Testing the Combination of Olaparib and Durvalumab, Cediranib and Durvalumab, Olaparib and Capivasertib, and Cediranib Alone in Recurrent or Refractory Endometrial Cancer Following the Earlier Phase of the Study That Tested Olaparib and Cediranib in Comparison to Cediranib Alone, and Olaparib Alone

• Sponsor: National Cancer Institute (NCI) (NIH)
• Overall Status: Recruiting
• CT.gov ID: NCT03660826
• Collaborator: NRG Oncology (Other)
• Enrollment: 168
• Locations: 736
• Arms: 6
• Anticipated Duration (Months): 48
• Patients Per Site: 0.2
• Patients Per Site Per Month: 0

Study Details

Study Description

Brief Summary

This phase II trial studies the effects of the combination of olaparib and durvalumab, cediranib and durvalumab, olaparib and capivasertib, and cediranib alone in treating patients with endometrial cancer that has come back (recurrent) or does not respond to treatment (refractory). Olaparib, cediranib, and capivasertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Durvalumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Testing the combinations may lower the chance of endometrial cancer growing or spreading compared to usual care.

Condition or Disease	Intervention/Treatment	Phase
Endometrial Undifferentiated Carcinoma; Endometrioid Adenocarcinoma; Recurrent Endometrial Serous Adenocarcinoma; Recurrent Uterine Corpus Cancer; Stage IV Uterine Corpus Cancer AJCC v7; Stage IVA Uterine Corpus Cancer AJCC v7; Stage IVB Uterine Corpus Cancer AJCC v7	Drug: Capivasertib; Drug: Cediranib; Drug: Cediranib Maleate; Biological: Durvalumab; Drug: Olaparib	Phase 2

Detailed Description

PRIMARY OBJECTIVES:

1. To compare the efficacy of single-agent olaparib and the combination of olaparib and cediranib (and potentially other combination arms that may be added by subsequent amendment) versus single agent cediranib as measured by progression free survival (PFS), in patients with recurrent, persistent or metastatic endometrial cancer.

2. To compare the efficacy of the combination of olaparib and AZD5363 (capivasertib), and the combination of olaparib and durvalumab (MEDI4736), and the combination of cediranib and durvalumab (MEDI4736) versus single agent cediranib as measured by progression free survival (PFS), in patients with recurrent, persistent or metastatic endometrial cancer.

SECONDARY OBJECTIVES:

1. To compare the efficacy of single-agent olaparib and the combination of olaparib and cediranib (and potentially other combination arms that may be added by subsequent amendment) versus single-agent cediranib as measured by overall survival (OS) in patients with recurrent, persistent or metastatic endometrial cancer.

2. To compare the efficacy of the combination of olaparib and AZD5363 (capivasertib), and the combination of olaparib and durvalumab (MEDI4736), and the combination of cediranib and durvalumab (MEDI4736) versus single agent cediranib as measured by overall survival (OS), in patients with recurrent, persistent or metastatic endometrial cancer.

3. To compare the efficacy of single-agent olaparib and the combination of olaparib and cediranib (and potentially other combination arms may be added by subsequent amendment versus single-agent cediranib as measured by response rate in patients with recurrent, persistent or metastatic endometrial cancer.

4. To compare the efficacy of the combination of olaparib and AZD5363 (capivasertib), and the combination of olaparib and durvalumab (MEDI4736), and the combination of cediranib and durvalumab (MEDI4736) versus single agent cediranib as measured by response rate in patients with recurrent, persistent or metastatic endometrial cancer.

5. To assess the safety and tolerability of single-agent cediranib, single-agent olaparib, and the combination of olaparib and cediranib (and potentially other combination arms may be added by subsequent amendment).

6. To assess the safety and tolerability of the combination of olaparib and AZD5363 (capivasertib), and the combination of olaparib and durvalumab (MEDI4736), and the combination of cediranib and durvalumab (MEDI4736).

7. To assess if mutations in deoxyribonucleic acid (DNA) homologous repair genes (assayed prior to all treatment and prior to the study treatment) are predictive of response to olaparib alone or in combination with cediranib. (Integrated Biomarker) VIII. To assess if markers of angiogenesis in serial plasma samples are associated with response to cediranib alone or in combination with olaparib. (Integrated Biomarker)

EXPLORTORY OBJECTIVE:

1. To compare the efficacy of the combination of olaparib and cediranib versus single agent olaparib as measured by PFS, response rate and OS, if and only if the combination is superior to the single-agent cediranib arm.

OUTLINE: Patients are randomized to 1 of 6 arms.

ARM I: Patients receive cediranib maleate orally (PO) once daily (QD). Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity.

ARM II (ENROLLMENT COMPLETE): Patients receive olaparib PO twice daily (BID). Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity.

ARM III (ENROLLMENT COMPLETE): Patients receive olaparib PO BID and cediranib maleate PO QD. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity.

ARM IV: Patients receive olaparib PO BID on days 1-28 and capivasertib PO BID on days 1-4 each week. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity.

ARM V: Patients receive olaparib PO BID on days 1-28 and durvalumab intravenously (IV) on day

1. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity.

ARM VI: Patients receive cediranib maleate PO BID on days 1-28 and durvalumab IV on day 1. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 168 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: A Randomized Phase II Study Comparing Single-Agent Olaparib, Single Agent Cediranib, and the Combinations of Cediranib/Olaparib, Olaparib/Durvalumab (MEDI4736), Cediranib/Durvalumab (MEDI4736), Olaparib/AZD5363 (Capivasertib) in Women With Recurrent, Persistent or Metastatic Endometrial Cancer. A Multi-Arm Trial for Women With Recurrent or Persistent Endometrial Cancer
• Actual Study Start Date: Sep 4, 2018
• Anticipated Primary Completion Date: Sep 4, 2022
• Anticipated Study Completion Date: Sep 4, 2022

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Arm I (cediranib maleate) Patients receive cediranib maleate PO QD. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity.	Drug: Cediranib; Given PO; Other Names: AZD2171 ; Drug: Cediranib Maleate; Given PO; Other Names: AZD2171 AZD2171 Maleate Recentin
Experimental: Arm II (olaparib) Patients receive olaparib PO BID. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity.	Drug: Olaparib; Given PO; Other Names: AZD 2281 AZD-2281 AZD2281 KU-0059436 Lynparza PARP Inhibitor AZD2281
Experimental: Arm III (cediranib maleate, olaparib) Patients receive olaparib PO BID and cediranib maleate PO QD. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity.	Drug: Cediranib; Given PO; Other Names: AZD2171 ; Drug: Cediranib Maleate; Given PO; Other Names: AZD2171 AZD2171 Maleate Recentin ; Drug: Olaparib; Given PO; Other Names: AZD 2281 AZD-2281 AZD2281 KU-0059436 Lynparza PARP Inhibitor AZD2281
Experimental: Arm IV (olaparib, capivasertib) Patients receive olaparib PO BID on days 1-28 and capivasertib PO BID on days 1-4 each week. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity.	Drug: Capivasertib; Given PO; Other Names: AZD5363 ; Drug: Olaparib; Given PO; Other Names: AZD 2281 AZD-2281 AZD2281 KU-0059436 Lynparza PARP Inhibitor AZD2281
Experimental: Arm V (olaparib, durvalumab) Patients receive olaparib PO BID on days 1-28 and durvalumab IV on day 1. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity.	Biological: Durvalumab; Given IV; Other Names: Imfinzi Immunoglobulin G1, Anti-(Human Protein B7-H1) (Human Monoclonal MEDI4736 Heavy Chain), Disulfide with Human Monoclonal MEDI4736 Kappa-chain, Dimer MEDI-4736 MEDI4736 ; Drug: Olaparib; Given PO; Other Names: AZD 2281 AZD-2281 AZD2281 KU-0059436 Lynparza PARP Inhibitor AZD2281
Experimental: Arm VI (cediranib maleate, durvalumab) Patients receive cediranib maleate PO BID on days 1-28 and durvalumab IV on day 1. Cycles repeat every 28 days in the absence of disease progression or unaccepted toxicity.	Drug: Cediranib Maleate; Given PO; Other Names: AZD2171 AZD2171 Maleate Recentin ; Biological: Durvalumab; Given IV; Other Names: Imfinzi Immunoglobulin G1, Anti-(Human Protein B7-H1) (Human Monoclonal MEDI4736 Heavy Chain), Disulfide with Human Monoclonal MEDI4736 Kappa-chain, Dimer MEDI-4736 MEDI4736

Outcome Measures

Primary Outcome Measures

1. Progression-free survival [From the date of study enrollment to the investigator-determined date of progression, or death due to any cause, whichever occurs first, assessed up to 5 years]

   Will be assessed by Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. Will be tested using pairwise log-rank tests stratified by the factors.

Secondary Outcome Measures

1. Overall survival [From the date of study enrollment to the date of death regardless of the cause, assessed up to 5 years]

   Will be tested using pairwise log-rank tests stratified by the factors.

2. Objective tumor response [Up to 5 years]

   Will be assessed by RECIST version 1.1. Will be tested using pairwise Cochran-Mantel-Haenszel tests stratified by the factors.

3. Incidence of adverse events [Up to 5 years]

   The frequency and severity of adverse effects are defined using Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.

