Identification of Endometriosis and Migraine Criteria in Women With the Comorbidity of Both Conditions in Comparison With Women Who Only Suffer From Endometriosis - A Pilot Study
Study Details
Study Description
Brief Summary
Patients with both, migraine and endometriosis, present the case-group, while women with endometriosis without migraine serve as controls. The primary endpoint is endometriosis stage confirmed by laparascopy compared to the control group. Further points to compare between groups are infertility, dysmenorrhea, dyschezia, dyspareunia, number of operations, family history with first-degree relatives, and age of first symptoms for both conditions and age at first operation.
Secondary endpoints to evaluate in percentages within the migraine group are migraine frequency, migraine aura/non-aura, age at migraine start, hormonal migraine, family history, treatment response, response to prophylactic agents, localization, types of aura and triggers. Other medical conditions and comorbidities like depression will be noted as well as response to Dienogest treatment.
In the questionnaire we will ask 62 Questions overall. The Questions for endometriosis are based on a questionnaire from the world endometriosis research foundation and to evaluate the severity of the migraine we will use the MIDAS (Migraine Disability Assessment) questionnaire (8).
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Endometriosis & Migraine Premenopausal women aged 18-55 years, at time of operation Endometriosis confirmed with surgery and histologic staging (Report of the surgery available) For the cases migraine needs to be confirmed during the interview according to the IHS criteria. |
Other: Questionaire
only questionaire
|
Endometriosis Premenopausal women aged 18-55 years, at time of operation Endometriosis confirmed with surgery and histologic staging (Report of the surgery available) |
Other: Questionaire
only questionaire
|
Outcome Measures
Primary Outcome Measures
- Endometriosis stage [4 years]
endometriosis stage confirmed by laparascopy compared to the control group
Secondary Outcome Measures
- infertility, dysmenorrhea, dyschezia, dyspareunia, number of operations [4 years]
s.o.
- and age of first symptoms for both conditions and age at first operation [4 years]
s.o.
- family history with first-degree relatives, [4 years]
s.o.
- Secondary endpoints to evaluate in percentages within the migraine group are migraine frequency, migraine aura/non-aura, age at migraine start, hormonal migraine, family history, treatment response, [4 years]
s.o.
- response to prophylactic agents, localization, types of aura and triggers. Other medical conditions and comorbidities like depression will be noted [4 years]
s.o.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Premenopausal women aged 18-55 years, at time of operation
-
Endometriosis confirmed with surgery and histologic staging (Report of the surgery available)
-
For the cases migraine needs to be confirmed during the interview according to the IHS criteria.
Exclusion Criteria:
• Inability to perform the interview (insufficient knowledge of language, psychological disorder, dementia)
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Universitätsspital Zürich | Zürich | Switzerland | 8008 |
Sponsors and Collaborators
- Zurich University of Applied Sciences
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2021-00285