Endoscopy in CKD With Iron Deficiency Anemia
Study Details
Study Description
Brief Summary
Iron deficiency anemia is very common in CKD patients. Data about gastrointestinal lesions in Arab patients are insufficient.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Anemia is a prevalent complication of renal diseases, and its magnitude intensifies as glomerular filtration rate deteriorates. Other factors causing anemia include iron, folate, or cobalamin deficit, hemolytic anemia, digestive system losses, bone marrow failure and erythropoietin resistance. Moreover, Uremia causes changes at several levels of the digestive system and there is a higher rate of gastrointestinal disorders in patients with chronic kidney disease (CKD).
Endoscopic disorders are predicted to be present in 40-90% of CKD patients. Asymptomatic individuals represent a diagnostic issue since they may be detected only during routine tests performed, or they may manifest with unusual non gastrointestinal complaints. Furthermore, asymptomatic malignancy of gastrointestinal system could exhibit a deceive clinical picture in the form of unexplained iron deficiency anemia, and discrimination of these pathologies is essential to minimize the eventual poor outcomes of these disorders in CKD patients.Data about gastrointestinal lesions in Arab patients are insufficient.
Thus aims of this study 1. To assess presence of potential GI disorders in CKD patients with iron deficiency anemia who don't have gastrointestinal symptoms.
- To assess the risk factors contributing to the various endoscopic findings.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Group 1 Chronic kidney diseases patients with iron deficiency anemia and eGFR ≥ 60 ml/min/1.73 m2 |
Procedure: Upper GIT endoscopy
Upper gastrointestinal endoscpy for all participants and gastric biopsy for histopathological examination for suspicious lesions
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| Group 2 Chronic kidney diseases patients with iron deficiency anemia and eGFR < 60 ml/min/1.73 m2. |
Procedure: Upper GIT endoscopy
Upper gastrointestinal endoscpy for all participants and gastric biopsy for histopathological examination for suspicious lesions
|
Outcome Measures
Primary Outcome Measures
- Rate of upper gastrointestinal endoscopic findings In chronic kidney disease patients with iron deficiency anemia [6 months]
Detect rate of upper GIT lesions in asymptomatic CKD patients with iron deficiency anemia using endoscopy followed by biopsy and histopathological examination
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patients consent to enter the study.
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CKD patients grade 1 to grade 5.
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Iron deficiency anemia without gastrointestinal symptoms.
Exclusion Criteria:
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Patients refusing to enter the study.
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Patients having gastrointestinal symptoms.
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Active infection, malignancy and hemolytic anemia.
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Advanced liver disease or cirrhosis.
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Folate or cobalamin deficiency.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Zagazig university | Zagazig | Egypt |
Sponsors and Collaborators
- Walid Ahmed Ragab Abdelhamid
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 9145/2-2-2022