Other Outcome Measures

1. Mutations in deoxyribonucleic acid (DNA) Homologous Repair Genes [Up to 5 years]

2. Markers of angiogenesis in serial plasma samples [Up to 5 years]

   Will assess if markers of angiogenesis in serial plasma samples are associated with response to cediranib alone or in combination with olaparib.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: Female
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Patients must have recurrent or persistent endometrial carcinoma, which is refractory to curative therapy or established treatments; histologic confirmation of the original primary tumor is required; patients with the following histologic epithelial cell types are eligible: endometrioid adenocarcinoma, serous adenocarcinoma, undifferentiated carcinoma, mixed epithelial carcinoma, adenocarcinoma not otherwise specified (N.O.S.); NOTE: clear cell histology is excluded

• Patients must have evaluable disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or non-measurable (detectable) disease

• Measurable disease is defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded); each lesion must be >= 10 mm when measured by computed tomography (CT), magnetic resonance imaging (MRI) or caliper measurement by clinical exam; or >= 20 mm when measured by chest x-ray; lymph nodes must be > 15 mm in short axis when measured by CT or MRI; patients with measurable disease must have at least one "target lesion" to be used to assess response on this protocol as defined by RECIST version 1.1; tumors within a previously irradiated field will be designated as "non-target" lesions unless progression is documented or a biopsy is obtained to confirm persistence at least 90 days following completion of radiation therapy

• Non-measurable (detectable) disease in a patient is defined in this protocol as one who does not have measurable disease but has at least one of the following conditions:

• Ascites and/or pleural effusion attributed to tumor;

• Solid and/or cystic abnormalities on radiographic imaging that do not meet RECIST 1.1 definitions for target lesions

• Patients must have signed an approved informed consent and authorization permitting release of personal health information

• Patients must have had one prior chemotherapeutic regimen for management of endometrial carcinoma; initial treatment may include chemotherapy, chemotherapy and radiation therapy, and/or consolidation/maintenance therapy; chemotherapy administered in conjunction with primary radiation as a radio-sensitizer WILL be counted as a systemic chemotherapy regimen

• Patients are allowed to receive, but are not required to receive, one additional cytotoxic regimen for management of recurrent or persistent disease according to the following definition: cytotoxic regimens include any agent that targets the genetic and/or mitotic apparatus of dividing cells, resulting in dose-limiting toxicity to the bone marrow and/or gastrointestinal mucosa; Note: patients on this non-cytotoxic study are allowed to receive one additional cytotoxic chemotherapy regimen for management of recurrent or persistent disease, as defined above; however, patients are encouraged to enroll on second-line non-cytotoxic studies prior to receiving additional cytotoxic therapy

• Patients may have received non cytotoxic therapy including immunotherapy (1 prior line in either upfront or recurrent setting) but excluding cediranib, olaparib, AZD5363 (capivasertib), durvalumab (MEDI4736), or the combination of lenvatinib and pembrolizumab for the management of recurrent or persistent disease; prior hormonal therapy is allowed; hormonal therapy for grade 1 endometrial cancers with low volume or indolent disease is encouraged

• Bevacizumab, or one course of single-agent immune-checkpoint therapy, excluding durvalumab (MEDI4736), is permitted prior to enrollment on this trial

• Body weight > 30 kg

• Age >= 18

• The trial is open to females only (including women with an intact uterus with uterine cancer); fertile females of childbearing potential need to agree to use adequate contraceptive measures from 2 weeks prior to the study and until 1 month after study treatment discontinuation, and have a negative serum or urine pregnancy test within 3 days prior to the start of study treatment

• Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0,1 or 2 (Karnofsky >= 60%) within 7 days prior to registration; patients should have no deterioration over the previous two weeks

• Hemoglobin >= 10 mg/dL with no blood transfusion in the past 28 days (within 28 days prior to administration of study drug)

• Platelet count >= 100 x 10^9/L (within 28 days prior to administration of study drug)

• Absolute neutrophil count (ANC) >= 1.5 x 10^9/L (within 28 days prior to administration of study drug)

• Patients must have creatinine clearance estimated of >= 51 mL/min using the Cockcroft Gault equation or based on a 24-hour urine test (within 28 days prior to administration of study drug)

• Serum bilirubin =< 1.5 X upper limit of normal (ULN) (within 28 days prior to administration of study drug)

• Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x ULN (within 28 days prior to administration of study drug)

• Urine protein: creatinine (UPC) < 1 or < 2+ proteinuria on two consecutive dipsticks taken no less than 1 week apart. Patients with 2+ proteinuria on dipstick must also have UPC < 0.5 on 2 consecutive samples (within 28 days prior to administration of study drug)

• Patients must be able to swallow and retain oral medications and without gastrointestinal illnesses that would preclude absorption of cediranib, olaparib, or AZD5363 (capivasertib)

• Patients must have adequately controlled blood pressure (BP), with a BP no greater than 140 mmHg (systolic) and 90 mmHg (diastolic) for eligibility; patients must have a BP of =< 140/90 mmHg taken in the clinic setting by a medical professional within 2 weeks prior to starting study; patients with hypertension may be managed with up to a maximum of three antihypertensive medications; it is strongly recommended that patients who are on three antihypertensive medications be followed by a cardiologist or blood pressure specialist for management of blood pressure while on protocol

• Note: Patients must be willing and able to check and record daily blood pressure readings

• The patient or a legally authorized representative must provide study-specific informed consent prior to study entry

• Adequately controlled thyroid function, with no symptoms of thyroid dysfunction

• Postmenopausal or evidence of non-childbearing status for women of childbearing potential as confirmed by a negative urine or serum pregnancy test within 7 days prior to start of investigational products (IPs); postmenopausal is defined as:

• Age >= 60 years, or

• Age < 60 with any one or more of the conditions below:

• Amenorrheic for >= 1 year in the absence of chemotherapy and/or hormonal treatments,

• Luteinizing hormone and/or follicle stimulating hormone and/or estradiol levels in the post-menopausal range

• Radiation-induced oophorectomy with last menses > 1 year ago,

• Chemotherapy-induced menopause with > 1 year interval since last menses,

• Surgical sterilization (bilateral oophorectomy or hysterectomy)

• Patients must have a life expectancy of greater than 16 weeks

• Patients with a previous diagnosis of immune or inflammatory colitis or chronic diarrhea > 1 month without immune or inflammatory colitis are eligible with adequately controlled colitis (no diarrhea greater than grade 1 for at least 28 days) and in the absence of symptoms related to colonic dysfunction; patients who required steroids for prior immune related colitis are not eligible

• Females of child-bearing potential should use two forms of highly reliable methods of contraception from the time of screening until 4 weeks after discontinuing study treatment.

• Acceptable methods of contraception include:

• Established use of oral, injected or implanted hormonal methods of contraception.

• Placement of an intrauterine device or intrauterine system.

• Barrier methods of contraception: condom or occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/suppository.

• Male partner sterilization (with the appropriate post-vasectomy documentation of the absence of sperm in the ejaculate).

• True abstinence (i.e., not engaging in sexual activity for the total duration of study treatment and the treatment washout period is an acceptable practice; however, periodic abstinence, the rhythm method, and the withdrawal method are not acceptable methods of birth control).

• Bilateral tubal occlusion or salpingectomy

• Acceptable non-hormonal birth control methods include:

• Total/True abstinence: When the patient refrains from any form of sexual intercourse and this is in line with their usual and/or preferred lifestyle; this must continue for the total duration of the trial and for at least 1 month after the last dose of study drug <<for 3 months after last dose for male patients>>. [Periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods, or declaration of abstinence solely for the duration of a trial) and withdrawal are not acceptable methods of contraception]

• Vasectomised sexual partner PLUS male condom. With participant assurance that partner received post-vasectomy confirmation of azoospermia.

• Tubal occlusion PLUS male condom

• Intrauterine device (IUD) PLUS male condom. Provided coils are copper-banded.

• Acceptable hormonal methods:

• Normal and low dose combined oral pills PLUS male condom.

• Cerazette (desogestrel) PLUS male condom. Cerazette is currently the only highly efficacious progesterone-based pill.

• Hormonal shot or injection (e.g., Depo-Provera) PLUS male condom.

• Etonogestrel implants (e.g., Implanon, Norplant) PLUS male condom.

• Norelgestromin/EE transdermal system PLUS male condom

• Intrauterine system [IUS] device (e.g., levonorgestrel releasing IUS -Mirena) PLUS male condom.

• Intravaginal device (e.g., EE and etonogestrel) PLUS male condom

Exclusion Criteria:

• Prior enrollment into a clinical trial including cediranib or olaparib; Note: prior bevacizumab is not an exclusion criterion

• Prior enrollment into a clinical trial including cediranib, olaparib, AZD5363 (capivasertib), durvalumab (MEDI4736), or the combination of lenvatinib and pembrolizumab. Note: Prior bevacizumab or single-agent immune checkpoint blockade, excluding durvalumab (MEDI4736), is not an exclusion criterion

• Prior chemotherapy, endocrine therapy, radiotherapy, or investigational agents within 4 weeks

• More than one prior line of treatment with immune checkpoint blockade therapy

• Current signs/symptoms of bowel obstruction and/or signs/symptoms of bowel obstruction within the preceding 3 months

• History of gastrointestinal perforation; patients with a history of abdominal fistula will be considered eligible if the fistula was surgically repaired or has healed, there has been no evidence of fistula for at least 6 months, and patient is deemed to be at low risk of recurrent fistula

• Uncontrolled intercurrent illness including, but not limited to known ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, extensive interstitial bilateral lung disease on high resolution computed tomography (HRCT) scan or psychiatric illness/social situations that would limit compliance with study requirements

• Concomitant use of known strong cytochrome (CYP) 3A inhibitors (e.g., itraconazole, telithromycin, clarithromycin, protease inhibitors boosted with ritonavir or cobicistat, indinavir, saquinavir, nelfinavir, boceprevir, telaprevir) or moderate CYP3A inhibitors (e.g. ciprofloxacin, erythromycin, diltiazem, fluconazole, verapamil); the required washout period prior to starting study treatments is 2 weeks for strong inhibitors, and at least 1 week for moderate inhibitors

• Concomitant use of potent inhibitors or inducers of CYP3A4 within 2 weeks before the start of study treatment (3 weeks for St John's wort), or sensitive substrates of CYP3A4, CYP2C9 and/or CYP2D6 with a narrow therapeutic window within 1 week before the start of study treatment. Concomitant use of drugs known to prolong the QT interval within 5 half-lives of the first dose of study treatment

• Pregnant women are excluded from this study because cediranib and olaparib are agents with the potential for teratogenic or abortifacient effects; because there is an unknown but potential risk of adverse events in nursing infants secondary to treatment of the mother with cediranib and olaparib, breastfeeding should be discontinued if the mother is treated with cediranib or olaparib; these potential risks may also apply to other agents used in this study; for women of childbearing capacity a negative pregnancy test is required

• Known human immunodeficiency virus (HIV)-positive individuals are ineligible because of the potential for pharmacokinetic interactions between many anti-HIV drugs and cediranib, olaparib, and/or AZD5363 (capivasertib); in addition, these individuals are at increased risk of lethal infections when treated with marrow-suppressive therapy

• Known active hepatitis B or hepatitis C infection on antiviral treatment

• Prior history of stroke or transient ischemic attack within the last 6 months

• Left ventricular ejection fraction (LVEF) < lower limit of normal (LLN) per institutional guidelines, or < 55%, if threshold for normal not otherwise specified by institutional guidelines, for patients with the following risk factors:

• Prior treatment with anthracyclines

• Prior treatment with trastuzumab

• Prior central thoracic radiation therapy (RT), including exposure of heart to therapeutic doses of ionizing RT

• History of myocardial infarction within 6-12 months prior to start of IPs

• Prior history of other significant impaired cardiac function

• Patients with any of the following:

