Endometrial Lesions Predictions

Beijing Friendship Hospital (Other)
Overall Status
Active, not recruiting
CT.gov ID

Study Details

Study Description

Brief Summary

To explore the risk factors of endometrial lesions in patients with abnormal uterine bleeding and establish prediction models which can discriminate between different endometrial etiologies of abnormal uterine bleeding(AUB).

Condition or Disease Intervention/Treatment Phase
  • Other: no intervention

Study Design

Study Type:
Actual Enrollment :
900 participants
Observational Model:
Time Perspective:
Official Title:
Predictive Factors of Endometrial Lesions in Patients With Abnormal Uterine Bleeding
Actual Study Start Date :
Oct 1, 2021
Actual Primary Completion Date :
Oct 1, 2022
Anticipated Study Completion Date :
Dec 1, 2022

Arms and Interventions

Arm Intervention/Treatment
normal endometrial

Other: no intervention
no intervention

endometrial lesions

Outcome Measures

Primary Outcome Measures

  1. pathology of endometrial lesions [1 year]

    Endometrial tissue was curettaged and sent for pathological examination in 10% formalin. A senior pathologist who was not blinded to clinical and ultrasound information examined the samples and determined the final diagnosis. The outcomes of histology are classified as normal endometrium and endometrial lesions, which include 1)endometrial polyps,2)endometrial hyperplasia without atypia, 3)endometrial atypical hyperplasia and 4) endometrial carcinoma.

Secondary Outcome Measures

  1. Ultrasonographic Examination [1 year]

    VS examinations were performed by an experienced physician with a vaginal probe of 5.5 MHz of a GE VolusonE10 Ultrasound device to look for endometrial thickness and abnormal echoes. Endometrial thickness (ET) was measured at the thickest part with double layers

Eligibility Criteria


Ages Eligible for Study:
18 Years to 60 Years
Sexes Eligible for Study:
Inclusion Criteria:
    1. non-pregnancy related abnormal uttering bleeding(AUB) in women of 18-60 years old; 2)women who had indications for hysteroscopy and endometrial histology in the study period
Exclusion Criteria:
    1. postmenopausal women, 2) AUB due to other causes such as hormones or medications, coagulation disorders, and vascular malformation of the uterus; 3) final diagnosis outside the scope of this study.

Contacts and Locations


Site City State Country Postal Code
1 Beijing Friendship Hospital Beijing China

Sponsors and Collaborators

  • Beijing Friendship Hospital


  • Principal Investigator: Wenjing Zhang, Dr, Beijing Friendship Hospital

Study Documents (Full-Text)

None provided.

More Information


None provided.
Responsible Party:
Beijing Friendship Hospital
ClinicalTrials.gov Identifier:
Other Study ID Numbers:
First Posted:
Oct 20, 2022
Last Update Posted:
Oct 20, 2022
Last Verified:
Oct 1, 2022
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD:
Studies a U.S. FDA-regulated Drug Product:
Studies a U.S. FDA-regulated Device Product:
Additional relevant MeSH terms:

Study Results

No Results Posted as of Oct 20, 2022