion Date :
Jul 31, 2022
Anticipated Study Completion Date :
Dec 31, 2022

Arms and Interventions

Arm Intervention/Treatment
Health care workers without third COVID-19 booster

Health care workers received less than 3 doses of COVID-19 vaccine

HCWs with third COVID-19 booster

Health care workers received at least 3 doses of COVID-19 vaccine

Biological: Third COVID-19 booster
Third COVID-19 booster

Outcome Measures

Primary Outcome Measures

  1. COVID-19 Infection [During 1 February - 31 March 2022]

    Number of participants with COVID-19 infected

  2. Number of days return to work after COVID-19 infection [During 1 February - 31 March 2022]

    Number of days return to work after COVID-19 infection

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • All full time staff members of the private hospital
Exclusion Criteria:
  • History of COVID-19 before 2022

Contacts and Locations

Locations

Site City State Country Postal Code
1 Hong Kong Sanatorium & Hospital Hong Kong Hong Kong

Sponsors and Collaborators

  • Hong Kong Sanatorium & Hospital

Investigators

  • Principal Investigator: Jonpaul Sze Tsing Zee, MBChB, Hong Kong Sanatorium & Hospital

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Dr. Jonpaul ST Zee, Specialist in Infectious Disease, Hong Kong Sanatorium & Hospital
ClinicalTrials.gov Identifier:
NCT05373459
Other Study ID Numbers:
  • Third COVID-19 booster
First Posted:
May 13, 2022
Last Update Posted:
May 20, 2022
Last Verified:
May 1, 2022
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of May 20, 2022