• History of myocardial infarction within 6 months prior to starting treatment

• Unstable angina

• Resting electrocardiogram (ECG) with clinically significant abnormal findings or with corrected QT interval (QTc) > 470 msec on 2 or more time points within a 24 hour period or family history of long QT syndrome

• New York Heart Association functional classification of III or IV

• Prior history of hypertensive crisis or hypertensive encephalopathy

• Major surgical procedure within 4 weeks prior to starting treatment; patients must have recovered from any effects of any major surgery and surgical wound should have healed prior to starting treatment

• History of intra-abdominal abscess within 3 months prior to starting treatment

• Patients may not use any complementary or alternative medicines including natural herbal products or folk remedies as they may interfere with the effectiveness of the study treatments

• No prior allogeneic bone marrow transplant or double umbilical cord blood transplant

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	United States	35233
2	Anchorage Associates in Radiation Medicine	Anchorage	Alaska	United States	98508
3	Anchorage Radiation Therapy Center	Anchorage	Alaska	United States	99504
4	Alaska Breast Care and Surgery LLC	Anchorage	Alaska	United States	99508
5	Alaska Oncology and Hematology LLC	Anchorage	Alaska	United States	99508
6	Alaska Women's Cancer Care	Anchorage	Alaska	United States	99508
7	Anchorage Oncology Centre	Anchorage	Alaska	United States	99508
8	Katmai Oncology Group	Anchorage	Alaska	United States	99508
9	Providence Alaska Medical Center	Anchorage	Alaska	United States	99508
10	Fairbanks Memorial Hospital	Fairbanks	Alaska	United States	99701
11	CTCA at Western Regional Medical Center	Goodyear	Arizona	United States	85338
12	Kingman Regional Medical Center	Kingman	Arizona	United States	86401
13	Cancer Center at Saint Joseph's	Phoenix	Arizona	United States	85004
14	Mayo Clinic Hospital in Arizona	Phoenix	Arizona	United States	85054
15	Mayo Clinic in Arizona	Scottsdale	Arizona	United States	85259
16	University of Arizona Cancer Center-Orange Grove Campus	Tucson	Arizona	United States	85704
17	Banner University Medical Center - Tucson	Tucson	Arizona	United States	85719
18	University of Arizona Cancer Center-North Campus	Tucson	Arizona	United States	85719
19	Mercy Hospital Fort Smith	Fort Smith	Arkansas	United States	72903
20	CHI Saint Vincent Cancer Center Hot Springs	Hot Springs	Arkansas	United States	71913
21	University of Arkansas for Medical Sciences	Little Rock	Arkansas	United States	72205
22	Kaiser Permanente-Anaheim	Anaheim	California	United States	92806
23	Mission Hope Medical Oncology - Arroyo Grande	Arroyo Grande	California	United States	93420
24	PCR Oncology	Arroyo Grande	California	United States	93420
25	Sutter Auburn Faith Hospital	Auburn	California	United States	95602
26	Sutter Cancer Centers Radiation Oncology Services-Auburn	Auburn	California	United States	95603
27	Kaiser Permanente-Baldwin Park	Baldwin Park	California	United States	91706
28	Kaiser Permanente-Bellflower	Bellflower	California	United States	90706
29	Alta Bates Summit Medical Center-Herrick Campus	Berkeley	California	United States	94704
30	Tower Cancer Research Foundation	Beverly Hills	California	United States	90211
31	Providence Saint Joseph Medical Center/Disney Family Cancer Center	Burbank	California	United States	91505
32	Mills-Peninsula Medical Center	Burlingame	California	United States	94010
33	Sutter Cancer Centers Radiation Oncology Services-Cameron Park	Cameron Park	California	United States	95682
34	Mercy San Juan Medical Center	Carmichael	California	United States	95608
35	Eden Hospital Medical Center	Castro Valley	California	United States	94546
36	Sutter Davis Hospital	Davis	California	United States	95616
37	Mercy Cancer Center - Elk Grove	Elk Grove	California	United States	95758
38	Kaiser Permanente-Fontana	Fontana	California	United States	92335
39	Palo Alto Medical Foundation-Fremont	Fremont	California	United States	94538
40	Kaiser Permanente - Harbor City	Harbor City	California	United States	90710
41	Kaiser Permanente-Irvine	Irvine	California	United States	92618
42	Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	United States	90027
43	Kaiser Permanente West Los Angeles	Los Angeles	California	United States	90034
44	Cedars Sinai Medical Center	Los Angeles	California	United States	90048
45	Memorial Medical Center	Modesto	California	United States	95355
46	Palo Alto Medical Foundation-Camino Division	Mountain View	California	United States	94040
47	Palo Alto Medical Foundation-Gynecologic Oncology	Mountain View	California	United States	94040
48	Providence Queen of The Valley	Napa	California	United States	94558
49	Sutter Cancer Research Consortium	Novato	California	United States	94945
50	Kaiser Permanente-Ontario	Ontario	California	United States	91761
51	Palo Alto Medical Foundation Health Care	Palo Alto	California	United States	94301
52	Kaiser Permanente - Panorama City	Panorama City	California	United States	91402
53	Kaiser Permanente-Riverside	Riverside	California	United States	92505
54	Mercy Cancer Center - Rocklin	Rocklin	California	United States	95765
55	Sutter Cancer Centers Radiation Oncology Services-Roseville	Roseville	California	United States	95661
56	Sutter Roseville Medical Center	Roseville	California	United States	95661
57	Mercy Cancer Center - Sacramento	Sacramento	California	United States	95816
58	Sutter Medical Center Sacramento	Sacramento	California	United States	95816
59	Kaiser Permanente-San Diego Mission	San Diego	California	United States	92108
60	Kaiser Permanente-San Diego Zion	San Diego	California	United States	92120
61	California Pacific Medical Center-Pacific Campus	San Francisco	California	United States	94115
62	Pacific Central Coast Health Center-San Luis Obispo	San Luis Obispo	California	United States	93401
63	Kaiser Permanente-San Marcos	San Marcos	California	United States	92078
64	Palo Alto Medical Foundation-Santa Cruz	Santa Cruz	California	United States	95065
65	Mission Hope Medical Oncology - Santa Maria	Santa Maria	California	United States	93444
66	Providence Medical Foundation - Santa Rosa	Santa Rosa	California	United States	95403
67	Sutter Pacific Medical Foundation	Santa Rosa	California	United States	95403
68	Providence Santa Rosa Memorial Hospital	Santa Rosa	California	United States	95405
69	Palo Alto Medical Foundation-Sunnyvale	Sunnyvale	California	United States	94086
70	Torrance Memorial Physician Network - Cancer Care	Torrance	California	United States	90505
71	Sutter Cancer Centers Radiation Oncology Services-Vacaville	Vacaville	California	United States	95687
72	Sutter Solano Medical Center/Cancer Center	Vallejo	California	United States	94589
73	Kaiser Permanente-Woodland Hills	Woodland Hills	California	United States	91367
74	Woodland Memorial Hospital	Woodland	California	United States	95695
75	Rocky Mountain Cancer Centers-Aurora	Aurora	Colorado	United States	80012
76	The Medical Center of Aurora	Aurora	Colorado	United States	80012
77	University of Colorado Hospital	Aurora	Colorado	United States	80045
78	Boulder Community Hospital	Boulder	Colorado	United States	80301
79	Boulder Community Foothills Hospital	Boulder	Colorado	United States	80303
80	Rocky Mountain Cancer Centers-Boulder	Boulder	Colorado	United States	80304
81	Rocky Mountain Cancer Centers - Centennial	Centennial	Colorado	United States	80112
82	Penrose-Saint Francis Healthcare	Colorado Springs	Colorado	United States	80907
83	Rocky Mountain Cancer Centers-Penrose	Colorado Springs	Colorado	United States	80907
84	UCHealth Memorial Hospital Central	Colorado Springs	Colorado	United States	80909
85	Memorial Hospital North	Colorado Springs	Colorado	United States	80920
86	Saint Francis Cancer Center	Colorado Springs	Colorado	United States	80923
87	Denver Health Medical Center	Denver	Colorado	United States	80204
88	National Jewish Health-Main Campus	Denver	Colorado	United States	80206
89	The Women's Imaging Center	Denver	Colorado	United States	80209
90	Porter Adventist Hospital	Denver	Colorado	United States	80210
91	Colorado Blood Cancer Institute	Denver	Colorado	United States	80218
92	Presbyterian - Saint Lukes Medical Center - Health One	Denver	Colorado	United States	80218
93	Rocky Mountain Cancer Centers-Midtown	Denver	Colorado	United States	80218
94	SCL Health Saint Joseph Hospital	Denver	Colorado	United States	80218
95	Rocky Mountain Cancer Centers-Rose	Denver	Colorado	United States	80220
96	Rose Medical Center	Denver	Colorado	United States	80220
97	Western Surgical Care	Denver	Colorado	United States	80220
98	Mercy Medical Center	Durango	Colorado	United States	81301
99	Southwest Oncology PC	Durango	Colorado	United States	81301
100	Mountain Blue Cancer Care Center - Swedish	Englewood	Colorado	United States	80113
101	Rocky Mountain Cancer Centers - Swedish	Englewood	Colorado	United States	80113
102	Swedish Medical Center	Englewood	Colorado	United States	80113
103	The Melanoma and Skin Cancer Institute	Englewood	Colorado	United States	80113
104	Poudre Valley Hospital	Fort Collins	Colorado	United States	80524
105	Cancer Care and Hematology-Fort Collins	Fort Collins	Colorado	United States	80528
106	Mountain Blue Cancer Care Center	Golden	Colorado	United States	80401
107	National Jewish Health-Western Hematology Oncology	Golden	Colorado	United States	80401
108	Saint Mary's Hospital and Regional Medical Center	Grand Junction	Colorado	United States	81501
109	North Colorado Medical Center	Greeley	Colorado	United States	80631
110	UCHealth Greeley Hospital	Greeley	Colorado	United States	80631
111	Good Samaritan Medical Center	Lafayette	Colorado	United States	80026
112	Rocky Mountain Cancer Centers-Lakewood	Lakewood	Colorado	United States	80228
113	Saint Anthony Hospital	Lakewood	Colorado	United States	80228
