Endocrine Changes in Adults Undergoing Cardiac Surgery
Study Details
Study Description
Brief Summary
In this prospective study the investigators want to measure the serum level changes of the thyroid hormones (thyroid-stimulating hormone, reverse triiodothyronine, serum free T4), brain natriuretic peptide (BNP), testosterone and sexual hormone binding protein (SHBG) in adults undergoing cardiac surgery and search for correlations different psychosocial factors and analyze the influence on the survival and the length of ICU/hospital stay.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
In this study the investigators want to analyze routinely collected data of patients who underwent any kind of elective cardiac surgery in our university cardiovascular centre between 07.01.2018 and 30.06.2020. The database contains descriptive parameters, history of past illnesses, recent medication. The investigators record the type of surgery, the list of contributory physicians, the length of the surgery and the data of the anaesthesiological report. After the surgery the researchers want to record the postoperative parameters on the ICU ( infusion - fluid balance, blood transfusion, bleeding, main hemodynamic parameters, length of mechanical ventilation,main parameters of arterial blood gas analysis). Moreover th investigators want to collect psychosocial tests (Beck Depression Inventory, State Anxiety Scale, Trait Anxiety Scale and EQ-5D for the measurement of quality of life) to get more information from the postoperative condition of the patients.
Study Design
Outcome Measures
Primary Outcome Measures
- Length of hospital and intensive care unit stay [Participants will be followed for the duration of hospital stay, an expected average of 2 weeks.]
The correlation of the measured pre and postoperative endocrine profile and the length of intensive care unit stay
Secondary Outcome Measures
- The composite of in-hospital death from any cause. [Participants will be followed for the duration of hospital stay, an expected average of 12 weeks.]
Any cause of death in current group
- Correlation between preoperative Beck Depression Inventory and the length of hospital stay [Participants will be followed for the duration of hospital stay, an expected average of 12 weeks.]
The effect of psychological state of the length of hospital stay
- Correlation between preoperative State Anxiety Scale and the length of hospital stay [Participants will be followed for the duration of hospital stay, an expected average of 12 weeks.]
The effect of psychological state of the length of hospital stay
- Correlation between preoperative Trait Anxiety Scale and the length of hospital stay [Participants will be followed for the duration of hospital stay, an expected average of 12 weeks.]
The effect of psychological state of the length of hospital stay
- Correlation between preoperative EQ-5D inventory and the length of total hospital stay [Participants will be followed for the duration of hospital stay, an expected average of 12 weeks.]
Correlation between the preoperative quality of life state and the hospital stay
Eligibility Criteria
Criteria
Inclusion Criteria:
- elective cardiac surgery
Exclusion Criteria:
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lack of consent
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pregnancy
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acute surgery
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exposition with iodin-containing contrast material
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Heart and Vascular Center, Semmelweis University | Budapest | Hungary | 1122 | |
2 | Semmelweis Egyetem Heart and Vascular Center | Budapest | Hungary | 1122 | |
3 | Semmeweis Egyetem Heart and Vascular Center | Budapest | Hungary | 1122 |
Sponsors and Collaborators
- Semmelweis University Heart and Vascular Center
Investigators
- Study Director: Andrea Székely, ass. prof, Semmelweis Egyetem
- Principal Investigator: Ágnes Sándor, PhD st, Semmelweis Egyetem
- Principal Investigator: András Szabó, PhD st, Semmelweis Egyetem
Study Documents (Full-Text)
None provided.More Information
Publications
- Aversa A, Fabbri A. Testicular and thyroid function as survival predictors in the elderly patient candidate to surgery. Monaldi Arch Chest Dis. 2017 Jul 18;87(2):841. doi: 10.4081/monaldi.2017.841.
- Bianchi V, Mezzani A. Androgens and cardiac diseases. Monaldi Arch Chest Dis. 2013 Dec;80(4):161-9. Review.
- Brozaitiene J, Mickuviene N, Podlipskyte A, Burkauskas J, Bunevicius R. Relationship and prognostic importance of thyroid hormone and N-terminal pro-B-Type natriuretic peptide for patients after acute coronary syndromes: a longitudinal observational study. BMC Cardiovasc Disord. 2016 Feb 18;16:45. doi: 10.1186/s12872-016-0226-2.
- Fleischer J, McMahon DJ, Hembree W, Addesso V, Longcope C, Shane E. Serum testosterone levels after cardiac transplantation. Transplantation. 2008 Mar 27;85(6):834-9. doi: 10.1097/TP.0b013e318166ac10.
- Kunst G, Pfeilschifter J, Kummermehr G, Luntz S, Bauer H, Martin E, Motsch J. Assessment of sex hormone-binding globulin and osteocalcin in patients undergoing coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2000 Oct;14(5):546-52.
- Maggio M, Nicolini F, Cattabiani C, Beghi C, Gherli T, Schwartz RS, Valenti G, Ceda GP. Effects of testosterone supplementation on clinical and rehabilitative outcomes in older men undergoing on-pump CABG. Contemp Clin Trials. 2012 Jul;33(4):730-8. doi: 10.1016/j.cct.2012.02.019. Epub 2012 Mar 5.
- SE VSZÉK EndocrinHeart