114	Rocky Mountain Cancer Centers-Littleton	Littleton	Colorado	United States	80120
115	Littleton Adventist Hospital	Littleton	Colorado	United States	80122
116	Rocky Mountain Cancer Centers-Sky Ridge	Lone Tree	Colorado	United States	80124
117	Sky Ridge Medical Center	Lone Tree	Colorado	United States	80124
118	Longmont United Hospital	Longmont	Colorado	United States	80501
119	Rocky Mountain Cancer Centers-Longmont	Longmont	Colorado	United States	80501
120	Medical Center of the Rockies	Loveland	Colorado	United States	80538
121	McKee Medical Center	Loveland	Colorado	United States	80539
122	Parker Adventist Hospital	Parker	Colorado	United States	80138
123	Rocky Mountain Cancer Centers-Parker	Parker	Colorado	United States	80138
124	Saint Mary Corwin Medical Center	Pueblo	Colorado	United States	81004
125	Rocky Mountain Cancer Centers - Pueblo	Pueblo	Colorado	United States	81008
126	National Jewish Health-Northern Hematology Oncology	Thornton	Colorado	United States	80260
127	Rocky Mountain Cancer Centers-Thornton	Thornton	Colorado	United States	80260
128	SCL Health Lutheran Medical Center	Wheat Ridge	Colorado	United States	80033
129	Smilow Cancer Hospital-Derby Care Center	Derby	Connecticut	United States	06418
130	Smilow Cancer Hospital Care Center-Fairfield	Fairfield	Connecticut	United States	06824
131	Smilow Cancer Hospital Care Center - Guiford	Guilford	Connecticut	United States	06437
132	Hartford Hospital	Hartford	Connecticut	United States	06102
133	Smilow Cancer Hospital Care Center at Saint Francis	Hartford	Connecticut	United States	06105
134	The Hospital of Central Connecticut	New Britain	Connecticut	United States	06050
135	Smilow Cancer Center/Yale-New Haven Hospital	New Haven	Connecticut	United States	06510
136	Yale University	New Haven	Connecticut	United States	06520
137	Yale-New Haven Hospital North Haven Medical Center	North Haven	Connecticut	United States	06473
138	Smilow Cancer Hospital-Torrington Care Center	Torrington	Connecticut	United States	06790
139	Smilow Cancer Hospital Care Center-Trumbull	Trumbull	Connecticut	United States	06611
140	Smilow Cancer Hospital-Waterbury Care Center	Waterbury	Connecticut	United States	06708
141	Smilow Cancer Hospital Care Center - Waterford	Waterford	Connecticut	United States	06385
142	Beebe South Coastal Health Campus	Frankford	Delaware	United States	19945
143	Beebe Medical Center	Lewes	Delaware	United States	19958
144	Delaware Clinical and Laboratory Physicians PA	Newark	Delaware	United States	19713
145	Helen F Graham Cancer Center	Newark	Delaware	United States	19713
146	Medical Oncology Hematology Consultants PA	Newark	Delaware	United States	19713
147	Christiana Care Health System-Christiana Hospital	Newark	Delaware	United States	19718
148	Beebe Health Campus	Rehoboth Beach	Delaware	United States	19971
149	TidalHealth Nanticoke / Allen Cancer Center	Seaford	Delaware	United States	19973
150	Christiana Care Health System-Wilmington Hospital	Wilmington	Delaware	United States	19801
151	Sibley Memorial Hospital	Washington	District of Columbia	United States	20016
152	Florida Cancer Specialists - Bradenton	Bradenton	Florida	United States	34209
153	University of Florida Health Science Center - Gainesville	Gainesville	Florida	United States	32610
154	Sacred Heart Hospital	Pensacola	Florida	United States	32504
155	Florida Cancer Specialists - Sarasota	Sarasota	Florida	United States	34232
156	Florida Cancer Specialists - Sarasota Downtown	Sarasota	Florida	United States	34236
157	Sarasota Memorial Hospital	Sarasota	Florida	United States	34239
158	Florida Cancer Specialists - Venice Island	Venice	Florida	United States	34285
159	Florida Cancer Specialists - Venice Healthpark	Venice	Florida	United States	34292
160	Grady Health System	Atlanta	Georgia	United States	30303
161	Emory University Hospital Midtown	Atlanta	Georgia	United States	30308
162	Piedmont Hospital	Atlanta	Georgia	United States	30309
163	Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	United States	30322
164	Emory Saint Joseph's Hospital	Atlanta	Georgia	United States	30342
165	Piedmont Fayette Hospital	Fayetteville	Georgia	United States	30214
166	CTCA at Southeastern Regional Medical Center	Newnan	Georgia	United States	30265
167	Memorial Health University Medical Center	Savannah	Georgia	United States	31404
168	Summit Cancer Care-Memorial	Savannah	Georgia	United States	31404
169	Lewis Cancer and Research Pavilion at Saint Joseph's/Candler	Savannah	Georgia	United States	31405
170	Summit Cancer Care-Candler	Savannah	Georgia	United States	31405
171	Hawaii Cancer Care - Savio	'Aiea	Hawaii	United States	96701
172	Pali Momi Medical Center	'Aiea	Hawaii	United States	96701
173	Queen's Cancer Center - Pearlridge	'Aiea	Hawaii	United States	96701
174	The Cancer Center of Hawaii-Pali Momi	'Aiea	Hawaii	United States	96701
175	Hawaii Cancer Care Inc - Waterfront Plaza	Honolulu	Hawaii	United States	96813
176	Island Urology	Honolulu	Hawaii	United States	96813
177	Queen's Cancer Cenrer - POB I	Honolulu	Hawaii	United States	96813
178	Queen's Medical Center	Honolulu	Hawaii	United States	96813
179	Straub Clinic and Hospital	Honolulu	Hawaii	United States	96813
180	University of Hawaii Cancer Center	Honolulu	Hawaii	United States	96813
181	Hawaii Cancer Care Inc-Liliha	Honolulu	Hawaii	United States	96817
182	Kuakini Medical Center	Honolulu	Hawaii	United States	96817
183	Queen's Cancer Center - Kuakini	Honolulu	Hawaii	United States	96817
184	The Cancer Center of Hawaii-Liliha	Honolulu	Hawaii	United States	96817
185	Kapiolani Medical Center for Women and Children	Honolulu	Hawaii	United States	96826
186	Wilcox Memorial Hospital and Kauai Medical Clinic	Lihue	Hawaii	United States	96766
187	Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	United States	83706
188	Saint Luke's Cancer Institute - Boise	Boise	Idaho	United States	83712
189	Saint Alphonsus Cancer Care Center-Caldwell	Caldwell	Idaho	United States	83605
190	Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	United States	83814
191	Walter Knox Memorial Hospital	Emmett	Idaho	United States	83617
192	Saint Luke's Cancer Institute - Fruitland	Fruitland	Idaho	United States	83619
193	Idaho Urologic Institute-Meridian	Meridian	Idaho	United States	83642
194	Saint Luke's Cancer Institute - Meridian	Meridian	Idaho	United States	83642
195	Saint Alphonsus Medical Center-Nampa	Nampa	Idaho	United States	83686
196	Saint Luke's Cancer Institute - Nampa	Nampa	Idaho	United States	83686
197	Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	United States	83854
198	Kootenai Cancer Clinic	Sandpoint	Idaho	United States	83864
199	Saint Luke's Cancer Institute - Twin Falls	Twin Falls	Idaho	United States	83301
200	Saint Anthony's Health	Alton	Illinois	United States	62002
201	Rush - Copley Medical Center	Aurora	Illinois	United States	60504
202	Bromenn Lifecare Center	Bloomington	Illinois	United States	61701
203	Illinois CancerCare-Bloomington	Bloomington	Illinois	United States	61704
204	Illinois CancerCare-Canton	Canton	Illinois	United States	61520
205	Memorial Hospital of Carbondale	Carbondale	Illinois	United States	62902
206	SIH Cancer Institute	Carterville	Illinois	United States	62918
207	Illinois CancerCare-Carthage	Carthage	Illinois	United States	62321
208	Centralia Oncology Clinic	Centralia	Illinois	United States	62801
209	Northwestern University	Chicago	Illinois	United States	60611
210	John H Stroger Jr Hospital of Cook County	Chicago	Illinois	United States	60612
211	Rush University Medical Center	Chicago	Illinois	United States	60612
212	University of Chicago Comprehensive Cancer Center	Chicago	Illinois	United States	60637
213	Carle on Vermilion	Danville	Illinois	United States	61832
214	Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	United States	62526
215	Decatur Memorial Hospital	Decatur	Illinois	United States	62526
216	Illinois CancerCare-Dixon	Dixon	Illinois	United States	61021
217	Carle Physician Group-Effingham	Effingham	Illinois	United States	62401
218	Crossroads Cancer Center	Effingham	Illinois	United States	62401
219	Illinois CancerCare-Eureka	Eureka	Illinois	United States	61530
220	NorthShore University HealthSystem-Evanston Hospital	Evanston	Illinois	United States	60201
221	Illinois CancerCare-Galesburg	Galesburg	Illinois	United States	61401
222	Western Illinois Cancer Treatment Center	Galesburg	Illinois	United States	61401
223	Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	United States	60134
224	NorthShore University HealthSystem-Glenbrook Hospital	Glenview	Illinois	United States	60026
225	Ingalls Memorial Hospital	Harvey	Illinois	United States	60426
226	NorthShore University HealthSystem-Highland Park Hospital	Highland Park	Illinois	United States	60035
227	Sudarshan K Sharma MD Limited-Gynecologic Oncology	Hinsdale	Illinois	United States	60521
228	Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	United States	61443
229	Northwestern Medicine Lake Forest Hospital	Lake Forest	Illinois	United States	60045
230	Illinois CancerCare-Macomb	Macomb	Illinois	United States	61455
231	Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	United States	61938
232	Good Samaritan Regional Health Center	Mount Vernon	Illinois	United States	62864
233	UC Comprehensive Cancer Center at Silver Cross	New Lenox	Illinois	United States	60451
234	Bromenn Regional Medical Center	Normal	Illinois	United States	61761
235	Carle Cancer Institute Normal	Normal	Illinois	United States	61761
236	Cancer Care Center of O'Fallon	O'Fallon	Illinois	United States	62269
237	University of Chicago Medicine-Orland Park	Orland Park	Illinois	United States	60462
238	Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	United States	61350
239	Illinois CancerCare-Pekin	Pekin	Illinois	United States	61554
240	Illinois CancerCare-Peoria	Peoria	Illinois	United States	61615
241	Methodist Medical Center of Illinois	Peoria	Illinois	United States	61636
242	Illinois CancerCare-Peru	Peru	Illinois	United States	61354
243	Valley Radiation Oncology	Peru	Illinois	United States	61354
244	Illinois CancerCare-Princeton	Princeton	Illinois	United States	61356
245	Southern Illinois University School of Medicine	Springfield	Illinois	United States	62702
246	Springfield Clinic	Springfield	Illinois	United States	62702
247	Memorial Medical Center	Springfield	Illinois	United States	62781
248	Southwest Illinois Health Services LLP	Swansea	Illinois	United States	62226
249	Carle Cancer Center	Urbana	Illinois	United States	61801
250	The Carle Foundation Hospital	Urbana	Illinois	United States	61801
251	Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	United States	60555
252	Illinois CancerCare - Washington	Washington	Illinois	United States	61571
253	Rush-Copley Healthcare Center	Yorkville	Illinois	United States	60560
254	Midwestern Regional Medical Center	Zion	Illinois	United States	60099
255	Parkview Hospital Randallia	Fort Wayne	Indiana	United States	46805
256	Parkview Regional Medical Center	Fort Wayne	Indiana	United States	46845
257	Indiana University/Melvin and Bren Simon Cancer Center	Indianapolis	Indiana	United States	46202
258	Sidney and Lois Eskenazi Hospital	Indianapolis	Indiana	United States	46202
259	Saint Vincent Hospital and Health Care Center	Indianapolis	Indiana	United States	46260
260	Reid Health	Richmond	Indiana	United States	47374
261	Medical Oncology and Hematology Associates-West Des Moines	Clive	Iowa	United States	50325
262	Mercy Cancer Center-West Lakes	Clive	Iowa	United States	50325
263	Alegent Health Mercy Hospital	Council Bluffs	Iowa	United States	51503
264	Greater Regional Medical Center	Creston	Iowa	United States	50801
265	Iowa Methodist Medical Center	Des Moines	Iowa	United States	50309
266	Medical Oncology and Hematology Associates-Des Moines	Des Moines	Iowa	United States	50309
267	Broadlawns Medical Center	Des Moines	Iowa	United States	50314
268	Medical Oncology and Hematology Associates-Laurel	Des Moines	Iowa	United States	50314
269	Mercy Medical Center - Des Moines	Des Moines	Iowa	United States	50314
270	Iowa Lutheran Hospital	Des Moines	Iowa	United States	50316
271	Trinity Regional Medical Center	Fort Dodge	Iowa	United States	50501
272	University of Iowa/Holden Comprehensive Cancer Center	Iowa City	Iowa	United States	52242
273	Methodist West Hospital	West Des Moines	Iowa	United States	50266-7700
274	Mercy Medical Center-West Lakes	West Des Moines	Iowa	United States	50266
275	Central Care Cancer Center - Garden City	Garden City	Kansas	United States	67846
276	Central Care Cancer Center - Great Bend	Great Bend	Kansas	United States	67530
277	Associates In Womens Health	Wichita	Kansas	United States	67208
278	Cancer Center of Kansas-Wichita Medical Arts Tower	Wichita	Kansas	United States	67208
279	Ascension Via Christi Hospitals Wichita	Wichita	Kansas	United States	67214
280	Cancer Center of Kansas - Wichita	Wichita	Kansas	United States	67214
281	Flaget Memorial Hospital	Bardstown	Kentucky	United States	40004
282	Baptist Health Corbin	Corbin	Kentucky	United States	40701
283	Commonwealth Cancer Center-Corbin	Corbin	Kentucky	United States	40701
284	Saint Elizabeth Healthcare Edgewood	Edgewood	Kentucky	United States	41017
285	Baptist Health Lexington	Lexington	Kentucky	United States	40503
286	Saint Joseph Radiation Oncology Resource Center	Lexington	Kentucky	United States	40504
287	Saint Joseph Hospital East	Lexington	Kentucky	United States	40509
288	Saint Joseph London	London	Kentucky	United States	40741
289	Jewish Hospital	Louisville	Kentucky	United States	40202
290	Baptist Health Louisville	Louisville	Kentucky	United States	40207
291	Saints Mary and Elizabeth Hospital	Louisville	Kentucky	United States	40215
292	UofL Health Medical Center Northeast	Louisville	Kentucky	United States	40245
293	Baptist Health Madisonville/Merle Mahr Cancer Center	Madisonville	Kentucky	United States	42431
294	Baptist Health Paducah	Paducah	Kentucky	United States	42003
295	Baptist Health Richmond	Richmond	Kentucky	United States	40475
296	Jewish Hospital Medical Center South	Shepherdsville	Kentucky	United States	40165
297	Mary Bird Perkins Cancer Center	Baton Rouge	Louisiana	United States	70809
298	Women's Cancer Care-Covington	Covington	Louisiana	United States	70433
299	Ochsner Baptist Medical Center	New Orleans	Louisiana	United States	70115
300	Ochsner Medical Center Jefferson	New Orleans	Louisiana	United States	70121
301	Eastern Maine Medical Center	Bangor	Maine	United States	04401
302	Lafayette Family Cancer Center-EMMC	Brewer	Maine	United States	04412
303	Maine Medical Center- Scarborough Campus	Scarborough	Maine	United States	04074
304	Greater Baltimore Medical Center	Baltimore	Maryland	United States	21204
305	Johns Hopkins University/Sidney Kimmel Cancer Center	Baltimore	Maryland	United States	21287
306	Walter Reed National Military Medical Center	Bethesda	Maryland	United States	20889-5600
307	University of Maryland Shore Medical Center at Easton	Easton	Maryland	United States	21601
308	Beverly Hospital	Beverly	Massachusetts	United States	01915
309	Lahey Hospital and Medical Center	Burlington	Massachusetts	United States	01805
310	Addison Gilbert Hospital	Gloucester	Massachusetts	United States	01930
311	Lahey Medical Center-Peabody	Peabody	Massachusetts	United States	01960
312	Baystate Medical Center	Springfield	Massachusetts	United States	01199
313	Winchester Hospital	Winchester	Massachusetts	United States	01890
314	UMass Memorial Medical Center - Memorial Division	Worcester	Massachusetts	United States	01605
315	University of Michigan Comprehensive Cancer Center	Ann Arbor	Michigan	United States	48109
316	Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	United States	48201
317	Weisberg Cancer Treatment Center	Farmington Hills	Michigan	United States	48334
318	Huron Medical Center PC	Port Huron	Michigan	United States	48060
319	Lake Huron Medical Center	Port Huron	Michigan	United States	48060
320	Riverwood Healthcare Center	Aitkin	Minnesota	United States	56431
321	Essentia Health - Baxter Clinic	Baxter	Minnesota	United States	56425
322	Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	United States	56601
323	Essentia Health Saint Joseph's Medical Center	Brainerd	Minnesota	United States	56401
324	Fairview Ridges Hospital	Burnsville	Minnesota	United States	55337
325	Minnesota Oncology - Burnsville	Burnsville	Minnesota	United States	55337
326	Cambridge Medical Center	Cambridge	Minnesota	United States	55008
327	Mercy Hospital	Coon Rapids	Minnesota	United States	55433
328	Essentia Health - Deer River Clinic	Deer River	Minnesota	United States	56636
329	Essentia Health Saint Mary's - Detroit Lakes Clinic	Detroit Lakes	Minnesota	United States	56501
330	Essentia Health Cancer Center	Duluth	Minnesota	United States	55805
331	Essentia Health Saint Mary's Medical Center	Duluth	Minnesota	United States	55805
332	Miller-Dwan Hospital	Duluth	Minnesota	United States	55805
333	Fairview Southdale Hospital	Edina	Minnesota	United States	55435
334	Essentia Health - Ely Clinic	Ely	Minnesota	United States	55731
335	Lake Region Healthcare Corporation-Cancer Care	Fergus Falls	Minnesota	United States	56537
336	Essentia Health - Fosston	Fosston	Minnesota	United States	56542
337	Unity Hospital	Fridley	Minnesota	United States	55432
338	Essentia Health Hibbing Clinic	Hibbing	Minnesota	United States	55746
339	Essentia Health - International Falls Clinic	International Falls	Minnesota	United States	56649
340	Fairview Clinics and Surgery Center Maple Grove	Maple Grove	Minnesota	United States	55369
341	Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	United States	55109
342	Saint John's Hospital - Healtheast	Maplewood	Minnesota	United States	55109
343	Abbott-Northwestern Hospital	Minneapolis	Minnesota	United States	55407
344	Hennepin County Medical Center	Minneapolis	Minnesota	United States	55415
345	Health Partners Inc	Minneapolis	Minnesota	United States	55454
346	Monticello Cancer Center	Monticello	Minnesota	United States	55362
347	Essentia Health - Moose Lake Clinic	Moose Lake	Minnesota	United States	55767
348	New Ulm Medical Center	New Ulm	Minnesota	United States	56073
349	Essentia Health - Park Rapids	Park Rapids	Minnesota	United States	56470
350	Fairview Northland Medical Center	Princeton	Minnesota	United States	55371
351	North Memorial Medical Health Center	Robbinsdale	Minnesota	United States	55422
352	Mayo Clinic in Rochester	Rochester	Minnesota	United States	55905
353	Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	United States	55416
354	Regions Hospital	Saint Paul	Minnesota	United States	55101
355	United Hospital	Saint Paul	Minnesota	United States	55102
356	Essentia Health Sandstone	Sandstone	Minnesota	United States	55072
357	Saint Francis Regional Medical Center	Shakopee	Minnesota	United States	55379
358	Lakeview Hospital	Stillwater	Minnesota	United States	55082
359	Sanford Thief River Falls Medical Center	Thief River Falls	Minnesota	United States	56701
360	Essentia Health Virginia Clinic	Virginia	Minnesota	United States	55792
361	Ridgeview Medical Center	Waconia	Minnesota	United States	55387
362	Rice Memorial Hospital	Willmar	Minnesota	United States	56201
363	Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	United States	55125
364	Sanford Cancer Center Worthington	Worthington	Minnesota	United States	56187
365	Fairview Lakes Medical Center	Wyoming	Minnesota	United States	55092
366	University of Mississippi Medical Center	Jackson	Mississippi	United States	39216
367	Saint Louis Cancer and Breast Institute-Ballwin	Ballwin	Missouri	United States	63011
368	Central Care Cancer Center - Bolivar	Bolivar	Missouri	United States	65613
369	Parkland Health Center-Bonne Terre	Bonne Terre	Missouri	United States	63628
370	Cox Cancer Center Branson	Branson	Missouri	United States	65616
371	Saint Francis Medical Center	Cape Girardeau	Missouri	United States	63703
372	Southeast Cancer Center	Cape Girardeau	Missouri	United States	63703
373	University of Missouri - Ellis Fischel	Columbia	Missouri	United States	65212
374	Parkland Health Center - Farmington	Farmington	Missouri	United States	63640
375	Capital Region Southwest Campus	Jefferson City	Missouri	United States	65109
376	Freeman Health System	Joplin	Missouri	United States	64804
377	Mercy Hospital Joplin	Joplin	Missouri	United States	64804
378	Delbert Day Cancer Institute at PCRMC	Rolla	Missouri	United States	65401
379	Mercy Clinic-Rolla-Cancer and Hematology	Rolla	Missouri	United States	65401
380	Heartland Regional Medical Center	Saint Joseph	Missouri	United States	64506
381	Saint Louis Cancer and Breast Institute-South City	Saint Louis	Missouri	United States	63109
382	Washington University School of Medicine	Saint Louis	Missouri	United States	63110
383	Mercy Hospital South	Saint Louis	Missouri	United States	63128
384	Missouri Baptist Medical Center	Saint Louis	Missouri	United States	63131
385	Mercy Hospital Saint Louis	Saint Louis	Missouri	United States	63141
386	Sainte Genevieve County Memorial Hospital	Sainte Genevieve	Missouri	United States	63670
387	Mercy Hospital Springfield	Springfield	Missouri	United States	65804
388	CoxHealth South Hospital	Springfield	Missouri	United States	65807
389	Missouri Baptist Sullivan Hospital	Sullivan	Missouri	United States	63080
390	Missouri Baptist Outpatient Center-Sunset Hills	Sunset Hills	Missouri	United States	63127
391	Mercy Hospital Washington	Washington	Missouri	United States	63090
392	Community Hospital of Anaconda	Anaconda	Montana	United States	59711
393	Billings Clinic Cancer Center	Billings	Montana	United States	59101
394	Saint Vincent Healthcare	Billings	Montana	United States	59101
395	Saint Vincent Frontier Cancer Center	Billings	Montana	United States	59102
396	Bozeman Deaconess Hospital	Bozeman	Montana	United States	59715
397	Saint James Community Hospital and Cancer Treatment Center	Butte	Montana	United States	59701
398	Benefis Healthcare- Sletten Cancer Institute	Great Falls	Montana	United States	59405
399	Great Falls Clinic	Great Falls	Montana	United States	59405
400	Saint Peter's Community Hospital	Helena	Montana	United States	59601
401	Kalispell Regional Medical Center	Kalispell	Montana	United States	59901
402	Saint Patrick Hospital - Community Hospital	Missoula	Montana	United States	59802
403	Community Medical Hospital	Missoula	Montana	United States	59804
404	CHI Health Saint Francis	Grand Island	Nebraska	United States	68803
405	Heartland Hematology and Oncology	Kearney	Nebraska	United States	68845
406	CHI Health Good Samaritan	Kearney	Nebraska	United States	68847
407	Saint Elizabeth Regional Medical Center	Lincoln	Nebraska	United States	68510
408	Nebraska Cancer Specialists/Oncology Hematology West PC - MECC	Omaha	Nebraska	United States	68114
409	Nebraska Methodist Hospital	Omaha	Nebraska	United States	68114
410	Oncology Associates PC	Omaha	Nebraska	United States	68114
411	Nebraska Medicine-Village Pointe	Omaha	Nebraska	United States	68118
412	Alegent Health Immanuel Medical Center	Omaha	Nebraska	United States	68122
413	Hematology and Oncology Consultants PC	Omaha	Nebraska	United States	68122
414	Alegent Health Bergan Mercy Medical Center	Omaha	Nebraska	United States	68124
415	Alegent Health Lakeside Hospital	Omaha	Nebraska	United States	68130
416	Creighton University Medical Center	Omaha	Nebraska	United States	68131
417	University of Nebraska Medical Center	Omaha	Nebraska	United States	68198
418	Midlands Community Hospital	Papillion	Nebraska	United States	68046
419	Carson Tahoe Regional Medical Center	Carson City	Nevada	United States	89703
420	Cancer and Blood Specialists-Henderson	Henderson	Nevada	United States	89052
421	Comprehensive Cancer Centers of Nevada - Henderson	Henderson	Nevada	United States	89052
422	Comprehensive Cancer Centers of Nevada-Horizon Ridge	Henderson	Nevada	United States	89052
423	Las Vegas Cancer Center-Henderson	Henderson	Nevada	United States	89052
424	OptumCare Cancer Care at Seven Hills	Henderson	Nevada	United States	89052
425	Comprehensive Cancer Centers of Nevada-Southeast Henderson	Henderson	Nevada	United States	89074
426	GenesisCare USA - Henderson	Henderson	Nevada	United States	89074
427	Las Vegas Urology - Green Valley	Henderson	Nevada	United States	89074
428	Las Vegas Urology - Pebble	Henderson	Nevada	United States	89074
429	Urology Specialists of Nevada - Green Valley	Henderson	Nevada	United States	89074
430	Las Vegas Urology - Pecos	Las Vegas	Nevada	United States	89074
431	Desert West Surgery	Las Vegas	Nevada	United States	89102
432	OptumCare Cancer Care at Charleston	Las Vegas	Nevada	United States	89102
433	University Medical Center of Southern Nevada	Las Vegas	Nevada	United States	89102
434	Hope Cancer Care of Nevada	Las Vegas	Nevada	United States	89103
435	Cancer and Blood Specialists-Shadow	Las Vegas	Nevada	United States	89106
436	Radiation Oncology Centers of Nevada Central	Las Vegas	Nevada	United States	89106
437	Urology Specialists of Nevada - Central	Las Vegas	Nevada	United States	89106
438	Women's Cancer Center of Nevada	Las Vegas	Nevada	United States	89106
439	GenesisCare USA - Las Vegas	Las Vegas	Nevada	United States	89109
440	HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway	Las Vegas	Nevada	United States	89109
441	Sunrise Hospital and Medical Center	Las Vegas	Nevada	United States	89109
442	HealthCare Partners Medical Group Oncology/Hematology-San Martin	Las Vegas	Nevada	United States	89113
443	Las Vegas Prostate Cancer Center	Las Vegas	Nevada	United States	89113
444	Las Vegas Urology - Sunset	Las Vegas	Nevada	United States	89113
445	Urology Specialists of Nevada - Southwest	Las Vegas	Nevada	United States	89113
446	Radiation Oncology Centers of Nevada Southeast	Las Vegas	Nevada	United States	89119
447	Ann M Wierman MD LTD	Las Vegas	Nevada	United States	89128
448	Cancer and Blood Specialists-Tenaya	Las Vegas	Nevada	United States	89128
449	Comprehensive Cancer Centers of Nevada - Northwest	Las Vegas	Nevada	United States	89128
450	GenesisCare USA - Vegas Tenaya	Las Vegas	Nevada	United States	89128
451	HealthCare Partners Medical Group Oncology/Hematology-Tenaya	Las Vegas	Nevada	United States	89128
452	Las Vegas Urology - Cathedral Rock	Las Vegas	Nevada	United States	89128
453	Las Vegas Urology - Smoke Ranch	Las Vegas	Nevada	United States	89128
454	OptumCare Cancer Care at MountainView	Las Vegas	Nevada	United States	89128
455	Urology Specialists of Nevada - Northwest	Las Vegas	Nevada	United States	89128
456	Alliance for Childhood Diseases/Cure 4 the Kids Foundation	Las Vegas	Nevada	United States	89135
457	Comprehensive Cancer Centers of Nevada - Town Center	Las Vegas	Nevada	United States	89144
458	Comprehensive Cancer Centers of Nevada-Summerlin	Las Vegas	Nevada	United States	89144
459	Summerlin Hospital Medical Center	Las Vegas	Nevada	United States	89144
460	Las Vegas Cancer Center-Medical Center	Las Vegas	Nevada	United States	89148-2405
461	Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	United States	89148
462	GenesisCare USA - Fort Apache	Las Vegas	Nevada	United States	89148
463	OptumCare Cancer Care at Fort Apache	Las Vegas	Nevada	United States	89148
464	HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills	Las Vegas	Nevada	United States	89149
465	Comprehensive Cancer Centers of Nevada - Central Valley	Las Vegas	Nevada	United States	89169
466	University Cancer Center	Las Vegas	Nevada	United States	89169
467	Hope Cancer Care of Nevada-Pahrump	Pahrump	Nevada	United States	89048
468	Renown Regional Medical Center	Reno	Nevada	United States	89502
469	Saint Mary's Regional Medical Center	Reno	Nevada	United States	89503
470	Radiation Oncology Associates	Reno	Nevada	United States	89509
471	Dartmouth Hitchcock Medical Center	Lebanon	New Hampshire	United States	03756
472	Norris Cotton Cancer Center-Manchester	Manchester	New Hampshire	United States	03102
473	Norris Cotton Cancer Center-Nashua	Nashua	New Hampshire	United States	03063
474	Virtua Memorial	Mount Holly	New Jersey	United States	08060
475	Virtua Voorhees	Voorhees	New Jersey	United States	08043
476	University of New Mexico Cancer Center	Albuquerque	New Mexico	United States	87102
477	Southwest Gynecologic Oncology Associates Inc	Albuquerque	New Mexico	United States	87106
478	Presbyterian Rust Medical Center/Jorgensen Cancer Center	Rio Rancho	New Mexico	United States	87124
479	Women's Cancer Care Associates LLC	Albany	New York	United States	12208
480	Montefiore Medical Center-Einstein Campus	Bronx	New York	United States	10461
481	Montefiore Medical Center-Weiler Hospital	Bronx	New York	United States	10461
482	Montefiore Medical Center - Moses Campus	Bronx	New York	United States	10467
483	Roswell Park Cancer Institute	Buffalo	New York	United States	14263
484	Mount Sinai Chelsea	New York	New York	United States	10011
485	Laura and Isaac Perlmutter Cancer Center at NYU Langone	New York	New York	United States	10016
486	Mount Sinai Hospital	New York	New York	United States	10029
487	University of Rochester	Rochester	New York	United States	14642
488	Dickstein Cancer Treatment Center	White Plains	New York	United States	10601
489	Randolph Hospital	Asheboro	North Carolina	United States	27203
490	Hope Women's Cancer Centers-Asheville	Asheville	North Carolina	United States	28816
491	Cone Health Cancer Center at Alamance Regional	Burlington	North Carolina	United States	27215
492	UNC Lineberger Comprehensive Cancer Center	Chapel Hill	North Carolina	United States	27599
493	Novant Health Presbyterian Medical Center	Charlotte	North Carolina	United States	28204
494	Novant Health Carolina Surgical - Randolph	Charlotte	North Carolina	United States	28207
495	Oncology Specialists of Charlotte	Charlotte	North Carolina	United States	28207
496	Southern Oncology Specialists-Charlotte	Charlotte	North Carolina	United States	28262
497	Southeastern Medical Oncology Center-Clinton	Clinton	North Carolina	United States	28328
498	Duke University Medical Center	Durham	North Carolina	United States	27710
499	Southeastern Medical Oncology Center-Goldsboro	Goldsboro	North Carolina	United States	27534
500	Wayne Memorial Hospital	Goldsboro	North Carolina	United States	27534
501	Cone Health Cancer Center	Greensboro	North Carolina	United States	27403
502	Novant Health Cancer Institute - Huntersville	Huntersville	North Carolina	United States	28078
503	Novant Health Presbyterian Medical Center Huntersville	Huntersville	North Carolina	United States	28078
504	Southern Oncology Specialists-Huntersville	Huntersville	North Carolina	United States	28078
505	Onslow Memorial Hospital	Jacksonville	North Carolina	United States	28546
506	Southeastern Medical Oncology Center-Jacksonville	Jacksonville	North Carolina	United States	28546
507	Novant Health Cancer Institute - Kernersville	Kernersville	North Carolina	United States	27284
508	Matthews Radiation Oncology Center	Matthews	North Carolina	United States	28105
509	Novant Health Cancer Institute - Matthews	Matthews	North Carolina	United States	28105
510	Cone Heath Cancer Center at Mebane	Mebane	North Carolina	United States	27302
511	Lake Norman Radiation Oncology Center-Mooresville	Mooresville	North Carolina	United States	28117
512	Novant Health Cancer Institute - Mooresville	Mooresville	North Carolina	United States	28117
513	Novant Health Cancer Institute - Mount Airy	Mount Airy	North Carolina	United States	27030
514	Duke Women's Cancer Care Raleigh	Raleigh	North Carolina	United States	27607
515	Duke Raleigh Hospital	Raleigh	North Carolina	United States	27609
516	Annie Penn Memorial Hospital	Reidsville	North Carolina	United States	27320
517	Novant Health Cancer Institute - Rowan	Salisbury	North Carolina	United States	28144
518	Rowan Regional Medical Center	Salisbury	North Carolina	United States	28144
519	Novant Health Cancer Institute - Statesville	Statesville	North Carolina	United States	28625
520	Novant Health Cancer Institute - Thomasville	Thomasville	North Carolina	United States	27360
521	Novant Health Cancer Institute - Wilkesboro	Wilkesboro	North Carolina	United States	28659
522	Novant Health Forsyth Medical Center	Winston-Salem	North Carolina	United States	27103
523	Novant Health Oncology Specialists	Winston-Salem	North Carolina	United States	27103
524	Sanford Bismarck Medical Center	Bismarck	North Dakota	United States	58501
525	Essentia Health Cancer Center-South University Clinic	Fargo	North Dakota	United States	58103
526	Sanford South University Medical Center	Fargo	North Dakota	United States	58103
527	Sanford Medical Center Fargo	Fargo	North Dakota	United States	58104
528	Sanford Broadway Medical Center	Fargo	North Dakota	United States	58122
529	Sanford Roger Maris Cancer Center	Fargo	North Dakota	United States	58122
530	Essentia Health - Jamestown Clinic	Jamestown	North Dakota	United States	58401
531	Summa Health System - Akron Campus	Akron	Ohio	United States	44304
532	UHHS-Chagrin Highlands Medical Center	Beachwood	Ohio	United States	44122
533	Indu and Raj Soin Medical Center	Beavercreek	Ohio	United States	45431
534	Strecker Cancer Center-Belpre	Belpre	Ohio	United States	45714
535	Saint Elizabeth Boardman Hospital	Boardman	Ohio	United States	44512
536	Aultman Health Foundation	Canton	Ohio	United States	44710
537	Dayton Physicians LLC-Miami Valley South	Centerville	Ohio	United States	45459
538	Miami Valley Hospital South	Centerville	Ohio	United States	45459
539	Geauga Hospital	Chardon	Ohio	United States	44024
540	Adena Regional Medical Center	Chillicothe	Ohio	United States	45601
541	Good Samaritan Hospital - Cincinnati	Cincinnati	Ohio	United States	45220
542	Oncology Hematology Care Inc-Kenwood	Cincinnati	Ohio	United States	45236
543	Bethesda North Hospital	Cincinnati	Ohio	United States	45242
544	TriHealth Cancer Institute-Westside	Cincinnati	Ohio	United States	45247
545	TriHealth Cancer Institute-Anderson	Cincinnati	Ohio	United States	45255
546	Case Western Reserve University	Cleveland	Ohio	United States	44106
547	MetroHealth Medical Center	Cleveland	Ohio	United States	44109
548	Cleveland Clinic Cancer Center/Fairview Hospital	Cleveland	Ohio	United States	44111
549	Cleveland Clinic Foundation	Cleveland	Ohio	United States	44195
550	Ohio State University Comprehensive Cancer Center	Columbus	Ohio	United States	43210
551	Mount Carmel East Hospital	Columbus	Ohio	United States	43213
552	Columbus Oncology and Hematology Associates Inc	Columbus	Ohio	United States	43214
553	Riverside Methodist Hospital	Columbus	Ohio	United States	43214
554	Grant Medical Center	Columbus	Ohio	United States	43215
555	The Mark H Zangmeister Center	Columbus	Ohio	United States	43219
556	Mount Carmel Health Center West	Columbus	Ohio	United States	43222
557	Doctors Hospital	Columbus	Ohio	United States	43228
558	Good Samaritan Hospital - Dayton	Dayton	Ohio	United States	45406
559	Miami Valley Hospital	Dayton	Ohio	United States	45409
560	Dayton Physician LLC-Miami Valley Hospital North	Dayton	Ohio	United States	45415
561	Miami Valley Hospital North	Dayton	Ohio	United States	45415
562	Delaware Health Center-Grady Cancer Center	Delaware	Ohio	United States	43015
563	Delaware Radiation Oncology	Delaware	Ohio	United States	43015
564	Grady Memorial Hospital	Delaware	Ohio	United States	43015
565	Columbus Oncology and Hematology Associates	Dublin	Ohio	United States	43016
566	Mercy Cancer Center-Elyria	Elyria	Ohio	United States	44035
567	Armes Family Cancer Center	Findlay	Ohio	United States	45840
568	Blanchard Valley Hospital	Findlay	Ohio	United States	45840
569	Orion Cancer Care	Findlay	Ohio	United States	45840
570	Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	United States	45005-1066
571	Dayton Physicians LLC-Atrium	Franklin	Ohio	United States	45005
572	Dayton Physicians LLC-Wayne	Greenville	Ohio	United States	45331
573	Wayne Hospital	Greenville	Ohio	United States	45331
574	Mount Carmel Grove City Hospital	Grove City	Ohio	United States	43123
575	Greater Dayton Cancer Center	Kettering	Ohio	United States	45409
576	First Dayton Cancer Care	Kettering	Ohio	United States	45420
577	Kettering Medical Center	Kettering	Ohio	United States	45429
578	Fairfield Medical Center	Lancaster	Ohio	United States	43130
579	Saint Rita's Medical Center	Lima	Ohio	United States	45801
580	OhioHealth Mansfield Hospital	Mansfield	Ohio	United States	44903
581	Marietta Memorial Hospital	Marietta	Ohio	United States	45750
582	OhioHealth Marion General Hospital	Marion	Ohio	United States	43302
583	Hillcrest Hospital Cancer Center	Mayfield Heights	Ohio	United States	44124
584	UH Seidman Cancer Center at Lake Health Mentor Campus	Mentor	Ohio	United States	44060
585	UH Seidman Cancer Center at Southwest General Hospital	Middleburg Heights	Ohio	United States	44130
586	Knox Community Hospital	Mount Vernon	Ohio	United States	43050
587	Licking Memorial Hospital	Newark	Ohio	United States	43055
588	Newark Radiation Oncology	Newark	Ohio	United States	43055
589	Mercy Health Perrysburg Cancer Center	Perrysburg	Ohio	United States	43551
590	Southern Ohio Medical Center	Portsmouth	Ohio	United States	45662
591	UH Seidman Cancer Center at Firelands Regional Medical Center	Sandusky	Ohio	United States	44870
592	Springfield Regional Cancer Center	Springfield	Ohio	United States	45504
593	Springfield Regional Medical Center	Springfield	Ohio	United States	45505
594	ProMedica Flower Hospital	Sylvania	Ohio	United States	43560
595	ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital	Toledo	Ohio	United States	43606
596	Saint Vincent Mercy Medical Center	Toledo	Ohio	United States	43608
597	Mercy Health - Saint Anne Hospital	Toledo	Ohio	United States	43623
598	Dayton Physicians LLC-Upper Valley	Troy	Ohio	United States	45373
599	Upper Valley Medical Center	Troy	Ohio	United States	45373
600	University Hospitals Sharon Health Center	Wadsworth	Ohio	United States	44281
601	Saint Joseph Warren Hospital	Warren	Ohio	United States	44484
602	Saint Ann's Hospital	Westerville	Ohio	United States	43081
603	UH Seidman Cancer Center at Saint John Medical Center	Westlake	Ohio	United States	44145
604	UHHS-Westlake Medical Center	Westlake	Ohio	United States	44145
605	Saint Elizabeth Youngstown Hospital	Youngstown	Ohio	United States	44501
606	Genesis Healthcare System Cancer Care Center	Zanesville	Ohio	United States	43701
607	University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	United States	73104
608	Mercy Hospital Oklahoma City	Oklahoma City	Oklahoma	United States	73120
609	Oklahoma Cancer Specialists and Research Institute-Tulsa	Tulsa	Oklahoma	United States	74146
610	Saint Alphonsus Medical Center-Baker City	Baker City	Oregon	United States	97814
611	Saint Charles Health System	Bend	Oregon	United States	97701
612	Clackamas Radiation Oncology Center	Clackamas	Oregon	United States	97015
613	Providence Cancer Institute Clackamas Clinic	Clackamas	Oregon	United States	97015
614	Bay Area Hospital	Coos Bay	Oregon	United States	97420
615	Providence Newberg Medical Center	Newberg	Oregon	United States	97132
616	Saint Alphonsus Medical Center-Ontario	Ontario	Oregon	United States	97914
617	Legacy Good Samaritan Hospital and Medical Center	Portland	Oregon	United States	97210
618	Providence Portland Medical Center	Portland	Oregon	United States	97213
619	Providence Saint Vincent Medical Center	Portland	Oregon	United States	97225
620	Saint Charles Health System-Redmond	Redmond	Oregon	United States	97756
621	Legacy Meridian Park Hospital	Tualatin	Oregon	United States	97062
622	Jefferson Abington Hospital	Abington	Pennsylvania	United States	19001
623	Bryn Mawr Hospital	Bryn Mawr	Pennsylvania	United States	19010
624	Christiana Care Health System-Concord Health Center	Chadds Ford	Pennsylvania	United States	19317
625	Main Line Health Center-Collegeville	Collegeville	Pennsylvania	United States	19426
626	Main Line Health Center-Exton	Exton	Pennsylvania	United States	19341
627	Jefferson Hospital	Jefferson Hills	Pennsylvania	United States	15025
628	Riddle Memorial Hospital	Media	Pennsylvania	United States	19063
629	Forbes Hospital	Monroeville	Pennsylvania	United States	15146
630	Paoli Memorial Hospital	Paoli	Pennsylvania	United States	19301
631	Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	United States	19107
632	Allegheny General Hospital	Pittsburgh	Pennsylvania	United States	15212
633	West Penn Hospital	Pittsburgh	Pennsylvania	United States	15224
634	Chester County Hospital	West Chester	Pennsylvania	United States	19380
635	Reading Hospital	West Reading	Pennsylvania	United States	19611
636	Wexford Health and Wellness Pavilion	Wexford	Pennsylvania	United States	15090
637	Asplundh Cancer Pavilion	Willow Grove	Pennsylvania	United States	19090
638	Lankenau Medical Center	Wynnewood	Pennsylvania	United States	19096
639	Women and Infants Hospital	Providence	Rhode Island	United States	02905
640	AnMed Health Cancer Center	Anderson	South Carolina	United States	29621
641	Gibbs Cancer Center-Gaffney	Gaffney	South Carolina	United States	29341
642	Saint Francis Hospital	Greenville	South Carolina	United States	29601
643	Saint Francis Cancer Center	Greenville	South Carolina	United States	29607
644	Gibbs Cancer Center-Pelham	Greer	South Carolina	United States	29651
645	Spartanburg Medical Center	Spartanburg	South Carolina	United States	29303
646	MGC Hematology Oncology-Union	Union	South Carolina	United States	29379
647	Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	United States	57104
648	Avera Cancer Institute	Sioux Falls	South Dakota	United States	57105
649	Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	United States	57117-5134
650	Memorial Hospital	Chattanooga	Tennessee	United States	37404
651	Pulmonary Medicine Center of Chattanooga-Hixson	Hixson	Tennessee	United States	37343
652	Memorial GYN Plus	Ooltewah	Tennessee	United States	37363
653	Dell Seton Medical Center at The University of Texas	Austin	Texas	United States	78701
654	Saint Joseph Regional Cancer Center	Bryan	Texas	United States	77802
655	Parkland Memorial Hospital	Dallas	Texas	United States	75235
656	UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	United States	75390
657	Houston Methodist Hospital	Houston	Texas	United States	77030
658	M D Anderson Cancer Center	Houston	Texas	United States	77030
659	Methodist Willowbrook Hospital	Houston	Texas	United States	77070
660	Houston Methodist Sugar Land Hospital	Sugar Land	Texas	United States	77479
661	Providence Regional Cancer System-Aberdeen	Aberdeen	Washington	United States	98520
662	Overlake Medical Center	Bellevue	Washington	United States	98004
663	PeaceHealth Saint Joseph Medical Center	Bellingham	Washington	United States	98225
664	Harrison HealthPartners Hematology and Oncology-Bremerton	Bremerton	Washington	United States	98310
665	Harrison Medical Center	Bremerton	Washington	United States	98310
666	Highline Medical Center-Main Campus	Burien	Washington	United States	98166
667	Providence Regional Cancer System-Centralia	Centralia	Washington	United States	98531
668	Swedish Cancer Institute-Edmonds	Edmonds	Washington	United States	98026
669	Saint Elizabeth Hospital	Enumclaw	Washington	United States	98022
670	Providence Regional Cancer Partnership	Everett	Washington	United States	98201
671	Saint Francis Hospital	Federal Way	Washington	United States	98003
672	Swedish Cancer Institute-Issaquah	Issaquah	Washington	United States	98029
673	Kadlec Clinic Hematology and Oncology	Kennewick	Washington	United States	99336
674	Providence Regional Cancer System-Lacey	Lacey	Washington	United States	98503
675	Saint Clare Hospital	Lakewood	Washington	United States	98499
676	PeaceHealth Saint John Medical Center	Longview	Washington	United States	98632
677	Jefferson Healthcare	Port Townsend	Washington	United States	98368
678	Harrison HealthPartners Hematology and Oncology-Poulsbo	Poulsbo	Washington	United States	98370
679	Valley Medical Center	Renton	Washington	United States	98055
680	Pacific Gynecology Specialists	Seattle	Washington	United States	98104
681	Swedish Medical Center-Ballard Campus	Seattle	Washington	United States	98107
682	Fred Hutchinson Cancer Research Center	Seattle	Washington	United States	98109
683	Seattle Cancer Care Alliance	Seattle	Washington	United States	98109
684	Kaiser Permanente Washington	Seattle	Washington	United States	98112
685	Swedish Medical Center-First Hill	Seattle	Washington	United States	98122-4307
686	Swedish Medical Center-Cherry Hill	Seattle	Washington	United States	98122-5711
687	University of Washington Medical Center - Montlake	Seattle	Washington	United States	98195
688	PeaceHealth United General Medical Center	Sedro-Woolley	Washington	United States	98284
689	Providence Regional Cancer System-Shelton	Shelton	Washington	United States	98584
690	Franciscan Research Center-Northwest Medical Plaza	Tacoma	Washington	United States	98405
691	Northwest Medical Specialties PLLC	Tacoma	Washington	United States	98405
692	PeaceHealth Southwest Medical Center	Vancouver	Washington	United States	98664
693	Legacy Salmon Creek Hospital	Vancouver	Washington	United States	98686
694	Providence Saint Mary Regional Cancer Center	Walla Walla	Washington	United States	99362
695	North Star Lodge Cancer Center at Yakima Valley Memorial Hospital	Yakima	Washington	United States	98902
696	Providence Regional Cancer System-Yelm	Yelm	Washington	United States	98597
697	West Virginia University Charleston Division	Charleston	West Virginia	United States	25304
698	Duluth Clinic Ashland	Ashland	Wisconsin	United States	54806
699	Northwest Wisconsin Cancer Center	Ashland	Wisconsin	United States	54806
700	Aurora Cancer Care-Southern Lakes VLCC	Burlington	Wisconsin	United States	53105
701	Marshfield Clinic-Chippewa Center	Chippewa Falls	Wisconsin	United States	54729
702	Marshfield Medical Center-EC Cancer Center	Eau Claire	Wisconsin	United States	54701
703	Mayo Clinic Health System-Eau Claire Clinic	Eau Claire	Wisconsin	United States	54701
704	Aurora Health Center-Fond du Lac	Fond Du Lac	Wisconsin	United States	54937
705	Aurora Health Care Germantown Health Center	Germantown	Wisconsin	United States	53022
706	Aurora Cancer Care-Grafton	Grafton	Wisconsin	United States	53024
707	Aurora BayCare Medical Center	Green Bay	Wisconsin	United States	54311
708	Essentia Health-Hayward Clinic	Hayward	Wisconsin	United States	54843
709	Aurora Cancer Care-Kenosha South	Kenosha	Wisconsin	United States	53142
710	Gundersen Lutheran Medical Center	La Crosse	Wisconsin	United States	54601
711	Marshfield Clinic - Ladysmith Center	Ladysmith	Wisconsin	United States	54848
712	University of Wisconsin Carbone Cancer Center	Madison	Wisconsin	United States	53792
713	Aurora Bay Area Medical Group-Marinette	Marinette	Wisconsin	United States	54143
714	Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	United States	54449
715	Aurora Cancer Care-Milwaukee	Milwaukee	Wisconsin	United States	53209
716	Aurora Saint Luke's Medical Center	Milwaukee	Wisconsin	United States	53215
717	Aurora Sinai Medical Center	Milwaukee	Wisconsin	United States	53233
718	Marshfield Clinic-Minocqua Center	Minocqua	Wisconsin	United States	54548
719	Cancer Center of Western Wisconsin	New Richmond	Wisconsin	United States	54017
720	Vince Lombardi Cancer Clinic - Oshkosh	Oshkosh	Wisconsin	United States	54904
721	Aurora Cancer Care-Racine	Racine	Wisconsin	United States	53406
722	Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	United States	54868
723	Vince Lombardi Cancer Clinic-Sheboygan	Sheboygan	Wisconsin	United States	53081
724	Essentia Health-Spooner Clinic	Spooner	Wisconsin	United States	54801
725	Marshfield Medical Center-River Region at Stevens Point	Stevens Point	Wisconsin	United States	54482
726	Aurora Medical Center in Summit	Summit	Wisconsin	United States	53066
727	Essentia Health Saint Mary's Hospital - Superior	Superior	Wisconsin	United States	54880
728	Vince Lombardi Cancer Clinic-Two Rivers	Two Rivers	Wisconsin	United States	54241
729	Marshfield Clinic-Wausau Center	Wausau	Wisconsin	United States	54401
730	Aurora Cancer Care-Milwaukee West	Wauwatosa	Wisconsin	United States	53226
731	Aurora West Allis Medical Center	West Allis	Wisconsin	United States	53227
732	Marshfield Medical Center - Weston	Weston	Wisconsin	United States	54476
733	Marshfield Clinic - Wisconsin Rapids Center	Wisconsin Rapids	Wisconsin	United States	54494
734	Cheyenne Regional Medical Center-West	Cheyenne	Wyoming	United States	82001
735	Billings Clinic-Cody	Cody	Wyoming	United States	82414
736	Welch Cancer Center	Sheridan	Wyoming	United States	82801

Sponsors and Collaborators

• National Cancer Institute (NCI)
• NRG Oncology

Investigators

• Principal Investigator: Helen J Mackay, NRG Oncology

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: National Cancer Institute (NCI)
• ClinicalTrials.gov Identifier: NCT03660826
• Other Study ID Numbers: NCI-2017-01672; NCI-2017-01672; NRG-GY012; NRG-GY012; U10CA180868
• First Posted: Sep 7, 2018
• Last Update Posted: Aug 25, 2022
• Last Verified: May 1, 2022

• Studies a U.S. FDA-regulated Drug Product: Yes
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Adenocarcinoma; Endometrial Neoplasms; Cystadenocarcinoma, Serous; Carcinoma, Endometrioid; Carcinoma; Recurrence; Durvalumab; Olaparib; Cediranib; Poly(ADP-ribose) Polymerase Inhibitors; Immunoglobulins; Antibodies, Monoclonal; Immunoglobulin G; Maleic acid

Study Results

No Results Posted as of Aug 25, 2022